Nucleic Acids Research publication: New study reveals how targeting transcription termination can boost the impact of WEE1 inhibitors in cancer therapy
Scientists from the Department of Radiation Biology report a new strategy to enhance the effectiveness of WEE1 inhibitor–based cancer treatment, published recently in Nucleic Acids Research. The study shows that disrupting transcription termination — the process that properly stops RNA synthesis — significantly increases DNA damage and cancer cell death when combined with the WEE1 inhibitor adavosertib.
