Publication in Nature Immunology from Malmberg group
A paper entitled "Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping" was published in the highly ranked journal Nature Immunology on July 2. This work will be an important resource when designing new NK cell therapies.
The authors have been analyzing transcriptional data from 427 patients and 39 datasets, including 7 solid tumor types (lung, brain, skin, pancreas, prostate, breast, sarcoma). They could identify 6 different functional states of tumor-infiltrating NK cells, and the state of the NK cells correlate with survival for cancer patients.
