Llorente/Sandvig publish potential biomarkers for prostate cancer
Llorente (left) and Sandvig
Alicia Llorente and Kirsten Sandvig, Department of Biochemistry, Institute for Cancer Research and Centre for Cancer Biomedicine, have recently published in Molecular and Cellular Proteomics (impact factor 8.4) a proteomic analysis of microvesicles released from a human prostate cancer cell line. Most of the 266 proteins identified have previously been reported to be present in vesicles released from other cell types, but several proteins seem to be specific for prostate cancer cells. Since microvesicles can reach biological fluids, these proteins are thus potentially useful as new non invasive biomarkers for detection, diagnosis and/or prognosis of prostate cancer.
From major journals, first or last author from the Institute for Cancer Research
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Lund-Andersen C, Torgunrud A, Kanduri C, Dagenborg VJ, Frøysnes IS, Larsen MM, Davidson B, Larsen SG, Flatmark K(2024) Novel drug resistance mechanisms and drug targets in BRAF-mutated peritoneal metastasis from colorectal cancer J Transl Med, 22(1), 646 DOI 10.1186/s12967-024-05467-2, PubMed 38982444
Andresen NK, Røssevold AH, Borgen E, Schirmer CB, Gilje B, Garred Ø, Lømo J, Stensland M, Nordgård O, Falk RS, Mathiesen RR, Russnes HG, Kyte JA, Naume B(2024) Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors - a biomarker analysis of the ALICE and ICON trials Mol Oncol(in press) DOI 10.1002/1878-0261.13675, PubMed 38978352