Institute seminars spring semester 2010 First seminar: Anne-Lise Børresen-Dale Jan 13 at 10.30
The list over research seminars held at the Institute for Cancer Research for the spring season of 2010 is now available.
Click here to view the list.
The first seminar is held by Anne-Lise Børresen-Dale on Wednesday Janury 13th at 10.30 in the Auditorium (please note the time!)
Title of her talk: Exploring the systems pathology/ biology of breast cancer
Anne-Lise Børresen-Dale
Department of Genetics
Exploring the systems pathology/ biology of breast cancer
Abstract
Microarray technologies, applied to the study of DNA/mRNA/miRNA, can be used to portray a tumor's detailed phenotype in its unique context, and to generate molecular signatures that will improve our understanding of the causes and progression of the disease, for the discovery of new molecular markers, for therapeutic intervention and for developing new prevention strategies. We have performed such analyses of more than 1000 breast carcinomas of different stages and histological types aiming at novel tumour classification that can predict survival and treatment response. The effect of the patients own genotype on developing specific molecular profiles in tumor tissue, and genotypes influencing the specific patterns of gene activations that predict important clinical features, like sensitivity to specific therapies and metastatic potential is explored. By integrating data from DNA, mRNA, miRNA and protein we seek to reach a more fundamental understanding of the biological dynamics of breast cancer. This will facilitate identification of risk factors, search for novel cancer diagnostics, prediction of therapeutic effects and prognosis and identification of new targets for therapy.
Links:
Anne-Lise Børresen-Dale's research group: Molecular Biology of Breast Cancer