Publication in PNAS on the DNA glycosylase Neil3 by research group of Magnar Bjørås
The research group of Magnar Bjørås have recently published a paper in Proceedings of the National Academy of Sciences of the U.S.A (journal impact factor 9.77), entitled "Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia".
Inadequate oxygen availability before or during birth - birth asphyxia - may cause brain damage and death among infants. Lifelong disability is often a consequence, despite the plasticiy of the newborn brain, which to a certain degree has the ability to repair itself. Understanding the mechanisms underlying the regeneration of damaged brain tissue is crucial for finding new methods leading to therapeutical improvements.
Inadequate oxygen availability before or during birth - birth asphyxia - may cause brain damage and death among infants. Lifelong disability is often a consequence, despite the plasticiy of the newborn brain, which to a certain degree has the ability to repair itself. Understanding the mechanisms underlying the regeneration of damaged brain tissue is crucial for finding new methods leading to therapeutical improvements.
Summary, by the authors:
Expression of the DNA glycosylase endonuclease VIII-like 3 (Neil3) is confined to regenerative subregions in the embryonic and perinatal brains. Here we show profound neuropathology in Neil3-knockout mice characterized by a reduced number of microglia and loss of proliferating neuronal progenitors in the striatum after hypoxia-ischemia. In vitro expansion of Neil3-deficient neural stem/progenitor cells revealed an inability to augment neurogenesis and a reduced capacity to repair for oxidative base lesions in single-stranded DNA. We propose that Neil3 exercises a highly specialized function through accurate molecular repair of DNA in rapidly proliferating cells.
Links:
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia.
Sejersted Y, Hildrestrand GA, Kunke D, Rolseth V, Krokeide SZ, Neurauter CG, Suganthan R, Atneosen-Åsegg M, Fleming AM, Saugstad OD, Burrows CJ, Luna L, Bjørås M.
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18802-7. Epub 2011 Nov 7.
Link to PubMed - Link to PDF version
Home page of the Magnar Bjørås group - Laboratory for molecular biology
Magnar Bjørås's publications
Centre for Molecular Biology and Neuroscience (CMBN)
News article (in Norwegian) from the home page of Oslo University Hospital:
Reparasjonsprotein stimulerer dannelse av nytt nervevev
Expression of the DNA glycosylase endonuclease VIII-like 3 (Neil3) is confined to regenerative subregions in the embryonic and perinatal brains. Here we show profound neuropathology in Neil3-knockout mice characterized by a reduced number of microglia and loss of proliferating neuronal progenitors in the striatum after hypoxia-ischemia. In vitro expansion of Neil3-deficient neural stem/progenitor cells revealed an inability to augment neurogenesis and a reduced capacity to repair for oxidative base lesions in single-stranded DNA. We propose that Neil3 exercises a highly specialized function through accurate molecular repair of DNA in rapidly proliferating cells.
Links:
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia.
Sejersted Y, Hildrestrand GA, Kunke D, Rolseth V, Krokeide SZ, Neurauter CG, Suganthan R, Atneosen-Åsegg M, Fleming AM, Saugstad OD, Burrows CJ, Luna L, Bjørås M.
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18802-7. Epub 2011 Nov 7.
Link to PubMed - Link to PDF version
Home page of the Magnar Bjørås group - Laboratory for molecular biology
Magnar Bjørås's publications
Centre for Molecular Biology and Neuroscience (CMBN)
News article (in Norwegian) from the home page of Oslo University Hospital:
Reparasjonsprotein stimulerer dannelse av nytt nervevev