Groundbreaking Study Identifies Six New Cancer Susceptibility Genes
In a collaborative effort, an international team of researchers, including Eivind Hovig and Mev Dominguez-Valentin from the Department of Tumor Biology at the Institute for Cancer Research, has identified six new cancer susceptibility genes using gene-based burden tests of rare germline variants. This significant discovery enhances the understanding of genetic predispositions to cancer. The results have recently been published in the prestigious journal Nature Genetics.
Links:
The Nature Genetics publication:
Ivarsdottir EV, Gudmundsson J, Tragante V, Sveinbjornsson G, Kristmundsdottir S, Stacey SN, Halldorsson GH, Magnusson MI, Oddsson A, Walters GB, Sigurdsson A, Saevarsdottir S, Beyter D, Thorleifsson G, Halldorsson BV, Melsted P, Stefansson H, Jonsdottir I, Sørensen E, Pedersen OB, Erikstrup C, Bøgsted M, Pøhl M, Røder A, Stroomberg HV et al. (2024)
Gene-based burden tests of rare germline variants identify six cancer susceptibility genes
Nat Genet (in press)
DOI 10.1038/s41588-024-01966-6, PubMed 39472694
Previous ous-research.no news articles about Mev Dominguez-Valentin:
Dr Ragnar Mørk´s Prize for Excellent Cancer Research 2023 to Mev Dominguez-Valentin (11.12.2023)
Inherited and Familial Cancer Project Group, headed by Mev Dominguez-Valentin
Computational Cancer Genomics and Melanoma Systems Biology, headed by Eivind Hovig