The Scientific Advisory Board in NorHead – the Norwegian Centre for Headache Research – met in Trondheim to discuss the new projects. The Board is led by Aamodt and with Prof Hans Chr Diener, Essen, Professor Messoud Ashina from Copenhagen, Professor Simona Sacco from L` Aquila in Italy, Professor Peter Goadsby, London, and Prof. Hedvig Nordeng, Oslo as members. https://www.ntnu.no/norhead
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The Nordic Chronic Migraine Trial of CGRP monoclonal antibody and onabotulinumtoxin A dual therapy – a randomized-controlled double-blind trial (NorMig) – a new RCT led by Aamodt was awarded 9 mill NOK from the South Eastern Health Authority in December 2023
Individuell-innstillingsliste-tematisk-apen.pdf
In collaboration with the Department of Ophthalmology at Oslo University Hospital, the Department of Neurology is involved in several projects on visual impairment in stroke. The randomized placebo-controlled international study with tenecteplase in CRAO – TenCRAOS – led by Aamodt - ongoing in 7 countries is approaching the final inclusion. So far, 61 patients are included. Another key study in this field is the StrokeVIS study is also soon finalizing the inclusions. In this study the nurses are unsing the VISA tool in acute stroke patients assessing visual impairments. These assessments are compared to the gold standard, assessments by orthoptist Anna-Katharina Litzen-Jørstad, from the Department of Ophthalmology. During the project period she has been working at the Department of Neurology two days a week. Both studies are part of Stephen J. Ryan's PhD project.
Dr. Barbara Ratajczak-Tretel was created with PhD after the dissertation with dataa from the Nordic atrial fibrillation and stroke (NOR-FIB) study on the 24th November 2023. She has contributed in all phases of this international multicenter study and her thesis “Uncovering underlying aetiologies in cryptogenic stroke: The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study”, she has focused on long-term follow-up to uncover etiology in patients with cryptogenic cerebral infarction and TIA. After one-year follow-up of the patients in with cryptogenic stroke and TIA in NOR-FIB almost half of the patients had the etiology revealed. Nearly 30% of the patients had paroxysmal atrial fibrillation and cardioembolism as the probable cause.1 in 5 had a different etiology revealed, despite the fact that the etiology was unknown after thorough investigation initially. The NOR-FIB study has been led from the neurology department at OUS by Anne Hege Aamodt, who has also been Barbara's main supervisor. Prof. Dan Atar, Head of Research, Division of Medicine, Oslo University Hospital and University of Oslo. Prof. Erik Taubøll was the defense supervisor, Prof. Ana Catarina Fonseca from the University of Lisbon was the first opponent, Prof. Maja-Lisa Løchen from the University of Tromsø was the second opponent and Prof. Bjørnar Hassel was the committee leader.
The Brain Awareness Week was opened at Oslo University Hospital - Rikshospitalet on with a headache meeting in collaboration with the user organization Hodepine Norge, represented here by chairperson Tine Pole and secretary general Laila Mathisen together with the headache team at Oslo University hospital - Ass.Prof. Anne Hege Aamodt and dr. Bendik Winsvold. During the meeting, the winner of the award for the most head-friendly workplace was also announced - it was DNB. Many employees will benefit from this. There were many attendees and in addition over 150 who participated digitally.
The stroke meeting was held on the 21st November in the main auditorium at Oslo University Hospital in collaboration with all four stroke user organizations - LHL Stroke and Aphasia, the National Association for Stroke, the Norwegian Association for Stroke and the Norwegian Association of the Blind and Partially Sighted. The meeting was streamed with many online participants in addition to on-site participants.
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The Nordic Moyamoya study meeting was held in Oslo on 2nd-3rd of November with Prof. Anna Bersano from Milan and participants from the Nordic countries. The Nordic sites are building up collaborating on clinical work and research projects.
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Dr. Jesper Sømark, the coordinator in the moyamoya project at Oslo University Hospital, has presented moyamoya in the podcast for rare diseases “Sjeldenpodden”
Listen to an impressing patient history on Spotify, Apple podcast. Full text version of the podcast is available Sjeldenpoddens nettside.
Prof. Götz Thomalla, Aamodt and Prof. Martin Bendszuz.
The trial was presented by Prof. Martin Bendzus, Heidelberg at World Stroke Congress in Toronto i October. The results demonstrate the effect of endovascular therapy in patients with large core infarcts -18% absolute increase in patients able to walk unaided and 11% decreased mortality.
The study was led from Hamburg (Prof. Götz Thomalla) and Heidelberg (Prof. Martin Bendszus). Aamodt was national lead in Norway and PI at Oslo University Hospital – including 90% of the Norwegian patients in the study.
World Congress of Neurology is arranged every second year and is an important forum for strengthening neurology globally. Anne Hege Aamodt is chairing the Constitution and Bylaws Committee – the picture is from the committee meeting in Montreal https://worldneurologyonline.com/article/the-wfn-inside-continued-the-constitution-bylaws-committee-and-the-neurosonology-specialty-group/
The first biomarker results from the NOR-FIB study were presented at EAN 2023. PhD student Anna is the first author of this sub study that was presented by the Chief Investigator Anne Hege Aamodt. The study is published in the European Journal of Neurology https://onlinelibrary.wiley.com/doi/10.1111/ene.15746
Brain Health was the main topic at several sessions during the EAN Congress. Anne Hege Aamodt chaired the session on July 1st where Professor Giovanni B Frisoni from University of Geneva, Dr. Agne Straukiene from Torbay and South Devon NHS Foundation Trust and Orla Galvin Executive Director of the European Federation of Neurological Associations (EFNA) and dr Harris Eyre from Brain Capital Alliance; OECD Neuroscience-inspired Policy Initiative, USA (hybrid) gave their talks.Also, the NeuroCOVID, NorMoyamoya and the TenCRAOS trial were presented at the EAN Congress.
New data demonstrating decreasing incidence on stroke and dementia in Norway has been published by an international group working with brain health led by Prof Vladimir Hachinski, previous president of the World Federation of Neurology and founder of World Brain Alliance. Among the members are the president of the EAN Paul Boon and Anne Hege Aamodt. The paper was published in the European Journal of Neurology in May https://onlinelibrary.wiley.com/doi/10.1111/ene.15836 with an editorial.
Representatives from the Nordic moyamoya centres in the Nordic countries met at ESOC to discuss collaboration. The interest of collaborations is strong and there will be a follow-up hybrid meeting in Oslo November 3rd. If you are interested in participation, please contact a.h.aamodt@medisin.uio.no
Professor Michael Hill from University of Calgary was invited as the main speaker on the meeting. Participants from all parts of Norway contributed to this meeting arranged by the Norwegian Strok Organisation and the Norwegian Neuroradiological Association – both parts of the Norwegian Medical Asscoiation. Anne Hege Aamodt was the chair of the meeting.
TenCRAOS investigators from Australia and the European countries met at ESOC and the study was presented by PhD student Stephen J. Ryan during the congress. Thanks to all the investigators for contributions to the strong recruitement in TenCRAOS trial!
New results published in NEJM on thrombectomy in large core infarcts. As a consequence of the results of these trials the TENSION trial, led from Hamburg and Heidelberg and with Aamodt as the national lead in Norway, has completed the inclusions. The results will be presented later this year.
More information:
Ny forskning: – Stort fremskritt for trombektomi for de aller mest alvorlige hjerneslagene (Interview with Aamodt published in Dagens Medisin, 20.02.2023)
The TenCRAOS, NorVIS and StrokeVIS project presented in media by PhD student Stephen J. Ryan and Prof. Helle Falkenberg and Aamodt. The TenCRAOS is ongoing in 8 countries. 30 of 78 patients have been included so far. Visual impairment after stroke is very common. The NorVIS and StrokeVIS studies are focusing on lifting the burden of visual impairment after stroke and improving health care.
Congratulations to Prof Helle Falkenberg with the LHL Hjerneslag and Afasi Honorary Award 2023!
The National Heart & Brain Conference was arranged in Oslo February 16-17th 2023 in the tradition after David Russell who founded this multidisciplinary conference. All Norwegian health regions were represented among the participants, speakers and moderators.
The program committee consisted of Prof Dan Atar, Dr Kristoffer Russell, Prof Mona Skjelland, Dr Christian G. Lund, Dr. Stephen J. Ryan and Anne Hege Aamodt (Chair of the conference).
The Scientific Advisory Board (SAB) of the Norwegian Centre for Headache Research – NorHEAD – is led by Aamodt and with Prof Hans Christoph Diener (Germany), Simona Sacco (Italy), Peter Goadsby (UK) and Messoud Ashina (Denmark) in the board. The first meeting in the SAB was arranged on February 9-10th in Trondheim where the planned and ongoing projects in NorHEAD led by Director Prof Erling Tronvik were discussed.
A study led by Anne Hege Aamodt, head of the "Stroke, headache and covid research group" at the Department of Neurology and cardiologist Dan Atar has shown that atrial fibrillation is the hidden cause of stroke in many patients, and that long-term heart rhythm monitoring of patients can prevent recurrent strokes in this group.
The results are presented in the European Stroke Journal. The findings have been summarized in a news article on sciencenorway.no, the English version of the award-winning popular science web site forskning.no, and presented via major Norwegian news outlets.
Brain Health perspectives and lifestyle was the topic The Norwegian Research Days - "Forskningsdagene" - at Lillestrøm Innovation Centre the September 30th with Aamodt as lecturer.
Aamodt is part of the CHARGE Consortium and a co-author of the paper:
Stroke genetics informs drug discovery and risk prediction across ancestries
Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Daniel C. Posner, et al.
Nature. 2022 Sep 30:1-15. doi: 10.1038/s41586-022-05165-3.
PMID: 36180795
On the 22nd of September the moyamoya team at Oslo University Hospital arranged a course for patients with moyamoy and ther next-of-kin. In 2021 Aamodt got grants from Through a pilot project with previous grants from Dam and Odd Fellow to a quality project in moyamoya. In cooperation with the user organisation Norwegian Heart and Lung Patient Association and our user panel at the Division of Clinical Neuroscience, Oslo University Hospital, we have streamlined the workflow with a structured «one-door-in» strategy and state of the art diagnostic work-up for treatment and follow-up of moyamoya patients in Norway. We have established courses led by the moyamoya team and user representatives covering central topics including information on disease and treatment, coping strategies, lifestyle factors and networking platforms for patients and next-of-kin.
TenCRAOS started in Stavanger. Aamodt led the start-up meeting at Stavanger University Hospital – the last hospital in Norway to be activated. The trial has now 26 active sites with 18 of 78 patients included in the trial.
The TenCRAO trial presented at the 22nd Euretina Congress in Hamburg - EURETINA – European Society of Retina Specialists. Aamodt was invited by the organizer to present the trial at the congress during the research session.
https://euretina.org/resource/euretina-session-research-session-2/
The Norwegian Centre for Headache Research (NorHEAD) in Trondheim was opened the on 1st of September and will carry out world-leading research on headache disorders. NorHEAD is a Centre for Clinical Treatment Research, funded by the Research Council of Norway. NorHEAD will. The goal is to systematize and improve current treatment knowledge and develop new and innovative therapies for the benefit of patients suffering from headache disorders. Oslo University Hospital is a partner in NorHEAD and several of the headache studies led from Oslo, such as the CovaxHEAD study, is under the NorHEAD umbrella. Aamodt has a part-time position at the Norwegian University of Science and Technology and is the chair of the Scientific Advisory board with 4 leading international professors.
The Norwegian Headache Research Centre will have the formal opening the 1st of September.
Aamodt is the Chair of the Scientific Advisory Board of NorHEAD – the Norwegian Headache Research Centre - and is from the 1st of August 2022 affiliated to NTNU.
NorHEAD is a Centre for Clinical Treatment Research funded by the Research Council of Norway. NorHEAD will carry out world-leading research on headache disorders with the goal to systematize and improve current treatment knowledge, and develop new and innovative therapies for the benefit of patients suffering from headache disorders.
Many useful and inspiring meeting places and debate arenas during Arendalsuka, 15-19.8 2022.
The Norwegian centres participate in the ENERGY register.
The data are delivered from Prjcts Ledidi in the Norwegian NeuroCovid study, led by Aamodt.
Results from the Norwegian NeuroCovid Study led by Anne Hege Aamodt were presented at the EAN Congress in Vienna by postdoc Marion Boldingh, Department of Neurology, Oslo University Hospital.
The TenCRAOS trial is recruiting steadily new centres and have follow-up meetings with the activated centres heading for more inclusions.
Meetings with Belgian centres Antwerpen, Erasme, Leuven and Brussels, the Danish centres Bispebjerg University Hospital and Aarhus, Bergen and Kristiansand, the Austrian lead, dr. Slaven Pikija at Kristian Doppler University Hospital in Salzburg and the national lead in Lithuania, Associate Professor Jurgita Valaikiene have recently been arranged.
On 5 April, the 6th national meeting on endovascular intervention in acute cerebral infarction was organized in the Runde auditorium at Domus Medica with OUS and UiO as hosts. A number of OUS employees contributed with lectures in addition to contributions from other Norwegian thrombectomy centers and neurology professor Bruce Campbell from Melbourne, Australia.
The Norwegian Stroke Association and the Norwegian Neuroradiology Association are behind the meetings, which have been organized annually since the Year of the Brain 2015 with Anne Hege Aamodt as the prime mover. In addition, Rajiv Advani, Mona Skjelland, Christian Lund, Else Charlotte Sandset, Stephen J. Ryan, Brian Enriquez and neuroradiologist Terje Nome and anesthetist from OUS and Marianne Altmann from Ahus participated in the event committee.
It was the first physical meeting since the start of the pandemic and with the good help of IT in the Medical Association, the meeting was organized as a hybrid.
The topline results of the Nordic Atrial Fibrillation and Stroke Study (NOR-FIB) presented at the Annual congress of the European Heart Rhythm Association – EHRA in Copenhagen on 4th of April 2022 and at the European Stroke Organisation Conference in Lyon on the 4th of May 2022 by senior consultant and PhD student Barbara Ratajczak-Tretel.
Anne Hege Aamodt er tildelt Formidlingsprisen 2022 fra Norsk nevrologisk forening for sitt formidable arbeid med å fremme norsk nevrologi både nasjonalt og internasjonalt.
Les saken fra hjemmesiden til Norsk nevrologisk forening:
Formidlingsprisen 2022 gikk til Anne Hege Aamodt
Oppdatering om hjernehelse, korona og den norske nevrocovid-studien på NRK P1 Pluss.
Prosjektleder Anne Hege Aamodt var invitert som frokostgjest 11. januar 2022 for å fortelle om nevrologiske komplikasjoner ved covid-19 og den norske nevrocovid-studien.
Programinformasjon
De fleste som blir rammet av Covid-19 blir kvitt symptomene raskt, men noen pasienter kan få langvarige nevrologiske skader. Gjest: Anne Hege Aamodt
Link til sendingen (11.01.2022 · 1 t 55 min)
Mens en av tre får hjernerelaterte symptomer i akuttfasen ved covid-19, har hver tiende symptomer mer enn tre måneder etter å ha hatt covid-19. Hos mange av dem er nevrologiske manifestasjoner en vesentlig forklaring.
Link til artikkelen:
Hver tiende får langvarige plager etter covid-19 (Nevrologisk Tidsskrift, 24.01.2022)
Teamet i Oslo som er vist under var en av vinnerne av Christmas Challenge i denne internasjonale multisenterstudien som undersøker effekten av trombektomi av store hjerneinfarkter.
Studien ledes fra Heidelberg og foregår i en rekke land i Europa og Canada. Anne Hege Aamodt er nasjonal leder av studien i Norge og PI ved OUS.
The NOR-FIB study is presented at two sessions during ESOC with new data from the biomarker study and updated data on the inclusion of participants. Many of the investigators participated at the Investigator meeting during the first day of the congress.
Anne Hege Aamodt, manager of ECRI, was during the EAN conference given the "EAN Investigator Award 2018" for her presentasjonen entitled "Effect and safety of tenecteplase in stroke patients with atrial fibrillation".
Anne Hege Aamodt was invited speaker at the European Stroke Organisation Congress in Gothenburg in May to talk about treatment in Central Retinal Artery Occlusion and presented at new planned international randomised controlled trial with tenecteplase - the TEN-CRAOS Study.
The NOR-FIB study was also presented at ESOC by PhD student Anna T. Lambert and there was an Investigator meeting with participants from all Scandinavian countries.
Media coverage (collection of links from legeforeningen.no)
On 23/11-2017 we held an open meeting on stroke at Oslo University Hospital. There was great support for the meeting and many who attended. We thank everyone who attended the meeting.
Some of the presentations will be posted after the meeting.