The TenCRAOS trial

The TenCRAOS trial is recruiting steadily new centres and have follow-up meetings with the activated centres heading for more inclusions.

Meetings with Belgian centres Antwerpen, Erasme, Leuven and Brussels, the Danish centres Bispebjerg University Hospital and Aarhus, Bergen and Kristiansand, the Austrian lead, dr. Slaven Pikija at Kristian Doppler University Hospital in Salzburg and the national lead in Lithuania, Associate Professor Jurgita Valaikiene have recently been arranged.

Professor Jørgen Krohn - member of the steering committee in TenCRAOS, PI neurology Andrej Khanevski, Co-investigator Annette Fromm, Professor Eivind Rødahl - member of the steering committee in TenCRAO.

Our Vision&Stroke Project TenCRAOS presented at European Stroke Organisation Conference in Lyon in May 2022. TenCRAOS is a placebo controlled RCT with Tenecteplase in CRAO with 4.5. hours timewindow. Aamodt was invited speaker to the Vision and Stroke session together with the PIs of the two other RCTs on thrombolysis in CRAO – Prof Sven Poli from Tübingen, leading the German trial REVISION and Prof Benoit Guillon from Nantes, leading the French Trial

Study meeting in Antwerpen Belgium, the national lead in Belgium – Professor Peter Vanacker.

Study team at Aarhus led by Professor Claus Ziegler Simonsen and Professor Toke Bek.

Meeting at the EAN congress in Vienna with the national lead in Lithuania, Associate Professor Jurgita Valaikiene and the PhD student in TenCRAOS Stephen J. Ryan.

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Recent publications

Leone MA, Helbok R, Bianchi E, Yasuda CL, Konti M, Ramankulov D, Lolich M, Lovrencic-Huzjan A, Kovács T, Armon C, Cotelli MS, Cavallieri F, Grosu O, Kiteva-Trenchevska G, Rodriguez-Leyva I, Boldingh M, Brola W, Maia LF, de Seabra MML, Davidescu EI, Popescu BO, Kopishinskaia S, Bassetti CLA, Moro E, ENERGY Study Group (§) (2024)
Outcome predictors of post-COVID conditions in the European Academy of Neurology COVID-19 registry
J Neurol (in press)
DOI 10.1007/s00415-024-12212-8, PubMed 38436682

Gilhus NE, Andersen H, Andersen LK, Boldingh M, Laakso S, Leopoldsdottir MO, Madsen S, Piehl F, Popperud TH, Punga AR, Schirakow L, Vissing J (2024)
Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
Eur J Neurol, 31 (5), e16229
DOI 10.1111/ene.16229, PubMed 38321574

de Jonge JC, Sluis WM, Reinink H, Bath PM, Woodhouse LJ, Zweedijk B, van de Beek D, Aamodt AH, Alpers I, Ciccone A, Csiba L, Demotes J, Kõrv J, Kurkowska-Jastrzebska I, Dawson J, Macleod MR, Ntaios G, Poli S, Milionis H, Ricci S, Cenciarelli S, Candelaresi P, de Bruijn SF, Pathansali R, Krishnan K et al. (2023)
Prevention of infections and fever to improve outcome in older patients with acute stroke (PRECIOUS): a randomised, open, phase III, multifactorial, clinical trial with blinded outcome assessment
Lancet Reg Health Eur, 36, 100782
DOI 10.1016/j.lanepe.2023.100782, PubMed 38074444