Research projects

The TenCRAOS study -  Tenecteplase in Central Retinal Artery Occlusion (TenCRAOS)

A prospective, randomised-controlled, double-dummy, double-blind phase 3 multi-centre trial of TNK 0.25 mg/kg + placebo vs. ASA + placebo (2 arms with 1:1 block randomisation) started in October 2020 with participating centres in all 4 Norwegian health regions and six European countries including Denmark, Sweden, Finland, Belgium, Ireland and Lithuania. Inclusion will be completed in 2024.
 https://clinicaltrials.gov/ct2/show/NCT04526951?term=tenCRAOS&draw=2&rank=1 


NOR-FIB - The Nordic Atrial Fibrillation and Stroke Study

We are leading an international prospective multi-center study with long term rhythm monitoring and biomarkers to explore the impact of atrial fibrillation in patients with cryptogenic stroke.  The inclusion phase closed in 2020 and the follow-up phase was completed in 2021. Several papers have been published and the biomarker sub studies are ongoing.

https://clinicaltrials.gov/study/NCT02937077?term=The%20nordic%20atrial%20fibrillation%20and%20stroke%20study&rank=1


AI-STROKE - Optimizing Acute Ischemic Stroke Diagnostics Using Artificial Intelligence

A multicentre study in acute stroke diagnostics aiming to to organise and simplify the care pathway through a pragmatic approach to acute stroke imaging powered by cutting edge advances in image processing and artificial intelligence. https://clinicaltrials.gov/study/NCT05652933?term=AI-STROKE&rank=4


TENSION - Efficacy and safety of ThrombEctomy iN Stroke with extended leSION and extended time window: a randomized, controlled trial 

The results from the TENSION trial - Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial – was published in Lancet in October 2023. https://www.sciencedirect.com/science/article/pii/S0140673623020329?dgcid=coauthor

The results demonstrate the effect of endovascular therapy in patients with large core infarcts - 18% absolute increase in patients able to walk unaided and 11% decreased mortality. The substudies are now ongoing.


PRECIOUS - PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke. A randomised, open, phase III, clinical trial with blinded outcome assessment

Oslo Acute Reperfusion Stroke Study (OSCAR)  - prospective observational study of acute ischemic stroke patients undergoing endovasculare therapy


Brain health in atrial fibrillation: 

the impact of inflammation and fibrosis on the risk of stroke, cognitive impairment and AF recurrence in patients with atrial fibrillation in a prospective study that uses advanced technology with 18F-FDG-PET, MRI and biomarkers.
https://clinicaltrials.gov/ct2/show/NCT03816865?term=nor-fib&draw=2&rank=2


NorVIS - Stroke and Vision

Visual impairment in stroke project, NorVIS, a multidisciplinary project funded by the Norwegian Research Council and led by Prof. Helle Falkenberg, USN. Aamodt is Executive Board Member in NorVIS https://www.usn.no/forskning/hva-forsker-vi-pa/synsvitenskap/nasjonalt-senter-for-optikk-syn-og-oyehelse/forskning/synsergonomi-livskvalitet-og-samhandling/norwegian-vision-in-stroke-norvis


NeuroCOVID - The Norwegian Study of Nervous System Manifestations and Sequelae After COVID-19 

The NeuroCOVID study is a prospective observational multi-center study of neurological, neuropsychological and neuropsychiatric manifestations in patients with COVID-19. The project is a multidisciplinary collaboration between infection specialists, neurologists, neuropsychiatrists, neuropsychologists, anesthesiologist, radiologists, neurophysiologists and researchers and is coordinated with the NeuroCOVID initiative in the European Academy of Neurolog (EAN) and the EAN Neuro-covid ReGistrY (ENERGY). https://clinicaltrials.gov/ct2/show/NCT04576351?term=Neurocovid&draw=2&rank=1


The Nordic Moyamoya Study:

Multi-disciplinary Translational Project for Improving Patient Care in Norway and Unraveling the Mysteries of Moyamoya Disease” – a multi-disciplinary prospective observational study that is lead together with the Department of Neurosurgery in in collaboration with the Department of Nuclear Medicine and Radiology. 


The Oslo study of Visual Impairment after Stroke (StrokeVIS)

 


Prospective observational single centre study with the aim to 

  1. To determine the prevalence of visual impairment in stroke patients in the acute phase and after 3 months.
  2. To compare visual impairment in those treated with EVT and those not. 
  3. To determine the sensitivity and specificity of the Vision Screening Assessment (VISA) tool for detection of visual impairment in stroke patients.
  4. To assess possible association between brain MRI lesions and visual impairment in stroke patients in the acute phase. 
  5. To assess any cognitive deficits at 3-month follow-up that could impact visual function.

New-onset severe headache after Covid-19 vaccine


REK number 351097, ClinicalTrials.gov Identifier NCT05235776, EudraCT number 2021-005210-34


Research networks

Visual impairment in stroke project, NorVIS, https://www.usn.no/forskning/hva-forsker-vi-pa/synsvitenskap/nasjonalt-senter-for-optikk-syn-og-oyehelse/forskning/synsergonomi-livskvalitet-og-samhandling/norwegian-vision-in-stroke-norvis

The Norwegian Centre for Headache Research – Aamodt is Chair of the Advisory Board at the The Norwegian Centre for Headache Research at the Norwegian University of Science and Technology, Trondheim, Norway

 
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