Current news and events

New Centre of Excellence:The PRecision Immunotherapy Alliance (PRIMA) funded with 155 mNOK

Co-directors Johanne Olweus and Karl Johan Malmberg
Co-directors Johanne Olweus and Karl Johan Malmberg

On September 23rd he Research Council of Norway published the results of the latest Centre of Excellence call.
The PRecision Immunotherapy Alliance (PRIMA) was funded as a CoE with 155 mNOK over 10 years.

The center will have Kalle Malmberg and Johanna Olweus as co-directors and includes their groups and that of June Myklebust (PI) at ICR, and also Ludvig Munthe, Jan Terje Andersen and Fridtjof Lund-Johansen at Department of Immunology and Transfusion Medicine (RH) as well as Emma Haapaniemi (NCMM) as PIs and with UiO as host and OUH as partner.

Horizon Europe 2022 funding to research on personalised treatment with biologic drugs

Nils Bolstad
Nils Bolstad

The Tumour Marker Group at the Department of Medical Biochemistry, OUH-Radiumhospitalet, is part of the European SQUEEZE consortium, which in total receives more than NOK 100 million from the EU through the Horizon Europe 2022 call. 

"We are proud to provide analyses of serum drug and anti-drug antibody concentrations in such a prestigious and ambitious European collaboration", says senior consultant and research group leader Nils Bolstad.

School of Health Innovation arrange course for professors and managers:How to increase innovation in your lab

Assistant, associate and full professors, group leaders, clinicians, research coordinators from any public university or hospital from Norway, Sweden and Denmark are invited to sign up for a course on how to increase innovation in your lab and bridge the gap between scientist and health innovator in Trondheim 23–24 November.

The course is arranged by the School of Health Innovation, which was established by the University of Oslo, and aims to provide healthcare and life science researchers with tools and insight into how research can be put to use for the benefit of patients, the healthcare system and our society.

 

Article in "Cancers" receiving international attention:Fighting tumors through sugar deprivation

OUS co-authors, from left: Grigalavicius, Ezzatpanah, Raabe and Theodossiou.
OUS co-authors, from left: Grigalavicius, Ezzatpanah, Raabe and Theodossiou.

Scientists in the Protonics Group at the Institute of Cancer Research, together with colleagues from NCSR Demokritos, Athens, Greece, have found that apart from being a photosensitive drug, 5-ALA is also a potent inhibitor of the glycolytic enzyme lactate dehydrogenase (LDH).

Dr. Theodossis Theodossiou, leader of the research team, said, "We are delighted to have uncovered this alternative property of 5-ALA. The fact that 5-ALA is approved for the detection of malignant gliomas and GBM makes our findings more valuable and easier to apply in the clinic. "

Marina Vietri is awarded the NFR Young Research Talent grant

Marina Vietri
Marina Vietri

Marina Vietri, project leader at from the Department og Molecular Biology and at CanCell, has received the Research Council of Norway "Researcher Project for Young Talents" grant, amounting to 8 mill NOK, for her project "Ruptured nuclear envelopes in cancer". In this project she aims to study the dynamics and effects of damaged nuclear envelope in cancer cells. 

The Young Research Talent grant is intended to give talented young researchers under the age of 40 in all disciplines and thematic areas the opportunity to pursue their ideas and lead a research project. This call is targeted towards researchers in the early stages of their careers, 2–7 years after defence of an approved doctorate, who have demonstrated the potential to conduct research of high scientific quality.

 

Clinical Cancer Research publication:Functional testing of tumor cells can predict response to therapy in cancer patients

First author Yanping Yin (left) and senior author Sigrid Skånland
First author Yanping Yin (left) and senior author Sigrid Skånland

A study led by Sigrid S. Skånland, project group leader at Department of Cancer Immunology, demonstrates that functional testing of patient-derived tumor cells can predict response to therapy. 
In the new study, Skånland and her colleagues show that analysis of protein levels in tumor cells collected from CLL patients before they started therapy, or analysis of the cells’ sensitivity to a panel of different drugs, could predict how the patients responded to the therapy they received.

Novel findings published in Nature Communications: Epigenetic study identifies differential methylation associated with the neuropathology of Parkinson’s disease and dementia with Lewy bodies

Mathias Toft (left) and Lasse Pihlstrøm. Photo: Olav Hegge
Mathias Toft (left) and Lasse Pihlstrøm. Photo: Olav Hegge

In a recent study from the Department of Neurology, Oslo University Hospital, researchers investigated DNA methylation across the genome in postmortem frontal cortex brain tissue from neurologically healthy controls and two closely related neurodegenerative disorders;  Parkinson’s disease and dementia with Lewy bodies. The study identified a number of loci in the genome where DNA methylation is associated with the stage of neuropathological change seen in these brains. The results are reported in Nature Communications

Helene Knævelsrud receives ERC starting grant

Helene Knævelsrud (photo: Øystein Horgmo)
Helene Knævelsrud (photo: Øystein Horgmo)

CanCell project leader Helene Knævelsrud has secured an ERC starting grant for her project, FINALphagy - Final act of autophagy symphony: Whole organism orchestration of autophagy termination .

Using fruit flies as a model system, she aims to study how autophagy is turned off in the body.

Helene is one of the eight researchers who bring the prestigious funding to Norway this year.

Research uncovers new mechanisms of wound healing:Human skin possesses pre-installed mechanisms that guide self-repair

Emma Lång (first author) and Stig Ove Bøe (last author)
Emma Lång (first author) and Stig Ove Bøe (last author)

The human skin possesses amazing properties. It protects the human body from potential dangers from our environment, it is resilient and flexible, and it makes us capable of sensing the slightest touch.

Researchers at Oslo University Hospital (OUS) and the University of Oslo (UiO) have made new ground-breaking discoveries that show how the skin is automatically repaired after injury. The results have recently been published in Proceedings of the National Academy of Sciences (PNAS) USA.


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