New atlas over cells in the gut - may contribute to new forms of treatment

Pyloric cells (photo: Hogne Røed-Nilsen, OUS)
Pyloric cells (photo: Hogne Røed-Nilsen, OUS)
A collaboration between researchers at the Department of Pathology at OUH and in Cambridge has resulted in a detailed description of 1.6 million cells distributed over 136 cell types from both fresh and sick guts, providing new knowledge of their role to exacerbation of inflammation of chronic bowel diseases.  The study, published in the journal Nature, has incorporated and harmonized single cell data from 25 studies, which includes cells from fresh and sick mucosa from oral cavity, esophagus, stomach, stomach, small intestine and colon. To date, this is the world's largest atlas over cells in the gut. The map is a valuable resource for identifying key changes in the tissue that is the cause of disease and which may be the measure of the development of new therapies.

Links:

Comprehensive popular science summary of the findings, from the OUS blog "Ekspertsykehuset" (in Norwegian):
Nytt atlas over celler i tarmen - kan bidra til nye behandlingsformer (by co-authors Raquel Bartolome-Casado, Frode Lars Jahnsen and Espen Bækkevold)

The Nature article:
Single-cell integration reveals metaplasia in inflammatory gut diseases.
Oliver AJ, Huang N, Bartolome-Casado R, Li R, Koplev S, Nilsen HR, Moy M, Cakir B, Polanski K, Gudiño V, Melón-Ardanaz E, Sumanaweera D, Dimitrov D, Milchsack LM, FitzPatrick MEB, Provine NM, Boccacino JM, Dann E, Predeus AV, To K, Prete M, Chapman JA, Masi AC, Stephenson E, Engelbert J, Lobentanzer S, Perera S, Richardson L, Kapuge R, Wilbrey-Clark A, Semprich CI, Ellams S, Tudor C, Joseph P, Garrido-Trigo A, Corraliza AM, Oliver TRW, Hook CE, James KR, Mahbubani KT, Saeb-Parsy K, Zilbauer M, Saez-Rodriguez J, Høivik ML, Bækkevold ES, Stewart CJ, Berrington JE, Meyer KB, Klenerman P, Salas A, Haniffa M, Jahnsen FL, Elmentaite R, Teichmann SA.
Nature. 2024 Nov;635(8039):699-707. doi: 10.1038/s41586-024-07571-1. Epub 2024 Nov 20.
PMID: 39567783

The Human Cell Atlas: towards a first draft atlas (nature.com)

Personal ous-research web pages:

Raquel Bartolome-Casado

Espen Bækkevold

Hogne Røed-Nilsen

Frode Jahnsen

The Frode Jahnsen's group: Mucosal Immunology and Cancer Research

 
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