Discoveries from NoPSC researchers: New insight into severe liver disease

Xiaojun Jiang and Espen Melum
Xiaojun Jiang and Espen Melum

Primary Sclerosing Cholangitis (PSC) is a severe and chronic liver disease, characterized by inflammation in the bile ducts. There is no effective treatment, and the disease is the leading indication for liver transplantation in Norway. Scientists at the Norwegian PSC Research Center (NoPSC) have now provideded another piece in the scientific puzzle. The new discovery, published in Gastroenterology, provides an important new research direction. Xiaojun Jiang is first author and Espen Melum is senior author.
The findings are presented in a comprehensive popular science news article published on the UiO home page.


Comprehensive original news article from the University of Oslo home page:
New insight into severe liver disease (, by Julie Nybakk Kvaal

The Gastroenterology article:
Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation.
Jiang X, Otterdal K, Chung BK, Maucourant C, Rønneberg JD, Zimmer CL, Øgaard J, Boichuk Y, Holm S, Geanon D, Schneditz G, Bergquist A, Björkström NK, Melum E.
Gastroenterology. 2023 Nov 22:S0016-5085(23)05508-7. doi: 10.1053/j.gastro.2023.11.283. 
PMID: 37995866

Xiaojun Jiang (

Norwegian PSC Research Center (NoPSC) (

Norwegian PSC Research Center (NoPSC) (

The Experimental liver research group, headed by Espen Melum

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