NORMENT researchers contribute to PLOS Medicine article on genetic assessment of age-associated Alzheimer's disease risk

Ole Andreassen, Centre Director NORMENT
Ole Andreassen, Centre Director NORMENT

Researchers from the NORMENT KG Jebsen Centre for Psychosis Research at OUS and UiO have participated in a large international consortium to develop a novel tool for genetic risk prediction in Alzheimer’s disease. This is based on a long standing collaboration between the statistical genetics team at NORMENT and the University of California San Diego (UCSD) Center for Translational Imaging and Precision Medicine. The scientists are now working to improve the method for mental illness applications.
The results have recently been published in Plos Medicine (journal impact factor 13.6). The study has received widespread attention, including articles in major international newspapers.


The article:

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
Rahul S. Desikan , Chun Chieh Fan , Yunpeng Wang, Andrew J. Schork, Howard J. Cabral, L. Adrienne Cupples, Wesley K. Thompson, Lilah Besser, Walter A. Kukull, Dominic Holland, Chi-Hua Chen, James B. Brewer, David S. Karow, Karolina Kauppi, Aree Witoelar, Celeste M. Karch, Luke W. Bonham, Jennifer S. Yokoyama, Howard J. Rosen, Bruce L. Miller, William P. Dillon, David M. Wilson, Christopher P. Hess, Margaret Pericak-Vance, Jonathan L. Haines, Lindsay A. Farrer, Richard Mayeux, John Hardy, Alison M. Goate, Bradley T. Hyman, Gerard D. Schellenberg, Linda K. McEvoy, Ole A. Andreassen , Anders M. Dale
PLOS Medicine
Published: March 21, 2017

The study has received considerable attention in international media publications:


Ole A. Andreassen's publications

Home page of Norment: Norwegian Centre for Mental Disorders Research

News article from UiO home page:
Genetic test may predict risk of developing Alzheimer's disease

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