The next institute seminar takes place Wednesday November 4th at 12:00 in the Auditorium with the following speaker:
Jørgen Wesche – Dept. of Molecular Cell Biology
Title of his talk:
“Proteomic mapping reveals molecular determinants of FGF receptor signaling and trafficking”
The fibroblast growth factor receptors (FGFRs) are important oncogenes promoting tumor progression in many types of cancer, such as breast, bladder, and lung cancer as well as osteosarcoma and rhabdomyosarcoma. However, little is known about how these receptors are internalized and down-regulated in cancer cells. We have here applied proximity biotin labeling and quantitative mass spectrometry to identify proteins involved in signaling and trafficking of FGFR1 and FGFR4.
Through these studies, we hope to identify proteins and pathways involved in FGFR transport and signaling that could provide new targets and opportunities for therapeutic intervention in FGFR aberrant cancer.