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22.01.2021NSAIDs might exacerbate or suppress COVID-19 depending on timing, mouse study suggests

New research shows that non-steroidal anti-inflammatory drugs (NSAIDs) reduced both antibody and inflammatory responses to SARS-CoV-2 infection in mice.

22.01.2021PTSD link to pandemic fears

A new study of 1040 online participants from five western countries explores people's response to the stresses of the escalating pandemic, finding more than 13 percent of the sample had post-traumatic stress disorder (PTSD) related symptoms consistent with levels necessary to qualify for a clinical diagnosis.

22.01.2021Rhesus macaques develop promising immune response to SARS-CoV-2

In a promising result for the success of vaccines against COVID-19, rhesus macaque monkeys infected with the human coronavirus SARS-CoV-2 developed protective immune responses that might be reproduced with a vaccine.

22.01.2021COVID lockdown loneliness linked to more depressive symptoms in older adults

Loneliness in adults aged 50 and over during the COVID-19 lockdown was linked to worsening depressive and other mental health symptoms, according to a large-scale online study.

21.01.2021New insights into the link between sunlight exposure and kidney damage

A new collaborative study reveals unexpected insights into how skin exposure to ultraviolet light can worsen clinical symptoms in autoimmune diseases such as lupus.

21.01.2021Abnormal hyperactivation in the brain may be an early sign of Alzheimer's

A psychology and neuroscience professor has just targeted an early biomarker of the disease.

21.01.2021Mitochondrial mutation increases the risk of diabetes in Japanese men

A new study of Type 2 diabetes (T2D) in Japanese populations has uncovered a previously uncharacterized genetic variant that puts male carriers at greater risk for the disease, as well as the mechanism by which it does so. The impact of the variant was most pronounced in sedentary men; those with the variant had a 65% greater rate of T2D than sedentary men without it.

21.01.2021A closer look at T cells reveals big differences in mild vs. severe COVID-19 cases

How long does immunity to SARS-CoV-2 last following infection? Researchers have uncovered an interesting clue. Their new study suggests that people with severe COVID-19 cases may be left with more of the protective 'memory' T cells needed to fight reinfection.

21.01.2021Study finds genetic clues to pneumonia risk and COVID-19 disparities

Researchers have identified genetic factors that increase the risk for developing pneumonia and its severe, life-threatening consequences.

21.01.2021When a story is breaking, AI can help consumers identify fake news

Warnings about misinformation are now regularly posted on Twitter, Facebook, and other social media platforms, but not all of these cautions are created equal. New research from Rensselaer Polytechnic Institute shows that artificial intelligence can help form accurate news assessments -- but only when a news story is first emerging.

21.01.2021Why older adults must go to the front of the vaccine line

A new global, mathematical modeling study shows that in most cases prioritizing older adults for COVID-19 vaccines saves the most lives. It also found that, in some cases, more lives could be saved and infections prevented if those who've already tested positive step to the back of the line.

21.01.2021'Aging well' greatly affected by hopes and fears for later life

If you believe you are capable of becoming the healthy, engaged person you want to be in old age, you are much more likely to experience that outcome, a recent study shows.

21.01.2021COVID-19 infection in immunodeficient patient cured by infusing convalescent plasma, doctors report

Under FDA emergency-use authorization, doctors successfully resolved COVID-19 in a seriously ill, immunodeficient woman using a very high-neutralizing antibody-titer convalescent plasma from a recovered COVID-19 patient. However, further study suggested that use of convalescent plasma may not be warranted in many cases, for two reasons: 1) titer levels are too low in many convalescent plasmas, and 2) there are high endogenous neutralizing antibody titers already present in COVID-19 patients prior to infusion.

21.01.2021Vegan diet significantly remodels metabolism in young children

Researchers report a comprehensive pilot study on the metabolic effects of full vegan diet on young children. The study found vegan children to have remarkably altered metabolism and lower vitamin A and D status compared to children with no special diet.

21.01.2021Detailed tumour profiling

As part of a clinical study, researchers are conducting a thorough and highly precise investigation into the molecular and functional properties of tumors. Their goal is to help physicians to better determine which treatment will best match every patient's cancer and thus be most effective.

21.01.2021Survey: Frequent reports of missed medical care in US adults during the early phase of the COVID-19 pandemic

Two out of five individuals delayed or missed medical care in the early phase of the pandemic -- from March through mid-July 2020.

21.01.2021New, simplified genetic test effectively screens for hereditary cancers

Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of DNA in colon, endometrial, and other cancers. This alternative to complex, multi-step testing workflows can also determine causes of MMR deficiency often missed by current clinical tests.

21.01.2021Randomized trials could help to return children safely to schools, study finds

Schools are closing again in response to surging levels of COVID-19 infection, but staging randomized trials when students eventually return could help to clarify uncertainties around when we should send children back to the classroom, according to a new study.

21.01.2021Study defines small-cell lung cancer subtypes and distinct therapeutic vulnerabilities for each type

Researchers have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study.

21.01.2021Scientists make pivotal discovery on mechanism of Epstein-Barr virus latent infection

Researchers have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV's ability to transform human cells and cause cancer. Study provides new indications for inhibiting EBNA1 function, opening up fresh avenues for development of therapies to treat EBV-associated cancers.

21.01.2021Using VR training to boost our sense of agency and improve motor control

Patients with motor dysfunctions are on the rise across Japan as its population continues to age. A researcher has developed a new method of rehabilitation using virtual reality to increase the sense of agency over our body and aid motor skills.

21.01.2021Cartilage matrix as natural biomaterial for cartilage regeneration

A working group develops strategies for regeneration of articular cartilage and has found that natural cartilage matrix is suitable as a biomaterial for improved cartilage regeneration.

21.01.2021Hope for a vaccination against Staphylococcus areus infections?

With an epitope-based immunization, scientists have described a new vaccination strategy against Staphylococcus aureus.

21.01.2021Balancing brain cell activity

Electrical trigger sites in neurons surprisingly change with experience; they are either becoming smaller with increasing number of experiences and, vice versa, they grow larger when less input arrives in the brain.

21.01.2021Age provides a buffer to pandemic's mental health impact, researchers say

Older adults are managing the stress of the coronavirus pandemic better than younger adults, reporting less depression and anxiety despite also experiencing greater general concern about COVID-19, according to a recent study.

21.01.2021Researchers ID potential target for anti-viral drugs to battle COVID

Researchers have published the first structural biology analysis of a section of the COVID-19 viral RNA called the stem-loop II motif. This is a non-coding section of the RNA, which means that it is not translated into a protein, but it is likely key to the virus's replication.

21.01.2021Reviving exhausted immune cells to fight cancer

Eliminating a single gene can turn exhausted cancer-fighting immune cells known as CD8+ T cells back into refreshed soldiers that can continue to battle malignant tumors, a new study suggests. The findings could offer a new way to harness the body's immune system to attack cancers.

21.01.2021What happens to your body during tailgating

Researchers simulated a tailgating situation with a small group of overweight but healthy men and examined the impact of the eating and drinking on their livers using blood tests and a liver scan.

21.01.2021See how they run: 'Exercise protein' doubles running capacity, restores function and extends healthy lifespans in older mice

A new study shows that humans express a powerful hormone during exercise and that treating mice with the hormone improves physical performance, capacity and fitness. Researchers say the findings present new possibilities for addressing age-related physical decline.

21.01.2021The physics behind tumor growth

Researchers have developed a predictive theory for tumor growth that approaches the subject from a new point of view. Rather than focusing on the biological mechanisms of cellular growth, the researchers instead use thermodynamics and the physical space the tumor is expanding into to predict its evolution from a single cell to a complex cancerous mass.

21.01.2021Drug-delivery microcapsules tagged with zirconium-89 can be tracked by PET imaging

Polymer and radionuclide chemists report major advance in microcapsule drug delivery systems. Their microcapsules -- labeled with radioactive zirconium-89 -- are the first example of hollow polymer capsules capable of long-term, multiday positron emission tomography imaging in vivo. In previous work, the researchers showed that the hollow capsules could be filled with a potent dose of the cancer drug doxorubicin, which could then be released by therapeutic ultrasound that ruptures the microcapsules.

21.01.2021Immune system mounts a lasting defense after recovery from COVID-19, researchers find

Study participants continued to improve their antibodies months after initial infection, potentially due to exposure to remnants of the virus hidden in the gut.

21.01.2021Treating moms with postpartum depression helps their babies' brains

For the study 40 infants of women diagnosed with postpartum depression were matched with 40 infants of non-depressed mothers on infant age, gender and socioeconomic status. The mothers with postpartum depression received nine weeks of group CBT. The infants were all tested before the treatment and nine weeks later, including a questionnaire on the infant behaviour completed by the mother and her partner.

21.01.2021CRISPR technology to cure sickle cell disease

A new article reports two patients appear to have been cured of beta thalassemia and sickle cell disease after their own genes were edited with CRISPR-Cas9 technology. The two researchers who invented this technology received the Nobel Prize in Chemistry in 2020.

21.01.2021Message in a bottle: Info-rich bubbles respond to antibiotics

Researchers describe the effects of antibiotics on membrane vesicles, demonstrating that such drugs actively modify the properties of vesicle transport. Under the influence of antibiotics, MVs were produced and released by bacteria in greater abundance and traveled faster and further from their origin. The work sheds new light on these important information-carrying entities, implicated in many cellular communication processes, including antibiotic resistance.

21.01.2021Vaccine produces long-lasting anti-tumor response in patients with melanoma

Patients treated with a vaccine tailored to mutated proteins on patients' own tumor cells, continue to have a strong immune response to the cancer four years after being vaccinated. Results demonstrate the ability of personalized cancer vaccines to provide long-term immunity against some cancers.

21.01.2021Study compares low-fat, plant-based diet to low-carb, animal-based diet

People on a low-fat, plant-based diet ate fewer daily calories but had higher insulin and blood glucose levels, compared to when they ate a low-carbohydrate, animal-based diet, according to a small but highly controlled study. The study compared the effects of the two diets on calorie intake, hormone levels, body weight, and more.

21.01.2021Immunology: Functionality of immune cells in early life

A study shows that putatively immature dendritic cells found in young children are able to induce robust immune responses. The results could lead to improved vaccination protocols.

21.01.2021Natural hazard events and national risk reduction measures unconnected

Countries where massive natural hazard events occur frequently are not more likely than others to make changes to reduce risks from future disasters.

21.01.2021COVID-19 is dangerous for middle-aged adults, not just the elderly

COVID-19 has been spreading rapidly over the past several months, and the U.S. death toll has now reached 400,000. As evident from the age distribution of those fatalities, COVID-19 is dangerous not only for the elderly but for middle-aged adults, according to a new study.

21.01.2021Does aspirin lower colorectal cancer risk in older adults? It depends on when they start

A new study has found that there is no protection against colorectal cancer if people begin taking aspirin regularly after age 70. However, there appears to be such protection if aspirin is started before age 70 and continued.

21.01.2021How the brain learns that earmuffs are not valuable at the beach

Fast-spiking neurons in the basal ganglia allow monkeys to associate different values with the same objects based on the surrounding environment. Blocking input from these cells inhibited learning of new scene-based values, but did not erase already learned associations. This could help understand clinical conditions such as Tourette syndrome, which is characterized by reduced input from these cells.

21.01.2021Estrogen receptors in mom's placenta critical during viral infection

A team of researchers has found a mechanism that protects a fetus from harm when the mother's innate immune system responds to a viral infection. Inflammation that would harm the fetus is dampened by a cell-surface estrogen receptor called GPER1 that is especially abundant in the placenta and fetal tissues.

21.01.2021Electron transfer discovery is a step toward viable grid-scale batteries

The way to boost electron transfer in grid-scale batteries is different than researchers had believed, a new study has shown.

21.01.2021Study suggests that gut fungi are not associated with Parkinson's disease

The bacterial gut microbiome is strongly associated with Parkinson's disease (PD), but no studies had previously investigated he role of fungi in the gut. In this novel study a team of investigators examined whether the fungal constituents of the gut microbiome are associated with PD.

21.01.2021Strange colon discovery explains racial disparities in colorectal cancer

The colons of African-Americans and people of European descent age differently, new research reveals, helping explain racial disparities in colorectal cancer.

21.01.2021'Attitude of gratitude' keeps older people in Japan feeling hopeful as they age

Older people in Japan have an 'attitude of gratitude' which keeps them feeling hopeful despite the challenges of aging, a new study says.

21.01.2021For some, GI tract may be vulnerable to COVID-19 infection

Researchers have found that patients with Barrett's esophagus may be vulnerable to coronavirus infection from what they swallow.

21.01.2021Gold nanoparticles more stable by putting rings on them

Scientists have found a way to prevent gold nanoparticles from clumping, which could help towards their use as an anti-cancer therapy.

21.01.2021Patients in cancer remission at high risk for severe COVID-19 illness

Patients with inactive cancer and not currently undergoing treatments also face a significantly higher risk of severe illness from COVID-19, according to new research.

21.01.2021Antibiotic resistance may spread even more easily than expected

Pathogenic bacteria in humans are developing resistance to antibiotics much faster than expected. Now, computational research shows that one reason could be significant genetic transfer between bacteria in our ecosystems and to humans. This work has also led to new tools for resistance researchers.

21.01.2021People more likely to follow COVID rules when friends and family do, research finds

New research has shown that people are more likely to follow COVID-19 restrictions based on what their friends do, rather than their own principles.

21.01.2021Antidepressants largely ineffective for back pain and osteoarthritis

Antidepressant drugs are largely ineffective for back and osteoarthritis pain, despite being widely used for these conditions, suggests a review of the evidence.

21.01.2021New trial finds arthritis drug no better than standard care for severe COVID-19

Adding the arthritis drug tocilizumab to standard care for patients in hospital with severe or critical covid-19 is no better than standard care alone in improving clinical outcomes at 15 days, according to results of a new trial.

20.01.2021Hematopoietic stem cell transplants may provide long-term benefit for people with MS

A new study shows that intense immunosuppression followed by a hematopoietic stem cell transplant may prevent disability associated with multiple sclerosis (MS) from getting worse in 71% of people with relapsing-remitting MS for up to 10 years after the treatment. The study also found that in some people their disability improved over 10 years after treatment.

20.01.2021Brain pressure disorder that causes headache, vision problems on rise

A new study has found a brain pressure disorder called idiopathic intracranial hypertension is on the rise, and the increase corresponds with rising obesity rates.

20.01.2021Deep sleep takes out the trash

By examining fruit flies' brain activity and behavior, the researchers found that deep sleep has an ancient, restorative power to clear waste from the brain. This waste potentially includes toxic proteins that may lead to neurodegenerative disease.

20.01.2021New genetic disorder affects brain, craniofacial skeleton

Researchers have discovered a new genetic disorder characterized by developmental delays and malformations of the brain, heart, and facial features.

20.01.2021Designer DNA therapeutic wipes out cancer stem cells, treats multiple myeloma in mice

A new study supports launch of Phase I clinical trial to test a designer DNA agent -- an antisense oligonucleotide that targets a gene called IRF4 -- in patients with multiple myeloma.

20.01.2021Immune driver of brain aging identified

Stanford scientists have identified a key factor in mental aging and shown that it might be prevented or reversed by fixing a glitch in the immune system's frontline soldiers.

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