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01.06.2020COVID-19 outbreak lasts days longer for each day's delay in social distancing

A new analysis of COVID-19 outbreaks in 58 cities has found that places that took longer to begin implementing social distancing measures spent more time with the virus rapidly spreading than others that acted more quickly. Epidemiological researchers have published research finding every day a city delayed implementing social distancing measures after the appearance of a first case added 2.4 days to the length of the outbreak.

01.06.2020Study seeks to optimize comfort for patients removed from ventilators at end of life

A recently published paper reports on a study of the palliative ventilator withdrawal (PVW) procedure performed in intensive care units (ICU) at end of life.

01.06.2020Across the cell membrane

Aquaporins and glucose transporters facilitate the movement of substances across biological membranes and are present in all kingdoms of life.Biophysicists used a supercomputer to explore the atomic behavior of these proteins. The research suggests glucose transporters function by using a gate on the extracellular side that opens and closes based on body temperature.

01.06.2020Monitoring environmental exposures in dogs could be early warning system for human health

Man's best friend may also be man's best bet for figuring out how environmental chemicals could impact our health.

01.06.2020Warmer temperatures slow COVID-19 transmission, but not by much

Researchers looked at the impact of temperature, precipitation, and UV index on COVID-19 case rates in the United States during the spring months of 2020. The findings reveal that while the rate of COVID-19 incidence does decrease with warmer temperatures up until 52 degrees F, further warmer temperatures do not decrease disease transmission significantly.

01.06.2020How Americans are coping with COVID-19 stress

Almost overnight, the rapid emergence of the COVID-19 pandemic in the United States and subsequent state and federal prevention measures dramatically altered daily behavior. A new study provides the first snapshot of the immediate impact of COVID-19 on Americans' stress levels, coping strategies, and adherence to public health guidelines.

01.06.2020Extra choline may help pregnant women decrease negative effects of COVID-19 on their newborns

Pregnant women who take extra choline supplements may mitigate the negative impact that viral respiratory infections, including COVID-19, can have on their babies, according to a new study in the Journal of Psychiatric Research.

01.06.2020Squid studies suggest new route to therapy for ALS, targeting synaptic dysfunction

Amyotrophic lateral sclerosis (ALS) is one of the most devastating adult-onset neurodegenerative diseases. Patients, including the late actor/playwright Sam Shepard, become progressively weaker and eventually paralyzed as their motor neurons degenerate and die.

01.06.2020Universal virus detection platform to expedite viral diagnosis

The prompt, precise, and massive detection of a virus is the key to combat infectious diseases such as Covid-19. A new viral diagnostic strategy using reactive polymer-grafted, double-stranded RNAs will serve as a pre-screening tester for a wide range of viruses with enhanced sensitivity.

01.06.2020Cancer cells cause inflammation to protect themselves from viruses

Researchers have uncovered how cancer cells protect themselves from viruses that are harmful to tumors but not to healthy cells. These findings could lead to improved viral treatments for the disease.

01.06.2020Underlying illness risk factors for severe COVID-19 or death

Age, male sex, obesity, and underlying illness have emerged as risk factors for severe COVID-19 or death in the UK, according to the largest cohort study to date.

01.06.2020Study shows hydroxychloroquine's harmful effects on heart rhythm

The malaria drug hydroxychloroquine, which has been promoted as a potential treatment for Covid-19, is known to have potentially serious effects on heart rhythms. Now, a team of researchers has used an optical mapping system to observe exactly how the drug creates serious disturbances in the electrical signals that govern heartbeat.

01.06.2020Impact of children's loneliness today could manifest in depression for years to come

A rapid review into the mental health impacts of loneliness on children and young people concludes that there could be a spike in demand for mental health services in the years to come.

30.05.2020The fight goes on: Clinical trial shows promising new treatment for rare blood cancer

Although lymphoma is one of the most common types of blood cancer, it has a rare subtype for which no effective treatment regimens are known. For the first time, researchers have conducted clinical trials for a new treatment protocol and report it to be quite promising.

30.05.2020COVID-19 patients who undergo surgery are at increased risk of postoperative death

Patients undergoing surgery after contracting coronavirus are at greatly increased risk of postoperative death, a new global study reveals. Researchers found that amongst SARS-CoV-2 infected patients who underwent surgery, mortality rates approach those of the sickest patients admitted to intensive care after contracting the virus in the community.

30.05.2020How the coronavirus could be prevented from invading a host cell

How might the novel coronavirus be prevented from entering a host cell in an effort to thwart infection? A team of biomedical scientists has made a discovery that points to a solution. The scientists report that two proteases -- enzymes that break down proteins -- located on the surface of host cells and responsible for processing viral entry could be inhibited.

30.05.2020Scientists develop method to help epidemiologists map spread of COVID-19

Scientists have developed a method they believe will help epidemiologists more efficiently predict the spread of the COVID-19 pandemic. Their new study outlines a solution to the SIR epidemic model, which is commonly used to predict how many people are susceptible to, infected by, and recovered from viral epidemics.

29.05.2020Key player in hepatitis A virus infection

Researchers designed experiments using gene-editing tools to discover how molecules called gangliosides serve as de facto gatekeepers to allow the virus entry into liver cells and trigger disease.

29.05.2020Adolescent exposure to anesthetics may cause alcohol use disorder, new research shows

Early exposure to anesthetics may make adolescents more susceptible to developing alcohol use disorder (AUD), according to new research.

29.05.2020Evolution of pandemic coronavirus outlines path from animals to humans

A team of scientists studying the origin of SARS-CoV-2, the virus that has caused the COVID-19 pandemic, found that it was especially well-suited to jump from animals to humans by shapeshifting as it gained the ability to infect human cells.

29.05.2020Paid sick leave mandates hold promise in containing COVID-19

Mandates like those found in the federal government's Families First Coronavirus Response Act may be helping to slow the pandemic.

29.05.2020Older men worry less than others about COVID-19

Older men may be at greater risk of contracting COVID-19 because they worry less about catching or dying from it, according to a new study.

29.05.2020Using brain imaging to demonstrate weaker neural suppression for those with autism

A new study shows the differences in visual motion perception in autism spectrum disorder are accompanied by weaker neural suppression in the visual cortex of the brain.

29.05.2020When COVID-19 meets flu season

As if the COVID-19 pandemic isn't scary enough, the flu season is not far away. How severe will the flu season be as it converges with the COVID-19 outbreak? What can we do to prepare?

29.05.2020Study charts developmental map of inner ear sound sensor in mice

A team of researchers has generated a developmental map of a key sound-sensing structure in the mouse inner ear. Scientists analyzed data from 30,000 cells from mouse cochlea, the snail-shaped structure of the inner ear. The results provide insights into the genetic programs that drive the formation of cells important for detecting sounds and the underlying causes for some forms of inner ear hearing loss.

29.05.2020Researchers develop experimental rapid COVID-19 test using nanoparticle technique

Scientists have developed an experimental diagnostic test for COVID-19 that can visually detect the presence of the virus in 10 minutes. It uses a simple assay containing plasmonic gold nanoparticles to detect a color change when the virus is present.

29.05.2020Using riboflavin, UV light reduces SARS-CoV-2 pathogens in plasma, whole blood

Researchers used existing technologies to show that exposing the coronavirus to riboflavin and ultraviolet light reduces blood-borne pathogens in human plasma and whole-blood products.

29.05.2020Growing evidence that minority ethnic groups in England may be at higher risk of COVID-19

Evidence available to date suggests that minority ethnic groups in England, particularly black and south Asian people, may be at increased risk of testing positive for Covid-19, compared to people from white British backgrounds, according to a new study.

29.05.2020How toxic protein spreads in Alzheimer's disease

Toxic versions of the protein tau are believed to cause death of neurons of the brain in Alzheimer's disease. A new study shows that the spread of toxic tau in the human brain in elderly individuals may occur via connected neurons. The researchers could see that beta-amyloid facilitates the spread of toxic tau.

29.05.2020Anesthesia's effect on consciousness solved, settling century-old scientific debate

How does general anesthesia cause loss of consciousness? Despite its 175-year-history of use by the U.S. medical system, science has been unable to definitively answer that question, until now. The lipid-based answer could open other brain mysteries.

29.05.2020Solution to century-old math problem could predict transmission of infectious diseases

An academic has achieved a milestone in statistical/mathematical physics by solving a 100-year-old physics problem -- the discrete diffusion equation in finite space.

29.05.2020New method to map cholesterol metabolism in brain

Researchers have developed new technology to monitor cholesterol in brain tissue which could uncover its relation to neurodegenerative disease and pave the way for the development of new treatments.

29.05.2020'Watcher' tracks coronavirus in Cincinnati and beyond

As cases of COVID-19 soar, two University of Cincinnati students develop an interactive dashboard that shows cases and deaths related to the novel coronavirus throughout the nation.

29.05.2020New model predicts the peaks of the COVID-19 pandemic

Researchers describe a single function that accurately describes all existing available data on active COVID-19 cases and deaths -- and predicts forthcoming peaks.

29.05.2020New gut-brain link: How gut mucus could help treat brain disorders

Gut bacterial imbalance is linked with many neurological disorders. Now researchers have identified a common thread: changes in gut mucus. It's a new gut-brain connection that opens fresh paths for scientists searching for ways to treat brain disorders by targeting our 'second brain' -- the gut.

28.05.2020Using electrical stimulus to regulate genes

A team of researchers has succeeded in using an electric current to directly control gene expression for the first time. Their work provides the basis for medical implants that can be switched on and off using electronic devices outside the body.

28.05.2020New technology enables fast protein synthesis

Chemists have developed a protocol to rapidly produce protein chains up to 164 amino acids long. The flow-based technology could speed up drug development and allow scientists to design novel protein variants incorporating amino acids that don't occur naturally in cells.

28.05.2020Gold mining with mercury poses health threats for miles downstream

Small-scale gold mining in the Peruvian Amazon poses a health hazard not only to the miners and communities near where mercury is used to extract gold from ore, but also to downstream communities hundreds of kilometers away where people eat mercury-contaminated river fish as part of their diet. Downstream children under 12 with the highest levels of mercury in their bodies were found to have lost IQ points and become anemic.

28.05.2020Breaking up is hard to do (especially for sex chromosomes)

A team of scientists has discovered how the X and Y chromosomes find one another, break, and recombine during meiosis even though they have little in common.

28.05.2020Heart surgery stalled as COVID-19 spread

Two recent journal articles explore how hospitals worldwide scaled back on heart surgeries as the pandemic hit, and how they can resume those operations in a world still plagued by the SARS-CoV-2 virus.

28.05.2020Imaging reveals unexpected contractions in the human placenta

High-resolution imaging of the human placenta provides new insights into blood circulation patterns that are crucial for fetal development, according to a new study. These findings improve our understanding of the functioning of this understudied organ, both in healthy pregnancies and in serious medical conditions such as pre-eclampsia.

28.05.2020Researchers identify mechanisms that make skin a protective barrier

A research team has identified one of the mechanisms that establish the skin as a protective barrier, a breakthrough that is critical to understanding and treating common skin conditions including eczema and psoriasis, according to a new study.

28.05.2020Combination therapy well-tolerated and highly effective for patients with IDH1-mutated AML

A combination therapy of ivosenidib (IVO) plus venetoclax (VEN) with or without azacitidine (AZA) was found to be effective against a specific genetic subtype of acute myeloid leukemia (AML) in a Phase Ib/II trial.

28.05.2020Immune landscape of multiple brain cancers charted

A new study has profiled, in a sweeping comparative analysis, the distinct immune landscapes of tumors that arise in the brain, or gliomas, and those that metastasize to the organ from the lungs, breast and skin.

28.05.2020Survey identifies learning opportunities related to health impacts of climate change

An international survey of Global Consortium on Climate and Health Education (GCCHE) membership found that the majority of members -- health professions schools and programs, including medical, nursing, and public health -- offer learning opportunities related to the health impacts of climate change, yet many also encountered challenges in instituting or developing curricula. The results of the survey provide a baseline assessment of the state of climate-health education internationally among health professions institutions.

28.05.2020An imbalance of electrons in the liver may be a common risk factor for disease

Researchers have uncovered an unexpected connection between an imbalance of electrons in liver cells and many metabolic problems that increase the risk for conditions such as cardiovascular disease and fatty liver disease.

28.05.2020Restoring nerve-muscle communication in ALS

A new study finds that restoring the protein SV2 in a genetic form of ALS can correct abnormalities in transmission and even prevent cells from dying, providing a new target for future therapies.

28.05.2020Stem cell treatments 'go deep' to regenerate sun-damaged skin

Some plastic surgeons have been using stem cells to treat aging, sun-damaged skin. But while they've been getting good results, it's been unclear exactly how these treatments work to rejuvenate 'photoaged' facial skin. A new study finds that within a few weeks, stem cell treatment eliminates the sun-damaged elastin network and replacing them with normal, undamaged tissues and structures.

28.05.2020gnomAD Consortium releases its first major studies of human genetic variation

For the last eight years, the Genome Aggregation Database (gnomAD) Consortium (and its predecessor, the Exome Aggregation Consortium, or ExAC), has been working with geneticists around the world to compile and study more than 125,000 exomes and 15,000 whole genomes from populations around the world. Now, in seven articles, gnomAD Consortium scientists describe their first set of discoveries from the database, showing the power of this vast collection of data.

28.05.2020Autism severity can change substantially during early childhood

A new study found that around 30 percent of young children with autism have less severe autism symptoms at age 6 than they did at age 3, with some children losing their autism diagnoses entirely. It also found that girls tend to show greater reduction and less rise in their autism symptom severity than boys with autism. Children with higher IQs were more likely to show a reduction in their symptoms.

28.05.2020As hospitals walk the tightrope of patient data-sharing, one system offers a new balance

Every major medical center in America sits on a gold mine of patient data that could be worth millions of dollars to companies that could use it to develop new treatments and technologies. A new framework could help them do so more responsibly, going beyond the minimum legal requirements and respecting patients by giving them more say in how their individual data may be used.

28.05.2020Molecular effects of exercise detailed

A simple blood test may be able to determine how physically fit you are, according to a new study.

28.05.2020New molecule stops drug cravings in mice, with fewer side effects

Researchers have developed a synthetic molecule that selectively controls the physiological rewards of cocaine in mice. It also may represent a new class of small-molecule drugs that are more specific and have fewer side effects. The molecule selectively activates beta-arrestin without activating the G protein, making its signal to the cell much more specific.

28.05.2020Beyond the garnish: Will a new type of produce get the microgreen light?

Microgreens. They're leafy green vegetables that are relatively new to the dining room, but a new study indicates that they will be welcome company at the table.

28.05.2020Key components of proteins are twisted to boost reactions useful to medicine

In proteins, amino acids are held together by amide bonds. These bonds are long-lived and are robust against changes in temperature, acidity or alkalinity. Certain medicines make use of reactions involving amide bonds, but the bonds are so strong they actually slow down reactions, impeding the effectiveness of the medicines. Researchers devised a way to modify amide bonds with a twist to their chemical structure that speeds up reactions by 14 times.

28.05.2020Impact of major life events on wellbeing

Researchers examined the effect of 18 major life events on wellbeing.

28.05.2020Exploiting viruses to attack cancer cells

Scientists have made an adenovirus that specifically replicates inside and kills cancer cells by employing special RNA-stabilizing elements.

28.05.2020Tackling airborne transmission of COVID-19 indoors

Preventing airborne transmission of Covid-19 should be the next front of the battle against the virus, argue experts in a new article.

28.05.2020Sugars could be the key to an earlier, more accurate test for prostate cancer

A new type of test that uses complex sugars to detect prostate cancer earlier and with greater accuracy.

28.05.2020Researchers flag similarities between COVID-19 deaths and severe rheumatic illnesses

Rheumatologists are flagging similarities between the deaths of some COVID-19 patients and those with rheumatic illnesses, and are testing proven rheumatic treatments to see whether they help against the pandemic virus.

 
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