Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Division of Head, Neck and Reconstructive Surgery

68 publications found

Andersson H, Jablonski GE, Nordahl SHG, Nordfalk K, Helseth E, Martens C, Røysland K, Goplen FK (2021)
The Risk of Benign Paroxysmal Positional Vertigo After Head Trauma
Laryngoscope
DOI 10.1002/lary.29851, PubMed 34487348

Andréasson M, Lagali N, Badian RA, Utheim TP, Scarpa F, Colonna A, Allgeier S, Bartschat A, Köhler B, Mikut R, Reichert KM, Solders G, Samuelsson K, Zetterberg H, Blennow K, Svenningsson P (2021)
Parkinson's disease with restless legs syndrome-an in vivo corneal confocal microscopy study
NPJ Parkinsons Dis, 7 (1), 4
DOI 10.1038/s41531-020-00148-5, PubMed 33402694

Anisimova N, Arbisser L, Tzamalis A, Petrovski BÉ, Shilova N, Petrovski G, Anisimov S, Malyugin B (2021)
Corectopia grading: A novel classification system
Semin Ophthalmol
DOI 10.1080/08820538.2021.1926517, PubMed 34057013

Badian RA, Andréasson M, Svenningsson P, Utheim TP, Lagali N (2021)
The pattern of the inferocentral whorl region of the corneal subbasal nerve plexus is altered with age
Ocul Surf, 22, 204-212
DOI 10.1016/j.jtos.2021.08.015, PubMed 34450219

Canonica GW, Klimek L, Acaster S, Dollner R, Kaulsay R, Lo SH, Price DB, Scadding GK, Valovirta E, Zieglmayer P (2021)
Burden of allergic rhinitis and impact of MP-AzeFlu from the patient perspective: pan European patient survey
Curr Med Res Opin, 37 (7), 1259-1272
DOI 10.1080/03007995.2021.1911973, PubMed 33840316

Christopoulos PF, Gjølberg TT, Krüger S, Haraldsen G, Andersen JT, Sundlisæter E (2021)
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases
Front Immunol, 12, 668207
DOI 10.3389/fimmu.2021.668207, PubMed 33912195

Dalby M, Drolsum L, Kristianslund O (2021)
Repositioning surgery of different intraocular lens designs in eyes with late in-the-bag intraocular lens dislocation
J Cataract Refract Surg, 47 (9), 1147-1152
DOI 10.1097/j.jcrs.0000000000000588, PubMed 33754659

Døving M, Anandan S, Rogne KG, Utheim TP, Brunborg C, Galteland P, Sunde K (2021)
Cost Analysis of Open Surgical Bedside Tracheostomy in Intensive Care Unit Patients
Ear Nose Throat J, 01455613211018578
DOI 10.1177/01455613211018578, PubMed 34006128

Drolsum L, Kristianslund O (2021)
Implantation of retropupillary iris-claw lenses: A review on surgical management and outcomes
Acta Ophthalmol
DOI 10.1111/aos.14824, PubMed 33683012

Ehrenstein V, Heide-Jørgensen U, Schiødt M, Akre O, Herlofson BB, Hansen S, Larsson Wexell C, Nørholt SE, Tretli S, Kjellman A, Glennane A, Lowe KA, Sørensen HT (2021)
Osteonecrosis of the jaw among patients with cancer treated with denosumab or zoledronic acid: Results of a regulator-mandated cohort postauthorization safety study in Denmark, Norway, and Sweden
Cancer, 127 (21), 4050-4058
DOI 10.1002/cncr.33802, PubMed 34310704

Eidet JR, Akopian M, Olstad OK, Jørstad ØK, Moe MC, Petrovski G, Pepaj M (2021)
The acute phase response protein SERPINA3 is increased in tear fluid from the unaffected eyes of patients with unilateral acute anterior uveitis
J Ophthalmic Inflamm Infect, 11 (1), 19
DOI 10.1186/s12348-021-00249-z, PubMed 34212267

Eszes DJ, Szabó DJ, Russell G, Lengyel C, Várkonyi T, Paulik E, Nagymajtényi L, Facskó A, Petrovski G, Petrovski BÉ (2021)
Diabetic Retinopathy Screening in Patients with Diabetes Using a Handheld Fundus Camera: The Experience from the South-Eastern Region in Hungary
J Diabetes Res, 2021, 6646645
DOI 10.1155/2021/6646645, PubMed 33628836

Fineide F, Chen X, Bjellaas T, Vitelli V, Utheim TP, Jensen JL, Galtung HK (2021)
Characterization of Lipids in Saliva, Tears and Minor Salivary Glands of Sjögren's Syndrome Patients Using an HPLC/MS-Based Approach
Int J Mol Sci, 22 (16)
DOI 10.3390/ijms22168997, PubMed 34445702

Fjaervoll H, Fjaervoll K, Magno M, Moschowits E, Vehof J, Dartt DA, Utheim TP (2021)
The association between visual display terminal use and dry eye: a review
Acta Ophthalmol (in press)
DOI 10.1111/aos.15049, PubMed 34697901

Frich L, Hermann R, Berentzen Å, Ryder T (2021)
Randomized Study of Wound Drainage on Early Complications After Lymph Node Dissection for Melanoma
J Surg Res, 267, 467-476
DOI 10.1016/j.jss.2021.05.005, PubMed 34245960

Giunta RE, Hansson E, Andresen C, Athanasopoulos E, Benedetto GD, Celebic AB, Caulfield R, Costa H, Demirdöver C, Georgescu A, Hemelryck TV, Henley M, Kappos EA, Karabeg R, Karhunen-Enckell U, Korvald C, Mortillet S, Murray DJ, Palenčár D, Piatkowski A, Pompeo FSD, Psaras G, Rakhorst H, Rogelj K, Rosenkrantz Hölmich L et al. (2021)
ESPRAS Survey on Breast Reconstruction in Europe
Handchir Mikrochir Plast Chir, 53 (4), 340-348
DOI 10.1055/a-1424-1428, PubMed 33784792

Gulseth E, Urdal A, Andersen MH, Diseth T, Aksnes G, Emblem R, Wæhre A (2021)
High satisfaction on genital self-perception and sexual function in healthy Norwegian male adolescents
J Pediatr Urol, 17 (4), 555.e1-555.e8
DOI 10.1016/j.jpurol.2021.02.015, PubMed 33750647

Hamdani EH, Popek M, Frontczak-Baniewicz M, Utheim TP, Albrecht J, Zielińska M, Chaudhry FA (2021)
Perturbation of astroglial Slc38 glutamine transporters by NH4 + contributes to neurophysiologic manifestations in acute liver failure
FASEB J, 35 (7), e21588
DOI 10.1096/fj.202001712RR, PubMed 34169573

Hedengran A, Begun X, Müllertz O, Mouhammad Z, Vohra R, Bair J, Dartt DA, Cvenkel B, Heegaard S, Petrovski G, Kolko M (2021)
Benzalkonium Chloride-Preserved Anti-Glaucomatous Eye Drops and Their Effect on Human Conjunctival Goblet Cells in vitro
Biomed Hub, 6 (2), 69-75
DOI 10.1159/000517845, PubMed 34616748

Heliövaara A, Küseler A, Skaare P, Bellardie H, Mølsted K, Karsten A, Marcusson A, Rizell S, Brinck E, Sæle P, Chalien MN, Mooney J, Eyres P, Shaw W, Semb G (2021)
Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: comparison of dental arch relationships and dental indices at 5, 8, and 10 years
Eur J Orthod (in press)
DOI 10.1093/ejo/cjab055, PubMed 34476476

Hikage F, Lennikov A, Mukwaya A, Lachota M, Ida Y, Utheim TP, Chen DF, Huang H, Ohguro H (2021)
NF-κB activation in retinal microglia is involved in the inflammatory and neovascularization signaling in laser-induced choroidal neovascularization in mice
Exp Cell Res, 403 (1), 112581
DOI 10.1016/j.yexcr.2021.112581, PubMed 33811906

Husum YS, Moe MC, Bragadóttir R, Jørstad ØK (2021)
Switching to aflibercept versus continuing bevacizumab for treatment-resistant neovascular age-related macular degeneration: a one-year comparative observational study
Acta Ophthalmol
DOI 10.1111/aos.14825, PubMed 33638291

Jain S, Seal A, Ojha A, Yazidi A, Bures J, Tacheci I, Krejcar O (2021)
A deep CNN model for anomaly detection and localization in wireless capsule endoscopy images
Comput Biol Med, 137, 104789
DOI 10.1016/j.compbiomed.2021.104789, PubMed 34455302

Jevnikar K, Jaki Mekjavic P, Vidovic Valentincic N, Petrovski G, Globocnik Petrovic M (2021)
An Update on COVID-19 Related Ophthalmic Manifestations
Ocul Immunol Inflamm, 29 (4), 684-689
DOI 10.1080/09273948.2021.1896008, PubMed 33826465

Jorgensen OJ, Steineger J, Bachmann-Harildstad G, Dheyauldeen S (2021)
A comparative study of two grading systems for epistaxis in hereditary haemorrhagic telangiectasia
Rhinology, 59 (2), 212-218
DOI 10.4193/Rhin20.540, PubMed 33821857

Khan AZ, Utheim TP, Jackson CJ, Tønseth KA, Eidet JR (2021)
Concise Review: Considering Optimal Temperature for Short-Term Storage of Epithelial Cells
Front Med (Lausanne), 8, 686774
DOI 10.3389/fmed.2021.686774, PubMed 34485330

Khan AZ, Utheim TP, Moe MC, Aass HCD, Sapkota D, Vallenari EM, Eidet JR (2021)
The Silk Protein Sericin Promotes Viability of ARPE-19 and Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells in vitro
Curr. Eye Res., 46 (4), 504-514
DOI 10.1080/02713683.2020.1809001

Khan H, Naseer N, Yazidi A, Eide PK, Hassan HW, Mirtaheri P (2021)
Analysis of Human Gait Using Hybrid EEG-fNIRS-Based BCI System: A Review
Front Hum Neurosci, 14, 613254
DOI 10.3389/fnhum.2020.613254, PubMed 33568979

Kristianslund O, Cholidis S (2021)
Persistent pupillary membranes and cataract
Am J Ophthalmol (in press)
DOI 10.1016/j.ajo.2021.05.030, PubMed 34175306

Kristianslund O, Dalby M, Drolsum L (2021)
Late in-the-bag intraocular lens dislocation
J Cataract Refract Surg, 47 (7), 942-954
DOI 10.1097/j.jcrs.0000000000000605, PubMed 33750091

Kristianslund O, Drolsum L (2021)
Prevalence of keratoconus in persons with Down syndrome: a review
BMJ Open Ophthalmol, 6 (1), e000754
DOI 10.1136/bmjophth-2021-000754, PubMed 33981858

Kristianslund O, Kure ISH, Drolsum L (2021)
Cataract surgery in Norway 2010-19
Tidsskr Nor Laegeforen, 141 (9)
DOI 10.4045/tidsskr.20.1005, PubMed 34107671

Kristianslund O, Sandvik GF, Drolsum L (2021)
Long-Term Suture Breakage After Scleral Fixation of a Modified Capsular Tension Ring with Polypropylene 10-0 Suture
Clin Ophthalmol, 15, 2473-2479
DOI 10.2147/OPTH.S310648, PubMed 34163130

Küseler A, Heliövaara A, Mølsted K, Marcusson A, Karsten A, Bellardie H, Sæle P, Brinck E, Skaare P, Rizell S, Chalien MN, Mooney J, Botticelli S, Eyres P, Shaw W, Semb G (2021)
Scandcleft trial of primary surgery for unilateral cleft lip and palate: Craniofacial cephalometrics at 8 years
Eur J Orthod, 43 (4), 374-380
DOI 10.1093/ejo/cjaa060, PubMed 33367600

Landsend ECS, Lagali N, Utheim TP (2021)
Congenital aniridia - A comprehensive review of clinical features and therapeutic approaches
Surv Ophthalmol, 66 (6), 1031-1050
DOI 10.1016/j.survophthal.2021.02.011, PubMed 33675823

Lombardi S, Aaen KH, Nilsen J, Ferrarese M, Gjølberg TT, Bernardi F, Pinotti M, Andersen JT, Branchini A (2021)
Fusion of engineered albumin with factor IX Padua extends half-life and improves coagulant activity
Br J Haematol, 194 (2), 453-462
DOI 10.1111/bjh.17559, PubMed 34109608

Lyngstad G, Skjelbred P, Swanson DM, Skoglund LA (2021)
Analgesic effect of oral ibuprofen 400, 600, and 800 mg; paracetamol 500 and 1000 mg; and paracetamol 1000 mg plus 60 mg codeine in acute postoperative pain: a single-dose, randomized, placebo-controlled, and double-blind study
Eur J Clin Pharmacol (in press)
DOI 10.1007/s00228-021-03231-9, PubMed 34655316

Lytvynchuk LM, Petrovski G, Dam A, Hiemstra J, Wimmer T, Savytska I, Binder S, Stieger K (2021)
Novel Needle for Intravitreal Drug Delivery: Comparative Study of Needle Tip Aspirates, Injection Stream and Penetration Forces
Clin Ophthalmol, 15, 723-734
DOI 10.2147/OPTH.S297139, PubMed 33642853

Magno M, Moschowits E, Arita R, Vehof J, Utheim TP (2021)
Intraductal meibomian gland probing and its efficacy in the treatment of meibomian gland dysfunction
Surv Ophthalmol, 66 (4), 612-622
DOI 10.1016/j.survophthal.2020.11.005, PubMed 33352147

Magno MS, Daniel T, Morthen MK, Snieder H, Jansonius N, Utheim TP, Hammond CJ, Vehof J (2021)
The relationship between alcohol consumption and dry eye
Ocul Surf, 21, 87-95
DOI 10.1016/j.jtos.2021.05.005, PubMed 34029755

Magno MS, Utheim TP, Snieder H, Hammond CJ, Vehof J (2021)
The relationship between dry eye and sleep quality
Ocul Surf, 20, 13-19
DOI 10.1016/j.jtos.2020.12.009, PubMed 33421635

Maurizi A, Ponzetti M, Gautvik KM, Reppe S, Teti A, Rucci N (2021)
Lipocalin 2 serum levels correlate with age and bone turnover biomarkers in healthy subjects but not in postmenopausal osteoporotic women
Bone Rep, 14, 101059
DOI 10.1016/j.bonr.2021.101059, PubMed 34026950

Mofrad AA, Mofrad SA, Yazidi A, Parker MG (2021)
On Neural Associative Memory Structures: Storage and Retrieval of Sequences in a Chain of Tournaments
Neural Comput, 33 (9), 2550-2577
DOI 10.1162/neco_a_01417, PubMed 34412117

Monsen RE, Herlofson BB, Gay C, Fjeld KG, Hove LH, Malterud KE, Saghaug E, Slaaen J, Sundal T, Tollisen A, Lerdal A (2021)
A mouth rinse based on a tea solution of Salvia officinalis for oral discomfort in palliative cancer care: a randomized controlled trial
Support Care Cancer, 29 (9), 4997-5007
DOI 10.1007/s00520-021-06021-2, PubMed 33586003

Morthen MK, Magno MS, Utheim TP, Snieder H, Hammond CJ, Vehof J (2021)
The physical and mental burden of dry eye disease: A large population-based study investigating the relationship with health-related quality of life and its determinants
Ocul Surf, 21, 107-117
DOI 10.1016/j.jtos.2021.05.006, PubMed 34044135

Øverland B, Berdal H, Akre H (2021)
Surgery for obstructive sleep apnea in young children: Outcome evaluated by polysomnograhy and quality of life
Int J Pediatr Otorhinolaryngol, 142, 110609
DOI 10.1016/j.ijporl.2021.110609, PubMed 33418205

Rizell S, Küseler A, Heliövaara A, Skaare P, Brinck E, Bellardie H, Mooney J, Mølsted K, Karsten A, Sæle P, Chalien MN, Marcusson A, Eyres P, Shaw W, Semb G (2021)
Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: impact of maxillary dental agenesis on craniofacial growth and dental arch relationship in 8 year olds
Eur J Orthod, 43 (4), 381-386
DOI 10.1093/ejo/cjab007, PubMed 33693582

Rødvik AK, Myhrum M, Larsson ELA, Falkenberg ES, Kværner KJ (2021)
Sustained reduction of tinnitus several years after sequential cochlear implantation
Int J Audiol
DOI 10.1080/14992027.2021.1939448, PubMed 34278941

Sand MK, Cholidis S, Rimstad K, Krekling ED, Kristianslund O, Drolsum L (2021)
Long-term outcome of primary intraocular lens implantation in bilateral congenital cataract in infants with a median age of 35 days at surgery: a case series
BMJ Open Ophthalmol, 6 (1), e000836
DOI 10.1136/bmjophth-2021-000836, PubMed 34651084

Sandvik GF, Rand-Hendriksen S, Drolsum L, Kristianslund O (2021)
Photophobia and disability glare in adult patients with Marfan syndrome: a case-control study
Acta Ophthalmol
DOI 10.1111/aos.14935, PubMed 34173343

Singer S, Hammerlid E, Tomaszewska IM, Amdal CD, Bjordal K, Herlofson BB, Santos M, Silva JC, Mehanna H, Fullerton A, Brannan C, Gonzalez LF, Inhestern J, Pinto M, Arraras JI, Yarom N, Bonomo P, Baumann I, Galalae R, Nicolatou-Galitis O, Kiyota N, Raber-Durlacher J, Salem D, Fabian A, Boehm A et al. (2021)
Methodological approach for determining the Minimal Important Difference and Minimal Important Change scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module (EORTC QLQ-HN43) exemplified by the Swallowing scale
Qual Life Res
DOI 10.1007/s11136-021-02939-6, PubMed 34272632

Sivertsen MS, Lode HE, Gjølberg TT, Petrovski G, Andersen JT, Jørstad ØK, Moe MC (2021)
Cluster of symptomatic silicone oil droplets following intravitreal injections: a 1-year observational study
BMJ Open Ophthalmol, 6 (1), e000764
DOI 10.1136/bmjophth-2021-000764, PubMed 34485702

Skalleberg J, Myhrum M, Småstuen MC, Osnes TA, Fosså SD, Bunne M (2021)
Speech perception 30 years after cisplatin-based chemotherapy in adults: limited clinical relevance of long-term ototoxicity?
Acta Oncol, 60 (4), 426-433
DOI 10.1080/0284186X.2021.1887514, PubMed 33617403

Slettedal JK, Sandvik L, Ringvold A (2021)
Significant lifespan difference between primary open-angle glaucoma and pseudoexfoliation glaucoma
Heliyon, 7 (3), e06421
DOI 10.1016/j.heliyon.2021.e06421, PubMed 33763607

Spasojevic M, Mariathasan AB, Frich L, Bruland ØS, Larsen SG, Stoldt S (2021)
Kreftbehandling med isolert ekstremitetsperfusjon
Tidsskr Nor Laegeforen, 141 (2021-12)
DOI 10.4045/tidsskr.21.0194, PubMed 34505491

Spasojevic M, Mariathasan AB, Frich L, Brulund OS, Larsen SG, Stoldt S (2021)
Cancer treatment with isolated extremity perfusion
Tidsskr. Nor. Laegeforen., 141 (12), 1186-1189

Tichotová L, Studenovska H, Petrovski G, Popelka Š, Nemesh Y, Sedláčková M, Drutovič S, Rohiwal S, Jendelová P, Erceg S, Brymová A, Artero-Castro A, Lytvynchuk L, Straňák Z, Ellederová Z, Motlík J, Ardan T (2021)
Advantages of nanofibrous membranes for culturing of primary RPE cells compared to commercial scaffolds
Acta Ophthalmol (in press)
DOI 10.1111/aos.15034, PubMed 34687141

Tønset TS, Jakobsen JE, Tveit JH, Jørstad AL, Brevik TB, Sten LB, Drolsum L (2021)
Circumferential (360°) trabeculotomy in primary congenital glaucoma: 19-245 months of follow-up
Acta Ophthalmol
DOI 10.1111/aos.14846, PubMed 33742566

Traaen GM, Aakerøy L, Hunt TE, Øverland B, Bendz C, Sande LØ, Aakhus S, Fagerland MW, Steinshamn S, Anfinsen OG, Massey RJ, Broch K, Ueland T, Akre H, Loennechen JP, Gullestad L (2021)
Effect of Continuous Positive Airway Pressure on Arrhythmia in Atrial Fibrillation and Sleep Apnea: A Randomized Controlled Trial
Am J Respir Crit Care Med, 204 (5), 573-582
DOI 10.1164/rccm.202011-4133OC, PubMed 33938787

Tulek A, Mulic A, Hogset M, Utheim TP, Sehic A (2021)
Therapeutic Strategies for Dry Mouth Management with Emphasis on Electrostimulation as a Treatment Option
Int J Dent, 2021, 6043488
DOI 10.1155/2021/6043488, PubMed 34691182

Tulek A, Mulic A, Runningen M, Lillemo J, Utheim TP, Khan Q, Sehic A (2021)
Genetic Aspects of Dental Erosive Wear and Dental Caries
Int J Dent, 2021, 5566733
DOI 10.1155/2021/5566733, PubMed 34335772

Veiby NCBB, Simeunovic A, Heier M, Brunborg C, Saddique N, Moe MC, Dahl-Jørgensen K, Petrovski G, Margeirsdottir HD (2021)
Retinal venular oxygen saturation is associated with non-proliferative diabetic retinopathy in young patients with type 1 diabetes
Acta Ophthalmol (in press)
DOI 10.1111/aos.15018, PubMed 34668632

Westgaard KL, Hynne H, Amdal CD, Young A, Singh PB, Chen X, Rykke M, Hove LH, Aqrawi LA, Utheim TP, Herlofson BB, Jensen JL (2021)
Oral and ocular late effects in head and neck cancer patients treated with radiotherapy
Sci Rep, 11 (1), 4026
DOI 10.1038/s41598-021-83635-w, PubMed 33597629

Wolpert LE, Snieder H, Jansonius NM, Utheim TP, Hammond CJ, Vehof J (2021)
Medication use and dry eye symptoms: A large, hypothesis-free, population-based study in the Netherlands
Ocul Surf, 22, 1-12
DOI 10.1016/j.jtos.2021.06.009, PubMed 34171471

Yazdani M, Elgstøen KBP, Utheim TP (2021)
Eye Make-up Products and Dry Eye Disease: A Mini Review
Curr Eye Res
DOI 10.1080/02713683.2021.1966476, PubMed 34365876

Yazdani M, Fiskådal J, Chen X, Utheim ØA, Ræder S, Vitelli V, Utheim TP (2021)
Tear Film Break-Up Time and Dry Eye Disease Severity in a Large Norwegian Cohort
J Clin Med, 10 (4)
DOI 10.3390/jcm10040884, PubMed 33671667

Zawadzka M, Ràcz B, Ambrosini D, Görbitz CH, Morth JP, Wilkins AL, Østeby A, Elgstøen KBP, Lundanes E, Rise F, Ringvold A, Wilson SR (2021)
Searching for a UV-filter in the eyes of high-flying birds
Sci Rep, 11 (1), 273
DOI 10.1038/s41598-020-79533-2, PubMed 33431985

Zhou W, Reinstein DZ, Archer TJ, Chen X, Utheim TP, Feng Y, Stojanovic A (2021)
Intraoperative Swept-Source OCT-Based Corneal Topography for Measurement and Analysis of Stromal Surface After Epithelial Removal
J Refract Surg, 37 (7), 484-492
DOI 10.3928/1081597X-20210405-01, PubMed 34236903

 
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