Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Division of Surgery, Inflammatory Medicine and Transplantation

53 publications found

Alidjanov JF, Cai T, Bartoletti R, Bonkat G, Bruyère F, Köves B, Kulchavenya E, Medina-Polo J, Naber K, Perepanova T, Pilatz A, Tandogdu Z, Bjerklund Johansen TE, Wagenlehner FM (2021)
The negative aftermath of prostate biopsy: prophylaxis, complications and antimicrobial stewardship: results of the global prevalence study of infections in urology 2010-2019
World J Urol (in press)
DOI 10.1007/s00345-021-03614-8, PubMed 33615393

Amrutkar M, Gladhaug IP (2021)
Stellate Cells Aid Growth-Permissive Metabolic Reprogramming and Promote Gemcitabine Chemoresistance in Pancreatic Cancer
Cancers (Basel), 13 (4)
DOI 10.3390/cancers13040601, PubMed 33546284

Azhar N, Johanssen A, Sundström T, Folkesson J, Wallon C, Kørner H, Blecic L, Forsmo HM, Øresland T, Yaqub S, Buchwald P, Schultz JK, SCANDIV Study Group (2021)
Laparoscopic Lavage vs Primary Resection for Acute Perforated Diverticulitis: Long-term Outcomes From the Scandinavian Diverticulitis (SCANDIV) Randomized Clinical Trial
JAMA Surg, 156 (2), 121-127
DOI 10.1001/jamasurg.2020.5618, PubMed 33355658

Balduzzi A, van Hilst J, Korrel M, Lof S, Al-Sarireh B, Alseidi A, Berrevoet F, Björnsson B, van den Boezem P, Boggi U, Busch OR, Butturini G, Casadei R, van Dam R, Dokmak S, Edwin B, Sahakyan MA, Ercolani G, Fabre JM, Falconi M, Forgione A, Gayet B, Gomez D, Koerkamp BG, Hackert T et al. (2021)
Laparoscopic versus open extended radical left pancreatectomy for pancreatic ductal adenocarcinoma: an international propensity-score matched study
Surg Endosc
DOI 10.1007/s00464-020-08206-y, PubMed 33398565

Bjørkto MH, Barratt-Due A, Nordøy I, Dörje C, Galteland E, Lind A, Hilli A, Aukrust P, Mjøen G (2021)
The use of eculizumab in Capnocytophaga canimorsus associated thrombotic microangiopathy: a case report
BMC Infect Dis, 21 (1), 137
DOI 10.1186/s12879-021-05789-2, PubMed 33526010

Blagotinšek Cokan K, Urlep Ž, Moškon M, Mraz M, Kong XY, Eskild W, Rozman D, Juvan P, Režen T (2021)
Common Transcriptional Program of Liver Fibrosis in Mouse Genetic Models and Humans
Int J Mol Sci, 22 (2)
DOI 10.3390/ijms22020832, PubMed 33467660

Brustugun OT, Heggelund L (2021)
Koronavaksinering av kreftpasienter
Tidsskr Nor Laegeforen, 141 (3)
DOI 10.4045/tidsskr.21.0026, PubMed 33624982

Cai T, Gallelli L, Cione E, Perletti G, Ciarleglio F, Malossini G, De Pretis G, Palmieri A, Mirone V, Bartoletti R, Johansen TEB (2021)
The use of Lactobacillus casei DG® prevents symptomatic episodes and reduces the antibiotic use in patients affected by chronic bacterial prostatitis: results from a phase IV study
World J Urol
DOI 10.1007/s00345-020-03580-7, PubMed 33442769

Cakir OO, Castiglione F, Tandogdu Z, Collins J, Alnajjar HM, Akers C, Albersen M, Alifrangis C, Ayres B, Brouwer O, Cullen I, Hawkey P, Jakobsen JK, Johansen TEB, Kalejaiye O, Kaul A, Köves B, Kumar V, Mancini M, Mitra AV, Parnham A, Pozzi E, Protzel C, Sangar VK, Wagenlehner F et al. (2021)
Management of penile cancer patients during the COVID-19 pandemic: An eUROGEN accelerated Delphi consensus study
Urol Oncol, 39 (3), 197.e9-197.e17
DOI 10.1016/j.urolonc.2020.12.005, PubMed 33397593

Dahl KG, Wahl AK, Urstad KH, Falk RS, Andersen MH (2021)
Changes in Health Literacy during the first year following a kidney transplantation: Using the Health Literacy Questionnaire
Patient Educ Couns (in press)
DOI 10.1016/j.pec.2020.12.028, PubMed 33454146

Degenhardt F, Mayr G, Wendorff M, Boucher G, Ellinghaus E, Ellinghaus D, ElAbd H, Rosati E, Hübenthal M, Juzenas S, Abedian S, Vahedi H, Thelma BK, Yang SK, Ye BD, Cheon JH, Datta LW, Daryani NE, Ellul P, Esaki M, Fuyuno Y, McGovern DPB, Haritunians T, Hong M, Juyal G et al. (2021)
Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations
Hum Mol Genet (in press)
DOI 10.1093/hmg/ddab017, PubMed 33555323

Dhillon AK, Rupp C, Bergquist A, Voitl R, Folseraas T, Trøseid M, Midttun Ø, Ueland PM, Karlsen TH, Vesterhus M, Kummen M, Hov JR (2021)
Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis
Scand J Gastroenterol
DOI 10.1080/00365521.2021.1880627, PubMed 33583308

Didriksen H, Molberg Ø, Fretheim H, Gude E, Jordan S, Brunborg C, Palchevskiy V, Garen T, Midtvedt Ø, Andreassen AK, Distler O, Belperio J, Hoffmann-Vold AM (2021)
Lymphangiogenic factors are associated with pulmonary arterial hypertension in systemic sclerosis
Arthritis Rheumatol (in press)
DOI 10.1002/art.41665, PubMed 33497027

Drivsholm N, Knudsen AD, Faurholt-Jepsen M, Midttun Ø, TrØseid M, Kirkegaard-Klitbo DM, Ueland PM, Nielsen SD, Gelpi M (2021)
Alterations in the kynurenine pathway of tryptophan metabolism are associated with depression in people living with HIV
J Acquir Immune Defic Syndr (in press)
DOI 10.1097/QAI.0000000000002664, PubMed 33633032

Edvardsen MS, Hindberg K, Hansen ES, Morelli VM, Ueland T, Aukrust P, Brækkan SK, Evensen LH, Hansen JB (2021)
Plasma levels of von Willebrand factor and future risk of incident venous thromboembolism
Blood Adv, 5 (1), 224-232
DOI 10.1182/bloodadvances.2020003135, PubMed 33570640

Endre KMA, Landrø L, LeBlanc M, Gjersvik P, Lødrup Carlsen KC, Haugen G, Hedlin G, Jonassen CM, Nordlund B, Rudi K, Skjerven HO, Staff AC, Söderhäll C, Vettukattil R, Rehbinder EM (2021)
Diagnosing Atopic Dermatitis in Infancy Using Established Diagnostic Criteria: A Cohort Study
Br J Dermatol (in press)
DOI 10.1111/bjd.19831, PubMed 33511639

Fraz MSA, Moe N, Revheim ME, Stavrinou ML, Durheim MT, Nordøy I, Macpherson ME, Aukrust P, Jørgensen SF, Aaløkken TM, Fevang B (2021)
Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency-Features of CT and 18F-FDG Positron Emission Tomography/CT in Clinically Progressive Disease
Front Immunol, 11, 617985
DOI 10.3389/fimmu.2020.617985, PubMed 33584710

Frisk M, Le C, Shen X, Røe ÅT, Hou Y, Manfra O, Silva GJJ, van Hout I, Norden ES, Aronsen JM, Laasmaa M, Espe EKS, Zouein FA, Lambert RR, Dahl CP, Sjaastad I, Lunde IG, Coffey S, Cataliotti A, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE (2021)
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044, PubMed 33509397

Gatti F, Mia S, Hammarström C, Frerker N, Fosby B, Wang J, Pietka W, Sundnes O, Hol J, Kasprzycka M, Haraldsen G (2021)
Nuclear IL-33 restrains the early conversion of fibroblasts to an extracellular matrix-secreting phenotype
Sci Rep, 11 (1), 108
DOI 10.1038/s41598-020-80509-5, PubMed 33420328

Hamre H, Lassen K (2021)
Bedre oversikt over pankreaskreft i Norge
Tidsskr Nor Laegeforen, 141 (1)
DOI 10.4045/tidsskr.20.0869, PubMed 33433104

Hasselgren K, Røsok BI, Larsen PN, Sparrelid E, Lindell G, Schultz NA, Bjørnbeth BA, Isaksson B, Larsson AL, Rizell M, Björnsson B, Sandström P (2021)
ALPPS Improves Survival Compared With TSH in Patients Affected of CRLM: Survival Analysis From the Randomized Controlled Trial LIGRO
Ann Surg, 273 (3), 442-448
DOI 10.1097/SLA.0000000000003701, PubMed 32049675

Haugen AJ, Hallan S, Langberg NE, Dahle DO, Pihlstrøm H, Birkeland KI, Reisæter AV, Midtvedt K, Hartmann A, Holdaas H, Mjøen G (2021)
Increased risk of ischemic heart disease after kidney donation
Nephrol Dial Transplant (in press)
DOI 10.1093/ndt/gfab054, PubMed 33624826

Haugen AJ, Mjøen G (2021)
Living donation - any news on the donor?
Curr Opin Organ Transplant, 26 (1), 85-90
DOI 10.1097/MOT.0000000000000830, PubMed 33278148

Hausken J, Haugaa H, Hagness M, Line PD, Melum E, Tønnessen TI (2021)
Thoracic Epidural Analgesia for Postoperative Pain Management in Liver Transplantation: A 10-year Study on 685 Liver Transplant Recipients
Transplant Direct, 7 (2), e648
DOI 10.1097/TXD.0000000000001101, PubMed 33437863

Helve J, Kramer A, Abad Diez JM, Aresté-Fosalba N, Arici M, Cases A, Collart F, Heaf J, De Meester J, Nordio M, Palsson R, Pobes A, Rydell H, Reisæter AV, Massy ZA, Jager KJ, Finne P (2021)
Effect of comorbidities on survival in patients >80 years at onset of renal replacement therapy: data from the ERA-EDTA Registry
Nephrol Dial Transplant (in press)
DOI 10.1093/ndt/gfaa278, PubMed 33537775

Highland KB, Distler O, Kuwana M, Allanore Y, Assassi S, Azuma A, Bourdin A, Denton CP, Distler JHW, Hoffmann-Vold AM, Khanna D, Mayes MD, Raghu G, Vonk MC, Gahlemann M, Clerisme-Beaty E, Girard M, Stowasser S, Zoz D, Maher TM, SENSCIS trial investigators (2021)
Efficacy and safety of nintedanib in patients with systemic sclerosis-associated interstitial lung disease treated with mycophenolate: a subgroup analysis of the SENSCIS trial
Lancet Respir Med, 9 (1), 96-106
DOI 10.1016/S2213-2600(20)30330-1, PubMed 33412120

Hoff G, Botteri E, Huppertz-Hauss G, Kvamme JM, Holme Ø, Aabakken L, Dahler S, Medhus AW, Blomgren I, Sandvei P, Darre-Næss O, Kjellevold Ø, Seip B (2021)
The effect of train-the-colonoscopy-trainer course on colonoscopy quality indicators
Endoscopy (in press)
DOI 10.1055/a-1352-4583, PubMed 33622001

Hoffmann-Vold AM, Bendstrup E, Dimitroulas T, Hesselstrand R, Morais A, Peltomaa R, Smith V, Welling J, Vonk MC, Wuyts WA (2021)
Identifying unmet needs in SSc-ILD by semi-qualitative in-depth interviews
Rheumatology (Oxford) (in press)
DOI 10.1093/rheumatology/keab154, PubMed 33587103

Holme SS, Kilian K, Eggesbø HB, Moen JM, Molberg Ø (2021)
Impact of baseline clinical and radiological features on outcome of chronic rhinosinusitis in granulomatosis with polyangiitis
Arthritis Res Ther, 23 (1), 18
DOI 10.1186/s13075-020-02401-x, PubMed 33430923

Hugenschmidt H, Labori KJ, Borgen E, Brunborg C, Schirmer CB, Seeberg LT, Naume B, Wiedswang G (2021)
Preoperative CTC-Detection by CellSearch® Is Associated with Early Distant Metastasis and Impaired Survival in Resected Pancreatic Cancer
Cancers (Basel), 13 (3)
DOI 10.3390/cancers13030485, PubMed 33513877

Jiang X, Bergquist A, Löscher BS, Venkatesh G, Mold JE, Holm K, Laerdahl JK, Skånland SS, Maleki KT, Cornillet M, Taskén K, Franke A, Karlsen TH, Björkström NK, Melum E (2021)
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci Transl Med, 13 (582)
DOI 10.1126/scitranslmed.abb0036, PubMed 33627483

Kelleher MM, Cro S, Cornelius V, Lodrup Carlsen KC, Skjerven HO, Rehbinder EM, Lowe AJ, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Axon E, Surber C, Cork M, Cooke A, Tran L, Van Vogt E, Schmitt J, Weidinger S, McClanahan D, Simpson E, Duley L, Askie LM et al. (2021)
Skin care interventions in infants for preventing eczema and food allergy
Cochrane Database Syst Rev, 2, CD013534
DOI 10.1002/14651858.CD013534.pub2, PubMed 33545739

Kelleher MM, Cro S, Van Vogt E, Cornelius V, Lodrup Carlsen KC, Ove Skjerven H, Rehbinder EM, Lowe A, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Cork M, Cooke A, Simpson EL, McClanahan D, Weidinger S, Schmitt J, Axon E, Tran L, Surber C, Askie LM, Duley L et al. (2021)
Skincare interventions in infants for preventing eczema and food allergy: A cochrane systematic review and individual participant data meta-analysis
Clin Exp Allergy (in press)
DOI 10.1111/cea.13847, PubMed 33550675

Kindem IA, Bjerre A, Åsberg MScPharm A, Midtvedt K, Bergan MScPharm S, Vethe MScPharm NT (2021)
Tacrolimus measured in capillary volumetric microsamples in pediatric patients-a cross-validation study
Ther Drug Monit (in press)
DOI 10.1097/FTD.0000000000000873, PubMed 33596033

Lindeman I, Zhou C, Eggesbø LM, Miao Z, Polak J, Lundin KEA, Jahnsen J, Qiao SW, Iversen R, Sollid LM (2021)
Longevity, clonal relationship, and transcriptional program of celiac disease-specific plasma cells
J Exp Med, 218 (2)
DOI 10.1084/jem.20200852, PubMed 33095260

Mahawar KK, Omar I, Singhal R, Aggarwal S, Allouch MI, Alsabah SK, Angrisani L, Badiuddin FM, Balibrea JM, Bashir A, Behrens E, Bhatia K, Biertho L, Biter LU, Dargent J, De Luca M, DeMaria E, Elfawal MH, Fried M, Gawdat KA, Graham Y, Herrera MF, Himpens JM, Hussain FA, Kasama K et al. (2021)
The first modified Delphi consensus statement on sleeve gastrectomy
Surg Endosc
DOI 10.1007/s00464-020-08216-w, PubMed 33433676

Måseide RJ, Berntorp E, Astermark J, Hansen J, Olsson A, Bruzelius M, Frisk T, Aspdahl M, Nummi V, Tjønnfjord GE, Holme PA (2021)
Haemophilia early arthropathy detection with ultrasound and haemophilia joint health score in the moderate haemophilia (MoHem) study
Haemophilia
DOI 10.1111/hae.14245, PubMed 33550602

Mjøen G, Maggiore U, Kessaris N, Kimenai D, Watschinger B, Mariat C, Sever MS, Crespo M, Peruzzi L, Spasovski G, Sørensen SS, Heemann U, Pascual J, Viklicky O, Courtney AE, Hadaya K, Wagner L, Nistor I, Hadjianastassiou V, Durlik M, Helanterä I, Oberbauer R, Oniscu G, Hilbrands L, Abramowicz D et al. (2021)
Long-term risks after kidney donation: How do we inform potential donors? A survey from descartes and EKITA transplantation working groups
Nephrol Dial Transplant (in press)
DOI 10.1093/ndt/gfab035, PubMed 33585931

Mori Y, Neumann H, Misawa M, Kudo SE, Bretthauer M (2021)
Artificial intelligence in colonoscopy - Now on the market. What's next?
J Gastroenterol Hepatol, 36 (1), 7-11
DOI 10.1111/jgh.15339, PubMed 33179322

Nast A, Smith C, Spuls PI, Avila Valle G, Bata-Csörgö Z, Boonen H, De Jong E, Garcia-Doval I, Gisondi P, Kaur-Knudsen D, Mahil S, Mälkönen T, Maul JT, Mburu S, Mrowietz U, Reich K, Remenyik E, Rønholt KM, Sator PG, Schmitt-Egenolf M, Sikora M, Strömer K, Sundnes O, Trigos D, Van Der Kraaij G et al. (2021)
EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris - Part 2: specific clinical and comorbid situations
J Eur Acad Dermatol Venereol, 35 (2), 281-317
DOI 10.1111/jdv.16926, PubMed 33547728

Nordheim E, Lindahl JP, Carlsen RK, Åsberg A, Birkeland KI, Horneland R, Boye B, Scholz H, Jenssen TG (2021)
Patient selection for islet or solid organ pancreas transplantation: experiences from a multidisciplinary outpatient-clinic approach
Endocr Connect (in press)
DOI 10.1530/EC-20-0519, PubMed 33544090

Pereira MP, Zeidler C, Wallengren J, Halvorsen JA, Weisshaar E, Garcovich S, Misery L, Brenaut E, Şavk E, Potekaev N, Lvov A, Bobko S, Szepietowski JC, Reich A, Bozek A, Legat FJ, Metz M, Streit M, Serra-Baldrich E, Gonçalo M, Storck M, Nau T, Hoffmann V, Steinke S, Greiwe I et al. (2021)
Chronic Nodular Prurigo: A European Cross-sectional Study of Patient Perspectives on Therapeutic Goals and Satisfaction
Acta Derm Venereol, 101 (2), adv00403
DOI 10.2340/00015555-3726, PubMed 33320272

Ramberg H, Richardsen E, de Souza GA, Rakaee M, Stensland ME, Braadland PR, Nygård S, Ögren O, Guldvik IJ, Berge V, Svindland A, Taskén KA, Andersen S (2021)
Proteomic analyses Identify Major Vault Protein as a Prognostic Biomarker for Fatal Prostate Cancer
Carcinogenesis (in press)
DOI 10.1093/carcin/bgab015, PubMed 33609362

Rehbinder EM, Skjerven HO, Carlsen KCL (2021)
Emollient creams and bath oils do not prevent atopic eczema
Tidsskr Nor Laegeforen, 141 (2)
DOI 10.4045/tidsskr.20.0884, PubMed 33528125

Sahakyan MA, Røsok BI, Tholfsen T, Kleive D, Waage A, Ignjatovic D, Buanes T, Labori KJ, Edwin B (2021)
Implementation and training with laparoscopic distal pancreatectomy: 23-year experience from a high-volume center
Surg Endosc
DOI 10.1007/s00464-021-08306-3, PubMed 33534075

Sampaziotis F, Muraro D, Tysoe OC, Sawiak S, Beach TE, Godfrey EM, Upponi SS, Brevini T, Wesley BT, Garcia-Bernardo J, Mahbubani K, Canu G, Gieseck R, Berntsen NL, Mulcahy VL, Crick K, Fear C, Robinson S, Swift L, Gambardella L, Bargehr J, Ortmann D, Brown SE, Osnato A, Murphy MP et al. (2021)
Cholangiocyte organoids can repair bile ducts after transplantation in the human liver
Science, 371 (6531), 839-846
DOI 10.1126/science.aaz6964, PubMed 33602855

Soreide K, Yaqub S, Hallet J, Kvaløy JT, Kleppe TS (2021)
A Risk Model of Admitting Patients With Silent SARS-CoV-2 Infection to Surgery and Development of Severe Postoperative Outcomes and Death: Projections Over 24 Months for 5 Geographical Regions
Ann Surg, 273 (2), 208-216
DOI 10.1097/SLA.0000000000004583, PubMed 33156071

Sparrelid E, Hasselgren K, Røsok BI, Larsen PN, Schultz NA, Carling U, Fallentin E, Gilg S, Sandström P, Lindell G, Björnsson B (2021)
How should liver hypertrophy be stimulated? A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) and portal vein embolization (PVE) with rescue possibility
Hepatobiliary Surg Nutr, 10 (1), 1-8
DOI 10.21037/hbsn.2019.10.36, PubMed 33575285

Thorlacius GE, Hultin-Rosenberg L, Sandling JK, Bianchi M, Imgenberg-Kreuz J, Pucholt P, Theander E, Kvarnström M, Forsblad-d'Elia H, Bucher SM, Norheim KB, Johnsen SJA, Hammenfors D, Skarstein K, Jonsson MV, Baecklund E, Aqrawi LA, Jensen JL, Palm Ø, Morris AP, , , Meadows JRS, Rantapää-Dahlqvist S, Mandl T et al. (2021)
Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome
Rheumatology (Oxford), 60 (2), 837-848
DOI 10.1093/rheumatology/keaa367, PubMed 32889544

Tollisen A, Flatø B, Selvaag AM, Aasland A, Ingebrigtsen T, Sagen J, Lerdal A (2021)
Treatment Satisfaction With and Adherence to Disease-Modifying Antirheumatic Drugs in Adult Patients With Juvenile Idiopathic Arthritis
Arthritis Care Res (Hoboken), 73 (2), 221-231
DOI 10.1002/acr.24113, PubMed 31758669

Torayraju P, Kalidindi K, Hartgill U, Moi H (2021)
Retrospective Study of the Effectiveness of Azithromycin Single Dose Versus One-week Doxycycline for Anorectal Chlamydia in Men Who Have Sex with Men
Acta Derm Venereol, 101 (2), adv00396
DOI 10.2340/00015555-3750, PubMed 33491098

Usher-Smith JA, Mills KM, Riedinger C, Saunders CL, Helsingen LM, Lytvyn L, Buskermolen M, Lansdorp-Vogelaar I, Bretthauer M, Guyatt G, Griffin SJ (2021)
The impact of information about different absolute benefits and harms on intention to participate in colorectal cancer screening: A think-aloud study and online randomised experiment
PLoS One, 16 (2), e0246991
DOI 10.1371/journal.pone.0246991, PubMed 33592037

Wahl AK, Osborne RH, Larsen MH, Andersen MH, Holter IA, Borge CR (2021)
Exploring health literacy needs in Chronic obstructive pulmonary disease (COPD): Associations between demographic, clinical variables, psychological well-being and health literacy
Heart Lung, 50 (3), 417-424 (in press)
DOI 10.1016/j.hrtlng.2021.02.007, PubMed 33618148

 
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