Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Dept. of Gastroenterology RH (Div SIMT)

24 publications found

Adami HO, Bretthauer M, Kalager M (2020)
Assessment of cancer screening effectiveness in the era of screening programs
Eur J Epidemiol, 35 (10), 891-897
DOI 10.1007/s10654-020-00684-7, PubMed 32929645

Barua I, Vinsard DG, Jodal HC, Løberg M, Kalager M, Holme Ø, Misawa M, Bretthauer M, Mori Y (2020)
Artificial intelligence for polyp detection during colonoscopy: a systematic review and meta-analysis
Endoscopy, 53 (3), 277-284
DOI 10.1055/a-1201-7165, PubMed 32557490

Beg S, Wronska E, Araujo I, González Suárez B, Ivanova E, Fedorov E, Aabakken L, Seitz U, Rey JF, Saurin JC, Tari R, Card T, Ragunath K (2020)
Use of rapid reading software to reduce capsule endoscopy reading times while maintaining accuracy
Gastrointest Endosc, 91 (6), 1322-1327
DOI 10.1016/j.gie.2020.01.026, PubMed 31981645

Ebigbo A, Karstensen JG, Bhat P, Ijoma U, Osuagwu C, Desalegn H, Oyeleke GK, Gebru RB, Guy C, Antonelli G, Vilmann P, Aabakken L, Hassan C (2020)
Impact of the COVID-19 pandemic on gastrointestinal endoscopy in Africa
Endosc Int Open, 8 (8), E1097-E1101
DOI 10.1055/a-1210-4274, PubMed 32782923

Goeppert B, Folseraas T, Roessler S, Kloor M, Volckmar AL, Endris V, Buchhalter I, Stenzinger A, Grzyb K, Grimsrud MM, Gornicka B, von Seth E, Reynolds GM, Franke A, Gotthardt DN, Mehrabi A, Cheung A, Verheij J, Arola J, Mäkisalo H, Eide TJ, Weidemann S, Cheville JC, Mazza G, Hirschfield GM et al. (2020)
Genomic Characterization of Cholangiocarcinoma in Primary Sclerosing Cholangitis Reveals Therapeutic Opportunities
Hepatology, 72 (4), 1253-1266
DOI 10.1002/hep.31110, PubMed 31925805

Helsingen LM, Refsum E, Gjøstein DK, Løberg M, Bretthauer M, Kalager M, Emilsson L, Clinical Effectiveness Research group (2020)
The COVID-19 pandemic in Norway and Sweden - threats, trust, and impact on daily life: a comparative survey
BMC Public Health, 20 (1), 1597
DOI 10.1186/s12889-020-09615-3, PubMed 33097011

Helsingen LM, Zeng L, Siemieniuk RA, Lytvyn L, Vandvik PO, Agoritsas T, Bretthauer M, Guyatt G (2020)
Establishing thresholds for important benefits considering the harms of screening interventions
BMJ Open, 10 (12), e037854
DOI 10.1136/bmjopen-2020-037854, PubMed 33268400

Karstensen JG, Ebigbo A, Bhat P, Dinis-Ribeiro M, Gralnek I, Guy C, Le Moine O, Vilmann P, Antonelli G, Ijoma U, Anigbo G, Afiheni M, Duduyemi B, Desalegn H, De Franchis R, Ponchon T, Hassan C, Aabakken L (2020)
Endoscopic treatment of variceal upper gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Cascade Guideline
Endosc Int Open, 8 (7), E990-E997
DOI 10.1055/a-1187-1154, PubMed 32626821

Kjellman M, Knigge U, Welin S, Thiis-Evensen E, Gronbæk H, Schalin-Jäntti C, Sorbye H, Joergensen MT, Johanson V, Metso S, Waldum H, Søreide JA, Ebeling T, Lindberg F, Landerholm K, Wallin G, Salem F, Schneider MDP, Belusa R (2020)
A plasma protein biomarker strategy for detection of small intestinal neuroendocrine tumors
Neuroendocrinology (in press)
DOI 10.1159/000510483, PubMed 32721955

Kummen M, Solberg OG, Storm-Larsen C, Holm K, Ragnarsson A, Trøseid M, Vestad B, Skårdal R, Yndestad A, Ueland T, Svardal A, Berge RK, Seljeflot I, Gullestad L, Karlsen TH, Aaberge L, Aukrust P, Hov JR (2020)
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y, PubMed 32214138

Kummen M, Thingholm LB, Rühlemann MC, Holm K, Hansen SH, Moitinho-Silva L, Liwinski T, Zenouzi R, Storm-Larsen C, Midttun Ø, McCann A, Ueland PM, Høivik ML, Vesterhus M, Trøseid M, Laudes M, Lieb W, Karlsen TH, Bang C, Schramm C, Franke A, Hov JR (2020)
Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis
Gastroenterology, 160 (5), 1784-1798.e0
DOI 10.1053/j.gastro.2020.12.058, PubMed 33387530

Mori Y, Kudo SE, East JE, Rastogi A, Bretthauer M, Misawa M, Sekiguchi M, Matsuda T, Saito Y, Ikematsu H, Hotta K, Ohtsuka K, Kudo T, Mori K (2020)
Cost savings in colonoscopy with artificial intelligence-aided polyp diagnosis: an add-on analysis of a clinical trial (with video)
Gastrointest Endosc, 92 (4), 905-911.e1
DOI 10.1016/j.gie.2020.03.3759, PubMed 32240683

Pedersen IB, Bretthauer M, Kalager M, Løberg M, Hoff G, Matapour S, Hugin S, Frigstad SO, Seip B, Kleist BA, Løvdal L, Botteri E, Holme Ø (2020)
Incomplete endoscopic resection of colorectal polyps: a prospective quality assurance study
Endoscopy, 53 (4), 383-391
DOI 10.1055/a-1243-0379, PubMed 32961579

Randel KR, Schult AL, Botteri E, Hoff G, Bretthauer M, Ursin G, Natvig E, Berstad P, Jørgensen A, Sandvei PK, Olsen ME, Frigstad SO, Darre-Næss O, Norvard ER, Bolstad N, Kørner H, Wibe A, Wensaas KA, de Lange T, Holme Ø (2020)
Colorectal Cancer Screening With Repeated Fecal Immunochemical Test Versus Sigmoidoscopy: Baseline Results From a Randomized Trial
Gastroenterology, 160 (4), 1085-1096.e5
DOI 10.1053/j.gastro.2020.11.037, PubMed 33227280

Severe Covid-19 GWAS Group, Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta R, Grimsrud MM, Milani C, Aziz F, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez AE et al. (2020)
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
N Engl J Med, 383 (16), 1522-1534
DOI 10.1056/NEJMoa2020283, PubMed 32558485

Thaventhiran JED, Lango Allen H, Burren OS, Rae W, Greene D, Staples E, Zhang Z, Farmery JHR, Simeoni I, Rivers E, Maimaris J, Penkett CJ, Stephens J, Deevi SVV, Sanchis-Juan A, Gleadall NS, Thomas MJ, Sargur RB, Gordins P, Baxendale HE, Brown M, Tuijnenburg P, Worth A, Hanson S, Linger RJ et al. (2020)
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Nature, 583 (7814), 90-95
DOI 10.1038/s41586-020-2265-1, PubMed 32499645

Ting YT, Dahal-Koirala S, Kim HSK, Qiao SW, Neumann RS, Lundin KEA, Petersen J, Reid HH, Sollid LM, Rossjohn J (2020)
A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease
Proc Natl Acad Sci U S A, 117 (6), 3063-3073
DOI 10.1073/pnas.1914308117, PubMed 31974305

Tønnesen CJ, Young J, Glomsaker T, Mala T, Løberg M, Bretthauer M, Refsum E, Aabakken L (2020)
Laparoscopy-assisted versus balloon enteroscopy-assisted ERCP after Roux-en-Y gastric bypass
Endoscopy, 52 (8), 654-661
DOI 10.1055/a-1139-9313, PubMed 32316042

Valestrand L, Berntsen NL, Zheng F, Schrumpf E, Hansen SH, Karlsen TH, Blumberg RS, Hov JR, Jiang X, Melum E (2020)
Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells
Clin Exp Immunol, 203 (2), 304-314
DOI 10.1111/cei.13541, PubMed 33089489

Vesterhus M, Karlsen TH (2020)
Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities
J Gastroenterol, 55 (6), 588-614
DOI 10.1007/s00535-020-01681-z, PubMed 32222826

Vesterhus M, Nielsen MJ, Hov JR, Saffioti F, Manon-Jensen T, Leeming DJ, Moum B, Boberg KM, Pinzani M, Karlsen TH, Karsdal MA, Thorburn D (2020)
Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease
JHEP Rep, 3 (1), 100178
DOI 10.1016/j.jhepr.2020.100178, PubMed 33225252

Wieszczy P, Waldmann E, Løberg M, Regula J, Rupinski M, Bugajski M, Gray K, Kalager M, Ferlitsch M, Kaminski MF, Bretthauer M (2020)
Colonoscopist Performance and Colorectal Cancer Risk After Adenoma Removal to Stratify Surveillance: Two Nationwide Observational Studies
Gastroenterology, 160 (4), 1067-1074.e6
DOI 10.1053/j.gastro.2020.10.009, PubMed 33065063

Zeng L, Helsingen LM, Kenji Nampo F, Wang Y, Yao L, Siemieniuk RA, Bretthauer M, Guyatt GH (2020)
How do cancer screening guidelines trade off benefits versus harms and burdens of screening? A systematic survey
BMJ Open, 10 (12), e038322
DOI 10.1136/bmjopen-2020-038322, PubMed 33268404

Zimmermann-Fraedrich K, Pohl H, Rösch T, Rex DK, Hassan C, Dekker E, Kaminski MF, Bretthauer M, de Heer J, Werner Y, Schachschal G, Groth S (2020)
Designs of colonoscopic adenoma detection trials: more positive results with tandem than with parallel studies - an analysis of studies on imaging techniques and mechanical devices
Gut, 70 (2), 268-275
DOI 10.1136/gutjnl-2020-320984, PubMed 32409588

 
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