Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2017 from OUS - Research Institute of Internal Medicine
76 publications found
Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses
Brain Behav Immun, 65, 342-349
DOI 10.1016/j.bbi.2017.06.005, PubMed 28619247
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
Sci Rep, 7 (1), 3490
DOI 10.1038/s41598-017-03625-9, PubMed 28615692
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J Mol Med (Berl), 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1, PubMed 28357477
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598, PubMed 28779025
Estrogen induced expression of tissue factor pathway inhibitor-2 in MCF7 cells involves lysine-specific demethylase 1
Mol Cell Endocrinol, 443, 80-88
DOI 10.1016/j.mce.2017.01.016, PubMed 28088469
Associations of brain-natriuretic peptide, high-sensitive troponin T, and high-sensitive C-reactive protein with outcomes in severe aortic stenosis
PLoS One, 12 (6), e0179304
DOI 10.1371/journal.pone.0179304, PubMed 28604834
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
J Immunol, 199 (8), 2910-2920
DOI 10.4049/jimmunol.1700302, PubMed 28855312
Vancomycin levels are frequently subtherapeutic in critically ill patients: a prospective observational study
Acta Anaesthesiol Scand, 61 (6), 627-635
DOI 10.1111/aas.12897, PubMed 28444760
Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function
Arterioscler Thromb Vasc Biol, 37 (6), 1157-1167
DOI 10.1161/ATVBAHA.116.308187, PubMed 28408371
Establishment of a surgical bile duct injection technique giving direct access to the bile ducts for studies of the murine biliary tree
Am J Physiol Gastrointest Liver Physiol, 314 (3), G349-G359
DOI 10.1152/ajpgi.00124.2017, PubMed 29212771
Soluble ST2 is associated with disease severity in arrhythmogenic right ventricular cardiomyopathy
Biomarkers, 22 (3-4), 367-371
DOI 10.1080/1354750X.2016.1278266, PubMed 28067540
Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis
Am J Pathol, 188 (3), 627-639
DOI 10.1016/j.ajpath.2017.11.010, PubMed 29248458
CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer
J Immunol, 198 (4), 1729-1739
DOI 10.4049/jimmunol.1600061, PubMed 28053236
Factor VII deficiency: Unveiling the cellular and molecular mechanisms underlying three model alterations of the enzyme catalytic domain
Biochim Biophys Acta Mol Basis Dis, 1864 (3), 660-667
DOI 10.1016/j.bbadis.2017.12.016, PubMed 29246447
Comprehensive lipid and metabolite profiling of children with and without familial hypercholesterolemia: A cross-sectional study
Atherosclerosis, 266, 48-57
DOI 10.1016/j.atherosclerosis.2017.09.021, PubMed 28963918
Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease
Dig Dis, 35 (4), 323-333
DOI 10.1159/000456583, PubMed 28468012
Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma
Biochim Biophys Acta Mol Basis Dis, 1864 (4 Pt B), 1390-1400
DOI 10.1016/j.bbadis.2017.08.020, PubMed 28844951
A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7
Thromb Res, 157, 111-116
DOI 10.1016/j.thromres.2017.07.013, PubMed 28734156
A novel ultra high-throughput 16S rRNA gene amplicon sequencing library preparation method for the Illumina HiSeq platform
Microbiome, 5 (1), 68
DOI 10.1186/s40168-017-0279-1, PubMed 28683838
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediators Inflamm, 2017, 9450439
DOI 10.1155/2017/9450439, PubMed 28490840
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages
Biochem Biophys Res Commun, 491 (2), 442-448
DOI 10.1016/j.bbrc.2017.07.070, PubMed 28712870
Gene expression profiling of fast- and slow-growing non-functioning gonadotroph pituitary adenomas
Eur J Endocrinol, 178 (3), 295-307
DOI 10.1530/EJE-17-0702, PubMed 29259037
Functional Bowel Disorders Are Associated with a Central Immune Activation
Gastroenterol Res Pract, 2017, 1642912
DOI 10.1155/2017/1642912, PubMed 29201045
Effect of thrombopoietin receptor agonists on markers of coagulation and P-selectin in patients with immune thrombocytopenia
Platelets, 30 (2), 206-212
DOI 10.1080/09537104.2017.1394451, PubMed 29215956
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation
PLoS One, 12 (11), e0188387
DOI 10.1371/journal.pone.0188387, PubMed 29176764
Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection
BMC Infect Dis, 17 (1), 445
DOI 10.1186/s12879-017-2547-x, PubMed 28645263
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076, PubMed 28695657
TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
PLoS One, 12 (10), e0185708
DOI 10.1371/journal.pone.0185708, PubMed 28973009
Effect of interleukin-6 inhibition on coronary microvascular and endothelial function in myocardial infarction
Heart, 103 (19), 1521-1527
DOI 10.1136/heartjnl-2016-310875, PubMed 28432157
A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue
Schizophr Bull, 43 (4), 881-890
DOI 10.1093/schbul/sbw183, PubMed 28049760
The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts
Semin Liver Dis, 37 (4), 314-331
DOI 10.1055/s-0037-1608801, PubMed 29272894
Intestinal microbiota in primary sclerosing cholangitis
Curr Opin Gastroenterol, 33 (2), 85-92
DOI 10.1097/MOG.0000000000000334, PubMed 28030369
HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation
BMC Infect Dis, 17 (1), 234
DOI 10.1186/s12879-017-2334-8, PubMed 28356058
Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?
Trends Immunol, 39 (3), 196-208
DOI 10.1016/j.it.2017.10.006, PubMed 29162322
Intact CD100-CD72 Interaction Necessary for TCR-Induced T Cell Proliferation
Front Immunol, 8, 765
DOI 10.3389/fimmu.2017.00765, PubMed 28713384
Genetics of primary sclerosing cholangitis and pathophysiological implications
Nat Rev Gastroenterol Hepatol, 14 (5), 279-295
DOI 10.1038/nrgastro.2016.154, PubMed 28293027
Primary sclerosing cholangitis - a comprehensive review
J Hepatol, 67 (6), 1298-1323
DOI 10.1016/j.jhep.2017.07.022, PubMed 28802875
High physical fitness is associated with reduction in basal- and exercise-induced inflammation
Scand J Med Sci Sports, 28 (1), 172-179
DOI 10.1111/sms.12878, PubMed 28314078
Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
Eur J Clin Nutr, 71 (8), 995-1001
DOI 10.1038/ejcn.2017.43, PubMed 28378853
Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus
Cardiovasc Diabetol, 16 (1), 5
DOI 10.1186/s12933-016-0492-4, PubMed 28068986
CXC chemokine ligand 16 is increased in gestational diabetes mellitus and preeclampsia and associated with lipoproteins in gestational diabetes mellitus at 5 years follow-up
Diab Vasc Dis Res, 14 (6), 525-533
DOI 10.1177/1479164117728011, PubMed 28856928
Large Reduction in Adiponectin During Pregnancy Is Associated With Large-for-Gestational-Age Newborns
J Clin Endocrinol Metab, 102 (7), 2552-2559
DOI 10.1210/jc.2017-00289, PubMed 28460045
Bowel Damage in Patients With Long-term Crohn's Disease, Assessed by Magnetic Resonance Enterography and the Lémann Index
Clin Gastroenterol Hepatol, 16 (1), 75-82.e5
DOI 10.1016/j.cgh.2017.06.053, PubMed 28694130
Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure
J Card Fail, 23 (9), 666-671
DOI 10.1016/j.cardfail.2017.06.007, PubMed 28688889
Modelling the burden of hepatitis C infection among people who inject drugs in Norway, 1973-2030
BMC Infect Dis, 17 (1), 541
DOI 10.1186/s12879-017-2631-2, PubMed 28774261
Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study
Acta Psychiatr Scand, 136 (4), 400-408
DOI 10.1111/acps.12783, PubMed 28815548
Decreasing incidence of cancer after liver transplantation-A Nordic population-based study over 3 decades
Am J Transplant, 18 (4), 952-963
DOI 10.1111/ajt.14507, PubMed 28925583
The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy
J Cardiovasc Transl Res, 10 (4), 401-410
DOI 10.1007/s12265-017-9748-y, PubMed 28474304
Limited Added Value of Circulating Inflammatory Biomarkers in Chronic Heart Failure
JACC Heart Fail, 5 (4), 256-264
DOI 10.1016/j.jchf.2017.01.008, PubMed 28359413
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262
Estrogen Receptor α, a Sex-Dependent Predictor of Aggressiveness in Nonfunctioning Pituitary Adenomas: SSTR and Sex Hormone Receptor Distribution in NFPA
J Clin Endocrinol Metab, 102 (9), 3581-3590
DOI 10.1210/jc.2017-00792, PubMed 28911153
Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial
PLoS One, 12 (5), e0176527
DOI 10.1371/journal.pone.0176527, PubMed 28464042
Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics
Lipids Health Dis, 16 (1), 115
DOI 10.1186/s12944-017-0511-9, PubMed 28606150
Overview of methodologies for T-cell receptor repertoire analysis
BMC Biotechnol, 17 (1), 61
DOI 10.1186/s12896-017-0379-9, PubMed 28693542
Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci
Gut Microbes, 9 (1), 68-75
DOI 10.1080/19490976.2017.1356979, PubMed 28816579
β-Thromboglobulin may not reflect platelet activation during haemodialysis with the HeprAN membrane
Scand J Clin Lab Invest, 77 (8), 679-684
DOI 10.1080/00365513.2017.1397288, PubMed 29117741
The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation
Physiol Rep, 5 (4)
DOI 10.14814/phy2.13117, PubMed 28219981
The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII in apixaban-treated patients in vitro
Res Pract Thromb Haemost, 1 (1), 49-56
DOI 10.1002/rth2.12015, PubMed 30046673
The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor
Thromb J, 15, 6
DOI 10.1186/s12959-017-0129-1, PubMed 28239301
The alternative complement pathway is dysregulated in patients with chronic heart failure
Sci Rep, 7, 42532
DOI 10.1038/srep42532, PubMed 28195242
Osteoprotegerin levels in ST-elevation myocardial infarction: Temporal profile and association with myocardial injury and left ventricular function
PLoS One, 12 (3), e0173034
DOI 10.1371/journal.pone.0173034, PubMed 28253327
Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia
Eur J Clin Invest, 48 (1)
DOI 10.1111/eci.12865, PubMed 29171871
Increased expression of TFPI in human carotid stenosis
Thromb Res, 155, 31-37
DOI 10.1016/j.thromres.2017.04.024, PubMed 28482260
Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia
Sci Rep, 7, 39710
DOI 10.1038/srep39710, PubMed 28054583
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
J Autoimmun, 81, 110-119
DOI 10.1016/j.jaut.2017.04.004, PubMed 28476239
Association of Circulating Wnt Antagonists With Severe Abdominal Aortic Calcification in Elderly Women
J Endocr Soc, 1 (1), 26-38
DOI 10.1210/js.2016-1040, PubMed 29264443
Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease
Inflamm Bowel Dis, 23 (10), 1752-1761
DOI 10.1097/MIB.0000000000001264, PubMed 28902124
Extracellular matrix markers and risk of myocardial infarction: The HUNT Study in Norway
Eur J Prev Cardiol, 24 (11), 1161-1167
DOI 10.1177/2047487317703826, PubMed 28429960
Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study
Int J Cardiol, 243, 502-504
DOI 10.1016/j.ijcard.2017.05.106, PubMed 28615143
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J Hepatol, 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019, PubMed 28161472
A Young, Immunocompetent Woman with Small Bowel and Hepatic Mucormycosis Successfully Treated with Aggressive Surgical Debridements and Antifungal Therapy
Case Rep Infect Dis, 2017, 4173246
DOI 10.1155/2017/4173246, PubMed 29435377
Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts
BMJ Open Gastroenterol, 4 (1), e000134
DOI 10.1136/bmjgast-2017-000134, PubMed 28761687
Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study
Eur J Heart Fail, 20 (2), 268-277
DOI 10.1002/ejhf.988, PubMed 28960777
Scoring Systems for Postthrombotic Syndrome
Semin Thromb Hemost, 43 (5), 500-504
DOI 10.1055/s-0037-1599142, PubMed 28470653
Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases
JAMA Neurol, 74 (7), 780-792
DOI 10.1001/jamaneurol.2017.0469, PubMed 28586827
Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients
Open Heart, 4 (2), e000635
DOI 10.1136/openhrt-2017-000635, PubMed 29225901