Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Department of Rheumatology, Dermatology and Infectious Diseases

44 publications found

Aamodt AH, Høgestøl EA, Popperud TH, Holter JC, Dyrhol-Riise AM, Tonby K, Stiksrud B, Quist-Paulsen E, Berge T, Barratt-Due A, Aukrust P, Heggelund L, Blennow K, Zetterberg H, Harbo HF (2021)
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19
J Neurol
DOI 10.1007/s00415-021-10517-6, PubMed 33743046

Aune SK, Byrkjeland R, Solheim S, Arnesen H, Trøseid M, Awoyemi A, Seljeflot I, Helseth R (2021)
Gut related inflammation and cardiorespiratory fitness in patients with CAD and type 2 diabetes: a sub-study of a randomized controlled trial on exercise training
Diabetol Metab Syndr, 13 (1), 36
DOI 10.1186/s13098-021-00655-2, PubMed 33794977

Bjørkto MH, Barratt-Due A, Nordøy I, Dörje C, Galteland E, Lind A, Hilli A, Aukrust P, Mjøen G (2021)
The use of eculizumab in Capnocytophaga canimorsus associated thrombotic microangiopathy: a case report
BMC Infect Dis, 21 (1), 137
DOI 10.1186/s12879-021-05789-2, PubMed 33526010

Broch K, Anstensrud AK, Woxholt S, Sharma K, Tøllefsen IM, Bendz B, Aakhus S, Ueland T, Amundsen BH, Damås JK, Berg ES, Bjørkelund E, Bendz C, Hopp E, Kleveland O, Stensæth KH, Opdahl A, Kløw NE, Seljeflot I, Andersen GØ, Wiseth R, Aukrust P, Gullestad L (2021)
Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction
J Am Coll Cardiol, 77 (15), 1845-1855
DOI 10.1016/j.jacc.2021.02.049, PubMed 33858620

Brustugun OT, Heggelund L (2021)
COVID-19 vaccination of cancer patients
Tidsskr Nor Laegeforen, 141 (3)
DOI 10.4045/tidsskr.21.0026, PubMed 33624982

Dhillon AK, Rupp C, Bergquist A, Voitl R, Folseraas T, Trøseid M, Midttun Ø, Ueland PM, Karlsen TH, Vesterhus M, Kummen M, Hov JR (2021)
Associations of neopterin and kynurenine-tryptophan ratio with survival in primary sclerosing cholangitis
Scand J Gastroenterol, 56 (4), 443-452
DOI 10.1080/00365521.2021.1880627, PubMed 33583308

Didriksen H, Molberg Ø, Fretheim H, Gude E, Jordan S, Brunborg C, Palchevskiy V, Garen T, Midtvedt Ø, Andreassen AK, Distler O, Belperio J, Hoffmann-Vold AM (2021)
Lymphangiogenic factors are associated with pulmonary arterial hypertension in systemic sclerosis
Arthritis Rheumatol (in press)
DOI 10.1002/art.41665, PubMed 33497027

Dobrota R, Jordan S, Juhl P, Maurer B, Wildi L, Bay-Jensen AC, Karsdal MA, Herrick AL, Distler JHW, Allanore Y, Hoffmann-Vold AM, Siebuhr AS, Distler O (2021)
Circulating collagen neo-epitopes and their role in the prediction of fibrosis in patients with systemic sclerosis: a multicentre cohort study
Lancet Rheumatol., 3 (3), E175-E184

Drivsholm N, Knudsen AD, Faurholt-Jepsen M, Midttun Ø, TrØseid M, Kirkegaard-Klitbo DM, Ueland PM, Nielsen SD, Gelpi M (2021)
Alterations in the kynurenine pathway of tryptophan metabolism are associated with depression in people living with HIV
J Acquir Immune Defic Syndr (in press)
DOI 10.1097/QAI.0000000000002664, PubMed 33633032

Endre KMA, Landrø L, LeBlanc M, Gjersvik P, Carlsen KL, Haugen G, Hedlin G, Jonassen CM, Nordlund B, Rudi K, Skjerven HO, Staff AC, Söderhäll C, Vettukattil R, Rehbinder EM (2021)
Eczema distribution in girls and boys during infancy: a cohort study on atopic dermatitis
J Allergy Clin Immunol Pract (in press)
DOI 10.1016/j.jaip.2021.04.053, PubMed 33964509

Endre KMA, Landrø L, LeBlanc M, Gjersvik P, Lødrup Carlsen KC, Haugen G, Hedlin G, Jonassen CM, Nordlund B, Rudi K, Skjerven HO, Staff AC, Söderhäll C, Vettukattil R, Rehbinder EM (2021)
Diagnosing atopic dermatitis in infancy using established diagnostic criteria: a cohort study
Br J Dermatol (in press)
DOI 10.1111/bjd.19831, PubMed 33511639

Felbo SK, Wiell C, Østergaard M, Poggenborg RP, Bøyesen P, Hammer HB, Boonen A, Pedersen SJ, Juul Sørensen I, Madsen OR, Slot O, Møller JM, Szkudlarek M, Terslev L (2021)
Do tender joints in active psoriatic arthritis reflect inflammation assessed by ultrasound and magnetic resonance imaging?
Rheumatology (Oxford) (in press)
DOI 10.1093/rheumatology/keab384, PubMed 33895799

Fraz MSA, Moe N, Revheim ME, Stavrinou ML, Durheim MT, Nordøy I, Macpherson ME, Aukrust P, Jørgensen SF, Aaløkken TM, Fevang B (2021)
Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency-Features of CT and 18F-FDG Positron Emission Tomography/CT in Clinically Progressive Disease
Front Immunol, 11, 617985
DOI 10.3389/fimmu.2020.617985, PubMed 33584710

Gatti F, Mia S, Hammarström C, Frerker N, Fosby B, Wang J, Pietka W, Sundnes O, Hol J, Kasprzycka M, Haraldsen G (2021)
Nuclear IL-33 restrains the early conversion of fibroblasts to an extracellular matrix-secreting phenotype
Sci Rep, 11 (1), 108
DOI 10.1038/s41598-020-80509-5, PubMed 33420328

Gigante A, Hoffmann-Vold AM, Fegatelli DA, Gabrielli A, Leodori G, Coleiro B, De Santis M, Dagna L, Alegre-Sancho JJ, Montecucco C, Carreira PE, Balbir-Gurman A, Doria A, Riemekasten G, Airò P, Distler J, Distler O, Rosato E, EUSTAR collaborators (2021)
Estimated glomerular filtration rate is a marker of mortality in the European Scleroderma Trials and Research Group (EUSTAR) database
Rheumatology (Oxford) (in press)
DOI 10.1093/rheumatology/keab302, PubMed 33769468

Gjersvik P (2021)
Everything that can be said in English can be said in Norwegian
Tidsskr Nor Laegeforen, 141 (7)
DOI 10.4045/tidsskr.21.0260, PubMed 33950639

Helseth R, Kleveland O, Ueland T, Wiseth R, Damas JK, Broch K, Michelsen A, Bendz B, Gullestad L, Aukrust P, Seljeflot I (2021)
Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction
Open Heart, 8 (1)
DOI 10.1136/openhrt-2020-001492, PubMed 33972404

Highland KB, Distler O, Kuwana M, Allanore Y, Assassi S, Azuma A, Bourdin A, Denton CP, Distler JHW, Hoffmann-Vold AM, Khanna D, Mayes MD, Raghu G, Vonk MC, Gahlemann M, Clerisme-Beaty E, Girard M, Stowasser S, Zoz D, Maher TM, SENSCIS trial investigators (2021)
Efficacy and safety of nintedanib in patients with systemic sclerosis-associated interstitial lung disease treated with mycophenolate: a subgroup analysis of the SENSCIS trial
Lancet Respir Med, 9 (1), 96-106
DOI 10.1016/S2213-2600(20)30330-1, PubMed 33412120

Hoffmann-Vold AM, Bendstrup E, Dimitroulas T, Hesselstrand R, Morais A, Peltomaa R, Smith V, Welling J, Vonk MC, Wuyts WA (2021)
Identifying unmet needs in SSc-ILD by semi-qualitative in-depth interviews
Rheumatology (Oxford) (in press)
DOI 10.1093/rheumatology/keab154, PubMed 33587103

Hoffmann-Vold AM, Maher TM, Philpot EE, Ashrafzadeh A, Distler O (2021)
Assessment of recent evidence for the management of patients with systemic sclerosis-associated interstitial lung disease: a systematic review
ERJ Open Res, 7 (1)
DOI 10.1183/23120541.00235-2020, PubMed 33644224

Hoffmann-Vold AM, Volkmann ER (2021)
Gastrointestinal involvement in systemic sclerosis: Effects on morbidity and mortality and new therapeutic approaches
J. Scleroderma Relat. Disord., 6 (1), 2397198319891282-43

Holme SS, Kilian K, Eggesbø HB, Moen JM, Molberg Ø (2021)
Impact of baseline clinical and radiological features on outcome of chronic rhinosinusitis in granulomatosis with polyangiitis
Arthritis Res Ther, 23 (1), 18
DOI 10.1186/s13075-020-02401-x, PubMed 33430923

Kaarbø MB, Danielsen KG, Haugstad GK, Helgesen ALO, Wojniusz S (2021)
The Tampon Test as a Primary Outcome Measure in Provoked Vestibulodynia: A Mixed Methods Study
J Sex Med (in press)
DOI 10.1016/j.jsxm.2021.03.010, PubMed 33967000

Kelleher MM, Cro S, Cornelius V, Lodrup Carlsen KC, Skjerven HO, Rehbinder EM, Lowe AJ, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Axon E, Surber C, Cork M, Cooke A, Tran L, Van Vogt E, Schmitt J, Weidinger S, McClanahan D, Simpson E, Duley L, Askie LM et al. (2021)
Skin care interventions in infants for preventing eczema and food allergy
Cochrane Database Syst Rev, 2, CD013534
DOI 10.1002/14651858.CD013534.pub2, PubMed 33545739

Kelleher MM, Cro S, Van Vogt E, Cornelius V, Lodrup Carlsen KC, Ove Skjerven H, Rehbinder EM, Lowe A, Dissanayake E, Shimojo N, Yonezawa K, Ohya Y, Yamamoto-Hanada K, Morita K, Cork M, Cooke A, Simpson EL, McClanahan D, Weidinger S, Schmitt J, Axon E, Tran L, Surber C, Askie LM, Duley L et al. (2021)
Skincare interventions in infants for preventing eczema and food allergy: A cochrane systematic review and individual participant data meta-analysis
Clin Exp Allergy, 51 (3), 402-418
DOI 10.1111/cea.13847, PubMed 33550675

Lossius AH, Lorentzen M, Austad J, Bergersen TK (2021)
Contact allergy in patients with chronic venous leg ulcers
Contact Dermatitis, 84 (6), 470-472
DOI 10.1111/cod.13770, PubMed 33368388

Lossius AH, Sundnes O, Ingham AC, Edslev SM, Bjørnholt JV, Lilje B, Bradley M, Asad S, Haraldsen G, Skytt-Andersen P, Holm JØ, Berents TL (2021)
Shifts in the Skin Microbiota after UVB Treatment in Adult Atopic Dermatitis
Dermatology, 1-12 (in press)
DOI 10.1159/000515236, PubMed 33887725

Marstein HS, Godang K, Flatø B, Sjaastad I, Bollerslev J, Sanner H (2021)
Bone mineral density and explanatory factors in children and adults with juvenile dermatomyositis at long term follow-up; a cross sectional study
Pediatr Rheumatol Online J, 19 (1), 56
DOI 10.1186/s12969-021-00543-z, PubMed 33902632

Nast A, Smith C, Spuls PI, Avila Valle G, Bata-Csörgö Z, Boonen H, De Jong E, Garcia-Doval I, Gisondi P, Kaur-Knudsen D, Mahil S, Mälkönen T, Maul JT, Mburu S, Mrowietz U, Reich K, Remenyik E, Rønholt KM, Sator PG, Schmitt-Egenolf M, Sikora M, Strömer K, Sundnes O, Trigos D, Van Der Kraaij G et al. (2021)
EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris - Part 2: specific clinical and comorbid situations
J Eur Acad Dermatol Venereol, 35 (2), 281-317
DOI 10.1111/jdv.16926, PubMed 33547728

Oppen K, Ueland T, Siljan WW, Skadberg Ø, Brede C, Lauritzen T, Aukrust P, Steinsvik T, Husebye E, Michelsen AE, Holter JC, Heggelund L (2021)
Hepcidin and Ferritin Predict Microbial Etiology in Community-Acquired Pneumonia
Open Forum Infect Dis, 8 (4), ofab082
DOI 10.1093/ofid/ofab082, PubMed 33880390

Pereira MP, Zeidler C, Wallengren J, Halvorsen JA, Weisshaar E, Garcovich S, Misery L, Brenaut E, Şavk E, Potekaev N, Lvov A, Bobko S, Szepietowski JC, Reich A, Bozek A, Legat FJ, Metz M, Streit M, Serra-Baldrich E, Gonçalo M, Storck M, Nau T, Hoffmann V, Steinke S, Greiwe I et al. (2021)
Chronic Nodular Prurigo: A European Cross-sectional Study of Patient Perspectives on Therapeutic Goals and Satisfaction
Acta Derm Venereol, 101 (2), adv00403
DOI 10.2340/00015555-3726, PubMed 33320272

Rehbinder EM, Skjerven HO, Carlsen KCL (2021)
Correction: Emollient creams and bath oils do not prevent atopic eczema
Tidsskr Nor Laegeforen, 141 (4)
DOI 10.4045/tidsskr.21.0095, PubMed 33685113

Rehbinder EM, Skjerven HO, Carlsen KCL (2021)
Emollient creams and bath oils do not prevent atopic eczema
Tidsskr Nor Laegeforen, 141 (2)
DOI 10.4045/tidsskr.20.0884, PubMed 33528125

Reid S, Hagberg N, Sandling JK, Alexsson A, Pucholt P, Sjöwall C, Lerang K, Jönsen A, Gunnarsson I, Syvänen AC, Troldborg AM, Voss A, Bengtsson AA, Molberg Ø, Jacobsen S, Svenungsson E, Rönnblom L, Leonard D (2021)
Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus
Ann Rheum Dis (in press)
DOI 10.1136/annrheumdis-2020-219727, PubMed 33766895

Robsahm TE, Helsing P, Svendsen HL, Veierød MB (2021)
Clinical Suspicion Sensitivity of Nodular and Superficial Spreading Melanoma
Acta Derm Venereol, 101 (4), adv00427
DOI 10.2340/00015555-3782, PubMed 33686445

Sande NK, Bøyesen P, Aga AB, Hammer HB, Flatø B, Roth J, Lilleby V (2021)
Development and reliability of a novel ultrasonographic joint-specific scoring system for synovitis with reference atlas for patients with juvenile idiopathic arthritis
RMD Open, 7 (2)
DOI 10.1136/rmdopen-2021-001581, PubMed 33883255

Sundnes O, Ottestad W, Schjalm C, Lundbäck P, la Cour Poulsen L, Mollnes TE, Haraldsen G, Eken T (2021)
Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
Mol Med, 27 (1), 29
DOI 10.1186/s10020-021-00288-1, PubMed 33771098

Syversen SW, Goll GL, Jørgensen KK, Sandanger Ø, Sexton J, Olsen IC, Gehin JE, Warren DJ, Brun MK, Klaasen RA, Karlsen LN, Noraberg G, Zettel C, Ljoså MKA, Haugen AJ, Njålla RJ, Bruun TJ, Seeberg KA, Michelsen B, Strand EK, Skorpe S, Blomgren IM, Bragnes YH, Dotterud CK, Thune T et al. (2021)
Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial
JAMA, 325 (17), 1744-1754
DOI 10.1001/jama.2021.4172, PubMed 33944876

Tedner SG, Söderhäll C, Konradsen JR, Bains KES, Borres MP, Carlsen KH, Carlsen KCL, Färdig M, Gerdin SW, Gudmundsdóttir HK, Haugen G, Hedlin G, Jonassen CM, Kreyberg I, Mägi CO, Nordhagen LS, Rehbinder EM, Rudi K, Skjerven HO, Staff AC, Vettukattil R, van Hage M, Nordlund B, Asarnoj A (2021)
Extract and molecular-based early infant sensitization and associated factors-A PreventADALL study
Allergy (in press)
DOI 10.1111/all.14805, PubMed 33751598

Thorlacius GE, Hultin-Rosenberg L, Sandling JK, Bianchi M, Imgenberg-Kreuz J, Pucholt P, Theander E, Kvarnström M, Forsblad-d'Elia H, Bucher SM, Norheim KB, Johnsen SJA, Hammenfors D, Skarstein K, Jonsson MV, Baecklund E, Aqrawi LA, Jensen JL, Palm Ø, Morris AP, DISSECT consortium, the ImmunoArray consortium, Meadows JRS, Rantapää-Dahlqvist S, Mandl T et al. (2021)
Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome
Rheumatology (Oxford), 60 (2), 837-848
DOI 10.1093/rheumatology/keaa367, PubMed 32889544

Thorsen IS, Gøransson LG, Ueland T, Aukrust P, Manhenke CA, Skadberg Ø, Jonsson G, Ørn S (2021)
The relationship between Fibroblast Growth Factor 23 (FGF23) and cardiac MRI findings following primary PCI in patients with acute first time STEMI
Int J Cardiol Heart Vasc, 33, 100727
DOI 10.1016/j.ijcha.2021.100727, PubMed 33665349

Tollisen A, Flatø B, Selvaag AM, Aasland A, Ingebrigtsen T, Sagen J, Lerdal A (2021)
Treatment Satisfaction With and Adherence to Disease-Modifying Antirheumatic Drugs in Adult Patients With Juvenile Idiopathic Arthritis
Arthritis Care Res (Hoboken), 73 (2), 221-231
DOI 10.1002/acr.24113, PubMed 31758669

Ueland T, Abraityte A, Norum H, Varathalingam S, Gullestad L, Aukrust P, Andreassen AK (2021)
Circulating regulators of the wingless pathway in precapillary pulmonary hypertension
Respirology
DOI 10.1111/resp.14048, PubMed 33830565

Ueland T, Astrup E, Otterdal K, Lekva T, Janardhanan J, Prakash JAJ, Thomas K, Michelsen AE, Aukrust P, Varghese GM, Damås JK (2021)
Secreted Wnt antagonists in scrub typhus
PLoS Negl Trop Dis, 15 (4), e0009185
DOI 10.1371/journal.pntd.0009185, PubMed 33914733

 
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