Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2019 from OUS - Department of Gastrointestinal and Paediatric Surgery
82 publications found
High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer
BMC Cancer, 19 (1), 488
DOI 10.1186/s12885-019-5724-z, PubMed 31122213
Laparoscopic versus open liver resection in the posterosuperior segments: a sub-group analysis from the OSLO-COMET randomized controlled trial
HPB (Oxford), 21 (11), 1485-1490
DOI 10.1016/j.hpb.2019.03.358, PubMed 30962136
Laparoscopic liver resection for non-colorectal non-neuroendocrine metastases: perioperative and oncologic outcomes
World J Surg Oncol, 17 (1), 156
DOI 10.1186/s12957-019-1700-y, PubMed 31484583
Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells
BMC Cancer, 19 (1), 596
DOI 10.1186/s12885-019-5803-1, PubMed 31208372
Immune stimulatory effect of anti-EpCAM immunotoxin - improved overall survival of metastatic colorectal cancer patients
Acta Oncol, 59 (4), 404-409
DOI 10.1080/0284186X.2019.1704864, PubMed 31876430
Trends in management and outcome of cystic pancreatic lesions - analysis of 322 cases undergoing surgical resection
Scand J Gastroenterol, 54 (8), 1051-1057
DOI 10.1080/00365521.2019.1642379, PubMed 31322457
Immunogenic cell death by neoadjuvant oxaliplatin and radiation protects against metastatic failure in high-risk rectal cancer
Cancer Immunol Immunother, 69 (3), 355-364
DOI 10.1007/s00262-019-02458-x, PubMed 31893287
Resident memory CD8 T cells persist for years in human small intestine
J Exp Med, 216 (10), 2412-2426
DOI 10.1084/jem.20190414, PubMed 31337737
Multicentre analysis of the learning curve for laparoscopic liver resection of the posterosuperior segments
Br J Surg, 106 (11), 1512-1522
DOI 10.1002/bjs.11286, PubMed 31441944
Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains
Oncogene, 38 (33), 6109-6122
DOI 10.1038/s41388-019-0868-5, PubMed 31308487
Irritable bowel syndrome-like symptoms and health related quality of life two years after Roux-en-Y gastric bypass - a prospective cohort study
BMC Gastroenterol, 19 (1), 204
DOI 10.1186/s12876-019-1103-0, PubMed 31791249
Changes in Bone Marrow Adipose Tissue One Year After Roux-en-Y Gastric Bypass: A Prospective Cohort Study
J Bone Miner Res, 34 (10), 1815-1823
DOI 10.1002/jbmr.3814, PubMed 31216081
Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy
Pancreatology, 19 (2), 316-324
DOI 10.1016/j.pan.2019.01.019, PubMed 30713128
RAS Mutation Clinical Risk Score to Predict Survival After Resection of Colorectal Liver Metastases
Ann Surg, 269 (1), 120-126
DOI 10.1097/SLA.0000000000002319, PubMed 28549012
Limitations of molecular biomarkers in patients with resectable colorectal liver metastases
Chin Clin Oncol, 8 (5), 48
DOI 10.21037/cco.2019.08.02, PubMed 31500431
Survey of the attitudes of hepatopancreatobiliary surgeons in northern Europe to resection of choledochal cysts in asymptomatic Western adults
BJS Open, 3 (6), 785-792
DOI 10.1002/bjs5.50208, PubMed 31832585
Heterogeneous radiological response to neoadjuvant therapy is associated with poor prognosis after resection of colorectal liver metastases
Eur J Surg Oncol, 45 (12), 2340-2346
DOI 10.1016/j.ejso.2019.07.017, PubMed 31350075
High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases
Clin Colorectal Cancer, 19 (1), e26-e47
DOI 10.1016/j.clcc.2019.09.003, PubMed 31982351
Can we ablate liver lesions close to large portal and hepatic veins with MR-guided HIFU? An experimental study in a porcine model
Eur Radiol, 29 (9), 5013-5021
DOI 10.1007/s00330-018-5996-8, PubMed 30737565
Abdominal pain and symptoms before and after Roux-en-Y gastric bypass
BJS Open, 3 (3), 317-326
DOI 10.1002/bjs5.50148, PubMed 31183448
A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer
Surg Endosc, 34 (1), 349-360
DOI 10.1007/s00464-019-06774-2, PubMed 30989374
Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer
Ann Oncol, 30 (10), 1622-1629
DOI 10.1093/annonc/mdz287, PubMed 31504112
ERNICA Consensus Conference on the Management of Patients with Esophageal Atresia and Tracheoesophageal Fistula: Diagnostics, Preoperative, Operative, and Postoperative Management
Eur J Pediatr Surg, 30 (4), 326-336
DOI 10.1055/s-0039-1693116, PubMed 31266084
ERNICA Consensus Conference on the Management of Patients with Esophageal Atresia and Tracheoesophageal Fistula: Follow-up and Framework
Eur J Pediatr Surg, 30 (6), 475-482
DOI 10.1055/s-0039-3400284, PubMed 31777030
Technical differences between sequencing and microarray platforms impact transcriptomic subtyping of colorectal cancer
Cancer Lett, 469, 246-255
DOI 10.1016/j.canlet.2019.10.040, PubMed 31678167
A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases
Transl Oncol, 12 (7), 951-958
DOI 10.1016/j.tranon.2019.04.001, PubMed 31096111
Quality of life from a randomized trial of laparoscopic or open liver resection for colorectal liver metastases
Br J Surg, 106 (10), 1372-1380
DOI 10.1002/bjs.11227, PubMed 31322735
ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis
Eur J Surg Oncol, 47 (1), 134-138
DOI 10.1016/j.ejso.2019.04.014, PubMed 31036394
Short-term parent reported recovery following open and laparoscopic fundoplication
J Pediatr Surg, 55 (9), 1796-1801
DOI 10.1016/j.jpedsurg.2019.11.006, PubMed 31826815
Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
Br J Cancer, 121 (6), 474-482
DOI 10.1038/s41416-019-0540-4, PubMed 31388185
Outcome after iatrogenic esophageal perforation
Scand J Gastroenterol, 54 (2), 140-144
DOI 10.1080/00365521.2019.1575464, PubMed 30857441
Intravenous Patient-controlled Analgesia Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority Trial
Ann Surg, 270 (2), 193-199
DOI 10.1097/SLA.0000000000003209, PubMed 30676382
Psychometric performance of the PAncreatic CAncer disease impact (PACADI) score
Pancreatology, 19 (7), 971-978
DOI 10.1016/j.pan.2019.09.001, PubMed 31530448
Management strategies and treatment results of pediatric choledochal malformations in the Nordic countries
HPB (Oxford), 22 (1), 161-168
DOI 10.1016/j.hpb.2019.07.001, PubMed 31371244
"Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review
Clin Epigenetics, 11 (1), 135
DOI 10.1186/s13148-019-0718-x, PubMed 31519213
IgE-sensitization to food and inhalant allergens in IBD patients compared with normal blood donors at Oslo University Hospital, Norway
Scand J Gastroenterol, 54 (9), 1107-1110
DOI 10.1080/00365521.2019.1663445, PubMed 31524013
Survival and costs of colorectal cancer treatment and effects of changing treatment strategies: a model approach
Eur J Health Econ, 21 (3), 321-334
DOI 10.1007/s10198-019-01130-6, PubMed 31707584
Laparoscopic Multiple Parenchyma-sparing Concomitant Liver Resections for Colorectal Liver Metastases
Surg Laparosc Endosc Percutan Tech, 29 (3), 187-193
DOI 10.1097/SLE.0000000000000606, PubMed 30520815
Does tumor size influence the outcome of laparoscopic distal pancreatectomy?
HPB (Oxford), 22 (9), 1280-1287
DOI 10.1016/j.hpb.2019.11.014, PubMed 31843445
Pancreatoduodenectomy with venous resection for ductal adenocarcinoma rarely achieves complete (R0) resection
HPB (Oxford), 22 (1), 50-57
DOI 10.1016/j.hpb.2019.05.005, PubMed 31186199
Nasogastric Tube on Demand is Rarely Necessary After Pancreatoduodenectomy Within an Enhanced Recovery Pathway
World J Surg, 43 (10), 2616-2622
DOI 10.1007/s00268-019-05045-4, PubMed 31161355
Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR): An International Multicenter Analysis
Ann Surg Oncol, 26 (3), 772-781
DOI 10.1245/s10434-018-07101-0, PubMed 30610560
Associations between perceived somatic symptoms and mental health after Roux-en-Y gastric bypass: a 3-year prospective cohort study
Surg Obes Relat Dis, 16 (5), 626-632
DOI 10.1016/j.soard.2019.12.018, PubMed 32007433
Laparoscopic Gastrostomy Placement in Children Has Few Major, but Many Minor Early Complications
Eur J Pediatr Surg, 30 (6), 548-553
DOI 10.1055/s-0039-3401988, PubMed 31891947
Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells
Cells, 8 (1)
DOI 10.3390/cells8010023, PubMed 30621293
Treatment Options for Metastatic Gastrointestinal Stromal Tumors to the Liver: A Review
Semin Liver Dis, 39 (3), 395-402
DOI 10.1055/s-0039-1685517, PubMed 31100757
Outcomes of Elective and Emergency Conversion in Minimally Invasive Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma: An International Multicenter Propensity Score-matched Study
Ann Surg (in press)
DOI 10.1097/SLA.0000000000003717, PubMed 31850984
Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2
Lab Invest, 100 (1), 120-134
DOI 10.1038/s41374-019-0336-4, PubMed 31641225
Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response
Cold Spring Harb Mol Case Stud, 5 (2)
DOI 10.1101/mcs.a003566, PubMed 30862609
Prenatal extravasation of urine seems to preserve renal function in boys with posterior urethral valves
J Pediatr Urol, 15 (3), 241.e1-241.e7
DOI 10.1016/j.jpurol.2019.02.010, PubMed 30982696
Semi-automated vs. manual 3D reconstruction of central mesenteric vascular models: the surgeon’s verdict
Surgical Endoscopy, 0, 1-11
PublikaID 336
Semi-automated vs. manual 3D reconstruction of central mesenteric vascular models: the surgeon's verdict
Surg Endosc, 34 (11), 4890-4900
DOI 10.1007/s00464-019-07275-y, PubMed 31745632
Construct validity of eoSim - a low-cost and portable laparoscopic simulator
Minim Invasive Ther Allied Technol, 29 (5), 261-268
DOI 10.1080/13645706.2019.1638411, PubMed 31280633
Sex-related differences in primary metastatic site in rectal cancer; associated with hemodynamic factors?
Clin Transl Radiat Oncol, 21, 5-10
DOI 10.1016/j.ctro.2019.11.006, PubMed 31872084
Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer
Transl Oncol, 12 (8), 1038-1044
DOI 10.1016/j.tranon.2019.04.014, PubMed 31146167
Right Colectomy with Extended D3 Mesenterectomy: Anterior and Posterior to the Mesenteric Vessels
Surg Technol Int, 35, 138-142
PubMed 31237343
Association of multiple patient and disease characteristics with the presence and type of pain in chronic pancreatitis
J Gastroenterol Hepatol, 35 (2), 326-333
DOI 10.1111/jgh.14783, PubMed 31314128
Pancreatic calcifications associate with diverse aetiological risk factors in patients with chronic pancreatitis: A multicentre study of 1500 cases
Pancreatology, 19 (7), 922-928
DOI 10.1016/j.pan.2019.08.009, PubMed 31462382
Chronic Pancreatitis Is Characterized by Distinct Complication Clusters That Associate With Etiological Risk Factors
Am J Gastroenterol, 114 (4), 656-664
DOI 10.14309/ajg.0000000000000147, PubMed 30741740
Use of mixed reality for improved spatial understanding of liver anatomy
Minimally Invasive Therapy & Allied Technologies, 0, 1-7
DOI 10.1080/13645706.2019.1616558, PublikaID 332
Use of mixed reality for improved spatial understanding of liver anatomy
Minim Invasive Ther Allied Technol, 29 (3), 154-160
DOI 10.1080/13645706.2019.1616558, PubMed 31116053
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
Cancer Immunol Res, 7 (5), 701-706
DOI 10.1158/2326-6066.CIR-18-0777, PubMed 30804006
Characterization of early recurrences following liver resection by ALPPS and two stage hepatectomy in patients with colorectal liver-metastases and small future liver remnants; a translational substudy of the LIGRO-RCT
HPB (Oxford), 21 (8), 1017-1023
DOI 10.1016/j.hpb.2018.12.003, PubMed 30765198
Minimally invasive pancreatic surgerywhere are we going?
Eur. Surg., 51 (3), 98-104
Bariatric surgery at Oslo University Hospital 2004–14
Tidsskr Nor Laegeforen, 139 (10)
DOI 10.4045/tidsskr.18.0495, PubMed 31238674
Bariatric surgery at Oslo University Hospital 2004-14
Tidsskr. Nor. Laegeforen., 139 (10), 921-926
Meta-Analysis of 1,200 Transcriptomic Profiles Identifies a Prognostic Model for Pancreatic Ductal Adenocarcinoma
JCO Clin Cancer Inform, 3, 1-16
DOI 10.1200/CCI.18.00102, PubMed 31070984
Preoperative detection of colorectal liver metastases: DWI alone or combined with MDCT is no substitute for Gd-EOB-DTPA-enhanced MRI
Acta Radiol, 61 (3), 302-311
DOI 10.1177/0284185119864000, PubMed 31335157
Weight loss and BMI criteria in GLIM's definition of malnutrition is associated with postoperative complications following abdominal resections - Results from a National Quality Registry
Clin Nutr, 39 (5), 1593-1599
DOI 10.1016/j.clnu.2019.07.003, PubMed 31375303
Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer
ESMO Open, 4 (3), e000523
DOI 10.1136/esmoopen-2019-000523, PubMed 31321083
Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
Oncogenesis, 8 (6), 35
DOI 10.1038/s41389-019-0141-3, PubMed 31092812
Variation in use of open and laparoscopic distal pancreatectomy and associated outcome metrics in a universal health care system
Pancreatology, 19 (6), 880-887
DOI 10.1016/j.pan.2019.07.047, PubMed 31395453
Molecular biology in pancreatic ductal adenocarcinoma: implications for future diagnostics and therapy
Eur. Surg., 51 (3), 126-134
Intraperitoneal mitomycin C improves survival compared to cytoreductive surgery alone in an experimental model of high-grade pseudomyxoma peritonei
Clin Exp Metastasis, 36 (6), 511-518
DOI 10.1007/s10585-019-09991-0, PubMed 31541325
Bone Turnover Markers After Standard and Distal Roux-en-Y Gastric Bypass: Results from a Randomized Controlled Trial
Obes Surg, 29 (9), 2886-2895
DOI 10.1007/s11695-019-03909-1, PubMed 31065919
The effect of intraoperative imaging on surgical navigation for laparoscopic liver resection surgery
Nature: Scientific Reports, 9, 1-11
DOI 10.1038/s41598-019-54915-3, PublikaID 333
The effect of intraoperative imaging on surgical navigation for laparoscopic liver resection surgery
Sci Rep, 9 (1), 18687
DOI 10.1038/s41598-019-54915-3, PubMed 31822701
The Role of Complement in Liver Injury, Regeneration, and Transplantation
Hepatology, 70 (2), 725-736
DOI 10.1002/hep.30508, PubMed 30653682
Liver transplantation as a lifesaving procedure for posthepatectomy liver failure and iatrogenic liver injuries
Langenbecks Arch Surg, 404 (3), 301-308
DOI 10.1007/s00423-019-01780-3, PubMed 30929063
Multicentre propensity score-matched study of laparoscopic versus open repeat liver resection for colorectal liver metastases
Br J Surg, 106 (6), 783-789
DOI 10.1002/bjs.11096, PubMed 30706451
Neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for cancer of the esophagus or gastroesophageal junction: long-term results of a randomized clinical trial
Dis Esophagus, 32 (2)
DOI 10.1093/dote/doy078, PubMed 30137281
Transanal total mesorectal excision for rectal cancer has been suspended in Norway
Br J Surg, 107 (1), 121-130
DOI 10.1002/bjs.11459, PubMed 31802481