Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Institute for Experimental Medical Research (IEMR)

32 publications found

Alam J, Musiime M, Romaine A, Sawant M, Melleby AO, Lu N, Eckes B, Christensen G, Gullberg D (2020)
Generation of a novel mouse strain with fibroblast-specific expression of Cre recombinase
Matrix Biol Plus, 8, 100045
DOI 10.1016/j.mbplus.2020.100045, PubMed 33543038

Altara R, da Silva GJJ, Frisk M, Spelta F, Zouein FA, Louch WE, Booz GW, Cataliotti A (2020)
Cardioprotective Effects of the Novel Compound Vastiras in a Preclinical Model of End-Organ Damage
Hypertension, 75 (5), 1195-1204
DOI 10.1161/HYPERTENSIONAHA.120.14704, PubMed 32200677

Berge K, Lyngbakken MN, Myhre PL, Brynildsen J, Røysland R, Strand H, Christensen G, Høiseth AD, Omland T, Røsjø H (2020)
High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study
Clin Biochem, 88, 30-36
DOI 10.1016/j.clinbiochem.2020.11.009, PubMed 33245872

Bergo KK, Larstorp AC, Hoffmann P, Hjørnholm U, Cataliotti A, Høieggen A, Rostrup M, Fadl Elmula FEM (2020)
Renal sympathetic denervation lowers systemic vascular resistance in true treatment-resistant hypertension
Blood Press, 30 (1), 31-40
DOI 10.1080/08037051.2020.1789446, PubMed 32633141

Berntsen KS, Raastad T, Marstein H, Kirkhus E, Merckoll E, Cumming KT, Flatø B, Sjaastad I, Sanner H (2020)
Functional and Structural Adaptations of Skeletal Muscle in Long-Term Juvenile Dermatomyositis: A Controlled Cross-Sectional Study
Arthritis Rheumatol, 72 (5), 837-848
DOI 10.1002/art.41174, PubMed 31746550

Booz GW, Altara R, Eid AH, Wehbe Z, Fares S, Zaraket H, Habeichi NJ, Zouein FA (2020)
Macrophage responses associated with COVID-19: A pharmacological perspective
Eur J Pharmacol, 887, 173547
DOI 10.1016/j.ejphar.2020.173547, PubMed 32919938

Bredmose PP, Stave H, Eriksen M, Osbakk SA, Farstad G, Hagemo JS (2020)
Live Tissue Training on Anesthetized Pigs for Air Ambulance Crews
Air Med J, 40 (1), 60-64
DOI 10.1016/j.amj.2020.10.003, PubMed 33455629

Bye A, Klevjer M, Ryeng E, Silva GJJD, Moreira JBN, Stensvold D, Wisløff U (2020)
Identification of novel genetic variants associated with cardiorespiratory fitness
Prog Cardiovasc Dis, 63 (3), 341-349
DOI 10.1016/j.pcad.2020.02.001, PubMed 32035127

Espe EKS, Bendiksen BA, Zhang L, Sjaastad I (2020)
Analysis of right ventricular mass from magnetic resonance imaging data: a simple post-processing algorithm for correction of partial-volume effects
Am J Physiol Heart Circ Physiol, 320 (2), H912-H922
DOI 10.1152/ajpheart.00494.2020, PubMed 33337965

Frisk M, Hoyland M, Zhang LL, Vindas MA, Overli O, Johansen IB (2020)
Intensive smolt production is associated with deviating cardiac morphology in Atlantic salmon (Salmo salar L.)
Aquaculture, 529, 735615

González A, Nome CG, Bendiksen BA, Sjaastad I, Zhang L, Aleksandersen M, Taubøll E, Aurlien D, Heuser K (2020)
Assessment of cardiac structure and function in a murine model of temporal lobe epilepsy
Epilepsy Res, 161, 106300
DOI 10.1016/j.eplepsyres.2020.106300, PubMed 32126491

Habeichi NJ, Mroueh A, Kaplan A, Ghali R, Al-Awassi H, Tannous C, Husari A, Jurjus A, Altara R, Booz GW, El-Yazbi A, Zouein FA (2020)
Sex-based differences in myocardial infarction-induced kidney damage following cigarette smoking exposure: more renal protection in premenopausal female mice
Biosci Rep, 40 (6)
DOI 10.1042/BSR20193229, PubMed 32519752

Harbo MB, Nordén ES, Narula J, Sjaastad I, Espe EKS (2020)
Quantifying left ventricular function in heart failure: What makes a clinically valuable parameter?
Prog Cardiovasc Dis, 63 (5), 552-560
DOI 10.1016/j.pcad.2020.05.007, PubMed 32502560

Hazen J, Vistnes M, Barca ML, Eldholm RS, Persson K, Brækhus A, Saltvedt I, Selbæk G, Engedal K, Knapskog AB (2020)
The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian Memory Clinic Patients With Mild Cognitive Impairment or Dementia
Alzheimer Dis Assoc Disord, 34 (1), 47-53
DOI 10.1097/WAD.0000000000000342, PubMed 31414991

Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, Christensen G (2020)
Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin
J Am Heart Assoc, 9 (3), e013518
DOI 10.1161/JAHA.119.013518, PubMed 32000579

Kaur S, Shen X, Power A, Ward ML (2020)
Stretch modulation of cardiac contractility: importance of myocyte calcium during the slow force response
Biophys Rev, 12 (1), 135-142
DOI 10.1007/s12551-020-00615-6, PubMed 31939110

Kobirumaki-Shimozawa F, Nakanishi T, Shimozawa T, Terui T, Oyama K, Li J, Louch WE, Ishiwata S, Fukuda N (2020)
Real-Time In Vivo Imaging of Mouse Left Ventricle Reveals Fluctuating Movements of the Intercalated Discs
Nanomaterials (Basel), 10 (3)
DOI 10.3390/nano10030532, PubMed 32188039

Krogstad V, Peric A, Robertsen I, Kringen MK, Vistnes M, Hjelmesæth J, Sandbu R, Johnson LK, Angeles PC, Jansson-Löfmark R, Karlsson C, Andersson S, Åsberg A, Andersson TB, Christensen H (2020)
Correlation of Body Weight and Composition With Hepatic Activities of Cytochrome P450 Enzymes
J Pharm Sci, 110 (1), 432-437
DOI 10.1016/j.xphs.2020.10.027, PubMed 33091408

Louwe MC, Olsen MB, Kaasbøll OJ, Yang K, Fosshaug LE, Alfsnes K, Øgaard JDS, Rashidi A, Skulberg VM, Yang M, de Miranda Fonseca D, Sharma A, Aronsen JM, Schrumpf E, Ahmed MS, Dahl CP, Nyman TA, Ueland T, Melum E, Halvorsen BE, Bjørås M, Attramadal H, Sjaastad I, Aukrust P, Yndestad A (2020)
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377

Marstein H, Schwartz T, Aaløkken TM, Lund MB, Flatø B, Sjaastad I, Sanner H (2020)
Novel associations between cytokines and pulmonary involvement in juvenile dermatomyositis - a cross-sectional study of long-term disease
Rheumatology (Oxford), 59 (8), 1862-1870
DOI 10.1093/rheumatology/kez531, PubMed 31740970

Masjoan Juncos JX, Shakil S, Bradley WE, Wei CC, Zafar I, Powell P, Mariappan N, Louch WE, Ford DA, Ahmad A, Dell'Italia LJ, Ahmad S (2020)
Chronic cardiac structural damage, diastolic and systolic dysfunction following acute myocardial injury due to bromine exposure in rats
Arch Toxicol, 95 (1), 179-193
DOI 10.1007/s00204-020-02919-8, PubMed 32979061

Mathiesen SB, Lunde M, Stensland M, Martinsen M, Nyman TA, Christensen G, Carlson CR (2020)
The Cardiac Syndecan-2 Interactome
Front Cell Dev Biol, 8, 792
DOI 10.3389/fcell.2020.00792, PubMed 32984315

Mohammadzadeh N, Melleby AO, Palmero S, Sjaastad I, Chakravarti S, Engebretsen KVT, Christensen G, Lunde IG, Tønnessen T (2020)
Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload
Cardiology, 145 (3), 187-198
DOI 10.1159/000505318, PubMed 31968347

Noureddine FY, Altara R, Fan F, Yabluchanskiy A, Booz GW, Zouein FA (2020)
Impact of the Renin-Angiotensin System on the Endothelium in Vascular Dementia: Unresolved Issues and Future Perspectives
Int J Mol Sci, 21 (12)
DOI 10.3390/ijms21124268, PubMed 32560034

Perdreau-Dahl H, Progida C, Barfeld SJ, Guldsten H, Thiede B, Arntzen M, Bakke O, Mills IG, Krauss S, Morth JP (2020)
Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells
Commun Biol, 3 (1), 123
DOI 10.1038/s42003-020-0851-2, PubMed 32170109

Rønning SB, Carlson CR, Aronsen JM, Pisconti A, Høst V, Lunde M, Liland KH, Sjaastad I, Kolset SO, Christensen G, Pedersen ME (2020)
Syndecan-4-/- Mice Have Smaller Muscle Fibers, Increased Akt/mTOR/S6K1 and Notch/HES-1 Pathways, and Alterations in Extracellular Matrix Components
Front Cell Dev Biol, 8, 730
DOI 10.3389/fcell.2020.00730, PubMed 32850844

Rubinstein J, Woo JG, Garcia AM, Alsaied T, Li J, Lunde PK, Moore RA, Laasmaa M, Sammons A, Mays WA, Miyamoto SD, Louch WE, Veldtman GR (2020)
Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis
Pediatr Cardiol, 41 (8), 1675-1688
DOI 10.1007/s00246-020-02427-7, PubMed 32770262

Skogestad J, Aronsen JM, Tovsrud N, Wanichawan P, Hougen K, Stokke MK, Carlson CR, Sjaastad I, Sejersted OM, Swift F (2020)
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovasc Res, 116 (1), 78-90
DOI 10.1093/cvr/cvz087, PubMed 30949686

Sokolova M, Yang K, Hansen SH, Louwe MC, Kummen M, Hov JER, Sjaastad I, Berge RK, Halvorsen B, Aukrust P, Yndestad A, Ranheim T (2020)
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sci Rep, 10 (1), 21006
DOI 10.1038/s41598-020-76497-1, PubMed 33273482

Tannous C, Booz GW, Altara R, Muhieddine DH, Mericskay M, Refaat MM, Zouein FA (2020)
Nicotinamide adenine dinucleotide: Biosynthesis, consumption and therapeutic role in cardiac diseases
Acta Physiol (Oxf), 231 (3), e13551
DOI 10.1111/apha.13551, PubMed 32853469

Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogestad J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE (2020)
Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes
Circ Res, 126 (7), 889-906
DOI 10.1161/CIRCRESAHA.119.315641, PubMed 32070187

Weikum J, Kulakova A, Tesei G, Yoshimoto S, Jægerum LV, Schütz M, Hori K, Skepö M, Harris P, Leo JC, Morth JP (2020)
The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action
Sci Rep, 10 (1), 21249
DOI 10.1038/s41598-020-77706-7, PubMed 33277518

 
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