Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Institute for Cancer Genetics and Informatics

27 publications found

Cyll K, Kleppe A, Kalsnes J, Vlatkovic L, Pradhan M, Kildal W, Tobin KAR, Reine TM, Wæhre H, Brennhovd B, Askautrud HA, Skaaheim Haug E, Hveem TS, Danielsen HE (2021)
PTEN and DNA Ploidy Status by Machine Learning in Prostate Cancer
Cancers (Basel), 13 (17)
DOI 10.3390/cancers13174291, PubMed 34503100

Deyab G, Reine TM, Vuong TT, Jenssen T, Hjeltnes G, Agewall S, Mikkelsen K, Førre Ø, Fagerland MW, Kolset SO, Hollan I (2021)
Antirheumatic treatment is associated with reduced serum Syndecan-1 in Rheumatoid Arthritis
PLoS One, 16 (7), e0253247
DOI 10.1371/journal.pone.0253247, PubMed 34242246

Eide PK, Valnes LM, Lindstrøm EK, Mardal KA, Ringstad G (2021)
Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases
Fluids Barriers CNS, 18 (1), 16
DOI 10.1186/s12987-021-00251-6, PubMed 33794929

Groendahl AR, Skjei Knudtsen I, Huynh BN, Mulstad M, Moe YM, Knuth F, Tomic O, Indahl UG, Torheim T, Dale E, Malinen E, Futsaether CM (2021)
A comparison of methods for fully automatic segmentation of tumors and involved nodes in PET/CT of head and neck cancers
Phys Med Biol, 66 (6), 065012
DOI 10.1088/1361-6560/abe553, PubMed 33666176

Isaksen KT, Mastroianni MA, Rinde M, Rusten LS, Batzenje DA, Ramslien LF, Slaaen M, Jerm MB, Smeland EB, Rostoft S, Liestøl K, Brodtkorb M, Holte H (2021)
A simplified frailty score predicts survival and can aid treatment intensity decisions in older DLBCL patients
Blood Adv (in press)
DOI 10.1182/bloodadvances.2021004777, PubMed 34543384

Jiang D, Hveem TS, Glaire M, Church DN, Kerr DJ, Yang L, Danielsen HE (2021)
Automated assessment of CD8+ T-lymphocytes and stroma fractions complement conventional staging of colorectal cancer
EBioMedicine, 71, 103547
DOI 10.1016/j.ebiom.2021.103547, PubMed 34479131

Jones HJS, Cunningham C, Askautrud HA, Danielsen HE, Kerr DJ, Domingo E, Maughan T, Leedham SJ, Koelzer VH (2021)
Stromal composition predicts recurrence of early rectal cancer after local excision
Histopathology
DOI 10.1111/his.14438, PubMed 34174109

Kleppe A, Skrede OJ, De Raedt S, Liestøl K, Kerr DJ, Danielsen HE (2021)
Designing deep learning studies in cancer diagnostics
Nat Rev Cancer, 21 (3), 199-211
DOI 10.1038/s41568-020-00327-9, PubMed 33514930

Körner SK, Dreyer T, Haug ES, Jerlström T, Boström PJ, Gudjonsson S, Jensen JB (2021)
Which data are available in central registries on bladder cancer patients in the five Nordic countries
Scand J Urol, 55 (2), 135-141
DOI 10.1080/21681805.2021.1877344, PubMed 33504267

Kristiansen O, Zucknick M, Reine TM, Kolset SO, Jansson T, Powell TL, Haugen G, Henriksen T, Michelsen TM (2021)
Mediators Linking Maternal Weight to Birthweight and Neonatal Fat Mass in Healthy Pregnancies
J Clin Endocrinol Metab, 106 (7), 1977-1993
DOI 10.1210/clinem/dgab166, PubMed 33713406

Lindemann K, Smogeli E, Småstuen MC, Bruheim K, Trovik J, Nordberg T, Kristensen GB, Werner HMJ, Nakken E (2021)
Salvage Radiation for Pelvic Relapse after Surgically Treated Endometrial Cancer
Cancers (Basel), 13 (6)
DOI 10.3390/cancers13061367, PubMed 33803531

Liu MS, Zhao H, Xu CX, Xie PB, Wang W, Yang YY, Lee WH, Jin Y, Zhou HQ (2021)
Clinical significance of EPHX2 deregulation in prostate cancer
Asian J Androl, 23 (1), 109-115
DOI 10.4103/aja.aja_34_20, PubMed 32687069

Nunes-Xavier CE, Kildal W, Kleppe A, Danielsen HE, Waehre H, Llarena R, Maelandsmo GM, Fodstad Ø, Pulido R, López JI (2021)
Immune checkpoint B7-H3 protein expression is associated with poor outcome and androgen receptor status in prostate cancer
Prostate, 81 (12), 838-848
DOI 10.1002/pros.24180, PubMed 34125445

Pällmann N, Deng K, Livgård M, Tesikova M, Jin Y, Frengen NS, Kahraman N, Mokhlis HM, Ozpolat B, Kildal W, Danielsen HE, Fazli L, Rennie PS, Banerjee PP, Üren A, Jin Y, Kuzu OF, Saatcioglu F (2021)
Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease Progression
Cancer Res, 81 (15), 4066-4078
DOI 10.1158/0008-5472.CAN-20-3956, PubMed 34183356

Panagopoulos I, Andersen K, Eilert-Olsen M, Rognlien AG, Munthe-Kaas MC, Micci F, Heim S (2021)
Rare KMT2A-ELL and Novel ZNF56-KMT2A Fusion Genes in Pediatric T-cell Acute Lymphoblastic Leukemia
Cancer Genomics Proteomics, 18 (2), 121-131
DOI 10.21873/cgp.20247, PubMed 33608309

Panagopoulos I, Andersen K, Eilert-Olsen M, Zeller B, Munthe-Kaas MC, Buechner J, Osnes LTN, Micci F, Heim S (2021)
Therapy-induced Deletion in 11q23 Leading to Fusion of KMT2A With ARHGEF12 and Development of B Lineage Acute Lymphoplastic Leukemia in a Child Treated for Acute Myeloid Leukemia Caused by t(9;11)(p21;q23)/KMT2A-MLLT3
Cancer Genomics Proteomics, 18 (1), 67-81
DOI 10.21873/cgp.20242, PubMed 33419897

Panagopoulos I, Andersen K, Ramslien LF, Ikonomou IM, Micci F, Heim S (2021)
Therapy-related Myeloid Leukemia With the Translocation t(8;19)(p11;q13) Leading to a KAT6A-LEUTX Fusion Gene
Anticancer Res, 41 (4), 1753-1760
DOI 10.21873/anticanres.14940, PubMed 33813379

Panagopoulos I, Gorunova L, Andersen K, Lobmaier I, Heim S (2021)
Several Fusion Genes Identified in a Spermatic Cord Leiomyoma With Rearrangements of Chromosome Arms 3p and 21q
Cancer Genomics Proteomics, 18 (4), 531-542
DOI 10.21873/cgp.20278, PubMed 34183386

Panagopoulos I, Gorunova L, Lund-Iversen M, Heim S (2021)
Monosomy 13 in Mammary Myofibroblastoma
Anticancer Res, 41 (8), 3747-3751
DOI 10.21873/anticanres.15166, PubMed 34281833

Panagopoulos I, Heim S (2021)
Interstitial Deletions Generating Fusion Genes
Cancer Genomics Proteomics, 18 (3), 167-196
DOI 10.21873/cgp.20251, PubMed 33893073

Pandya AD, Iversen TG, Moestue S, Grinde MT, Mørch Ý, Snipstad S, Åslund AKO, Øy GF, Kildal W, Engebråten O, Sandvig K, Skotland T, Mælandsmo GM (2021)
Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
Nanomaterials (Basel), 11 (5)
DOI 10.3390/nano11051140, PubMed 33924869

Pihlstrøm N, Jin Y, Nenseth Z, Kuzu OF, Saatcioglu F (2021)
STAMP2 Expression Mediated by Cytokines Attenuates Their Growth-Limiting Effects in Prostate Cancer Cells
Cancers (Basel), 13 (7)
DOI 10.3390/cancers13071579, PubMed 33808059

Prasad PJR, Elle OJ, Lindseth F, Albregtsen F, Kumar RP (2021)
Modifying U-Net for small dataset - a simplified U-Net version for Liver Parenchyma segmentation
PROC SPIE, 11597, 115971O
DOI 10.1117/12.2582179

Prasad PJR, Survarachakan S, Khan ZA, Lindseth F, Elle OJ, Albregtsen F, Kumar RP (2021)
Numerical Evaluation on Parametric Choices Influencing Segmentation Results in Radiology Images-A Multi-Dataset Study
Electronics, 10 (4), 431
DOI 10.3390/electronics10040431

Quiles-Jiménez A, Gregersen I, Segers FM, Skarpengland T, Kroustallaki P, Yang K, Kong XY, Lauritzen KH, Olsen MB, Karlsen TR, Nyman TA, Sagen EL, Bjerkeli V, Suganthan R, Nygård S, Scheffler K, Prins J, Van der Veer E, Øgaard JD, Fløisand Y, Jørgensen HF, Holven KB, Biessen EA, Nilsen H, Dahl TB et al. (2021)
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
Atherosclerosis, 324, 123-132
DOI 10.1016/j.atherosclerosis.2021.02.023, PubMed 33714552

Rye IH, Huse K, Josefsson SE, Kildal W, Danielsen HE, Schlichting E, Garred Ø, Riis ML, Osbreac, Lingjaerde OC, Myklebust JH, Russnes HG (2021)
Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression
Mol Oncol
DOI 10.1002/1878-0261.13047, PubMed 34165864

Sert BM, Kristensen GB, Kleppe A, Dørum A (2021)
Long-term oncological outcomes and recurrence patterns in early-stage cervical cancer treated with minimally invasive versus abdominal radical hysterectomy: The Norwegian Radium Hospital experience
Gynecol Oncol, 162 (2), 284-291
DOI 10.1016/j.ygyno.2021.05.028, PubMed 34083029

 
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