Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2018 from OUS - Department of Paediatric Medicine
88 publications found
Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries
Liver Transpl, 24 (9), 1252-1259
DOI 10.1002/lt.25305, PubMed 30120902
Asthma, Eczema, and Food Allergy in Children Following Liver Transplantation
J Pediatr, 204, 263-269
DOI 10.1016/j.jpeds.2018.08.050, PubMed 30270158
Psychosocial and clinical outcomes of percutaneous versus surgical pulmonary valve implantation
Open Heart, 5 (1), e000758
DOI 10.1136/openhrt-2017-000758, PubMed 30018768
Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes
Diabetes, 67 (9), 1858-1866
DOI 10.2337/db17-1281, PubMed 29945890
Lymphocyte Apoptosis and FAS Expression in Patients with 22q11.2 Deletion Syndrome
J Clin Immunol, 39 (1), 65-74
DOI 10.1007/s10875-018-0579-7, PubMed 30569262
Effective treatment of steroid and therapy-refractory acute graft-versus-host disease with a novel mesenchymal stromal cell product (MSC-FFM)
Bone Marrow Transplant, 53 (7), 852-862
DOI 10.1038/s41409-018-0102-z, PubMed 29379171
Complex and monosomal karyotype are distinct cytogenetic entities with an adverse prognostic impact in paediatric acute myeloid leukaemia. A NOPHO-DBH-AML study
Br J Haematol, 183 (4), 618-628
DOI 10.1111/bjh.15587, PubMed 30406946
Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study
Br J Cancer, 118 (11), 1502-1512
DOI 10.1038/s41416-018-0098-6, PubMed 29755120
Body mass index standard deviation score and obesity in children with type 1 diabetes in the Nordic countries. HbA1c and other predictors of increasing BMISDS
Pediatr Diabetes, 19 (7), 1198-1205
DOI 10.1111/pedi.12693, PubMed 29781227
Addition of dose-intensified doxorubicin to standard chemotherapy for rhabdomyosarcoma (EpSSG RMS 2005): a multicentre, open-label, randomised controlled, phase 3 trial
Lancet Oncol, 19 (8), 1061-1071
DOI 10.1016/S1470-2045(18)30337-1, PubMed 29941280
Morphological changes and myocardial function assessed by traditional and novel echocardiographic methods in preadolescent athlete's heart
Eur J Prev Cardiol, 25 (9), 1000-1007
DOI 10.1177/2047487318776079, PubMed 29785884
A randomized comparison of three data collection models for the measurement of parent experiences with diabetes outpatient care
BMC Med Res Methodol, 18 (1), 95
DOI 10.1186/s12874-018-0557-z, PubMed 30236067
Outcome for biliary atresia patients treated at a low-volume centre
Scand J Gastroenterol, 53 (4), 471-474
DOI 10.1080/00365521.2018.1439097, PubMed 29546790
Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology
J Allergy Clin Immunol, 143 (3), 864-879
DOI 10.1016/j.jaci.2018.08.049, PubMed 30273709
Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study
Lancet Diabetes Endocrinol, 6 (8), 637-646
DOI 10.1016/S2213-8587(18)30106-2, PubMed 29880308
Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe
J Natl Cancer Inst, 110 (6), 649-660
DOI 10.1093/jnci/djx235, PubMed 29165710
The five-year survival of children with Down syndrome in Norway 1994-2009 differed by associated congenital heart defects and extracardiac malformations
Acta Paediatr, 107 (5), 845-853
DOI 10.1111/apa.14223, PubMed 29341296
Chimeric Antigen Receptor-T Cell Therapy: Practical Considerations for Implementation in Europe
Hemasphere, 2 (1), e18
DOI 10.1097/HS9.0000000000000018, PubMed 31723747
The PanCareSurFup consortium: research and guidelines to improve lives for survivors of childhood cancer
Eur J Cancer, 103, 238-248
DOI 10.1016/j.ejca.2018.08.017, PubMed 30286417
Exploring Variation in Glycemic Control Across and Within Eight High-Income Countries: A Cross-sectional Analysis of 64,666 Children and Adolescents With Type 1 Diabetes
Diabetes Care, 41 (6), 1180-1187
DOI 10.2337/dc17-2271, PubMed 29650804
Hyperthyroidism as a late effect in childhood cancer survivors - an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study
Acta Oncol, 58 (2), 227-231
DOI 10.1080/0284186X.2018.1535187, PubMed 30585514
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction
EBioMedicine, 36, 367-375
DOI 10.1016/j.ebiom.2018.09.040, PubMed 30269996
Family history of cancer and the risk of childhood solid tumours: a Norwegian nationwide register-based cohort study
Br J Cancer, 118 (6), 905-912
DOI 10.1038/bjc.2017.493, PubMed 29462129
Survival in patients with univentricular hearts: the impact of right versus left ventricular morphology
Open Heart, 5 (2), e000902
DOI 10.1136/openhrt-2018-000902, PubMed 30364544
Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature
Genes Chromosomes Cancer, 57 (7), 359-365
DOI 10.1002/gcc.22538, PubMed 29569294
Increased rate of acute caesarean sections in women with epilepsy: results from the Oppland Perinatal Database in Norway
Eur J Neurol, 26 (4), 617-623
DOI 10.1111/ene.13865, PubMed 30414297
Risk of Subsequent Bone Cancers Among 69 460 Five-Year Survivors of Childhood and Adolescent Cancer in Europe
J Natl Cancer Inst, 110 (2)
DOI 10.1093/jnci/djx165, PubMed 28954302
Fusion status in patients with lymph node-positive (N1) alveolar rhabdomyosarcoma is a powerful predictor of prognosis: Experience of the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)
Cancer, 124 (15), 3201-3209
DOI 10.1002/cncr.31553, PubMed 29797665
MECOM-associated syndrome: a heterogeneous inherited bone marrow failure syndrome with amegakaryocytic thrombocytopenia
Blood Adv, 2 (6), 586-596
DOI 10.1182/bloodadvances.2018016501, PubMed 29540340
Parental severity assessment predicts supportive care in infant bronchiolitis
Acta Paediatr, 108 (1), 131-137
DOI 10.1111/apa.14443, PubMed 29889987
Large-scale reduction of tyrosine kinase activities in human monocytes stimulated in vitro with N. meningitidis
PLoS One, 13 (1), e0181912
DOI 10.1371/journal.pone.0181912, PubMed 29357362
The PanCareSurFup cohort of 83,333 five-year survivors of childhood cancer: a cohort from 12 European countries
Eur J Epidemiol, 33 (3), 335-349
DOI 10.1007/s10654-018-0370-3, PubMed 29497894
Survey of 23 Nordic university hospitals showed that 77% lacked written procedures for measuring and interpreting blood pressure in infants
Acta Paediatr, 108 (2), 266-270
DOI 10.1111/apa.14492, PubMed 29978501
Hb Oslo [β42(CD1)Phe→Ile; HBB: c.127T>A]: A Novel Unstable Hemoglobin Variant Found in a Norwegian Patient
Hemoglobin, 42 (2), 78-83
DOI 10.1080/03630269.2018.1468773, PubMed 30032685
Patients with advanced cancer and depression report a significantly higher symptom burden than non-depressed patients
Palliat Support Care, 17 (2), PII S1478951517001183-149
DOI 10.1017/S1478951517001183, PubMed 29317008
Lung function in patients with primary ciliary dyskinesia: an iPCD Cohort study
Eur Respir J, 52 (2)
DOI 10.1183/13993003.01040-2018, PubMed 30049738
ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing
Eur Respir J, 52 (5)
DOI 10.1183/13993003.01033-2018, PubMed 30361249
[Cardiomyopathy in hereditary muscular dystrophies]
Tidsskr Nor Laegeforen, 138 (1)
DOI 10.4045/tidsskr.16.0683, PubMed 29313627
Exploring the influence from whole blood DNA extraction methods on Infinium 450K DNA methylation
PLoS One, 13 (12), e0208699
DOI 10.1371/journal.pone.0208699, PubMed 30540848
Abnormal islet sphingolipid metabolism in type 1 diabetes
Diabetologia, 61 (7), 1650-1661
DOI 10.1007/s00125-018-4614-2, PubMed 29671030
Fluid accumulation after closure of atrial septal defects: the role of colloid osmotic pressure
Interact Cardiovasc Thorac Surg, 26 (2), 307-312
DOI 10.1093/icvts/ivx334, PubMed 29049836
Parent experiences of diabetes care questionnaire (PEQ-DC): reliability and validity following a national survey in Norway
BMC Health Serv Res, 18 (1), 774
DOI 10.1186/s12913-018-3591-y, PubMed 30314486
Endocarditis in children and adolescents with congenital heart defects: a Norwegian nationwide register-based cohort study
Arch Dis Child, 103 (7), 670-674
DOI 10.1136/archdischild-2017-313917, PubMed 29510997
Transfer of a bla CTX-M-1-carrying plasmid between different Escherichia coli strains within the human gut explored by whole genome sequencing analyses
Sci Rep, 8 (1), 280
DOI 10.1038/s41598-017-18659-2, PubMed 29321570
Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy
Nat Genet, 50 (3), 344-348
DOI 10.1038/s41588-018-0063-6, PubMed 29483653
No Evidence for Presence of Mucosal-Associated Invariant T Cells in the Insulitic Lesions in Patients Recently Diagnosed with Type 1 Diabetes
Am J Pathol, 188 (8), 1744-1748
DOI 10.1016/j.ajpath.2018.04.009, PubMed 29803829
Micronutrient Status and Nutritional Intake in 0- to 2-Year-old Children Consuming a Cows' Milk Exclusion Diet
J Pediatr Gastroenterol Nutr, 66 (5), 831-837
DOI 10.1097/MPG.0000000000001942, PubMed 29481443
Initial experience with percutaneous endoscopic gastrostomy with T-fastener fixation in pediatric patients
Endosc Int Open, 6 (2), E179-E185
DOI 10.1055/s-0043-122227, PubMed 29399615
Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial
Lancet Oncol, 19 (12), 1617-1629
DOI 10.1016/S1470-2045(18)30578-3, PubMed 30442501
Recommendations for the Appropriate Structure, Communication, and Investigation of Tobacco Harm Reduction Claims. An Official American Thoracic Society Policy Statement
Am J Respir Crit Care Med, 198 (8), e90-e105
DOI 10.1164/rccm.201808-1443ST, PubMed 30320525
The toxicity of E-cigarettes and children's respiratory health
Paediatr Respir Rev, 28, 63-67
DOI 10.1016/j.prrv.2018.01.002, PubMed 29580719
Associations between neutrophil recovery time, infections and relapse in pediatric acute myeloid leukemia
Pediatr Blood Cancer, 65 (9), e27231
DOI 10.1002/pbc.27231, PubMed 29781563
Neurosurgical treatment of gangliogliomas in children and adolescents: long-term follow-up of a single-institution series of 32 patients
Acta Neurochir (Wien), 160 (6), 1207-1214
DOI 10.1007/s00701-018-3550-8, PubMed 29680921
Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes
Int J Epidemiol, 47 (2), 417-426
DOI 10.1093/ije/dyx266, PubMed 29415279
Parental Smoking and Risk of Childhood-onset Type 1 Diabetes
Epidemiology, 29 (6), 848-856
DOI 10.1097/EDE.0000000000000911, PubMed 30074542
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
N Engl J Med, 378 (5), 439-448
DOI 10.1056/NEJMoa1709866, PubMed 29385370
Comparing osteonecrosis clinical phenotype, timing, and risk factors in children and young adults treated for acute lymphoblastic leukemia
Pediatr Blood Cancer, 65 (10), e27300
DOI 10.1002/pbc.27300, PubMed 29943905
Right ventricular pressure response to exercise in adults with isolated ventricular septal defect closed in early childhood
Cardiol Young, 28 (6), 797-803
DOI 10.1017/S1047951117002979, PubMed 29508686
Risk stratification of high-risk metastatic neuroblastoma: A report from the HR-NBL-1/SIOPEN study
Pediatr Blood Cancer, 65 (11), e27363
DOI 10.1002/pbc.27363, PubMed 30015396
Risk factors for impaired pulmonary function and cardiorespiratory fitness in very long-term adult survivors of childhood acute lymphoblastic leukemia after treatment with chemotherapy only
Acta Oncol, 57 (5), 658-664
DOI 10.1080/0284186X.2017.1423177, PubMed 29303026
Changes in quality of life in individuals with narcolepsy type 1 after the H1N1-influenza epidemic and vaccination campaign in Norway: a two-year prospective cohort study
Sleep Med, 50, 175-180
DOI 10.1016/j.sleep.2018.05.037, PubMed 30075393
Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia
Nat Med, 24 (10), 1504-1506
DOI 10.1038/s41591-018-0146-z, PubMed 30275569
Ocular findings and ocular graft-versus-host disease after allogeneic stem cell transplantation without total body irradiation
Bone Marrow Transplant, 53 (7), 863-872
DOI 10.1038/s41409-018-0090-z, PubMed 29382955
Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: a multicentre prospective registration study
Diabetologia, 62 (3), 408-417
DOI 10.1007/s00125-018-4763-3, PubMed 30483858
Self-Reported Executive Dysfunction, Fatigue, and Psychological and Emotional Symptoms in Physically Well-Functioning Long-Term Survivors of Pediatric Brain Tumor
Dev Neuropsychol, 44 (1), 88-103
DOI 10.1080/87565641.2018.1540007, PubMed 30395731
Hypoglycaemia was common in acute gastroenteritis in a prospective hospital-based study, but electrolyte imbalances were not
Acta Paediatr, 107 (8), 1455-1460
DOI 10.1111/apa.14318, PubMed 29532511
Thromboembolism in acute lymphoblastic leukemia: results of NOPHO ALL2008 protocol treatment in patients aged 1 to 45 years
Blood, 131 (22), 2475-2484
DOI 10.1182/blood-2018-01-827949, PubMed 29661787
Distribution of IL-1β immunoreactive cells in pancreatic biopsies from living volunteers with new-onset type 1 diabetes: comparison with donors without diabetes and with longer duration of disease
Diabetologia, 61 (6), 1362-1373
DOI 10.1007/s00125-018-4600-8, PubMed 29589071
Is amniotic fluid of women with uncomplicated term pregnancies free of bacteria?
Am J Obstet Gynecol, 219 (3), 289.e1-289.e12
DOI 10.1016/j.ajog.2018.05.028, PubMed 29852156
Predicting reactivity threshold in children with anaphylaxis to peanut
Clin Exp Allergy, 48 (4), 415-423
DOI 10.1111/cea.13078, PubMed 29284183
Feasibility of desensitizing children highly allergic to peanut by high-dose oral immunotherapy
Allergy, 74 (2), 337-348
DOI 10.1111/all.13604, PubMed 30225844
Norwegian standard for the safe practice of anaesthesia
Acta Anaesthesiol Scand, 62 (3), 411-417
DOI 10.1111/aas.13066, PubMed 29368359
Estimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations
Pediatr Nephrol, 34 (2), 301-311
DOI 10.1007/s00467-018-4067-3, PubMed 30171354
The Role of Primary Care Physicians in Childhood Cancer Survivorship Care: Multiperspective Interviews
Oncologist, 24 (5), 710-719
DOI 10.1634/theoncologist.2018-0103, PubMed 30171066
cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53
Oncotarget, 9 (54), 30434-30449
DOI 10.18632/oncotarget.25758, PubMed 30100998
Implementation and effectiveness of a video-based debriefing programme for neonatal resuscitation
Acta Anaesthesiol Scand, 62 (3), 394-403
DOI 10.1111/aas.13050, PubMed 29315458
The Role of Airway Inflammation and Bronchial Hyperresponsiveness in Athlete's Asthma
Med Sci Sports Exerc, 50 (4), 659-666
DOI 10.1249/MSS.0000000000001478, PubMed 29189668
Prenatal iron exposure and childhood type 1 diabetes
Sci Rep, 8 (1), 9067
DOI 10.1038/s41598-018-27391-4, PubMed 29899542
Antibiotics, acetaminophen and infections during prenatal and early life in relation to type 1 diabetes
Int J Epidemiol, 47 (5), 1538-1548
DOI 10.1093/ije/dyy092, PubMed 29868838
Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes: A Scandinavian Case-Cohort Study
Am J Epidemiol, 187 (6), 1174-1181
DOI 10.1093/aje/kwx361, PubMed 29186303
Small effort, high impact: Focus on physical activity improves oxygen uptake (VO2peak ), quality of life, and mental health after pediatric renal transplantation
Pediatr Transplant, 22 (6), e13242
DOI 10.1111/petr.13242, PubMed 29921004
Early conversion of pediatric kidney transplant patients to everolimus with reduced tacrolimus and steroid elimination: Results of a randomized trial
Am J Transplant, 19 (3), 811-822
DOI 10.1111/ajt.15081, PubMed 30125462
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort
Lancet Oncol, 19 (6), 785-798
DOI 10.1016/S1470-2045(18)30242-0, PubMed 29753700
Long-term health outcomes in survivors of childhood AML treated with allogeneic HSCT: a NOPHO-AML Study
Bone Marrow Transplant, 54 (5), 726-736
DOI 10.1038/s41409-018-0337-8, PubMed 30242226
Risk of cardiovascular disease among Nordic childhood cancer survivors with diabetes mellitus: A report from adult life after childhood cancer in Scandinavia
Cancer, 124 (22), 4393-4400
DOI 10.1002/cncr.31696, PubMed 30307617
Prevalence of disturbed eating behavior and associated symptoms of anxiety and depression among adult males and females with type 1 diabetes
J Eat Disord, 6, 28
DOI 10.1186/s40337-018-0209-z, PubMed 30214804
Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia
Pediatr Blood Cancer, 66 (1), e27437
DOI 10.1002/pbc.27437, PubMed 30216644
DNA methylation in childhood asthma: an epigenome-wide meta-analysis
Lancet Respir Med, 6 (5), 379-388
DOI 10.1016/S2213-2600(18)30052-3, PubMed 29496485