Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Ophthalmology

48 publications found

Badian RA, Utheim TP, Lagali N (2020)
Region of interest and directional analysis of subbasal nerves in wide-area corneal nerve plexus mosaics in type 2 diabetes mellitus
Sci Rep, 10 (1), 10802
DOI 10.1038/s41598-020-67737-5, PubMed 32612112

Barabino S, Benitez-Del-Castillo JM, Fuchsluger T, Labetoulle M, Malachkova N, Meloni M, Utheim TP, Rolando M (2020)
Dry eye disease treatment: the role of tear substitutes, their future, and an updated classification
Eur Rev Med Pharmacol Sci, 24 (17), 8642-8652
DOI 10.26355/eurrev_202009_22801, PubMed 32964952

Bern M, Nilsen J, Ferrarese M, Sand KMK, Gjølberg TT, Lode HE, Davidson RJ, Camire RM, Bækkevold ES, Foss S, Grevys A, Dalhus B, Wilson J, Høydahl LS, Christianson GJ, Roopenian DC, Schlothauer T, Michaelsen TE, Moe MC, Lombardi S, Pinotti M, Sandlie I, Branchini A, Andersen JT (2020)
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
Sci Transl Med, 12 (565)
DOI 10.1126/scitranslmed.abb0580, PubMed 33055243

Bisevac J, Anisimova NS, Nagymihály R, Kristianslund O, Katta K, Noer A, Sharafetdinov IH, Drolsum L, Moe MC, Malyugin BE, Petrovski G (2020)
Long-term myofibroblast persistence in the capsular bag contributes to the late spontaneous in-the-bag intraocular lens dislocation
Sci Rep, 10 (1), 20532
DOI 10.1038/s41598-020-77207-7, PubMed 33239706

Blom K, Bragadóttir R, Sivertsen MS, Moe MC, Jørstad ØK (2020)
Does Pharmaceutical Compounding of Vascular Endothelial Growth Factor Inhibitors for Intravitreal Use Alter the Risk of Post-injection Endophthalmitis?
Ocul Immunol Inflamm
DOI 10.1080/09273948.2020.1820530, PubMed 33026900

C B B Veiby N, Simeunovic A, Heier M, Brunborg C, Saddique N, Moe MC, Dahl-Jørgensen K, Margeirsdottir HD, Petrovski G (2020)
Venular oxygen saturation is increased in young patients with type 1 diabetes and mild nonproliferative diabetic retinopathy
Acta Ophthalmol, 98 (8), 800-807
DOI 10.1111/aos.14462, PubMed 32410388

Dalby M, Kristianslund O, Østern AE, Falk RS, Drolsum L (2020)
Longitudinal corneal endothelial cell loss after corrective surgery for late in-the-bag IOL dislocation: a randomized clinical trial
J Cataract Refract Surg, 46 (7), 1030-1036
DOI 10.1097/j.jcrs.0000000000000213, PubMed 32304486

Denis P, Duch S, Chen E, Klyve P, Skov J, Puska P, Erb C (2020)
European real-world data about the use of a new delivery system containing a preservative-free multi-dose glaucoma treatment
Eur J Ophthalmol, 31 (3), 1056-1063
DOI 10.1177/1120672120919342, PubMed 32375561

Eidet JR, Jørstad ØK, Fostad IG, Olstad OK, Sørland RØ, Moe MC, Petrovski G, Pepaj M (2020)
Unilateral acute anterior uveitis is associated with ipsilateral changes in the tear fluid proteome that involves the LXR/RXR pathway
J Ophthalmic Inflamm Infect, 10 (1), 13
DOI 10.1186/s12348-020-00204-4, PubMed 32458144

Eriksen KO, Jørstad ØK (2020)
Multiple Vitelliform Lesions as a Retinal Manifestation of Alport Syndrome
Case Rep Ophthalmol, 11 (1), 79-84
DOI 10.1159/000505948, PubMed 32231557

Fabian ID, Stacey AW, Foster A, Kivelä TT, Munier FL, Keren-Froim N, Gomel N, Cassoux N, Sagoo MS, Reddy MA, Harby LA, Zondervan M, Bascaran C, Abdallah E, Abdullahi SU, Boubacar SA, Ademola-Popoola DS, Adio A, Aghaji AE, Portabella SA, Alfa Bio AI, Ali AM, Alia DB, All-Eriksson C, Almeida AA et al. (2020)
Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries
Br J Ophthalmol, 105 (10), 1435-1443
DOI 10.1136/bjophthalmol-2020-316613, PubMed 32933936

Global Retinoblastoma Study Group, Fabian ID, Abdallah E, Abdullahi SU, Abdulqader RA, Adamou Boubacar S, Ademola-Popoola DS, Adio A, Afshar AR, Aggarwal P, Aghaji AE, Ahmad A, Akib MNR, Al Harby L, Al Ani MH, Alakbarova A, Portabella SA, Al-Badri SAF, Alcasabas APA, Al-Dahmash SA, Alejos A, Alemany-Rubio E, Alfa Bio AI, Alfonso Carreras Y, Al-Haddad C et al. (2020)
Global Retinoblastoma Presentation and Analysis by National Income Level
JAMA Oncol, 6 (5), 685-695
DOI 10.1001/jamaoncol.2019.6716, PubMed 32105305

Hertzberg SNW, Veiby NCBB, Bragadottir R, Eriksen K, Moe MC, Petrovski BÉ, Petrovski G (2020)
Cost-effectiveness of the triple procedure - phacovitrectomy with posterior capsulotomy compared to phacovitrectomy and sequential procedures
Acta Ophthalmol, 98 (6), 592-602
DOI 10.1111/aos.14367, PubMed 32078246

Holtan JP, Aukrust I, Jansson RW, Berland S, Bruland O, Gjerde BL, Stokowy T, Bojovic O, Forsaa V, Austeng D, Rødahl E, Bredrup C, Knappskog PM, Bragadóttir R (2020)
Clinical features and molecular genetics of patients with ABCA4-retinal dystrophies
Acta Ophthalmol, 99 (5), e733-e746
DOI 10.1111/aos.14679, PubMed 33258285

Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P et al. (2020)
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538

Islam R, Corraya RM, Pasovic L, Khan AZ, Aass HCD, Eidet JR, Utheim TP (2020)
The Effects of Prolonged Storage on ARPE-19 Cells Stored at Three Different Storage Temperatures
Molecules, 25 (24)
DOI 10.3390/molecules25245809, PubMed 33317020

Jacobsen HH, Sandell T, Jørstad ØK, Moe MC, Ringstad G, Eide PK (2020)
In Vivo Evidence for Impaired Glymphatic Function in the Visual Pathway of Patients With Normal Pressure Hydrocephalus
Invest Ophthalmol Vis Sci, 61 (13), 24
DOI 10.1167/iovs.61.13.24, PubMed 33201186

Jørstad ØK, Jonsdottir TE, Zysset S, Rowe F (2020)
A traffic perimetry test that adheres to the European visual field requirements
Acta Ophthalmol, 99 (4), e555-e561
DOI 10.1111/aos.14633, PubMed 32996716

Jørstad ØK, Wigers AR, Marthinsen PB, Evang JA, Moe MC (2020)
The Value of Macular Optical Coherence Tomography in Watchful Waiting of Suprasellar Masses: A 2-Year Observational Study
J Neuroophthalmol (in press)
DOI 10.1097/WNO.0000000000000993, PubMed 33252889

Josifovska N, Albert R, Nagymihály R, Lytvynchuk L, Moe MC, Kaarniranta K, Veréb ZJ, Petrovski G (2020)
Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells
Int J Mol Sci, 21 (3)
DOI 10.3390/ijms21030813, PubMed 32012692

Khan AZ, Jackson CJ, Utheim TP, Reppe S, Sapkota D, Olstad OK, Thiede B, Eidet JR (2020)
Sericin-Induced Melanogenesis in Cultured Retinal Pigment Epithelial Cells Is Associated with Elevated Levels of Hydrogen Peroxide and Inflammatory Proteins
Molecules, 25 (19)
DOI 10.3390/molecules25194395, PubMed 32987810

Khan AZ, Utheim TP, Moe MC, Aass HCD, Sapkota D, Vallenari EM, Eidet JR (2020)
The Silk Protein Sericin Promotes Viability of ARPE-19 and Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells in vitro
Curr Eye Res, 46 (4), 504-514
DOI 10.1080/02713683.2020.1809001, PubMed 32777180

Korhonen E, Bisevac J, Hyttinen JMT, Piippo N, Hytti M, Kaarniranta K, Petrovski G, Kauppinen A (2020)
UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells
Invest. Ophthalmol. Vis. Sci., 61 (4), 7
DOI 10.1167/iovs.61.4.7

Kristianslund O, Hagem AM, Thorsrud A, Drolsum L (2020)
Prevalence and incidence of keratoconus in Norway: a nationwide register study
Acta Ophthalmol, 99 (5), e694-e699
DOI 10.1111/aos.14668, PubMed 33196151

Kvernebo AK, Miyamoto T, Sporastøyl AH, Wikslund LK, Måsøy SE, Drolsum L, Moe MC, Salerud G, Fukamachi K, Kvernebo K (2020)
Quantification of ocular surface microcirculation by computer assisted video microscopy and diffuse reflectance spectroscopy
Exp Eye Res, 201, 108312
DOI 10.1016/j.exer.2020.108312, PubMed 33157128

Leivo T, Sarmela J, Enckell-Aaltonen M, Dafgård Kopp E, Schmitt C, Toft PB, Sigurdsson H, Uusitalo M (2020)
Nordic treatment practices survey and consensus for treatment of eyelid sebaceous carcinoma
BMC Ophthalmol, 20 (1), 103
DOI 10.1186/s12886-020-01367-3, PubMed 32178641

Lumi X, Mahnic M, Petrovski BÉ, Petrovski G (2020)
Outcomes of Vitrectomy for Long-Duration Macular Hole
J Clin Med, 9 (2)
DOI 10.3390/jcm9020444, PubMed 32041208

Nagymihaly RM, Moe MC, Petrovski G (2020)
Isolation and Culture of Corneal Stromal Stem Cells
Methods Mol Biol, 2145, 1-15
DOI 10.1007/978-1-0716-0599-8_1, PubMed 32542596

Navaratnam J, Salvanos P, Vavvas DG, Bragadóttir R (2020)
Ultra-widefield autofluorescence imaging findings in retinoschisis, rhegmatogenous retinal detachment and combined retinoschisis retinal detachment
Acta Ophthalmol, 99 (2), 195-200
DOI 10.1111/aos.14521, PubMed 32602221

Ness C, Katta K, Garred Ø, Kumar T, Olstad OK, Petrovski G, Moe MC, Noer A (2020)
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis
Exp Eye Res, 203, 108426
DOI 10.1016/j.exer.2020.108426, PubMed 33387485

Pandey S, Osman TA, Sharma S, Vallenari EM, Shahdadfar A, Pun CB, Gautam DK, Uhlin-Hansen L, Rikardsen O, Johannessen AC, Costea DE, Sapkota D (2020)
Loss of S100A14 expression at the tumor-invading front correlates with poor differentiation and worse prognosis in oral squamous cell carcinoma
Head Neck, 42 (8), 2088-2098
DOI 10.1002/hed.26140, PubMed 32202693

Pedersen HR, Baraas RC, Landsend ECS, Utheim ØA, Utheim TP, Gilson SJ, Neitz M (2020)
PAX6 Genotypic and Retinal Phenotypic Characterization in Congenital Aniridia
Invest Ophthalmol Vis Sci, 61 (5), 14
DOI 10.1167/iovs.61.5.14, PubMed 32396632

Poulsen ET, Lumi X, Hansen AK, Enghild JJ, Petrovski G (2020)
Protein Composition of the Subretinal Fluid Suggests Selective Diffusion of Vitreous Proteins in Retinal Detachment
Transl Vis Sci Technol, 9 (11), 16
DOI 10.1167/tvst.9.11.16, PubMed 33117608

Ringstad H, Reppe S, Schøyen TH, Tønseth KA, Utheim TP, Jackson CJ (2020)
Stem cell function is conserved during short-term storage of cultured epidermal cell sheets at 12°C
PLoS One, 15 (5), e0232270
DOI 10.1371/journal.pone.0232270, PubMed 32433698

Russell G, Hertzberg SNW, Anisimova N, Gavrilova N, Petrovski BÉ, Petrovski G (2020)
Digital Image Analysis of the Angle and Optic Nerve: A Simple, Fast, and Low-Cost Method for Glaucoma Assessment
J Ophthalmol, 2020, 3595610
DOI 10.1155/2020/3595610, PubMed 33194227

Slettedal JK, Traustadóttir VD, Sandvik L, Ringvold A (2020)
The prevalence and incidence of glaucoma in Norway 2004-2018: A nationwide population-based study
PLoS One, 15 (12), e0242786
DOI 10.1371/journal.pone.0242786, PubMed 33301476

Sulutvedt U, Zavagno D, Lubell J, Leknes S, de Rodez Benavent SA, Laeng B (2020)
Brightness perception changes related to pupil size
Vision Res, 178, 41-47
DOI 10.1016/j.visres.2020.09.004, PubMed 33113435

Swift W, Bair JA, Chen W, Li M, Lie S, Li D, Yang M, Shatos MA, Hodges RR, Kolko M, Utheim TP, Scott W, Dartt DA (2020)
Povidone iodine treatment is deleterious to human ocular surface conjunctival cells in culture
BMJ Open Ophthalmol, 5 (1), e000545
DOI 10.1136/bmjophth-2020-000545, PubMed 32995498

Tashbayev B, Garen T, Palm Ø, Chen X, Herlofson BB, Young A, Hove LH, Rykke M, Singh PB, Aqrawi LA, Utheim ØA, Utheim TP, Jensen JL (2020)
Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study
Sci Rep, 10 (1), 2063
DOI 10.1038/s41598-020-59078-0, PubMed 32034249

Tashbayev B, Utheim TP, Utheim ØA, Ræder S, Jensen JL, Yazdani M, Lagali N, Vitelli V, Dartt DA, Chen X (2020)
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease
Sci Rep, 10 (1), 5542
DOI 10.1038/s41598-020-62583-x, PubMed 32218518

Tashbayev B, Yazdani M, Arita R, Fineide F, Utheim TP (2020)
Intense pulsed light treatment in meibomian gland dysfunction: A concise review
Ocul Surf, 18 (4), 583-594
DOI 10.1016/j.jtos.2020.06.002, PubMed 32629039

Tellefsen Nøland S, Badian RA, Utheim TP, Utheim ØA, Stojanovic A, Tashbayev B, Raeder S, Dartt DA, Chen X (2020)
Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients
Ocul Surf, 19, 68-73
DOI 10.1016/j.jtos.2020.11.009, PubMed 33246035

Vehof J, Utheim TP, Bootsma H, Hammond CJ (2020)
Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjögren's syndrome
Clin Exp Rheumatol, 38 Suppl 126 (4), 301-309
PubMed 33025899

Vehof J, Utheim TP, Bootsma H, Hammond CJ (2020)
Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjogren's syndrome
Clin. Exp. Rheumatol., 38 (4 126), S301-S309

Veiby NCBB, Simeunovic A, Heier M, Brunborg C, Saddique N, Moe MC, Dahl-Jørgensen K, Margeirsdottir HD, Petrovski G (2020)
Associations between Macular OCT Angiography and Nonproliferative Diabetic Retinopathy in Young Patients with Type 1 Diabetes Mellitus
J Diabetes Res, 2020, 8849116
DOI 10.1155/2020/8849116, PubMed 33313325

Xeroudaki M, Thangavelu M, Lennikov A, Ratnayake A, Bisevac J, Petrovski G, Fagerholm P, Rafat M, Lagali N (2020)
A porous collagen-based hydrogel and implantation method for corneal stromal regeneration and sustained local drug delivery
Sci Rep, 10 (1), 16936
DOI 10.1038/s41598-020-73730-9, PubMed 33037282

Yazdani M, Shahdadfar A, Reppe S, Sapkota D, Vallenari EM, Lako M, Connon CJ, Figueiredo FC, Utheim TP (2020)
Response of human oral mucosal epithelial cells to different storage temperatures: A structural and transcriptional study
PLoS One, 15 (12), e0243914
DOI 10.1371/journal.pone.0243914, PubMed 33326470

Zaletel Benda P, Vratanar B, Petrovski G, Gavrić AU, Matović K, Gornik A, Vergot K, Lumi A, Lumi X (2020)
Prognostic Factor Analysis of Visual Outcome after Vitrectomy for Rhegmatogenous Retinal Detachment
J Clin Med, 9 (10)
DOI 10.3390/jcm9103251, PubMed 33053642

 
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