Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Department of Neurology

52 publications found

Aamodt AH, Høgestøl EA, Popperud TH, Holter JC, Dyrhol-Riise AM, Tonby K, Stiksrud B, Quist-Paulsen E, Berge T, Barratt-Due A, Aukrust P, Heggelund L, Blennow K, Zetterberg H, Harbo HF (2021)
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19
J Neurol
DOI 10.1007/s00415-021-10517-6, PubMed 33743046

Advani R (2021)
Addressing the Stroke Triage Challenge
Front Neurol, 12, 670204
DOI 10.3389/fneur.2021.670204, PubMed 33935959

Andersen MS, Bandres-Ciga S, Reynolds RH, Hardy J, Ryten M, Krohn L, Gan-Or Z, Holtman IR, Pihlstrøm L, International Parkinson's Disease Genomics Consortium (2021)
Heritability Enrichment Implicates Microglia in Parkinson's Disease Pathogenesis
Ann Neurol, 89 (5), 942-951
DOI 10.1002/ana.26032, PubMed 33502028

Andreassen S, Lindland EMS, Solheim AM, Beyer MK, Ljøstad U, Mygland Å, Lorentzen ÅR, Reiso H, Harbo HF, Løhaugen GCC, Eikeland R (2021)
Cognitive function, fatigue and Fazekas score in patients with acute neuroborreliosis
Ticks Tick Borne Dis, 12 (3), 101678
DOI 10.1016/j.ttbdis.2021.101678, PubMed 33529985

Berge-Seidl V, Pihlstrøm L, Toft M (2021)
Integrative analysis identifies bHLH transcription factors as contributors to Parkinson's disease risk mechanisms
Sci Rep, 11 (1), 3502
DOI 10.1038/s41598-021-83087-2, PubMed 33568722

Bjørke AB, Østby Y, Grahl SG, Larsson PG, Olsen KB, Johansen Nævra MC, Ringstad GA, Bjørnerud A, Gjerstad L, Taubøll E, Heuser K (2021)
Cognition in adult patients with newly diagnosed non-lesional temporal lobe epilepsy
Epilepsy Behav, 116, 107771
DOI 10.1016/j.yebeh.2021.107771, PubMed 33545650

Blauwendraat C, Iwaki H, Makarious MB, Bandres-Ciga S, Leonard H, Grenn FP, Lake J, Krohn L, Tan M, Kim JJ, Gibbs JR, Hernandez DG, Ruskey JA, Pihlstrøm L, Toft M, van Hilten JJ, Marinus J, Schulte C, Brockmann K, Sharma M, Siitonen A, Majamaa K, Eerola-Rautio J, Tienari PJ, Grosset DG et al. (2021)
Investigation of Autosomal Genetic Sex Differences in Parkinson's disease
Ann Neurol (in press)
DOI 10.1002/ana.26090, PubMed 33901317

Brækhus A, Kristiansen KM, Rønqvist TK (2021)
Vurdering av eldre bilføreres helse er nødvendig
Tidsskr Nor Laegeforen, 141 (6)
DOI 10.4045/tidsskr.21.0175, PubMed 33876609

Broch L, Simonsen CS, Flemmen HØ, Berg-Hansen P, Skardhamar Å, Ormstad H, Celius EG (2021)
High prevalence of fatigue in contemporary patients with multiple sclerosis
Mult Scler J Exp Transl Clin, 7 (1), 2055217321999826
DOI 10.1177/2055217321999826, PubMed 33796331

Celius EG, Thompson H, Pontaga M, Langdon D, Laroni A, Potra S, Bharadia T, Yeandle D, Shanahan J, van Galen P, Alexandri N, Kesselring J (2021)
Disease Progression in Multiple Sclerosis: A Literature Review Exploring Patient Perspectives
Patient Prefer Adherence, 15, 15-27
DOI 10.2147/PPA.S268829, PubMed 33447018

Christensen JO, Nilsen KB, Hopstock LA, Steingrímsdóttir ÓA, Nielsen CS, Zwart JA, Matre D (2021)
Shift work, low-grade inflammation, and chronic pain: a 7-year prospective study
Int Arch Occup Environ Health
DOI 10.1007/s00420-020-01626-2, PubMed 33550437

Dechsling A, Shic F, Zhang D, Marschik PB, Esposito G, Orm S, Sütterlin S, Kalandadze T, Øien RA, Nordahl-Hansen A (2021)
Virtual reality and naturalistic developmental behavioral interventions for children with autism spectrum disorder
Res Dev Disabil, 111, 103885
DOI 10.1016/j.ridd.2021.103885, PubMed 33548742

Dunker Ø, Lie MU, Nilsen KB (2021)
Can within-subject comparisons of thermal thresholds be used for diagnostic purposes?
Clin Neurophysiol Pract, 6, 63-71
DOI 10.1016/j.cnp.2021.01.002, PubMed 33665518

Eriksen E, Jørstad ØK (2021)
Transitorisk smarttelefonblindhet
Tidsskr Nor Laegeforen, 141 (5)
DOI 10.4045/tidsskr.20.0972, PubMed 33754676

Forslund MV, Perrin PB, Sigurdardottir S, Howe EI, van Walsem MR, Arango-Lasprilla JC, Lu J, Aza A, Jerstad T, Røe C, Andelic N (2021)
Health-Related Quality of Life Trajectories across 10 Years after Moderate to Severe Traumatic Brain Injury in Norway
J Clin Med, 10 (1)
DOI 10.3390/jcm10010157, PubMed 33466321

GjØra L, Strand BH, Bergh S, Borza T, Brækhus A, Engedal K, Johannessen A, Kvello-Alme M, Krokstad S, Livingston G, Matthews FE, Myrstad C, Skjellegrind H, Thingstad P, Aakhus E, Aam S, Selbæk G (2021)
Current and Future Prevalence Estimates of Mild Cognitive Impairment, Dementia, and Its Subtypes in a Population-Based Sample of People 70 Years and Older in Norway: The HUNT Study
J Alzheimers Dis, 79 (3), 1213-1226
DOI 10.3233/JAD-201275, PubMed 33427745

Grimstvedt TN, Miller JU, van Walsem MR, Feragen KJB (2021)
Speech and language difficulties in Huntington's disease: A qualitative study of patients' and professional caregivers' experiences
Int J Lang Commun Disord, 56 (2), 330-345
DOI 10.1111/1460-6984.12604, PubMed 33577706

Gundersen V (2021)
Parkinson's Disease: Can Targeting Inflammation Be an Effective Neuroprotective Strategy?
Front. Neurosci., 14, 580311

Hamre C, Fure B, Helbostad JL, Wyller TB, Ihle-Hansen H, Vlachos G, Ursin MH, Tangen GG (2021)
Factors Associated with Level of Physical Activity After Minor Stroke
J Stroke Cerebrovasc Dis, 30 (4), 105628
DOI 10.1016/j.jstrokecerebrovasdis.2021.105628, PubMed 33508728

Kristoffersen ES, Jahr SH, Faiz KW, Storstein AM, Winsvold BS, Sandset EC (2021)
Acute stroke care during the first phase of COVID-19 pandemic in Norway
Acta Neurol Scand, 143 (4), 349-354
DOI 10.1111/ane.13392, PubMed 33421104

Kristoffersen ES, Winsvold BS, Sandset EC, Storstein AM, Faiz KW (2021)
Experiences, distress and burden among neurologists in Norway during the COVID-19 pandemic
PLoS One, 16 (2), e0246567
DOI 10.1371/journal.pone.0246567, PubMed 33539418

Kuseyri Hübschmann O, Mohr A, Friedman J, Manti F, Horvath G, Cortès-Saladelafont E, Mercimek-Andrews S, Yildiz Y, Pons R, Kulhánek J, Oppebøen M, Koht JA, Podzamczer-Valls I, Domingo-Jimenez R, Ibáñez S, Alcoverro-Fortuny O, Gómez-Alemany T, de Castro P, Alfonsi C, Zafeiriou DI, López-Laso E, Guder P, Santer R, Honzík T, Hoffmann GF et al. (2021)
Brain MR patterns in inherited disorders of monoamine neurotransmitters: An analysis of 70 patients
J Inherit Metab Dis
DOI 10.1002/jimd.12360, PubMed 33443316

Langmyhr M, Henriksen SP, Cappelletti C, van de Berg WDJ, Pihlstrøm L, Toft M (2021)
Allele-specific expression of Parkinson's disease susceptibility genes in human brain
Sci Rep, 11 (1), 504
DOI 10.1038/s41598-020-79990-9, PubMed 33436766

Larsen K, Jaeger HS, Tveit LH, Hov MR, Thorsen K, Røislien J, Solyga V, Lund CG, Bache KG (2021)
Ultraearly Thrombolysis by an Anesthesiologist in a Mobile Stroke Unit A prospective, controlled intervention study
Eur J Neurol (in press)
DOI 10.1111/ene.14877, PubMed 33890385

Lossius IMB, Svendsen T, Sødal HF, Kjeldstadli K, Lossius MI, Nakken KO, Johannessen Landmark C (2021)
Effect and tolerability of perampanel in patients with drug-resistant epilepsy
Epilepsy Behav, 119, 107965 (in press)
DOI 10.1016/j.yebeh.2021.107965, PubMed 33940525

Lunden LK, Jorum E (2021)
The challenge of recognizing severe pain and autonomic abnormalities for early diagnosis of CRPS
Scand J Pain (in press)
DOI 10.1515/sjpain-2021-0036, PubMed 33838088

Magelssen M, Rasmussen M, Wallace S, Førde R (2021)
Priority setting at the clinical level: the case of nusinersen and the Norwegian national expert group
BMC Med Ethics, 22 (1), 54
DOI 10.1186/s12910-021-00623-5, PubMed 33947377

McWhinney SR, Abé C, Alda M, Benedetti F, Bøen E, Del Mar Bonnin C, Borgers T, Brosch K, Canales-Rodríguez EJ, Cannon DM, Dannlowski U, Díaz-Zuluaga AM, Elvsåshagen T, Eyler LT, Fullerton JM, Goikolea JM, Goltermann J, Grotegerd D, Haarman BCM, Hahn T, Howells FM, Ingvar M, Kircher TTJ, Krug A, Kuplicki RT et al. (2021)
Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals
Mol Psychiatry (in press)
DOI 10.1038/s41380-021-01098-x, PubMed 33863996

Neyer S, Witthöft M, Cropley M, Pawelzik M, Lugo RG, Sütterlin S (2021)
Reduction of depressive symptoms during inpatient treatment is not associated with changes in heart rate variability
PLoS One, 16 (3), e0248686
DOI 10.1371/journal.pone.0248686, PubMed 33755668

Pham U, Skogseid IM, Pripp AH, Boen E, Toft M (2021)
Impulsivity in Parkinson's disease patients treated with subthalamic nucleus deep brain stimulation-An exploratory study
PLoS One, 16 (3), e0248568

Popperud TH, Gul KA, Brunborg C, Olaussen RW, Abrahamsen TG, Osnes LT, Kerty E (2021)
Thymectomy in Juvenile Myasthenia Gravis Is Safe Regarding Long Term Immunological Effects
Front. Neurol., 12, 596859

Rahman MS, Winsvold BS, Chavez Chavez SO, Børte S, Tsepilov YA, Sharapov SZ, HUNT All-In Pain, Aulchenko YS, Hagen K, Fors EA, Hveem K, Zwart JA, van Meurs JB, Freidin MB, Williams FM (2021)
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain
Ann Rheum Dis (in press)
DOI 10.1136/annrheumdis-2020-219624, PubMed 33926923

Roaldsen MB, Lindekleiv H, Eltoft A, Jusufovic M, Søyland MH, Petersson J, Indredavik B, Tveiten A, Putaala J, Christensen H, Kõrv J, Jatužis D, Engelter ST, De Marchis GM, Wilsgaard T, Werring DJ, Robinson T, Mathiesen EB, Berge E (2021)
Tenecteplase in wake-up ischemic stroke trial: Protocol for a randomized-controlled trial
Int J Stroke, 1747493020984073
DOI 10.1177/1747493020984073, PubMed 33446083

Rødevand L, Bahrami S, Frei O, Lin A, Gani O, Shadrin A, Smeland OB, Connell KSO, Elvsåshagen T, Winterton A, Quintana DS, Hindley GFL, Werner MCF, Djurovic S, Dale AM, Lagerberg TV, Steen NE, Andreassen OA (2021)
Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
Transl Psychiatry, 11 (1), 3
DOI 10.1038/s41398-020-01142-4, PubMed 33414458

Sandset EC, Goldstein LB (2021)
Treatments-Preventive
Stroke, 52 (3), 1118-1120
DOI 10.1161/STROKEAHA.120.033236, PubMed 33563014

Schultz NH, Sørvoll IH, Michelsen AE, Munthe LA, Lund-Johansen F, Ahlen MT, Wiedmann M, Aamodt AH, Skattør TH, Tjønnfjord GE, Holme PA (2021)
Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination
N Engl J Med
DOI 10.1056/NEJMoa2104882, PubMed 33835768

Solbakken G, Løseth S, Froholdt A, Eikeland TD, Nærland T, Frich JC, Dietrichs E, Ørstavik K (2021)
Pain in adult myotonic dystrophy type 1: relation to function and gender
BMC Neurol, 21 (1), 101
DOI 10.1186/s12883-021-02124-9, PubMed 33663406

Song L, Wang X, Ouyang M, Sun L, Chen X, Arima H, Sandset EC, Delcourt C, Wang J, Chen G, Robinson T, Lindley RI, Chalmers J, Anderson CS, INTERACT2 Investigators (2021)
Associations of an Abnormal Physiological Score With Outcomes in Acute Intracerebral Hemorrhage: INTERACT2 Study
Stroke, 52 (2), 722-725
DOI 10.1161/STROKEAHA.120.030435, PubMed 33423518

Stubberud A, Linde M, Brenner E, Heier M, Olsen A, Aamodt AH, Gravdahl GB, Tronvik E (2021)
Self-administered biofeedback treatment app for pediatric migraine: A randomized pilot study
Brain Behav., 11 (2), e01974

Tahmasian M, Aleman A, Andreassen OA, Arab Z, Baillet M, Benedetti F, Bresser T, Bright J, Chee MWL, Chylinski D, Cheng W, Deantoni M, Dresler M, Eickhoff SB, Eickhoff CR, Elvsåshagen T, Feng J, Foster-Dingley JC, Ganjgahi H, Grabe HJ, Groenewold NA, Ho TC, Bong Hong S, Houenou J, Irungu B et al. (2021)
ENIGMA-Sleep: Challenges, opportunities, and the road map
J Sleep Res, e13347 (in press)
DOI 10.1111/jsr.13347, PubMed 33913199

Tallaksen C, Narverud SF (2021)
Shoshin beriberi
Tidsskr Nor Laegeforen, 141 (6)
DOI 10.4045/tidsskr.21.0215, PubMed 33876616

Tsivgoulis G, Kargiotis O, De Marchis G, Kohrmann M, Sandset EC, Karapanayiotides T, de Sousa DA, Sarraj A, Safouris A, Psychogios K, Vadikolias K, Leys D, Schellinger PD, Alexandrov AV (2021)
Off-label use of intravenous thrombolysis for acute ischemic stroke: a critical appraisal of randomized and real-world evidence
Ther. Adv. Neurol. Disord., 14, 1756286421997368

Tsivgoulis G, Katsanos AH, Mandava P, Köhrmann M, Soinne L, Barreto AD, Sharma VK, Mikulik R, Muir KW, Rothlisberger T, Grotta JC, Levi CR, Molina CA, Saqqur M, Mavridis D, Psaltopoulou T, Vosko MR, Fiebach JB, Sandset EC, Kent TA, Alexandrov AW, Schellinger PD, Alexandrov AV, CLOTBUST-ER Trial Investigators (2021)
Blood pressure excursions in acute ischemic stroke patients treated with intravenous thrombolysis
J Hypertens, 39 (2), 266-272
DOI 10.1097/HJH.0000000000002628, PubMed 32956103

Tunold JA, Geut H, Rozemuller JMA, Henriksen SP, Toft M, van de Berg WDJ, Pihlstrøm L (2021)
APOE and MAPT Are Associated With Dementia in Neuropathologically Confirmed Parkinson's Disease
Front Neurol, 12, 631145
DOI 10.3389/fneur.2021.631145, PubMed 33613437

Ulrichsen KM, Kolskår KK, Richard G, Alnæs D, Dørum ES, Sanders AM, Tornås S, Sánchez JM, Engvig A, Ihle-Hansen H, de Schotten MT, Nordvik JE, Westlye LT (2021)
Structural brain disconnectivity mapping of post-stroke fatigue
Neuroimage Clin, 30, 102635 (in press)
DOI 10.1016/j.nicl.2021.102635, PubMed 33799271

Ummak E, Toplu-Demirtaş E, Jessen RS (2021)
Untangling the Relationship Between Internalized Heterosexism and Psychological Intimate Partner Violence Perpetration: A Comparative Study of Lesbians and Bisexual Women in Turkey and Denmark
J Interpers Violence, 8862605211004108 (in press)
DOI 10.1177/08862605211004108, PubMed 33876984

Vlachos G, Ihle-Hansen H, Bruun Wyller T, Brækhus A, Mangset M, Hamre C, Fure B (2021)
Cognitive and emotional symptoms in patients with first-ever mild stroke: The syndrome of hidden impairments
J Rehabil Med, 53 (1), jrm00135
DOI 10.2340/16501977-2764, PubMed 33145603

Wang X, Moullaali TJ, Ouyang M, Billot L, Sandset EC, Song L, Delcourt C, Hackett ML, Watkins CL, Robinson TG, Yang J, Lavados PM, Brunser A, Olavarría VV, Muñoz-Venturelli P, Arima H, Middleton S, Pontes-Neto OM, Pandian JD, Rogers K, Anderson CS (2021)
Influence of Including Patients with Premorbid Disability in Acute Stroke Trials: The HeadPoST Experience
Cerebrovasc Dis, 50 (1), 78-87
DOI 10.1159/000512608, PubMed 33434907

Welland NL, Hæstad H, Fossmo HL, Giltvedt K, Ørstavik K, Nordstrøm M (2021)
The Role of Nutrition and Physical Activity as Trigger Factors of Paralytic Attacks in Primary Periodic Paralysis
J Neuromuscul Dis (in press)
DOI 10.3233/JND-200604, PubMed 33646174

Werland F, Hirth M, Rukwied R, Ringkamp M, Turnquist B, Jorum E, Namer B, Schmelz M, Obreja O (2021)
Maximum axonal following frequency separates classes of cutaneous unmyelinated nociceptors in the pig
J Physiol, 599 (5), 1595-1610
DOI 10.1113/JP280269, PubMed 33369733

Wesnes K, Myhr KM, Riise T, Kvistad SS, Torkildsen Ø, Wergeland S, Holmøy T, Midgard R, Bru A, Edland A, Eikeland R, Gosal S, Harbo HF, Kleveland G, Sørenes YS, Øksendal N, Bjørnevik K (2021)
Low vitamin D, but not tobacco use or high BMI, is associated with long-term disability progression in multiple sclerosis
Mult Scler Relat Disord, 50, 102801
DOI 10.1016/j.msard.2021.102801, PubMed 33636616

Wimmer H, Lundqvist C, Šaltytė Benth J, Stavem K, Andersen GØ, Henriksen J, Drægni T, Sunde K, Nakstad ER (2021)
Health-related quality of life after out-of-hospital cardiac arrest - a five-year follow-up studyJūratė Šaltytė Benth
Resuscitation, 162, 372-380
DOI 10.1016/j.resuscitation.2021.01.036, PubMed 33571604

 
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