Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2017 from OUS - Department of Neurology
85 publications found
CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling
J Bone Miner Res, 32 (5), 913-926
DOI 10.1002/jbmr.3069, PubMed 28019696
Biallelic variants in LINGO1 are associated with autosomal recessive intellectual disability, microcephaly, speech and motor delay
Genet Med, 20 (7), 778-784
DOI 10.1038/gim.2017.113, PubMed 28837161
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
J Immunol, 199 (8), 2910-2920
DOI 10.4049/jimmunol.1700302, PubMed 28855312
The GBA variant E326K is associated with Parkinson's disease and explains a genome-wide association signal
Neurosci Lett, 658, 48-52
DOI 10.1016/j.neulet.2017.08.040, PubMed 28830825
Signal Enhancement of the Dentate Nucleus at Unenhanced MR Imaging after Very High Cumulative Doses of the Macrocyclic Gadolinium-based Contrast Agent Gadobutrol: An Observational Study
Radiology, 285 (2), 434-444
DOI 10.1148/radiol.2017170391, PubMed 28885891
NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases
Neurobiol Aging, 57, 247.e9-247.e13
DOI 10.1016/j.neurobiolaging.2017.05.009, PubMed 28602509
Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease
Neurobiol Aging, 64, 159.e5-159.e8
DOI 10.1016/j.neurobiolaging.2017.12.012, PubMed 29398121
Prevalence and clinical aspects of immigrants with myasthenia gravis in northern Europe
Muscle Nerve, 55 (6), 819-827
DOI 10.1002/mus.25408, PubMed 27641227
The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study
PLoS One, 12 (4), e0175908
DOI 10.1371/journal.pone.0175908, PubMed 28410431
The Evans' Index revisited: New cut-off levels for use in radiological assessment of ventricular enlargement in the elderly
Eur J Radiol, 95, 28-32
DOI 10.1016/j.ejrad.2017.07.013, PubMed 28987681
Cognitive function among long-term survivors of heart transplantation
Clin Transplant, 31 (12)
DOI 10.1111/ctr.13143, PubMed 29055147
Cognitive function after heart transplantation: Comparing everolimus-based and calcineurin inhibitor-based regimens
Clin Transplant, 31 (4)
DOI 10.1111/ctr.12927, PubMed 28185318
Infections in patients with multiple sclerosis: Implications for disease-modifying therapy
Acta Neurol Scand, 136 Suppl 201, 34-36
DOI 10.1111/ane.12835, PubMed 29068490
Stroke in women - from evidence to inequalities
Nat Rev Neurol, 13 (9), 521-532
DOI 10.1038/nrneurol.2017.95, PubMed 28731036
Disrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum
Sci Rep, 7, 40268
DOI 10.1038/srep40268, PubMed 28074926
The Association between Work-Related Rumination and Heart Rate Variability: A Field Study
Front Hum Neurosci, 11, 27
DOI 10.3389/fnhum.2017.00027, PubMed 28197087
Fatigue and cognition: Pupillary responses to problem-solving in early multiple sclerosis patients
Brain Behav, 7 (7), e00717
DOI 10.1002/brb3.717, PubMed 28729927
Rejection sensitivity as a vulnerability marker for depressive symptom deterioration in men
PLoS One, 12 (10), e0185802
DOI 10.1371/journal.pone.0185802, PubMed 29049292
Psychophysiological correlates of emotion regulation training in adolescent anxiety: Evidence from the novel PIER task
J Affect Disord, 214, 89-96
DOI 10.1016/j.jad.2017.03.012, PubMed 28285242
Algorithms for the treatment of motor problems in Parkinson's disease
Acta Neurol Scand, 136 (5), 378-385
DOI 10.1111/ane.12733, PubMed 28133726
Human and mouse cortical astrocytes differ in aquaporin-4 polarization toward microvessels
Glia, 65 (6), 964-973
DOI 10.1002/glia.23138, PubMed 28317216
Brain Capillary Ultrastructure in Idiopathic Normal Pressure Hydrocephalus: Relationship With Static and Pulsatile Intracranial Pressure
J Neuropathol Exp Neurol, 76 (12), 1034-1045
DOI 10.1093/jnen/nlx091, PubMed 29040647
Evidence for cortical structural plasticity in humans after a day of waking and sleep deprivation
Neuroimage, 156, 214-223
DOI 10.1016/j.neuroimage.2017.05.027, PubMed 28526620
Human Herpesvirus 6B Induces Hypomethylation on Chromosome 17p13.3, Correlating with Increased Gene Expression and Virus Integration
J Virol, 91 (11)
DOI 10.1128/JVI.02105-16, PubMed 28298607
Automated gold particle quantification of immunogold labeled micrographs
J Neurosci Methods, 286, 31-37
DOI 10.1016/j.jneumeth.2017.05.018, PubMed 28527623
Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice
Cereb Cortex, 27 (1), 24-33
DOI 10.1093/cercor/bhw359, PubMed 28365776
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages
Biochem Biophys Res Commun, 491 (2), 442-448
DOI 10.1016/j.bbrc.2017.07.070, PubMed 28712870
Use of advanced therapies for Parkinson's disease in Norway
Tidsskr Nor Laegeforen, 137 (9), 619-623
DOI 10.4045/tidsskr.16.0711, PubMed 28468476
Genetic risk factors for cognitive decline in Parkinson's disease: a review of the literature
Eur J Neurol, 24 (4), 561-e20
DOI 10.1111/ene.13258, PubMed 28220571
Prognostic Factors for Persistent Leg-Pain in Patients Hospitalized With Acute Sciatica
Spine (Phila Pa 1976), 42 (5), E272-E279
DOI 10.1097/BRS.0000000000001773, PubMed 28244968
Clinical and genetic characteristics of sporadic adult-onset degenerative ataxia
Neurology, 89 (10), 1043-1049
DOI 10.1212/WNL.0000000000004311, PubMed 28794257
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation
PLoS One, 12 (11), e0188387
DOI 10.1371/journal.pone.0188387, PubMed 29176764
Inverse relationship between type 1 diabetes mellitus and migraine. Data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008
Cephalalgia, 38 (3), 417-426
DOI 10.1177/0333102417690488, PubMed 28114807
[Do you know the secret services?]
Tidsskr Nor Laegeforen, 137 (22)
DOI 10.4045/tidsskr.17.0882, PubMed 29181926
Cognitive Event-Related Potentials during the Sub-Acute Phase of Severe Traumatic Brain Injury and Their Relationship to Outcome
J Neurotrauma, 34 (22), 3124-3133
DOI 10.1089/neu.2017.5062, PubMed 28594285
The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement
Eur J Epidemiol, 32 (10), 909-919
DOI 10.1007/s10654-017-0250-2, PubMed 28597127
Pain thresholds, supra-threshold pain and lidocaine sensitivity in patients with erythromelalgia, including the I848Tmutation in NaV 1.7
Eur J Pain, 21 (8), 1316-1325
DOI 10.1002/ejp.1030, PubMed 28418213
Physical activity level at work and risk of chronic low back pain: A follow-up in the Nord-Trøndelag Health Study
PLoS One, 12 (4), e0175086
DOI 10.1371/journal.pone.0175086, PubMed 28394896
Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group
Mol Psychiatry, 23 (4), 932-942
DOI 10.1038/mp.2017.73, PubMed 28461699
The presence of anaemia negatively influences survival in patients with POLG disease
J Inherit Metab Dis, 40 (6), 861-866
DOI 10.1007/s10545-017-0084-9, PubMed 28865037
USING DISCRETE EVENT SIMULATION AND SOFT SYSTEMS METHODOLOGY FOR OPTIMIZING PATIENT FLOW AND RESOURCE UTILIZATION AT THE SURGICAL UNIT OF RADIUMHOSPITALET IN OSLO, NORWAY
WINT SIMUL C PROC, 1646-1657
Pre-hospital ct diagnosis of subarachnoid hemorrhage
Scand J Trauma Resusc Emerg Med, 25 (1), 21
DOI 10.1186/s13049-017-0365-1, PubMed 28245880
Interpretation of Brain CT Scans in the Field by Critical Care Physicians in a Mobile Stroke Unit
J Neuroimaging, 28 (1), 106-111
DOI 10.1111/jon.12458, PubMed 28766306
IgG-specific cell-based assay detects potentially pathogenic MuSK-Abs in seronegative MG
Neurol Neuroimmunol Neuroinflamm, 4 (4), e357
DOI 10.1212/NXI.0000000000000357, PubMed 28626780
Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture
Dement Geriatr Cogn Dis Extra, 7 (3), 309-317
DOI 10.1159/000478723, PubMed 29118783
Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia
PLoS One, 12 (3), e0174667
DOI 10.1371/journal.pone.0174667, PubMed 28362824
Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar Hypoplasia and Alter Cortical Development
Am J Hum Genet, 101 (3), 428-440
DOI 10.1016/j.ajhg.2017.07.010, PubMed 28823707
Seizure outcomes of temporal lobe epilepsy surgery in patients with normal MRI and without specific histopathology
Acta Neurochir (Wien), 159 (5), 757-766
DOI 10.1007/s00701-017-3127-y, PubMed 28281007
Organocatalyst-assisted Ar-18F bond formation: a universal procedure for direct aromatic radiofluorination
Chem Commun (Camb), 53 (96), 12906-12909
DOI 10.1039/c7cc07211b, PubMed 29143838
The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study
Osteoarthritis Cartilage, 25 (6), 817-823
DOI 10.1016/j.joca.2016.12.021, PubMed 28049019
18F-FDG PET/CT for the quantification of inflammation in large carotid artery plaques
J Nucl Cardiol, 26 (3), 883-893
DOI 10.1007/s12350-017-1121-7, PubMed 29209949
Maternal psychological responses during pregnancy after ultrasonographic detection of structural fetal anomalies: A prospective longitudinal observational study
PLoS One, 12 (3), e0174412
DOI 10.1371/journal.pone.0174412, PubMed 28350879
M. König svarer
Tidsskr Nor Laegeforen, 137 (4), 260-261
DOI 10.4045/tidsskr.17.0103, PubMed 28225227
Antiplatelet Therapy in Noncardioembolic Stroke: A Review of Current Evidence
Semin Neurol, 37 (3), 366-375
DOI 10.1055/s-0037-1603469, PubMed 28759917
A tonic heat test stimulus yields a larger and more reliable conditioned pain modulation effect compared to a phasic heat test stimulus
Pain Rep, 2 (6), e626
DOI 10.1097/PR9.0000000000000626, PubMed 29392240
Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial
Lancet Neurol, 16 (10), 781-788
DOI 10.1016/S1474-4422(17)30253-3, PubMed 28780236
Lyme neuroborreliosis: do we treat according to guidelines?
J Neurol, 264 (7), 1506-1510
DOI 10.1007/s00415-017-8559-z, PubMed 28676925
Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis
Ann Clin Transl Neurol, 4 (10), 756-761
DOI 10.1002/acn3.451, PubMed 29046884
Interoceptive sensitivity as a proxy for emotional intensity and its relationship with perseverative cognition
Psychol Res Behav Manag, 11, 1-8
DOI 10.2147/PRBM.S139790, PubMed 29296103
Night-shift work is associated with increased pain perception
Scand J Work Environ Health, 43 (3), 260-268
DOI 10.5271/sjweh.3627, PubMed 28259894
Changes in Ionic Conductance Signature of Nociceptive Neurons Underlying Fabry Disease Phenotype
Front Neurol, 8, 335
DOI 10.3389/fneur.2017.00335, PubMed 28769867
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
NPJ Genom Med, 2, 24
DOI 10.1038/s41525-017-0027-2, PubMed 29263835
Effects of Music on Agitation in Dementia: A Meta-Analysis
Front Psychol, 8, 742
DOI 10.3389/fpsyg.2017.00742, PubMed 28559865
Comparison of automated volumetry of the hippocampus using NeuroQuant® and visual assessment of the medial temporal lobe in Alzheimer's disease
Acta Radiol, 59 (8), 997-1001
DOI 10.1177/0284185117743778, PubMed 29172642
Visual Evaluation of Medial Temporal Lobe Atrophy as a Clinical Marker of Conversion from Mild Cognitive Impairment to Dementia and for Predicting Progression in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease
Dement Geriatr Cogn Disord, 44 (1-2), 12-24
DOI 10.1159/000477342, PubMed 28614836
Finding of increased caudate nucleus in patients with Alzheimer's disease
Acta Neurol Scand, 137 (2), 224-232
DOI 10.1111/ane.12800, PubMed 28741672
MRI-assessed atrophy subtypes in Alzheimer's disease and the cognitive reserve hypothesis
PLoS One, 12 (10), e0186595
DOI 10.1371/journal.pone.0186595, PubMed 29036183
Juvenile myasthenia gravis in Norway: Clinical characteristics, treatment, and long-term outcome in a nationwide population-based cohort
Eur J Paediatr Neurol, 21 (5), 707-714
DOI 10.1016/j.ejpn.2017.04.003, PubMed 28457757
Juvenile myasthenia gravis in Norway: HLA-DRB1*04:04 is positively associated with prepubertal onset
PLoS One, 12 (10), e0186383
DOI 10.1371/journal.pone.0186383, PubMed 29036181
Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice
Neuroscience, 359, 258-266
DOI 10.1016/j.neuroscience.2017.07.029, PubMed 28735099
Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders
Front Neuroendocrinol, 45, 1-10
DOI 10.1016/j.yfrne.2016.12.004, PubMed 28049009
Diurnal Variation and Twenty-Four Hour Sleep Deprivation Do Not Alter Supine Heart Rate Variability in Healthy Male Young Adults
PLoS One, 12 (2), e0170921
DOI 10.1371/journal.pone.0170921, PubMed 28151944
Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial
Transl Psychiatry, 7 (5), e1136
DOI 10.1038/tp.2017.103, PubMed 28534875
Reaching out for Sensitive Evaluation of the Mu Opioid Receptor in Vivo: Positron Emission Tomography Imaging of the Agonist [11C]AH7921
ACS Chem Neurosci, 8 (9), 1847-1852
DOI 10.1021/acschemneuro.7b00075, PubMed 28590714
The validity of the Gait Variability Index for individuals with mild to moderate Parkinson's disease
Gait Posture, 54, 311-317
DOI 10.1016/j.gaitpost.2017.03.023, PubMed 28395171
Novel UCHL1 mutations reveal new insights into ubiquitin processing
Hum Mol Genet, 26 (6), 1031-1040
DOI 10.1093/hmg/ddw391, PubMed 28007905
Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition
J Alzheimers Dis, 58 (3), 829-840
DOI 10.3233/JAD-161146, PubMed 28505968
Magnetic resonance imaging perfusion is associated with disease severity and activity in multiple sclerosis
Neuroradiology, 59 (7), 655-664
DOI 10.1007/s00234-017-1849-4, PubMed 28585082
Increased expression of TFPI in human carotid stenosis
Thromb Res, 155, 31-37
DOI 10.1016/j.thromres.2017.04.024, PubMed 28482260
Health-related quality of life and unmet healthcare needs in Huntington's disease
Health Qual Life Outcomes, 15 (1), 6
DOI 10.1186/s12955-016-0575-7, PubMed 28069034
Is the hygiene hypothesis relevant for the risk of multiple sclerosis?
Acta Neurol Scand, 136 Suppl 201, 26-30
DOI 10.1111/ane.12844, PubMed 29068485
The impact of body mass index and height on the risk for glioblastoma and other glioma subgroups: a large prospective cohort study
Neuro Oncol, 19 (7), 976-985
DOI 10.1093/neuonc/now272, PubMed 28040713
Overweight, obesity and height as risk factors for meningioma, glioma, pituitary adenoma and nerve sheath tumor: a large population-based prospective cohort study
Acta Oncol, 56 (10), 1302-1309
DOI 10.1080/0284186X.2017.1330554, PubMed 28548875
Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants
PLoS One, 12 (9), e0185663
DOI 10.1371/journal.pone.0185663, PubMed 28957430
Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study
Cephalalgia, 38 (2), 312-322
DOI 10.1177/0333102417690111, PubMed 28103696