Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Department of Neurosurgery

59 publications found

Andelic N, Røe C, Tenovuo O, Azouvi P, Dawes H, Majdan M, Ranta J, Howe EI, Wiegers EJA, Tverdal C, Borgen I, Forslund MV, Kleffelgaard I, Dahl HM, Jacob L, Cogné M, Lu J, von Steinbuechel N, Zeldovich M (2021)
Unmet Rehabilitation Needs after Traumatic Brain Injury across Europe: Results from the CENTER-TBI Study
J Clin Med, 10 (5)
DOI 10.3390/jcm10051035, PubMed 33802336

Andersson H, Jablonski GE, Nordahl SHG, Nordfalk K, Helseth E, Martens C, Røysland K, Goplen FK (2021)
The Risk of Benign Paroxysmal Positional Vertigo After Head Trauma
Laryngoscope
DOI 10.1002/lary.29851, PubMed 34487348

Aukrust CG, Kamalo PD, Prince RJ, Sundby J, Mula C, Manda-Taylor L (2021)
Improving competencies and skills across clinical contexts of care: a qualitative study on Malawian nurses' experiences in an institutional health and training programme
Nurs Open, 8 (6), 3170-3180
DOI 10.1002/nop2.1030, PubMed 34355870

Bahrami S, Hindley G, Winsvold BS, O'Connell KS, Frei O, Shadrin A, Cheng W, Bettella F, Rødevand L, Odegaard KJ, Fan CC, Pirinen MJ, Hautakangas HM, Headache HA, Dale AM, Djurovic S, Smeland OB, Andreassen OA (2021)
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools
Brain (in press)
DOI 10.1093/brain/awab267, PubMed 34273149

Bjørke AB, Østby Y, Grahl SG, Larsson PG, Olsen KB, Johansen Nævra MC, Ringstad GA, Bjørnerud A, Gjerstad L, Taubøll E, Heuser K (2021)
Cognition in adult patients with newly diagnosed non-lesional temporal lobe epilepsy
Epilepsy Behav, 116, 107771
DOI 10.1016/j.yebeh.2021.107771, PubMed 33545650

Boer CG, Hatzikotoulas K, Southam L, Stefánsdóttir L, Zhang Y, Coutinho de Almeida R, Wu TT, Zheng J, Hartley A, Teder-Laving M, Skogholt AH, Terao C, Zengini E, Alexiadis G, Barysenka A, Bjornsdottir G, Gabrielsen ME, Gilly A, Ingvarsson T, Johnsen MB, Jonsson H, Kloppenburg M, Luetge A, Lund SH, Mägi R et al. (2021)
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Cell, 184 (18), 4784-4818.e17
DOI 10.1016/j.cell.2021.07.038, PubMed 34450027

Buades-Rotger M, Solbakk AK, Liebrand M, Endestad T, Funderud I, Siegwardt P, Enter D, Roelofs K, Krämer UM (2021)
Patients with Ventromedial Prefrontal Lesions Show an Implicit Approach Bias to Angry Faces
J Cogn Neurosci, 33 (6), 1069-1081
DOI 10.1162/jocn_a_01706, PubMed 34428788

Da Broi M, Borrelli P, Meling TR (2021)
Predictors of Survival in Atypical Meningiomas
Cancers (Basel), 13 (8)
DOI 10.3390/cancers13081970, PubMed 33919475

Da Broi M, Borrelli P, Meling TR (2021)
Predictors of Survival in Subtotally Resected WHO Grade I Skull Base Meningiomas
Cancers (Basel), 13 (6)
DOI 10.3390/cancers13061451, PubMed 33810089

Eide PK (2021)
Abnormal Intracranial Pulse Pressure Amplitude Despite Normalized Static Intracranial Pressure in Idiopathic Intracranial Hypertension Refractory to Conservative Medical Therapy
Life (Basel), 11 (6)
DOI 10.3390/life11060537, PubMed 34207519

Eide PK, Mariussen E, Uggerud H, Pripp AH, Lashkarivand A, Hassel B, Christensen H, Hovd MH, Ringstad G (2021)
Clinical application of intrathecal gadobutrol for assessment of cerebrospinal fluid tracer clearance to blood
JCI Insight, 6 (9)
DOI 10.1172/jci.insight.147063, PubMed 33822769

Eide PK, Pripp AH, Ringstad G, Valnes LM (2021)
Impaired glymphatic function in idiopathic intracranial hypertension
Brain Commun, 3 (2), fcab043
DOI 10.1093/braincomms/fcab043, PubMed 34235434

Eide PK, Ringstad G (2021)
Cerebrospinal fluid egress to human parasagittal dura and the impact of sleep deprivation
Brain Res, 1772, 147669
DOI 10.1016/j.brainres.2021.147669, PubMed 34587499

Eide PK, Valnes LM, Lindstrøm EK, Mardal KA, Ringstad G (2021)
Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases
Fluids Barriers CNS, 18 (1), 16
DOI 10.1186/s12987-021-00251-6, PubMed 33794929

Eide PK, Vinje V, Pripp AH, Mardal KA, Ringstad G (2021)
Sleep deprivation impairs molecular clearance from the human brain
Brain, 144 (3), 863-874
DOI 10.1093/brain/awaa443, PubMed 33829232

Freidin MB, Tsepilov YA, Stanaway IB, Meng W, Hayward C, Smith BH, Khoury S, Parisien M, Bortsov A, Diatchenko L, Børte S, Winsvold BS, Brumpton BM, Zwart JA, Aulchenko YS, Suri P, Williams FMK, HUNT All-In Pain (2021)
Sex- and age-specific genetic analysis of chronic back pain
Pain, 162 (4), 1176-1187
DOI 10.1097/j.pain.0000000000002100, PubMed 33021770

Frič R, Langvatn EA, Due-Tønnessen BJ, Eide PK (2021)
The role of pulsatile and static intracranial pressure measurements in the management of children with craniosynostosis-an institutional experience from 49 patients
Acta Neurochir (Wien), 163 (7), 2015-2023
DOI 10.1007/s00701-020-04680-4, PubMed 33389123

Grønbæk JK, Wibroe M, Toescu S, Frič R, Thomsen BL, Møller LN, Grillner P, Gustavsson B, Mallucci C, Aquilina K, Fellows GA, Molinari E, Hjort MA, Westerholm-Ormio M, Kiudeliene R, Mudra K, Hauser P, van Baarsen K, Hoving E, Zipfel J, Nysom K, Schmiegelow K, Sehested A, Juhler M, Mathiasen R et al. (2021)
Postoperative speech impairment and surgical approach to posterior fossa tumours in children: a prospective European multicentre cohort study
Lancet Child Adolesc Health (in press)
DOI 10.1016/S2352-4642(21)00274-1, PubMed 34624241

Harder AVE, Winsvold BS, Noordam R, Vijfhuizen LS, Børte S, Kogelman LJA, de Boer I, Tronvik E, Rosendaal FR, Willems van Dijk K, O'Connor E, Fourier C, Thomas LF, Kristoffersen ES, Cluster Headache Genetics Working Group, Fronczek R, Pozo-Rosich P, Jensen RH, Ferrari MD, Hansen TF, Zwart JA, Terwindt GM, van den Maagdenberg AMJM (2021)
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
Ann Neurol, 90 (2), 203-216
DOI 10.1002/ana.26146, PubMed 34180076

Hatlestad-Hall C, Bruña R, Erichsen A, Andersson V, Syvertsen MR, Skogan AH, Renvall H, Marra C, Maestú F, Heuser K, Taubøll E, Solbakk AK, Haraldsen IH (2021)
The organization of functional neurocognitive networks in focal epilepsy correlates with domain-specific cognitive performance
J Neurosci Res
DOI 10.1002/jnr.24896, PubMed 34173259

Hellstrøm T, Andelic N, de Lange AG, Helseth E, Eiklid K, Westlye LT (2021)
Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging
J Clin Med, 10 (3)
DOI 10.3390/jcm10030418, PubMed 33499167

Hosainey SAM, Hald JK, Meling TR (2021)
Risk of early failure of VP shunts implanted for hydrocephalus after craniotomies for brain tumors in adults
Neurosurg Rev
DOI 10.1007/s10143-021-01549-7, PubMed 33905002

Johansen TO, Sundseth J, Fredriksli OA, Andresen H, Zwart JA, Kolstad F, Pripp AH, Gulati S, Nygaard ØP (2021)
Effect of Arthroplasty vs Fusion for Patients With Cervical Radiculopathy: A Randomized Clinical Trial
JAMA Netw Open, 4 (8), e2119606
DOI 10.1001/jamanetworkopen.2021.19606, PubMed 34351401

Kam JWY, Helfrich RF, Solbakk AK, Endestad T, Larsson PG, Lin JJ, Knight RT (2021)
Top-Down Attentional Modulation in Human Frontal Cortex: Differential Engagement during External and Internal Attention
Cereb Cortex, 31 (2), 873-883
DOI 10.1093/cercor/bhaa262, PubMed 33063100

Khan H, Naseer N, Yazidi A, Eide PK, Hassan HW, Mirtaheri P (2021)
Analysis of Human Gait Using Hybrid EEG-fNIRS-Based BCI System: A Review
Front Hum Neurosci, 14, 613254
DOI 10.3389/fnhum.2020.613254, PubMed 33568979

Kleppestø M, Bjørnerud A, Groote IR, Kim M, Vardal J, Larsson C (2021)
Operator dependency of arterial input function in dynamic contrast-enhanced MRI
MAGMA
DOI 10.1007/s10334-021-00926-z, PubMed 34213687

Kristoffersen ES, Jahr SH, Faiz KW, Storstein AM, Winsvold BS, Sandset EC (2021)
Acute stroke care during the first phase of COVID-19 pandemic in Norway
Acta Neurol Scand, 143 (4), 349-354
DOI 10.1111/ane.13392, PubMed 33421104

Kristoffersen ES, Winsvold BS, Sandset EC, Storstein AM, Faiz KW (2021)
Experiences, distress and burden among neurologists in Norway during the COVID-19 pandemic
PLoS One, 16 (2), e0246567
DOI 10.1371/journal.pone.0246567, PubMed 33539418

Liebrand M, Solbakk AK, Funderud I, Buades-Rotger M, Knight RT, Krämer UM (2021)
Intact Proactive Motor Inhibition after Unilateral Prefrontal Cortex or Basal Ganglia Lesions
J Cogn Neurosci, 33 (9), 1862-1879
DOI 10.1162/jocn_a_01691, PubMed 34375417

Llorens A, Tzovara A, Bellier L, Bhaya-Grossman I, Bidet-Caulet A, Chang WK, Cross ZR, Dominguez-Faus R, Flinker A, Fonken Y, Gorenstein MA, Holdgraf C, Hoy CW, Ivanova MV, Jimenez RT, Jun S, Kam JWY, Kidd C, Marcelle E, Marciano D, Martin S, Myers NE, Ojala K, Perry A, Pinheiro-Chagas P et al. (2021)
Gender bias in academia: A lifetime problem that needs solutions
Neuron, 109 (13), 2047-2074
DOI 10.1016/j.neuron.2021.06.002, PubMed 34237278

Lundar T, Due-Tønnessen BJ, Frič R, Sundseth J, Brandal P, Due-Tønnessen P (2021)
Outcome after treatment of pediatric supratentorial ependymoma: long-term follow-up of a single consecutive institutional series of 26 patients
Br J Neurosurg
DOI 10.1080/02688697.2021.1914821, PubMed 34096810

Lundar T, Due-Tønnessen BJ, Frič R, Sundseth J, Brandal P, Due-Tønnessen P (2021)
Outcome After Treatment of Spinal Ependymoma in Children and Adolescents: Long-Term Follow-up of a Single Consecutive Institutional Series of 33 Patients Treated Over Eight Decades
World Neurosurg, 150, e228-e235
DOI 10.1016/j.wneu.2021.02.131, PubMed 33684583

Mannerak MA, Lashkarivand A, Eide PK (2021)
Trigeminal neuralgia and genetics: A systematic review
Mol Pain, 17, 17448069211016139
DOI 10.1177/17448069211016139, PubMed 34000891

Mullins N, Forstner AJ, O'Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, Børte S, Bryois J, Charney AW, Drange OK, Gandal MJ, Hagenaars SP, Ikeda M, Kamitaki N, Kim M, Krebs K, Panagiotaropoulou G, Schilder BM, Sloofman LG, Steinberg S, Trubetskoy V, Winsvold BS, Won HH et al. (2021)
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Nat Genet, 53 (6), 817-829
DOI 10.1038/s41588-021-00857-4, PubMed 34002096

O'Connor E, Fourier C, Ran C, Sivakumar P, Liesecke F, Southgate L, Harder AVE, Vijfhuizen LS, Yip J, Giffin N, Silver N, Ahmed F, Hostettler IC, Davies B, Cader MZ, Simpson BS, Sullivan R, Efthymiou S, Adebimpe J, Quinn O, Campbell C, Cavalleri GL, Vikelis M, Kelderman T, Paemeleire K et al. (2021)
Genome-Wide Association Study Identifies Risk Loci for Cluster Headache
Ann Neurol, 90 (2), 193-202
DOI 10.1002/ana.26150, PubMed 34184781

Puhr A, Ruud E, Anderson V, Due-Tønnessen BJ, Skarbø AB, Finset A, Andersson S (2021)
Executive Function and Psychosocial Adjustment in Adolescent Survivors of Pediatric Brain Tumor
Dev Neuropsychol, 46 (2), 149-168
DOI 10.1080/87565641.2021.1900191, PubMed 33783291

Rahman MS, Winsvold BS, Chavez Chavez SO, Børte S, Tsepilov YA, Sharapov SZ, HUNT All-In Pain, Aulchenko YS, Hagen K, Fors EA, Hveem K, Zwart JA, van Meurs JB, Freidin MB, Williams FM (2021)
Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain
Ann Rheum Dis, 80 (9), 1227-1235
DOI 10.1136/annrheumdis-2020-219624, PubMed 33926923

Rizvi SAM, Helseth E, Aarhus M, Harr ME, Mirzamohammadi J, Rønning P, Mejlænder-Evjensvold M, Linnerud H (2021)
Favorable prognosis with nonsurgical management of type III acute odontoid fractures: a consecutive series of 212 patients
Spine J, 21 (7), 1149-1158
DOI 10.1016/j.spinee.2021.02.003, PubMed 33577924

Robertsen A, Helseth E, Førde R (2021)
Inter-physician variability in strategies linked to treatment limitations after severe traumatic brain injury; proactivity or wait-and-see
BMC Med Ethics, 22 (1), 43
DOI 10.1186/s12910-021-00612-8, PubMed 33849500

Rønning P, Helseth E, Skaansar O, Tverdal C, Andelic N, Bhatnagar R, Melberg M, Skaga NO, Aarhus M, Halvorsen S, Helseth R (2021)
Impact of Preinjury Antithrombotic Therapy on 30-Day Mortality in Older Patients Hospitalized With Traumatic Brain Injury (TBI)
Front Neurol, 12, 650695
DOI 10.3389/fneur.2021.650695, PubMed 34054695

Rostalski H, Korhonen V, Kuulasmaa T, Solje E, Krüger J, Gen F, Kaivola K, Eide PK, Lambert JC, Julkunen V, Tienari PJ, Remes AM, Leinonen V, Hiltunen M, Haapasalo A (2021)
A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population
J Alzheimers Dis, 83 (3), 1325-1332
DOI 10.3233/JAD-210599, PubMed 34397416

Schultz NH, Sørvoll IH, Michelsen AE, Munthe LA, Lund-Johansen F, Ahlen MT, Wiedmann M, Aamodt AH, Skattør TH, Tjønnfjord GE, Holme PA (2021)
Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination
N Engl J Med, 384 (22), 2124-2130
DOI 10.1056/NEJMoa2104882, PubMed 33835768

Skaga E, Skretteberg MA, Johannesen TB, Brandal P, Vik-Mo EO, Helseth E, Langmoen IA (2021)
Real-world validity of randomized controlled phase III trials in newly diagnosed glioblastoma: to whom do the results of the trials apply?
Neurooncol Adv, 3 (1), vdab008
DOI 10.1093/noajnl/vdab008, PubMed 33665615

Slama SJK, Jimenez R, Saha S, King-Stephens D, Laxer KD, Weber PB, Endestad T, Ivanovic J, Larsson PG, Solbakk AK, Lin JJ, Knight RT (2021)
Intracranial Recordings Demonstrate Both Cortical and Medial Temporal Lobe Engagement in Visual Search in Humans
J Cogn Neurosci, 33 (9), 1833-1861
DOI 10.1162/jocn_a_01739, PubMed 34375422

Sletteberg R, Nordengen K, Sorteberg W, Jacobsen EA (2021)
A woman in her seventies with acute onset of blindness
Tidsskr Nor Laegeforen, 141
DOI 10.4045/tidsskr.20.1034, PubMed 34597004

Slettebø H (2021)
Is this really trigeminal neuralgia? Diagnostic re-evaluation of patients referred for neurosurgery
Scand J Pain, 21 (4), 788-793
DOI 10.1515/sjpain-2021-0045, PubMed 34333890

Solbakk AK, Lubell J, Leske S, Funderud I, Llorens A, Blenkmann AO, Foldal MD, Meling TR, Knight RT, Endestad T (2021)
Monitoring of Self-Paced Action Timing and Sensory Outcomes After Lesions to the Orbitofrontal Cortex
J Cogn Neurosci, 33 (9), 1956-1975
DOI 10.1162/jocn_a_01733, PubMed 34375421

Sorteberg A, Romundstad L, Sorteberg W (2021)
Timelines and rebleeds in patients admitted into neurosurgical care for aneurysmal subarachnoid haemorrhage
Acta Neurochir (Wien), 163 (3), 771-781
DOI 10.1007/s00701-020-04673-3, PubMed 33409740

Sorteberg W, Sorteberg A, Jacobsen EA, Rønning P, Nome T, Eide PK (2021)
Endovascular versus surgical treatment of cranial dural arteriovenous fistulas: a single-center 8-year experience
Acta Neurochir (Wien)
DOI 10.1007/s00701-021-04950-9, PubMed 34486069

Svendsen HA, Meling TR, Nygaard V, Waagene S, Russnes H, Juell S, Rogne SG, Pahnke J, Helseth E, Fodstad Ø, Maelandsmo GM (2021)
Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site-specific metastasis patterns reflecting their clinical origin
Cancer Med
DOI 10.1002/cam4.4334, PubMed 34612023

Svensson SF, De Arcos J, Darwish OI, Fraser-Green J, Storås TH, Holm S, Vik-Mo EO, Sinkus R, Emblem KE (2021)
Robustness of MR Elastography in the Healthy Brain: Repeatability, Reliability, and Effect of Different Reconstruction Methods
J Magn Reson Imaging, 53 (5), 1510-1521
DOI 10.1002/jmri.27475, PubMed 33403750

Switlyk MD, Niehusmann P, Sprauten M, Magelssen H, Aarhus M, Rasmussen FØ, Knutstad K, Brandal P (2021)
Neurosarcoidosis resembling multiple meningiomas: A misleading presentation of the disease and diagnostic challenge
Acta Radiol Open, 10 (7), 20584601211036550
DOI 10.1177/20584601211036550, PubMed 34377543

Tverdal C, Andelic N, Helseth E, Brunborg C, Rønning P, Hellstrøm T, Røe C, Aarhus M (2021)
In the Aftermath of Acute Hospitalization for Traumatic Brain Injury: Factors Associated with the Direct Pathway into Specialized Rehabilitation
J Clin Med, 10 (16)
DOI 10.3390/jcm10163577, PubMed 34441872

Western E, Nordenmark TH, Sorteberg W, Karic T, Sorteberg A (2021)
Fatigue After Aneurysmal Subarachnoid Hemorrhage: Clinical Characteristics and Associated Factors in Patients With Good Outcome
Front Behav Neurosci, 15, 633616
DOI 10.3389/fnbeh.2021.633616, PubMed 34054441

Wiedmann M, Lashkarivand A, Berg-Johnsen J, Dahlberg D (2021)
How I do it: endoscopic endonasal resection of tuberculum sellae meningioma
Acta Neurochir (Wien), 163 (8), 2193-2197
DOI 10.1007/s00701-021-04784-5, PubMed 33665730

Wiedmann M, Skattør T, Stray-Pedersen A, Romundstad L, Antal EA, Marthinsen PB, Sørvoll IH, Leiknes Ernstsen S, Lund CG, Holme PA, Johansen TO, Brunborg C, Aamodt AH, Schultz NH, Skagen K, Skjelland M (2021)
Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series
Front Neurol, 12, 721146
DOI 10.3389/fneur.2021.721146, PubMed 34393988

Wiedmann MKH, Davidoff C, Lo Presti A, Ni W, Rhim JK, Simons M, Stoodley MA (2021)
Treatment of ruptured aneurysms of the choroidal collateral system in moyamoya disease: a systematic review and data analysis
J Neurosurg, 1-10 (in press)
DOI 10.3171/2021.1.JNS203936, PubMed 34450582

Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, Rongve A, Børte S, Winsvold BS, Drange OK, Martinsen AE, Skogholt AH, Willer C, Bråthen G, Bosnes I, Nielsen JB, Fritsche LG, Thomas LF, Pedersen LM, Gabrielsen ME, Johnsen MB, Meisingset TW, Zhou W, Proitsi P, Hodges A et al. (2021)
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Nat Genet, 53 (9), 1276-1282
DOI 10.1038/s41588-021-00921-z, PubMed 34493870

Züchner M, Escalona MJ, Teige LH, Balafas E, Zhang L, Kostomitsopoulos N, Boulland JL (2021)
How to generate graded spinal cord injuries in swine - tools and procedures
Dis Model Mech, 14 (8)
DOI 10.1242/dmm.049053, PubMed 34464444

 
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