Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Department of Infectious Diseases

26 publications found

Aamodt AH, Høgestøl EA, Popperud TH, Holter JC, Dyrhol-Riise AM, Tonby K, Stiksrud B, Quist-Paulsen E, Berge T, Barratt-Due A, Aukrust P, Heggelund L, Blennow K, Zetterberg H, Harbo HF (2021)
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19
J Neurol, 268 (10), 3574-3583
DOI 10.1007/s00415-021-10517-6, PubMed 33743046

Amundsen EK, Binde C, Christensen EE, Klingenberg O, Kvale D, Holten AR (2021)
Prognostic Value of Nucleated RBCs for Patients With Suspected Sepsis in the Emergency Department: A Single-Center Prospective Cohort Study
Crit Care Explor, 3 (7), e0490
DOI 10.1097/CCE.0000000000000490, PubMed 34291222

Barratt-Due A, Olsen IC, Nezvalova-Henriksen K, Kåsine T, Lund-Johansen F, Hoel H, Holten AR, Tveita A, Mathiessen A, Haugli M, Eiken R, Kildal AB, Berg Å, Johannessen A, Heggelund L, Dahl TB, Skåra KH, Mielnik P, Le LAK, Thoresen L, Ernst G, Hoff DAL, Skudal H, Kittang BR, Olsen RB et al. (2021)
Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial
Ann Intern Med, 174 (9), 1261-1269
DOI 10.7326/M21-0653, PubMed 34251903

Chellappa S, Kushekhar K, Hagness M, Horneland R, Taskén K, Aandahl EM (2021)
The Presence of Activated T Cell Subsets Prior to Transplantation is Associated With Increased Rejection Risk in Pancreas Transplant Recipients
J Immunol (in press)
DOI 10.4049/jimmunol.2001103, PubMed 34607938

Chendi BH, Snyders CI, Tonby K, Jenum S, Kidd M, Walzl G, Chegou NN, Dyrhol-Riise AM (2021)
A Plasma 5-Marker Host Biosignature Identifies Tuberculosis in High and Low Endemic Countries
Front Immunol, 12, 608846
DOI 10.3389/fimmu.2021.608846, PubMed 33732236

Chendi BH, Tveiten H, Snyders CI, Tonby K, Jenum S, Nielsen SD, Hove-Skovsgaard M, Walzl G, Chegou NN, Dyrhol-Riise AM (2021)
CCL1 and IL-2Ra differentiate Tuberculosis disease from latent infection Irrespective of HIV infection in low TB burden countries
J Infect, 83 (4), 433-443
DOI 10.1016/j.jinf.2021.07.036, PubMed 34333033

Christensen EE, Jørgensen MJ, Nore KG, Dahl TB, Yang K, Ranheim T, Huse C, Lind A, Nur S, Stiksrud B, Jenum S, Tonby K, Holter JC, Holten AR, Halvorsen B, Dyrhol-Riise AM (2021)
Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns
J Intern Med, 290 (3), 677-692
DOI 10.1111/joim.13310, PubMed 34080738

Eimer J, Patimeteeporn C, Jensenius M, Gkrania-Klotsas E, Duvignaud A, Barnett ED, Hochberg NS, Chen LH, Trigo-Esteban E, Gertler M, Greenaway C, Grobusch MP, Angelo KM, Hamer DH, Caumes E, Asgeirsson H (2021)
Multidrug-resistant tuberculosis imported into low-incidence countries-a GeoSentinel analysis, 2008-2020
J Travel Med, 28 (6)
DOI 10.1093/jtm/taab069, PubMed 33987682

Grobusch MP, Weld L, Goorhuis A, Hamer DH, Schunk M, Jordan S, Mockenhaupt FP, Chappuis F, Asgeirsson H, Caumes E, Jensenius M, van Genderen PJJ, Castelli F, Lopez-Velez R, Field V, Bottieau E, Molina I, Rapp C, Menendez MD, Gkrania-Klotsas E, Larsen CS, Malvy D, Lalloo D, Gobbi F, Florescu SA et al. (2021)
Travel-related infections presenting in Europe: A 20-year analysis of EuroTravNet surveillance data
Lancet Reg. Health-Eur., 1, 100001
DOI 10.1016/j.lanepe.2020.100001

Johannessen A, Mekasha B, Desalegn H, Aberra H, Stene-Johansen K, Berhe N (2021)
Mother-to-Child Transmission of Hepatitis B Virus in Ethiopia
Vaccines (Basel), 9 (5)
DOI 10.3390/vaccines9050430, PubMed 33925930

Jøntvedt Jørgensen M, Nore KG, Aass HCD, Layre E, Nigou J, Mortensen R, Tasken K, Kvale D, Jenum S, Tonby K, Dyrhol-Riise AM (2021)
Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients
Front Cell Infect Microbiol, 11, 669623
DOI 10.3389/fcimb.2021.669623, PubMed 34307194

Kristiansen T, Pettersen FO, Lier T, Hinderaker SG, Greve G, Mørch K (2021)
Schistosomiasis in Norwegian students after travel to Africa
Tidsskr Nor Laegeforen, 141 (3)
DOI 10.4045/tidsskr.20.0268, PubMed 33624965

Lerum TV, Aaløkken TM, Brønstad E, Aarli B, Ikdahl E, Lund KMA, Durheim MT, Rodriguez JR, Meltzer C, Tonby K, Stavem K, Skjønsberg OH, Ashraf H, Einvik G (2021)
Dyspnoea, lung function and CT findings 3 months after hospital admission for COVID-19
Eur Respir J, 57 (4)
DOI 10.1183/13993003.03448-2020, PubMed 33303540

Livingston M, Pillay P, Zulu SG, Sandvik L, Kvalsvig JD, Gagai S, Galappaththi-Arachchige HN, Kleppa E, Ndhlovu P, Vennervald B, Gundersen SG, Taylor M, Kjetland EF (2021)
Mapping Schistosoma haematobium for Novel Interventions against Female Genital Schistosomiasis and Associated HIV Risk in KwaZulu-Natal, South Africa
Am J Trop Med Hyg, 104 (6), 2055-2064
DOI 10.4269/ajtmh.20-0679, PubMed 33939629

Lorvik KB, Meyer-Myklestad MH, Kushekar K, Handeland C, Medhus AW, Lund-Iversen M, Stiksrud B, Kvale D, Dyrhol-Riise AM, Taskén K, Reikvam DH (2021)
Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4+ T Cells in HIV-Infected Immunological Non-Responders
Front Immunol, 12, 744155
DOI 10.3389/fimmu.2021.744155, PubMed 34691047

Möller V, Östholm-Balkhed Å, Berild D, Fredriksson M, Gottfredsson M, Holmbom M, Järvinen A, Kristjansson M, Rydell U, Sönksen UW, Kolmos HJ, Hanberger H (2021)
Antibiotic resistance among major pathogens compared to hospital treatment guidelines and antibiotic use in Nordic hospitals 2010-2018
Infect Dis (Lond), 53 (8), 607-618
DOI 10.1080/23744235.2021.1910338, PubMed 33970737

Müller KE, Blomberg B, Tellevik MG, Jensenius M, Fladeby C, Lier T, Sand G, Hannula R, Langeland N, Mørch K (2021)
Leishmaniasis in Norway
Tidsskr Nor Laegeforen, 141 (3)
DOI 10.4045/tidsskr.19.0171, PubMed 33624958

Nissen-Meyer LSH, Brantsæter AB (2021)
The story of an extraordinary year: Challenges and opportunities in responding to Covid-19
Transfus Apher Sci, 60 (2), 103092
DOI 10.1016/j.transci.2021.103092, PubMed 33612447

Nydal SM, Munyaw Y, Bruun JN, Brantsæter AB (2021)
Achievements and Challenges in the Prevention of Mother-to-Child Transmission of HIV-A Retrospective Cohort Study from a Rural Hospital in Northern Tanzania
Int J Environ Res Public Health, 18 (5)
DOI 10.3390/ijerph18052751, PubMed 33803114

Sivakumaran D, Blatner G, Bakken R, Hokey D, Ritz C, Jenum S, Grewal HMS (2021)
A 2-Dose AERAS-402 Regimen Boosts CD8+ Polyfunctionality in HIV-Negative, BCG-Vaccinated Recipients
Front Immunol, 12, 673532
DOI 10.3389/fimmu.2021.673532, PubMed 34177914

Sivakumaran D, Ritz C, Gjøen JE, Vaz M, Selvam S, Ottenhoff THM, Doherty TM, Jenum S, Grewal HMS (2021)
Host Blood RNA Transcript and Protein Signatures for Sputum-Independent Diagnostics of Tuberculosis in Adults
Front Immunol, 11, 626049
DOI 10.3389/fimmu.2020.626049, PubMed 33613569

Søfteland S, Sebitloane MH, Taylor M, Roald BB, Holmen S, Galappaththi-Arachchige HN, Gundersen SG, Kjetland EF (2021)
A systematic review of handheld tools in lieu of colposcopy for cervical neoplasia and female genital schistosomiasis
Int J Gynaecol Obstet, 153 (2), 190-199
DOI 10.1002/ijgo.13538, PubMed 33316096

Sturt AS, Webb EL, Himschoot L, Phiri CR, Mapani J, Mudenda M, Kjetland EF, Mweene T, Levecke B, van Dam GJ, Corstjens PLAM, Ayles H, Hayes RJ, van Lieshout L, Hansingo I, Francis SC, Cools P, Bustinduy AL (2021)
Association of Female Genital Schistosomiasis With the Cervicovaginal Microbiota and Sexually Transmitted Infections in Zambian Women
Open Forum Infect Dis, 8 (9), ofab438
DOI 10.1093/ofid/ofab438, PubMed 34557562

Sturt AS, Webb EL, Patterson C, Phiri CR, Mweene T, Kjetland EF, Mudenda M, Mapani J, Mutengo MM, Chipeta J, van Dam GJ, Corstjens PLAM, Ayles H, Hayes RJ, Hansingo I, Cools P, van Lieshout L, Helmby H, McComsey GA, Francis SC, Bustinduy AL (2021)
Cervicovaginal Immune Activation in Zambian Women With Female Genital Schistosomiasis
Front Immunol, 12, 620657
DOI 10.3389/fimmu.2021.620657, PubMed 33737927

Sturt AS, Webb EL, Phiri CR, Mudenda M, Mapani J, Kosloff B, Cheeba M, Shanaube K, Bwalya J, Kjetland EF, Francis SC, Corstjens PLAM, van Dam GJ, van Lieshout L, Hansingo I, Ayles H, Hayes RJ, Bustinduy AL (2021)
Female Genital Schistosomiasis and HIV-1 Incidence in Zambian Women: A Retrospective Cohort Study
Open Forum Infect Dis, 8 (7), ofab349
DOI 10.1093/ofid/ofab349, PubMed 34337098

Wickstrøm KE, Vitelli V, Carr E, Holten AR, Bendayan R, Reiner AH, Bean D, Searle T, Shek A, Kraljevic Z, Teo J, Dobson R, Tonby K, Köhn-Luque A, Amundsen EK (2021)
Regional performance variation in external validation of four prediction models for severity of COVID-19 at hospital admission: An observational multi-centre cohort study
PLoS One, 16 (8), e0255748
DOI 10.1371/journal.pone.0255748, PubMed 34432797

 
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