Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Infectious Diseases

28 publications found

Bekken GK, Ritz C, Selvam S, Jesuraj N, Hesseling AC, Doherty TM, Grewal HMS, Vaz M, Jenum S (2020)
Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations
BMC Infect Dis, 20 (1), 96
DOI 10.1186/s12879-020-4800-y, PubMed 32005136

Christensen I, Haug JB, Berild D, Bjørnholt JV, Jelsness-Jørgensen LP (2020)
Hospital physicians' experiences with procalcitonin - implications for antimicrobial stewardship; a qualitative study
BMC Infect Dis, 20 (1), 515
DOI 10.1186/s12879-020-05246-6, PubMed 32677903

Desalegn H, Chanie Y, Shume P, Delil M, Gupta N, Johannessen A (2020)
Assessment of Noninvasive Markers of Liver Fibrosis in Patients With Chronic Hepatitis C in Ethiopia
Clin Liver Dis (Hoboken), 16 (4), 168-172
DOI 10.1002/cld.1040, PubMed 33163170

Døving M, Christensen EE, Huse LP, Vengen Ø (2020)
A case of septic arthritis of the temporomandibular joint with necrotic peri-articular infection and Lemierre's syndrome: an unusual presentation
Oral Maxillofac Surg, 25 (3), 411-415
DOI 10.1007/s10006-020-00921-z, PubMed 33151408

Floeystad HK, Berild JD, Brandsaeter BJ, Vestrheim DF, Berild D, Holm AM (2020)
Gastrointestinal symptoms in invasive pneumococcal disease: a cohort study
BMC Infect Dis, 20 (1), 479
DOI 10.1186/s12879-020-05211-3, PubMed 32631331

Gundem T, Olasveengen TM, Hovda KE, Gaustad K, Schøndorf C, Rostrup M, Frøyshov S, Undseth Ø, Tonby K, Holten AR, Sunde K (2020)
Ventilatory support for hypoxaemic intensive care patients with COVID-19
Tidsskr Nor Laegeforen, 140 (11)
DOI 10.4045/tidsskr.20.0445, PubMed 32815344

Helset E, Nordøy I, Sporsem H, Bakke VD, Bugge JF, Gammelsrud KW, Zucknick M, von der Lippe E (2020)
Factors increasing the risk of inappropriate vancomycin therapy in ICU patients: A prospective observational study
Acta Anaesthesiol Scand, 64 (9), 1295-1304
DOI 10.1111/aas.13658, PubMed 32578201

Hoel H, Heggelund L, Reikvam DH, Stiksrud B, Ueland T, Michelsen AE, Otterdal K, Muller KE, Lind A, Muller F, Dudman S, Aukrust P, Dyrhol-Riise AM, Holter JC, Trøseid M (2020)
Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement
J Intern Med, 289 (4), 523-531
DOI 10.1111/joim.13178, PubMed 32976665

Hoel IM, Sviland L, Syre H, Dyrhol-Riise AM, Skarstein I, Jebsen P, Jørstad MD, Wiker H, Mustafa T (2020)
Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting
BMC Infect Dis, 20 (1), 130
DOI 10.1186/s12879-020-4852-z, PubMed 32050915

Holten AR, Nore KG, Tveiten CEVWK, Olasveengen TM, Tonby K (2020)
Predicting severe COVID-19 in the Emergency Department
Resusc Plus, 4, 100042
DOI 10.1016/j.resplu.2020.100042, PubMed 33403367

Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P et al. (2020)
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538

Jøntvedt Jørgensen M, Holter JC, Christensen EE, Schjalm C, Tonby K, Pischke SE, Jenum S, Skeie LG, Nur S, Lind A, Opsand H, Enersen TB, Grøndahl R, Hermann A, Dudman S, Muller F, Ueland T, Mollnes TE, Aukrust P, Heggelund L, Holten AR, Dyrhol-Riise AM (2020)
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Sci Rep, 10 (1), 21697
DOI 10.1038/s41598-020-78710-7, PubMed 33303843

Jøntvedt Jørgensen M, Jenum S, Tonby K, Mortensen R, Walzl G, Du Plessis N, Dyrhol-Riise AM (2020)
Monocytic myeloid-derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase-2 inhibitors
J Leukoc Biol, 110 (1), 177-186
DOI 10.1002/JLB.4A0720-409RR, PubMed 33155730

Lyngbakken MN, Berdal JE, Eskesen A, Kvale D, Olsen IC, Rueegg CS, Rangberg A, Jonassen CM, Omland T, Røsjø H, Dalgard O (2020)
A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics
Nat Commun, 11 (1), 5284
DOI 10.1038/s41467-020-19056-6, PubMed 33082342

Mazani E, Taylor M, Kjetland EF, Ndhlovu PD (2020)
Knowledge and perceptions about schistosomiasis among primary school children and teachers in rural KwaZulu-Natal
S Afr J Infect Dis, 35 (1), 126
DOI 10.4102/sajid.v35i1.126, PubMed 34485472

Meyer-Myklestad MH, Medhus AW, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Stiksrud B, Trøseid M, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Reikvam DH (2020)
HIV-infected immunological non-responders have colon-restricted gut mucosal immune dysfunction
J Infect Dis (in press)
DOI 10.1093/infdis/jiaa714, PubMed 33216130

Mustafa T, Wergeland I, Baba K, Pathak S, Hoosen AA, Dyrhol-Riise AM (2020)
Mycobacterial antigens in pleural fluid mononuclear cells to diagnose pleural tuberculosis in HIV co-infected patients
BMC Infect Dis, 20 (1), 459
DOI 10.1186/s12879-020-05165-6, PubMed 32611401

Nore KG, Jørgensen MJ, Dyrhol-Riise AM, Jenum S, Tonby K (2020)
Elevated Levels of Anti-Inflammatory Eicosanoids and Monocyte Heterogeneity in Mycobacterium tuberculosis Infection and Disease
Front Immunol, 11, 579849
DOI 10.3389/fimmu.2020.579849, PubMed 33304347

Orlien SMS, Ahmed TA, Ismael NY, Berhe Belay N, Kran AB, Gundersen SG, Johannessen A (2020)
Field performance of HBsAg rapid diagnostic tests in rural Ethiopia
J Virol Methods, 289, 114061
DOI 10.1016/j.jviromet.2020.114061, PubMed 33388369

Patel P, Rose CE, Kjetland EF, Downs JA, Mbabazi PS, Sabin K, Chege W, Watts DH, Secor WE (2020)
Association of schistosomiasis and HIV infections: A systematic review and meta-analysis
Int J Infect Dis, 102, 544-553
DOI 10.1016/j.ijid.2020.10.088, PubMed 33157296

Pillay P, Downs JA, Changalucha JM, Brienen EAT, Ramarokoto CE, Leutscher PDC, Vennervald BJ, Taylor M, Kjetland EF, Van Lieshout L (2020)
Detection of Schistosoma DNA in genital specimens and urine: A comparison between five female African study populations originating from S. haematobium and/or S. mansoni endemic areas
Acta Trop, 204, 105363
DOI 10.1016/j.actatropica.2020.105363, PubMed 32035055

Rajar P, Saugstad OD, Berild D, Dutta A, Greisen G, Lausten-Thomsen U, Mande SS, Nangia S, Petersen FC, Dahle UR, Haaland K (2020)
Antibiotic Stewardship in Premature Infants: A Systematic Review
Neonatology, 117 (6), 673-686
DOI 10.1159/000511710, PubMed 33271554

Reikvam DH, Meyer-Myklestad MH, Trøseid M, Stiksrud B (2020)
Probiotics to manage inflammation in HIV infection
Curr Opin Infect Dis, 33 (1), 34-43
DOI 10.1097/QCO.0000000000000612, PubMed 31789692

Sivakumaran D, Jenum S, Vaz M, Selvam S, Ottenhoff THM, Haks MC, Malherbe ST, Doherty TM, Ritz C, Grewal HMS (2020)
Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes
Commun Biol, 3 (1), 359
DOI 10.1038/s42003-020-1087-x, PubMed 32647325

Ueland T, Heggelund L, Lind A, Holten AR, Tonby K, Michelsen AE, Jenum S, Jørgensen MJ, Barratt-Due A, Skeie LG, Nordøy I, Aanensen Fraz MS, Quist-Paulsen E E, Pischke SE, Johal SK, Hesstvedt L, Bogen M, Fevang B, Halvorsen B, Müller F, Bekken GK, Mollnes TE, Dudman S, Aukrust P, Dyrhol-Riise AM et al. (2020)
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109

Wolde M, Laan LC, Medhin G, Gadissa E, Berhe N, Tsegaye A (2020)
Human Monocytes/Macrophage Inflammatory Cytokine Changes Following in vivo and in vitro Schistomam manoni Infection
J Inflamm Res, 13, 35-43
DOI 10.2147/JIR.S233381, PubMed 32021377

Woldemedihn GM, Rueegg CS, Desalegn H, Aberra H, Berhe N, Johannessen A (2020)
Validity of a point-of-care viral load test for hepatitis B in a low-income setting
J Virol Methods, 289, 114057
DOI 10.1016/j.jviromet.2020.114057, PubMed 33359613

Zulu SG, Kjetland EF, Gundersen SG, Taylor M (2020)
Prevalence and intensity of neglected tropical diseases (schistosomiasis and soil-transmitted helminths) amongst rural female pupils in Ugu district, KwaZulu-Natal, South Africa
S Afr J Infect Dis, 35 (1), 123
DOI 10.4102/sajid.v35i1.123, PubMed 34485471

 
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