Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Dept. of Gastroenterology (Div Medicine)

31 publications found

Anisdahl K, Svatun Lirhus S, Medhus AW, Moum B, Melberg HO, Høivik ML (2021)
First-line biologic treatment of inflammatory bowel disease during the first 12 months after diagnosis from 2010 to 2016: a Norwegian nationwide registry study
Scand J Gastroenterol, 56 (10), 1163-1168
DOI 10.1080/00365521.2021.1955147, PubMed 34320885

Bakker OB, Ramírez-Sánchez AD, Borek ZA, de Klein N, Li Y, Modderman R, Kooy-Winkelaar Y, Johannesen MK, Matarese F, Martens JHA, Kumar V, van Bergen J, Qiao SW, Lundin KEA, Sollid LM, Koning F, Wijmenga C, Withoff S, Jonkers IH (2021)
Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells
Sci Rep, 11 (1), 9252
DOI 10.1038/s41598-021-86612-5, PubMed 33927210

Christophersen A, Zühlke S, Lund EG, Snir O, Dahal-Koirala S, Risnes LF, Jahnsen J, Lundin KEA, Sollid LM (2021)
Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies
Adv Sci (Weinh), 2102778
DOI 10.1002/advs.202102778, PubMed 34495570

Dahal-Koirala S, Risnes LF, Neumann RS, Christophersen A, Lundin KEA, Sandve GK, Qiao SW, Sollid LM (2021)
Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs
Front Immunol, 12, 639672
DOI 10.3389/fimmu.2021.639672, PubMed 33927715

Detlie TE, Lindstrøm JC, Jahnsen ME, Finnes E, Zoller H, Moum B, Jahnsen J (2021)
Hypophosphatemia after high-dose intravenous iron treatment in patients with inflammatory bowel disease: Mechanisms and possible clinical impact
World J Gastroenterol, 27 (17), 2039-2053
DOI 10.3748/wjg.v27.i17.2039, PubMed 34007138

El-Salhy M, Kristoffersen AB, Valeur J, Casen C, Hatlebakk JG, Gilja OH, Hausken T (2021)
Long-term effects of fecal microbiota transplantation (FMT) in patients with irritable bowel syndrome
Neurogastroenterol Motil, e14200
DOI 10.1111/nmo.14200, PubMed 34145677

Engjom T, Nordaas IK, Tjora E, Dimcevski G, Haldorsen IS, Olesen SS, Drewes AM, Zviniene K, Barauskas G, Riis Jespersen HS, Jensen N, Borch A, Nøjgaard C, Novovic S, Kardasheva SS, Okhlobystin A, Hauge T, Waage A, Frøkjær JB (2021)
Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database
Pancreatology, 21 (4), 688-697
DOI 10.1016/j.pan.2021.02.023, PubMed 33707113

Fadnes LT, Aas CF, Vold JH, Leiva RA, Ohldieck C, Chalabianloo F, Skurtveit S, Lygren OJ, Dalgård O, Vickerman P, Midgard H, Løberg EM, Johansson KA, INTRO-HCV Study Group (2021)
Integrated treatment of hepatitis C virus infection among people who inject drugs: A multicenter randomized controlled trial (INTRO-HCV)
PLoS Med, 18 (6), e1003653
DOI 10.1371/journal.pmed.1003653, PubMed 34061883

Frick R, Høydahl LS, Petersen J, du Pré MF, Kumari S, Berntsen G, Dewan AE, Jeliazkov JR, Gunnarsen KS, Frigstad T, Vik ES, Llerena C, Lundin KEA, Yaqub S, Jahnsen J, Gray JJ, Rossjohn J, Sollid LM, Sandlie I, Løset GÅ (2021)
A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation
Sci Immunol, 6 (62)
DOI 10.1126/sciimmunol.abg4925, PubMed 34417258

Hoff G, Botteri E, Huppertz-Hauss G, Kvamme JM, Holme Ø, Aabakken L, Dahler S, Medhus AW, Blomgren I, Sandvei P, Darre-Næss O, Kjellevold Ø, Seip B (2021)
The effect of train-the-colonoscopy-trainer course on colonoscopy quality indicators
Endoscopy
DOI 10.1055/a-1352-4583, PubMed 33622001

Hoffmann-Vold AM, Fretheim HH, Sarna VK, Barua I, Carstens MN, Distler O, Khanna D, Volkmann ER, Midtvedt Ø, Didriksen H, Dhainaut A, Halse AK, Bakland G, Pesonen M, Olsen I, Molberg Ø (2021)
Safety and efficacy of faecal microbiota transplantation by Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis: study protocol for the randomised controlled phase II ReSScue trial
BMJ Open, 11 (6), e048541
DOI 10.1136/bmjopen-2020-048541, PubMed 34168032

Kristensen VA, Opheim R, Perminow G, Huppertz-Hauss G, Detlie TE, Lund C, Andersen S, Olsen BC, Johansen I, Medhus AW, Vatn S, Brackmann S, Olbjørn C, Rove J, Henriksen M, Løvlund EE, Bengtson MB, Aabrekk TB, Tønnessen T, Vikskjold FB, Yassin H, Frigstad SO, Hasund A, Høie O, Schmidt K et al. (2021)
Inflammatory bowel disease in South-Eastern Norway III (IBSEN III): a new population-based inception cohort study from South-Eastern Norway
Scand J Gastroenterol, 56 (8), 899-905
DOI 10.1080/00365521.2021.1922746, PubMed 34154494

Kylänpää L, Koskensalo V, Saarela A, Ejstrud P, Udd M, Lindström O, Rainio M, Tenca A, Halttunen J, Qvigstad G, Arnelo U, Fagerström N, Hauge T, Aabakken L, Grönroos J (2021)
Transpancreatic biliary sphincterotomy versus double guidewire in difficult biliary cannulation: a randomized controlled trial
Endoscopy, 53 (10), 1011-1019
DOI 10.1055/a-1327-2025, PubMed 33440441

Lindeman I, Zhou C, Eggesbø LM, Miao Z, Polak J, Lundin KEA, Jahnsen J, Qiao SW, Iversen R, Sollid LM (2021)
Longevity, clonal relationship, and transcriptional program of celiac disease-specific plasma cells
J Exp Med, 218 (2)
DOI 10.1084/jem.20200852, PubMed 33095260

Lirhus SS, Høivik ML, Moum B, Anisdahl K, Melberg HO (2021)
Incidence and Prevalence of Inflammatory Bowel Disease in Norway and the Impact of Different Case Definitions: A Nationwide Registry Study
Clin Epidemiol, 13, 287-294
DOI 10.2147/CLEP.S303797, PubMed 33935519

Lorentzen J, Medhus AW, Hofsø D, Svanevik M, Seip B, Hjelmesæth J (2021)
Sleeve Gastrectomy Confers Higher Risk of Gastroesophageal Reflux Disease than Gastric Bypass: A Randomized Controlled Trial From the Oseberg Reflux Working Group
Gastroenterology (in press)
DOI 10.1053/j.gastro.2021.08.021, PubMed 34419459

Lorvik KB, Meyer-Myklestad MH, Kushekar K, Handeland C, Medhus AW, Lund-Iversen M, Stiksrud B, Kvale D, Dyrhol-Riise AM, Taskén K, Reikvam DH (2021)
Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4+ T Cells in HIV-Infected Immunological Non-Responders
Front Immunol, 12, 744155
DOI 10.3389/fimmu.2021.744155, PubMed 34691047

Lundin KE, Kelly CP, Sanders DS, Chen K, Kayaniyil S, Wang S, Wani RJ, Barrett C, Yoosuf S, Pettersen ES, Sambrook R, Leffler DA (2021)
Understanding celiac disease monitoring patterns and outcomes after diagnosis: A multinational, retrospective chart review study
World J Gastroenterol, 27 (20), 2603-2614
DOI 10.3748/wjg.v27.i20.2603, PubMed 34092978

Midgard H, Ulstein K, Backe Ø, Foshaug T, Sørli H, Vennesland K, Nilssen D, Dahl EH, Finbråten AK, Wüsthoff L, Dalgard O (2021)
Hepatitis C treatment and reinfection surveillance among people who inject drugs in a low-threshold program in Oslo, Norway
Int J Drug Policy, 103165 (in press)
DOI 10.1016/j.drugpo.2021.103165, PubMed 33642182

Monstad IL, Solberg IC, Cvancarova M, Hovde O, Henriksen M, Huppertz-Hauss G, Gunther E, Moum BA, Stray N, Vatn M, Hoie O, Jahnsen J (2021)
Outcome of Ulcerative Colitis 20 Years after Diagnosis in a Prospective Population-based Inception Cohort from South-Eastern Norway, the IBSEN Study
J Crohns Colitis, 15 (6), 969-979
DOI 10.1093/ecco-jcc/jjaa232, PubMed 33367569

Moum KM, Moum B, Opheim R (2021)
Patients with inflammatory bowel disease on immunosuppressive drugs: perspectives' on COVID-19 and health care service during the pandemic
Scand J Gastroenterol, 56 (5), 545-551
DOI 10.1080/00365521.2021.1901308, PubMed 33771086

Myhrstad MCW, Slydahl M, Hellmann M, Garnweidner-Holme L, Lundin KEA, Henriksen C, Telle-Hansen VH (2021)
Nutritional quality and costs of gluten-free products: a case-control study of food products on the Norwegian marked
Food Nutr Res, 65
DOI 10.29219/fnr.v65.6121, PubMed 33841066

Njølstad T, Young VS, Drolsum A, Dormagen JB, Hofstad B, Schulz A (2021)
Is there need for routine CT colonography after CT-verified uncomplicated diverticulitis of the sigmoid colon?
Eur J Radiol Open, 8, 100341
DOI 10.1016/j.ejro.2021.100341, PubMed 33898653

Qiao SW, Dahal-Koirala S, Eggesbø LM, Lundin KEA, Sollid LM (2021)
Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning
Front Immunol, 12, 646163
DOI 10.3389/fimmu.2021.646163, PubMed 33796112

Risnes LF, Eggesbø LM, Zühlke S, Dahal-Koirala S, Neumann RS, Lundin KEA, Christophersen A, Sollid LM (2021)
Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease
Mucosal Immunol, 14 (4), 842-851
DOI 10.1038/s41385-021-00385-8, PubMed 33654213

Shemesh O, Polak P, Lundin KEA, Sollid LM, Yaari G (2021)
Machine Learning Analysis of Naïve B-Cell Receptor Repertoires Stratifies Celiac Disease Patients and Controls
Front Immunol, 12, 627813
DOI 10.3389/fimmu.2021.627813, PubMed 33790900

Skaarud KJ, Hov JR, Hansen SH, Kummen M, Valeur J, Seljeflot I, Bye A, Paulsen V, Lundin KEA, Trøseid M, Tjønnfjord GE, Iversen PO (2021)
Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
Sci Rep, 11 (1), 11593
DOI 10.1038/s41598-021-90976-z, PubMed 34078971

Skaarud KJ, Hov JR, Hansen SH, Kummen M, Valeur J, Seljeflot I, Bye A, Paulsen V, Lundin KEA, Troseid M, Tjonnfjord GE, Iversen PO (2021)
Mortality and microbial diversity after allogeneic hematopoietic stem cell transplantation: secondary analysis of a randomized nutritional intervention trial
Sci Rep, 11 (1), 11593
DOI 10.1038/s41598-021-90976-z

Sousa P, Ministro P, Armuzzi A, Dignass A, Høivik ML, Barreiro-de Acosta M, Vavricka S, Saad-Hossne R, Gustavo Kotze P, Peyrin-Biroulet L, Magro F (2021)
Thiopurines: Use them or lose them? International survey on current and future use of thiopurines in inflammatory bowel disease
Dig Liver Dis (in press)
DOI 10.1016/j.dld.2021.05.038, PubMed 34187768

Stamnaes J, Stray D, Stensland M, Sarna VK, Nyman TA, Lundin KEA, Sollid LM (2021)
In Well-Treated Celiac Patients Low-Level Mucosal Inflammation Predicts Response to 14-day Gluten Challenge
Adv Sci (Weinh), 8 (4), 2003526
DOI 10.1002/advs.202003526, PubMed 33643806

van Megen F, Skodje GI, Stendahl M, Veierød MB, Lundin KEA, Henriksen C (2021)
High disease burden in treated celiac patients - a web-based survey
Scand J Gastroenterol, 56 (8), 882-888
DOI 10.1080/00365521.2021.1930146, PubMed 34057009

 
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