Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Psychosis Research (NORMENT)

47 publications found

Aas M, Ueland T, Mørch RH, Laskemoen JF, Lunding SH, Reponen EJ, Cattaneo A, Agartz I, Melle I, Steen NE, Andreassen OA (2021)
Physical activity and childhood trauma experiences in patients with schizophrenia or bipolar disorders
World J Biol Psychiatry, 1-9 (in press)
DOI 10.1080/15622975.2021.1907707, PubMed 33779484

Akkouh IA, Hughes T, Steen VM, Glover JC, Andreassen OA, Djurovic S, Szabo A (2021)
Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia
Brain Behav Immun, 94, 235-244
DOI 10.1016/j.bbi.2021.01.037, PubMed 33571628

Alameda L, Christy A, Rodriguez V, Salazar de Pablo G, Thrush M, Shen Y, Alameda B, Spinazzola E, Iacoponi E, Trotta G, Carr E, Ruiz Veguilla M, Aas M, Morgan C, Murray RM (2021)
Association Between Specific Childhood Adversities and Symptom Dimensions in People With Psychosis: Systematic Review and Meta-Analysis
Schizophr Bull (in press)
DOI 10.1093/schbul/sbaa199, PubMed 33836526

Andreou D, Jørgensen KN, Wortinger LA, Engen K, Vaskinn A, Ueland T, Yolken RH, Andreassen OA, Agartz I (2021)
Cytomegalovirus infection and IQ in patients with severe mental illness and healthy individuals
Psychiatry Res, 300, 113929 (in press)
DOI 10.1016/j.psychres.2021.113929, PubMed 33866186

Bahrami S, Shadrin A, Frei O, O'Connell KS, Bettella F, Krull F, Fan CC, Røssberg JI, Hindley G, Ueland T, Dale AM, Djurovic S, Steen NE, Smeland OB, Andreassen OA (2021)
Genetic loci shared between major depression and intelligence with mixed directions of effect
Nat Hum Behav
DOI 10.1038/s41562-020-01031-2, PubMed 33462475

Barth C, Nerland S, de Lange AG, Wortinger LA, Hilland E, Andreassen OA, Jørgensen KN, Agartz I (2021)
In Vivo Amygdala Nuclei Volumes in Schizophrenia and Bipolar Disorders
Schizophr Bull (in press)
DOI 10.1093/schbul/sbaa192, PubMed 33479754

Bjørnebekk A, Kaufmann T, Hauger LE, Klonteig S, Hullstein IR, Westlye LT (2021)
Long-term Anabolic-Androgenic Steroid Use Is Associated With Deviant Brain Aging
Biol Psychiatry Cogn Neurosci Neuroimaging, 6 (5), 579-589
DOI 10.1016/j.bpsc.2021.01.001, PubMed 33811018

Chen JY, Li X, Calhoun VD, Turner JA, van Erp TGM, Wang L, Andreassen OA, Agartz I, Westlye LT, Jonsson E, Ford JM, Mathalon DH, Macciardi F, O'Leary DS, Liu JY, Ji SH (2021)
Sparse deep neural networks on imaging genetics for schizophrenia case-control classification
Hum. Brain Mapp., 42 (8), 2556-2568

Dieset I, Løvhaug L, Selle M, Kolseth A, Smeland OB, Færden A (2021)
Lessons learned from a cross-sectional survey among patients and staff in an acute psychiatric unit during an ongoing pandemic outbreak
Psychiatry Res, 298, 113779
DOI 10.1016/j.psychres.2021.113779, PubMed 33561619

Ditmars HL, Logue MW, Toomey R, McKenzie RE, Franz CE, Panizzon MS, Reynolds CA, Cuthbert KN, Vandiver R, Gustavson DE, Eglit GML, Elman JA, Sanderson-Cimino M, Williams ME, Andreassen OA, Dale AM, Eyler LT, Fennema-Notestine C, Gillespie NA, Hauger RL, Jak AJ, Neale MC, Tu XM, Whitsel N, Xian H et al. (2021)
Associations between depression and cardiometabolic health: A 27-year longitudinal study
Psychol Med, 1-11 (in press)
DOI 10.1017/S003329172000505X, PubMed 33431106

Ellingsen DM, Beissner F, Moher Alsady T, Lazaridou A, Paschali M, Berry M, Isaro L, Grahl A, Lee J, Wasan AD, Edwards RR, Napadow V (2021)
A picture is worth a thousand words: linking fibromyalgia pain widespreadness from digital pain drawings with pain catastrophizing and brain cross-network connectivity
Pain, 162 (5), 1352-1363
DOI 10.1097/j.pain.0000000000002134, PubMed 33230008

ENIGMA Clinical High Risk for Psychosis Working Group, Jalbrzikowski M, Hayes RA, Wood SJ, Nordholm D, Zhou JH, Fusar-Poli P, Uhlhaas PJ, Takahashi T, Sugranyes G, Kwak YB, Mathalon DH, Katagiri N, Hooker CI, Smigielski L, Colibazzi T, Via E, Tang J, Koike S, Rasser PE, Michel C, Lebedeva I, Hegelstad WTV, de la Fuente-Sandoval C, Waltz JA et al. (2021)
Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis
JAMA Psychiatry (in press)
DOI 10.1001/jamapsychiatry.2021.0638, PubMed 33950164

Etain B, Aas M (2021)
Childhood Maltreatment in Bipolar Disorders
Curr Top Behav Neurosci, 48, 277-301
DOI 10.1007/7854_2020_149, PubMed 32653999

Farmer AD, Strzelczyk A, Finisguerra A, Gourine AV, Gharabaghi A, Hasan A, Burger AM, Jaramillo AM, Mertens A, Majid A, Verkuil B, Badran BW, Ventura-Bort C, Gaul C, Beste C, Warren CM, Quintana DS, Hämmerer D, Freri E, Frangos E, Tobaldini E, Kaniusas E, Rosenow F, Capone F, Panetsos F et al. (2021)
International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)
Front Hum Neurosci, 14, 568051
DOI 10.3389/fnhum.2020.568051, PubMed 33854421

Fjukstad KK, Athanasiu L, Bahrami S, O'Connell KS, van der Meer D, Bettella F, Dieset I, Steen NE, Djurovic S, Spigset O, Andreassen OA (2021)
Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study
Pharmacogenomics J
DOI 10.1038/s41397-021-00234-8, PubMed 33824429

Hannigan LJ, Askeland RB, Ask H, Tesli M, Corfield E, Ayorech Z, Helgeland Ø, Magnus P, Njølstad PR, Øyen AS, Stoltenberg C, Andreassen OA, Davey Smith G, Reichborn-Kjennerud T, Havdahl A (2021)
Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population
Schizophr Bull (in press)
DOI 10.1093/schbul/sbaa193, PubMed 33561255

Hellstrøm T, Andelic N, de Lange AG, Helseth E, Eiklid K, Westlye LT (2021)
Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging
J Clin Med, 10 (3)
DOI 10.3390/jcm10030418, PubMed 33499167

Huynh-Le MP, Fan CC, Karunamuni R, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir K, Schleutker J, Pashayan N, Batra J, Grönberg H, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nielsen SF, Nordestgaard BG, Wiklund F, Tangen CM, Giles GG, Wolk A, Albanes D, Travis RC, Blot WJ et al. (2021)
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
Nat Commun, 12 (1), 1236
DOI 10.1038/s41467-021-21287-0, PubMed 33623038

Huynh-Le MP, Karunamuni R, Fan CC, Thompson WK, Muir K, Lophatananon A, Tye K, Wolk A, Hakansson N, Mills IG, Andreassen OA, Dale AM, Seibert TM, PRACTICAL Consortium (2021)
Common genetic and clinical risk factors: association with fatal prostate cancer in the Cohort of Swedish Men
Prostate Cancer Prostatic Dis.

Karunamuni RA, Huynh-Le MP, Fan CC, Thompson W, Eeles RA, Kote-Jarai Z, Muir K, Lophatananon A, UKGPCS collaborators, Schleutker J, Pashayan N, Batra J, APCB BioResource (Australian Prostate Cancer BioResource), Grönberg H, Walsh EI, Turner EL, Lane A, Martin RM, Neal DE, Donovan JL, Hamdy FC, Nordestgaard BG, Tangen CM, MacInnis RJ, Wolk A et al. (2021)
Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer
Prostate Cancer Prostatic Dis
DOI 10.1038/s41391-020-00311-2, PubMed 33420416

Kessing LV, González-Pinto A, Fagiolini A, Bechdolf A, Reif A, Yildiz A, Etain B, Henry C, Severus E, Reininghaus EZ, Morken G, Goodwin GM, Scott J, Geddes JR, Rietschel M, Landén M, Manchia M, Bauer M, Martinez-Cengotitabengoa M, Andreassen OA, Ritter P, Kupka R, Licht RW, Nielsen RE, Schulze TG et al. (2021)
DSM-5 and ICD-11 criteria for bipolar disorder: Implications for the prevalence of bipolar disorder and validity of the diagnosis - A narrative review from the ECNP bipolar disorders network
Eur Neuropsychopharmacol (in press)
DOI 10.1016/j.euroneuro.2021.01.097, PubMed 33541809

Kinge JM, Øverland S, Flatø M, Dieleman J, Røgeberg O, Magnus MC, Evensen M, Tesli M, Skrondal A, Stoltenberg C, Vollset SE, Håberg S, Torvik FA (2021)
Parental income and mental disorders in children and adolescents: prospective register-based study
Int J Epidemiol (in press)
DOI 10.1093/ije/dyab066, PubMed 33975355

Laeng B, Flaaten CB, Walle KM, Hochkeppler A, Specht K (2021)
"Mickey Mousing" in the Brain: Motion-Sound Synesthesia and the Subcortical Substrate of Audio-Visual Integration
Front Hum Neurosci, 15, 605166
DOI 10.3389/fnhum.2021.605166, PubMed 33658913

Lie SØ, Bulik CM, Andreassen OA, Rø Ø, Bang L (2021)
The association between bullying and eating disorders: A case-control study
Int J Eat Disord (in press)
DOI 10.1002/eat.23522, PubMed 33942329

Lin Y, Maihofer AX, Stapp E, Ritchey M, Alliey-Rodriguez N, Anand A, Balaraman Y, Berrettini WH, Bertram H, Bhattacharjee A, Calkin CV, Conroy C, Coryell W, D'Arcangelo N, DeModena A, Biernacka JM, Fisher C, Frazier N, Frye M, Gao K, Garnham J, Gershon E, Glazer K, Goes FS, Goto T et al. (2021)
Clinical predictors of non-response to lithium treatment in the Pharmacogenomics of Bipolar Disorder (PGBD) study
Bipolar Disord (in press)
DOI 10.1111/bdi.13078, PubMed 33797828

Lunding SH, Simonsen C, Aas M, Rødevand L, Werner MCF, Laskemoen JF, Hjell G, Ringen PA, Lagerberg TV, Melle I, Andreassen OA, Ueland T, Steen NE (2021)
Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control
Eur Psychiatry, 64 (1), e24
DOI 10.1192/j.eurpsy.2021.14, PubMed 33775258

Maximov II, van der Meer D, de Lange AG, Kaufmann T, Shadrin A, Frei O, Wolfers T, Westlye LT (2021)
Fast qualitY conTrol meThod foR derIved diffUsion Metrics (YTTRIUM) in big data analysis: U.K. Biobank 18,608 example
Hum Brain Mapp
DOI 10.1002/hbm.25424, PubMed 33788350

O'Connell KS, Coombes BJ (2021)
Genetic contributions to bipolar disorder: current status and future directions
Psychol Med, 1-12 (in press)
DOI 10.1017/S0033291721001252, PubMed 33879273

O'Connell KS, Sønderby IE, Frei O, van der Meer D, Athanasiu L, Smeland OB, Alnæs D, Kaufmann T, Westlye LT, Steen VM, Andreassen OA, Hughes T, Djurovic S (2021)
Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank
Psychol Med, 1-11 (in press)
DOI 10.1017/S0033291721000179, PubMed 33653435

Olsen A, Babikian T, Bigler ED, Caeyenberghs K, Conde V, Dams-O'Connor K, Dobryakova E, Genova H, Grafman J, Håberg AK, Heggland I, Hellstrøm T, Hodges CB, Irimia A, Jha RM, Johnson PK, Koliatsos VE, Levin H, Li LM, Lindsey HM, Livny A, Løvstad M, Medaglia J, Menon DK, Mondello S et al. (2021)
Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group
Brain Imaging Behav, 15 (2), 526-554
DOI 10.1007/s11682-020-00313-7, PubMed 32797398

Pogosbekian EL, Pronin IN, Zakharova NE, Batalov AI, Turkin AM, Konakova TA, Maximov II (2021)
Feasibility of generalised diffusion kurtosis imaging approach for brain glioma grading
Neuroradiology
DOI 10.1007/s00234-020-02613-7, PubMed 33410948

Radonjić NV, Hess JL, Rovira P, Andreassen O, Buitelaar JK, Ching CRK, Franke B, Hoogman M, Jahanshad N, McDonald C, Schmaal L, Sisodiya SM, Stein DJ, van den Heuvel OA, van Erp TGM, van Rooij D, Veltman DJ, Thompson P, Faraone SV (2021)
Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
Mol Psychiatry
DOI 10.1038/s41380-020-01002-z, PubMed 33456050

Reindal L, Nærland T, Weidle B, Lydersen S, Andreassen OA, Sund AM (2021)
Structural and Pragmatic Language Impairments in Children Evaluated for Autism Spectrum Disorder (ASD)
J Autism Dev Disord
DOI 10.1007/s10803-020-04853-1, PubMed 33515169

Reis de Assis D, Szabo A, Requena Osete J, Puppo F, O'Connell KS, A Akkouh I, Hughes T, Frei E, A Andreassen O, Djurovic S (2021)
Using iPSC Models to Understand the Role of Estrogen in Neuron-Glia Interactions in Schizophrenia and Bipolar Disorder
Cells, 10 (2)
DOI 10.3390/cells10020209, PubMed 33494281

Rødevand L, Bahrami S, Frei O, Lin A, Gani O, Shadrin A, Smeland OB, Connell KSO, Elvsåshagen T, Winterton A, Quintana DS, Hindley GFL, Werner MCF, Djurovic S, Dale AM, Lagerberg TV, Steen NE, Andreassen OA (2021)
Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
Transl Psychiatry, 11 (1), 3
DOI 10.1038/s41398-020-01142-4, PubMed 33414458

Rodriguez V, Aas M, Vorontsova N, Trotta G, Gadelrab R, Rooprai NK, Alameda L (2021)
Exploring the Interplay Between Adversity, Neurocognition, Social Cognition, and Functional Outcome in People With Psychosis: A Narrative Review
Front Psychiatry, 12, 596949
DOI 10.3389/fpsyt.2021.596949, PubMed 33762975

Roelfs D, Alnæs D, Frei O, van der Meer D, Smeland OB, Andreassen OA, Westlye LT, Kaufmann T (2021)
Phenotypically independent profiles relevant to mental health are genetically correlated
Transl Psychiatry, 11 (1), 202
DOI 10.1038/s41398-021-01313-x, PubMed 33795632

Sønderby IE, Ching CRK, Thomopoulos SI, van der Meer D, Sun D, Villalon-Reina JE, Agartz I, Amunts K, Arango C, Armstrong NJ, Ayesa-Arriola R, Bakker G, Bassett AS, Boomsma DI, Bülow R, Butcher NJ, Calhoun VD, Caspers S, Chow EWC, Cichon S, Ciufolini S, Craig MC, Crespo-Facorro B, Cunningham AC, Dale AM et al. (2021)
Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs
Hum Brain Mapp
DOI 10.1002/hbm.25354, PubMed 33615640

Sønderby IE, van der Meer D, Moreau C, Kaufmann T, Walters GB, Ellegaard M, Abdellaoui A, Ames D, Amunts K, Andersson M, Armstrong NJ, Bernard M, Blackburn NB, Blangero J, Boomsma DI, Brodaty H, Brouwer RM, Bülow R, Bøen R, Cahn W, Calhoun VD, Caspers S, Ching CRK, Cichon S, Ciufolini S et al. (2021)
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans
Transl Psychiatry, 11 (1), 182
DOI 10.1038/s41398-021-01213-0, PubMed 33753722

Tahmasian M, Aleman A, Andreassen OA, Arab Z, Baillet M, Benedetti F, Bresser T, Bright J, Chee MWL, Chylinski D, Cheng W, Deantoni M, Dresler M, Eickhoff SB, Eickhoff CR, Elvsåshagen T, Feng J, Foster-Dingley JC, Ganjgahi H, Grabe HJ, Groenewold NA, Ho TC, Bong Hong S, Houenou J, Irungu B et al. (2021)
ENIGMA-Sleep: Challenges, opportunities, and the road map
J Sleep Res, e13347 (in press)
DOI 10.1111/jsr.13347, PubMed 33913199

Ulrichsen KM, Kolskår KK, Richard G, Alnæs D, Dørum ES, Sanders AM, Tornås S, Sánchez JM, Engvig A, Ihle-Hansen H, de Schotten MT, Nordvik JE, Westlye LT (2021)
Structural brain disconnectivity mapping of post-stroke fatigue
Neuroimage Clin, 30, 102635 (in press)
DOI 10.1016/j.nicl.2021.102635, PubMed 33799271

Værnes TG, Røssberg JI, Melle I, Nelson B, Romm KL, Møller P (2021)
Basic self-disturbance in subjects at clinical high risk for psychosis: Relationship with clinical and functional outcomes at one year follow-up
Psychiatry Res, 300, 113942 (in press)
DOI 10.1016/j.psychres.2021.113942, PubMed 33940444

Valstad M, Roelfs D, Slapø NB, Timpe CMF, Rai A, Matziorinis AM, Beck D, Richard G, Sæther LS, Haatveit B, Nordvik JE, Hatlestad-Hall C, Einevoll GT, Mäki-Marttunen T, Haram M, Ueland T, Lagerberg TV, Steen NE, Melle I, Westlye LT, Jönsson EG, Andreassen OA, Moberget T, Elvsåshagen T (2021)
Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder
Schizophr Bull (in press)
DOI 10.1093/schbul/sbab049, PubMed 33963856

van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, Walker RM, Morris SW, Lahti J, Küpers LK, Escaramis G, Alemany S, Jan Bonder M, Meijer M, Ip HF, Jansen R, Baselmans BML, Parmar P, Lowry E, Streit F, Sirignano L et al. (2021)
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
Mol Psychiatry (in press)
DOI 10.1038/s41380-020-00987-x, PubMed 33420481

Wisting L, Johnson SU, Bulik CM, Andreassen OA, Rø Ø, Bang L (2021)
Psychometric properties of the Norwegian version of the Patient Health Questionnaire-9 (PHQ-9) in a large female sample of adults with and without eating disorders
BMC Psychiatry, 21 (1), 6
DOI 10.1186/s12888-020-03013-0, PubMed 33402149

Wolfers T, Rokicki J, Alnaes D, Berthet P, Agartz I, Kia SM, Kaufmann T, Zabihi M, Moberget T, Melle I, Beckmann CF, Andreassen OA, Marquand AF, Westlye LT (2021)
Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder
Hum Brain Mapp, 42 (8), 2546-2555
DOI 10.1002/hbm.25386, PubMed 33638594

Wortinger LA, Jørgensen KN, Barth C, Nerland S, Smelror RE, Vaskinn A, Ueland T, Andreassen OA, Agartz I (2021)
Significant association between intracranial volume and verbal intellectual abilities in patients with schizophrenia and a history of birth asphyxia
Psychol Med, 1-10 (in press)
DOI 10.1017/S0033291721000489, PubMed 33750510

 
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