Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Department of Pharmacology

35 publications found

Andersen AM, Bergan S, Gedde-Dahl T, Buechner J, Vethe NT (2021)
Fast and reliable quantification of busulfan in blood plasma using two-channel liquid chromatography tandem mass spectrometry: Validation of assay performance in the presence of drug formulation excipients
J Pharm Biomed Anal, 203, 114216
DOI 10.1016/j.jpba.2021.114216, PubMed 34182411

Azevedo C, Andersen JT, Traverso G, Sarmento B (2021)
The potential of porcine ex vivo platform for intestinal permeability screening of FcRn-targeted drugs
Eur J Pharm Biopharm, 162, 99-104
DOI 10.1016/j.ejpb.2021.03.009, PubMed 33771621

Azevedo C, Pinto S, Benjakul S, Nilsen J, Santos HA, Traverso G, Andersen JT, Sarmento B (2021)
Prevention of diabetes-associated fibrosis: Strategies in FcRn-targeted nanosystems for oral drug delivery
Adv Drug Deliv Rev, 175, 113778
DOI 10.1016/j.addr.2021.04.016, PubMed 33887405

Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC et al. (2021)
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function
Pharmacol Rev, 73 (1), 310-520
DOI 10.1124/pr.118.015552, PubMed 33370241

Barratt-Due A, Olsen IC, Nezvalova-Henriksen K, Kåsine T, Lund-Johansen F, Hoel H, Holten AR, Tveita A, Mathiessen A, Haugli M, Eiken R, Kildal AB, Berg Å, Johannessen A, Heggelund L, Dahl TB, Skåra KH, Mielnik P, Le LAK, Thoresen L, Ernst G, Hoff DAL, Skudal H, Kittang BR, Olsen RB et al. (2021)
Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 : A Randomized Trial
Ann Intern Med, 174 (9), 1261-1269
DOI 10.7326/M21-0653, PubMed 34251903

Baumgartner T, Carreño M, Rocamora R, Bisulli F, Boni A, Brázdil M, Horak O, Craiu D, Pereira C, Guerrini R, San Antonio-Arce V, Schulze-Bonhage A, Zuberi SM, Hallböök T, Kalviainen R, Lagae L, Nguyen S, Quintas S, Franco A, Cross JH, Walker M, Arzimanoglou A, Rheims S, Granata T, Canafoglia L et al. (2021)
A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies
Epilepsia Open, 6 (1), 160-170
DOI 10.1002/epi4.12459, PubMed 33681659

Bergan S, Brunet M, Hesselink DA, Johnson-Davis KL, Kunicki PK, Lemaitre F, Marquet P, Molinaro M, Noceti O, Pattanaik S, Pawinski T, Seger C, Shipkova M, Swen JJ, van Gelder T, Venkataramanan R, Wieland E, Woillard JB, Zwart TC, Barten MJ, Budde K, Dieterlen MT, Elens L, Haufroid V, Masuda S et al. (2021)
Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology
Ther Drug Monit, 43 (2), 150-200
DOI 10.1097/FTD.0000000000000871, PubMed 33711005

Bergland OU, Halvorsen LV, Søraas CL, Hjørnholm U, Kjær VN, Rognstad S, Brobak KM, Aune A, Olsen E, Fauchald YM, Heimark S, Thorstensen CW, Liestøl K, Solbu MD, Gerdts E, Mo R, Rostrup M, Kjeldsen SE, Høieggen A, Opdal MS, Larstorp ACK, Fadl Elmula FEM (2021)
Detection of Nonadherence to Antihypertensive Treatment by Measurements of Serum Drug Concentrations
Hypertension, 78 (3), 617-628
DOI 10.1161/HYPERTENSIONAHA.121.17514, PubMed 34275336

Bjørnebekk A, Kaufmann T, Hauger LE, Klonteig S, Hullstein IR, Westlye LT (2021)
Long-term Anabolic-Androgenic Steroid Use Is Associated With Deviant Brain Aging
Biol Psychiatry Cogn Neurosci Neuroimaging, 6 (5), 579-589
DOI 10.1016/j.bpsc.2021.01.001, PubMed 33811018

Brede C, Vethe NT, Skadberg Ø (2021)
The Question of Accuracy Versus Interlaboratory Agreement for Monitoring the Immunosuppressants Everolimus and Sirolimus
Ther Drug Monit, 43 (3), 444-446
DOI 10.1097/FTD.0000000000000892, PubMed 33840796

Christopoulos PF, Gjølberg TT, Krüger S, Haraldsen G, Andersen JT, Sundlisæter E (2021)
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases
Front Immunol, 12, 668207
DOI 10.3389/fimmu.2021.668207, PubMed 33912195

Danielsen TK, Sadredini M, Manotheepan R, Aronsen JM, Frisk M, Hansen MH, Andressen KW, Hougen K, Levy FO, Louch WE, Sejersted OM, Sjaastad I, Stokke MK (2021)
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front Cardiovasc Med, 7, 623922
DOI 10.3389/fcvm.2020.623922, PubMed 33569394

Høydahl LS, Frigstad T, Rasmussen IB, Øynebråten I, Schjetne KW, Andersen JT, Michaelsen TE, Lunde E, Bogen B, Sandlie I (2021)
Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses
Vaccine, 39 (11), 1583-1592
DOI 10.1016/j.vaccine.2021.02.012, PubMed 33612340

Johannessen Landmark C, Potschka H, Auvin S, Wilmshurst JM, Johannessen SI, Kasteleijn-Nolst Trenité D, Wirrell EC (2021)
The role of new medical treatments for the management of developmental and epileptic encephalopathies: Novel concepts and results
Epilepsia, 62 (4), 857-873
DOI 10.1111/epi.16849, PubMed 33638459

Kindem IA, Bjerre A, Åsberg A, Midtvedt K, Bergan S, Vethe NT (2021)
Tacrolimus Measured in Capillary Volumetric Microsamples in Pediatric Patients-A Cross-Validation Study
Ther Drug Monit, 43 (3), 371-375
DOI 10.1097/FTD.0000000000000873, PubMed 33596033

Klæstad E, Sawicka JE, Engstrøm MJ, Ytterhus B, Valla M, Bofin AM (2021)
ZNF703 gene copy number and protein expression in breast cancer; associations with proliferation, prognosis and luminal subtypes
Breast Cancer Res Treat, 186 (1), 65-77
DOI 10.1007/s10549-020-06035-0, PubMed 33389351

Kristiansen O, Sverre E, Peersen K, Fagerland MW, Gjertsen E, Gullestad L, Perk J, Dammen T, Husebye E, Vethe NT, Munkhaugen J (2021)
The relationship between directly measured statin adherence, self-reported adherence measures and cholesterol levels in patients with coronary heart disease
Atherosclerosis, 336, 23-29 (in press)
DOI 10.1016/j.atherosclerosis.2021.09.020, PubMed 34610521

Landmark CJ, Rektorli L, Burns ML, Revdal E, Johannessen SI, Brodtkorb E (2021)
Pharmacokinetic data on brivaracetam, lacosamide and perampanel during pregnancy and lactation
Epileptic Disord, 23 (2), 426-431
DOI 10.1684/epd.2021.1273, PubMed 33935028

Lao YE, Vartdal T, Froeyshov S, Latimer B, Kvaerner C, Mataric M, Holm P, Foreid S, Jacobsen D, McMartin K, Hovda KE (2021)
Fomepizole dosing during continuous renal replacement therapy - an observational study
Clin Toxicol (Phila)
DOI 10.1080/15563650.2021.1980581, PubMed 34585641

Lombardi S, Aaen KH, Nilsen J, Ferrarese M, Gjølberg TT, Bernardi F, Pinotti M, Andersen JT, Branchini A (2021)
Fusion of engineered albumin with factor IX Padua extends half-life and improves coagulant activity
Br J Haematol, 194 (2), 453-462
DOI 10.1111/bjh.17559, PubMed 34109608

Lossius IMB, Svendsen T, Sødal HF, Kjeldstadli K, Lossius MI, Nakken KO, Johannessen Landmark C (2021)
Effect and tolerability of perampanel in patients with drug-resistant epilepsy
Epilepsy Behav, 119, 107965
DOI 10.1016/j.yebeh.2021.107965, PubMed 33940525

Manfra O, Calamera G, Froese A, Arunthavarajah D, Surdo NC, Meier S, Melleby AO, Aasrum M, Aronsen JM, Nikolaev VO, Zaccolo M, Moltzau LR, Levy FO, Andressen KW (2021)
CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI - difference from BNP visualized by targeted cGMP biosensors
Cardiovasc Res (in press)
DOI 10.1093/cvr/cvab167, PubMed 33970224

Midtlyng L, Høiseth G, Luytkis H, Kristoffersen L, Le Nygaard I, Strand MC, Arnestad M, Vevelstad M (2021)
Relationship between betahydroxybutyrate (BHB) and acetone concentrations in postmortem blood and cause of death
Forensic Sci Int, 321, 110726
DOI 10.1016/j.forsciint.2021.110726, PubMed 33631622

Olsen E, Holzhauer B, Julius S, Kjeldsen SE, Larstorp ACK, Mancia G, Mehlum MH, Mo R, Rostrup M, Søraas CL, Zappe D, Weber MA (2021)
Cardiovascular outcomes at recommended blood pressure targets in middle-aged and elderly patients with type 2 diabetes mellitus compared to all middle-aged and elderly hypertensive study patients with high cardiovascular risk
Blood Press, 30 (2), 90-97
DOI 10.1080/08037051.2020.1856642, PubMed 33403890

Olsen E, Holzhauer B, Julius S, Kjeldsen SE, Larstorp ACK, Mancia G, Mehlum MH, Mo R, Rostrup M, Søraas CL, Zappe D, Weber MA (2021)
Cardiovascular outcomes at recommended blood pressure targets in middle-aged and elderly patients with type 2 diabetes mellitus and hypertension
Blood Press, 30 (2), 82-89
DOI 10.1080/08037051.2020.1855968, PubMed 33403886

Pagnon de la Vega M, Giedraitis V, Michno W, Kilander L, Güner G, Zielinski M, Löwenmark M, Brundin R, Danfors T, Söderberg L, Alafuzoff I, Nilsson LNG, Erlandsson A, Willbold D, Müller SA, Schröder GF, Hanrieder J, Lichtenthaler SF, Lannfelt L, Sehlin D, Ingelsson M (2021)
The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid β fibril formation
Sci Transl Med, 13 (606)
DOI 10.1126/scitranslmed.abc6184, PubMed 34380771

Quiles-Jiménez A, Gregersen I, Segers FM, Skarpengland T, Kroustallaki P, Yang K, Kong XY, Lauritzen KH, Olsen MB, Karlsen TR, Nyman TA, Sagen EL, Bjerkeli V, Suganthan R, Nygård S, Scheffler K, Prins J, Van der Veer E, Øgaard JD, Fløisand Y, Jørgensen HF, Holven KB, Biessen EA, Nilsen H, Dahl TB et al. (2021)
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
Atherosclerosis, 324, 123-132
DOI 10.1016/j.atherosclerosis.2021.02.023, PubMed 33714552

Rognstad S, Søraas CL, Bergland OU, Høieggen A, Strømmen M, Helland A, Opdal MS (2021)
Establishing Serum Reference Ranges for Antihypertensive Drugs
Ther Drug Monit, 43 (1), 116-125
DOI 10.1097/FTD.0000000000000806, PubMed 32881780

Sivertsen MS, Lode HE, Gjølberg TT, Petrovski G, Andersen JT, Jørstad ØK, Moe MC (2021)
Cluster of symptomatic silicone oil droplets following intravitreal injections: a 1-year observational study
BMJ Open Ophthalmol, 6 (1), e000764
DOI 10.1136/bmjophth-2021-000764, PubMed 34485702

Skauby RH, Bergan S, Andersen AM, Vethe NT, Christensen H (2021)
In vitro assessments predict that CYP3A4 contributes to a greater extent than CYP3A5 to prednisolone clearance
Basic Clin Pharmacol Toxicol
DOI 10.1111/bcpt.13645, PubMed 34396687

Skauby RH, Gustavsen MT, Andersen AM, Bjerre A, Åsberg A, Midtvedt K, Vethe NT, Bergan S (2021)
Prednisolone and Prednisone Pharmacokinetics in Adult Renal Transplant Recipients
Ther Drug Monit, 43 (2), 247-255
DOI 10.1097/FTD.0000000000000835, PubMed 33181621

Solheim SA, Levernaes MCS, Mørkeberg J, Juul A, Upners EN, Nordsborg NB, Dehnes Y (2021)
Stability and detectability of testosterone esters in dried blood spots after intramuscular injections
Drug Test Anal
DOI 10.1002/dta.3030, PubMed 33733610

Solheim SA, Ringsted TK, Nordsborg NB, Dehnes Y, Levernaes MCS, Mørkeberg J (2021)
No pain, just gain: Painless, easy, and fast dried blood spot collection from fingertip and upper arm in doping control
Drug Test Anal, 13 (10), 1783-1790
DOI 10.1002/dta.3135, PubMed 34346172

Torp HA, Skurtveit S, Skaga NO, Gustavsen I, Gran JM, Rosseland LA (2021)
Pre-injury dispensing of psychoactive prescription drugs in a ten years trauma population: a retrospective registry analysis
Scand J Trauma Resusc Emerg Med, 29 (1), 125
DOI 10.1186/s13049-021-00939-6, PubMed 34454541

Wanichawan P, Skogestad J, Lunde M, Støle TP, Stensland M, Nyman TA, Sjaastad I, Sejersted OM, Aronsen JM, Carlson CR (2021)
Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies
Front Pharmacol, 12, 638646
DOI 10.3389/fphar.2021.638646, PubMed 34163352

 
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