Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Department of Pathology

43 publications found

Autio M, Leivonen SK, Brück O, Mustjoki S, Mészáros Jørgensen J, Karjalainen-Lindsberg ML, Beiske K, Holte H, Pellinen T, Leppä S (2021)
Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma
Haematologica, 106 (3), 718-729
DOI 10.3324/haematol.2019.243626, PubMed 32079690

Balta MG, Papathanasiou E, Christopoulos PF (2021)
Specialized Pro-Resolving Mediators as Potential Regulators of Inflammatory Macrophage Responses in COVID-19
Front. Immunol., 12, 632238

Bascuñana P, Brackhan M, Pahnke J (2021)
Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia
J Alzheimers Dis, 79 (2), 597-605
DOI 10.3233/JAD-201120, PubMed 33337377

Blümcke I, Coras R, Busch RM, Morita-Sherman M, Lal D, Prayson R, Cendes F, Lopes-Cendes I, Rogerio F, Almeida VS, Rocha CS, Sim NS, Lee JH, Kim SH, Baulac S, Baldassari S, Adle-Biassette H, Walsh CA, Bizzotto S, Doan RN, Morillo KS, Aronica E, Mühlebner A, Becker A, Cienfuegos J et al. (2021)
Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial
Epilepsia (in press)
DOI 10.1111/epi.16899, PubMed 33949696

Boye K, Longhi A, Guren T, Lorenz S, Næss S, Pierini M, Taksdal I, Lobmaier I, Cesari M, Paioli A, Løndalen AM, Setola E, Hompland I, Meza-Zepeda LA, Sundby Hall K, Palmerini E (2021)
Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial
Cancer Immunol Immunother
DOI 10.1007/s00262-021-02876-w, PubMed 33580363

Casar-Borota O, Boldt HB, Engström BE, Andersen MS, Baussart B, Bengtsson D, Berinder K, Ekman B, Feldt-Rasmussen U, Höybye C, Jørgensen JOL, Kolnes AJ, Korbonits M, Rasmussen ÅK, Lindsay JR, Loughrey PB, Maiter D, Manojlovic-Gacic E, Pahnke J, Poliani PL, Popovic V, Ragnarsson O, Schalin-Jäntti C, Scheie D, Tóth M et al. (2021)
Corticotroph Aggressive Pituitary Tumors and Carcinomas Frequently Harbor ATRX Mutations
J Clin Endocrinol Metab, 106 (4), 1183-1194
DOI 10.1210/clinem/dgaa749, PubMed 33106857

Christopoulos PF, Gjølberg TT, Krüger S, Haraldsen G, Andersen JT, Sundlisæter E (2021)
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases
Front Immunol, 12, 668207
DOI 10.3389/fimmu.2021.668207, PubMed 33912195

Corthay A, Bakacs T, Thangavelu G, Anderson CC (2021)
Tackling cancer cell dormancy: Insights from immune models, and transplantation
Semin Cancer Biol (in press)
DOI 10.1016/j.semcancer.2021.02.002, PubMed 33582171

Davidson B, Kleinberg L, Børresen IM, Slettevoll F, Fangberget A, Hindosh D, Zahl Eriksson AG, Bjerkehagen B (2021)
Primary uterine ectomesenchymoma harboring a DICER1 mutation: case report with molecular analysis
Virchows Arch
DOI 10.1007/s00428-021-03057-x, PubMed 33595736

Dib S, Pahnke J, Gosselet F (2021)
Role of ABCA7 in Human Health and in Alzheimer's Disease
Int J Mol Sci, 22 (9)
DOI 10.3390/ijms22094603, PubMed 33925691

Fosse JH, Haraldsen G, Falk K, Edelmann R (2021)
Endothelial Cells in Emerging Viral Infections
Front. Cardiovasc. Med., 8, 619690

Frerker N, Karlsen TA, Lilledahl MB, Brorson SH, Tibballs JE, Brinchmann JE (2021)
Scaffold-Free Engineering of Human Cartilage Implants
Cartilage, 19476035211007923 (in press)
DOI 10.1177/19476035211007923, PubMed 33858229

Gatti F, Mia S, Hammarström C, Frerker N, Fosby B, Wang J, Pietka W, Sundnes O, Hol J, Kasprzycka M, Haraldsen G (2021)
Nuclear IL-33 restrains the early conversion of fibroblasts to an extracellular matrix-secreting phenotype
Sci Rep, 11 (1), 108
DOI 10.1038/s41598-020-80509-5, PubMed 33420328

Georgiesh T, Namløs HM, Sharma N, Lorenz S, Myklebost O, Bjerkehagen B, Meza-Zepeda LA, Boye K (2021)
Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour
Pathology (in press)
DOI 10.1016/j.pathol.2020.11.010, PubMed 33745702

Hemsing AL, Gjertsen BT, Spetalen S, Helgeland L, Reikvam H (2021)
Favorable outcome of a patient with an unclassifiable myelodysplastic syndrome/myeloproliferative neoplasm treated with allogeneic hematopoietic stem cell transplantation
SAGE Open Med Case Rep, 9, 2050313X20988413
DOI 10.1177/2050313X20988413, PubMed 33628448

Hølmebakk T, Wiedswang AM, Meza-Zepeda LA, Hompland I, Lobmaier IVK, Berner JM, Stoldt S, Boye K (2021)
Integrating Anatomical, Molecular and Clinical Risk Factors in Gastrointestinal Stromal Tumor of the Stomach
Ann Surg Oncol
DOI 10.1245/s10434-021-09605-8, PubMed 33651216

Høydahl LS, Frigstad T, Rasmussen IB, Øynebråten I, Schjetne KW, Andersen JT, Michaelsen TE, Lunde E, Bogen B, Sandlie I (2021)
Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses
Vaccine, 39 (11), 1583-1592
DOI 10.1016/j.vaccine.2021.02.012, PubMed 33612340

Hugenschmidt H, Labori KJ, Borgen E, Brunborg C, Schirmer CB, Seeberg LT, Naume B, Wiedswang G (2021)
Preoperative CTC-Detection by CellSearch® Is Associated with Early Distant Metastasis and Impaired Survival in Resected Pancreatic Cancer
Cancers (Basel), 13 (3)
DOI 10.3390/cancers13030485, PubMed 33513877

Islam R, Islam MM, Nilsson PH, Mohlin C, Hagen KT, Paschalis EI, Woods RL, Bhowmick SC, Dohlman CH, Espevik T, Chodosh J, Gonzalez-Andrades M, Mollnes TE (2021)
Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses
Acta Biomater (in press)
DOI 10.1016/j.actbio.2021.03.047, PubMed 33785451

Jahnsen FL, Johansen FE (2021)
Legends of allergology/immunology: Per Brandtzaeg - Pillar of Mucosal Immunology
Allergy (in press)
DOI 10.1111/all.14824, PubMed 33752264

Janiszewska M, Stein S, Metzger Filho O, Eng J, Kingston NL, Harper NW, Rye IH, Alečković M, Trinh A, Murphy KC, Marangoni E, Cristea S, Oakes B, Winer EP, Krop I, Russnes HG, Spellman PT, Bucher E, Hu Z, Chin K, Gray JW, Michor F, Polyak K (2021)
The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2-positive breast cancer
JCI Insight (in press)
DOI 10.1172/jci.insight.147617, PubMed 33886505

Johansson ALV, Trewin CB, Fredriksson I, Reinertsen KV, Russnes H, Ursin G (2021)
In modern times, how important are breast cancer stage, grade and receptor subtype for survival: a population-based cohort study
Breast Cancer Res, 23 (1), 17
DOI 10.1186/s13058-021-01393-z, PubMed 33526044

Juraleviciute M, Nsengimana J, Newton-Bishop J, Hendriks GJ, Slipicevic A (2021)
MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy
Cancer Med., 10 (8), 2840-2854

Kalogirou EM, Tosios KI, Christopoulos PF (2021)
The Role of Macrophages in Oral Squamous Cell Carcinoma
Front Oncol, 11, 611115
DOI 10.3389/fonc.2021.611115, PubMed 33816242

Klingen TA, Chen Y, Aas H, Wik E, Akslen LA (2021)
Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer
PLoS One, 16 (4), e0249767
DOI 10.1371/journal.pone.0249767, PubMed 33836007

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM et al. (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Autophagy, 17 (1), 1-382
DOI 10.1080/15548627.2020.1797280, PubMed 33634751

Kromp F, Fischer L, Bozsaky E, Ambros IM, Dorr W, Beiske K, Ambros PF, Hanbury A, Taschner-Mandl S (2021)
Evaluation of Deep Learning architectures for complex immunofluorescence nuclear image segmentation
IEEE Trans Med Imaging, PP (in press)
DOI 10.1109/TMI.2021.3069558, PubMed 33784615

Krüger K, Silwal-Pandit L, Wik E, Straume O, Stefansson IM, Borgen E, Garred Ø, Naume B, Engebraaten O, Akslen LA (2021)
Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer
Sci Rep, 11 (1), 3388
DOI 10.1038/s41598-021-81914-0, PubMed 33564016

Leske H, Dalgleish R, Lazar AJ, Reifenberger G, Cree IA (2021)
A common classification framework for histone sequence alterations in tumours: an expert consensus proposal
J Pathol (in press)
DOI 10.1002/path.5666, PubMed 33779999

Lossius AH, Sundnes O, Ingham AC, Edslev SM, Bjørnholt JV, Lilje B, Bradley M, Asad S, Haraldsen G, Skytt-Andersen P, Holm JØ, Berents TL (2021)
Shifts in the Skin Microbiota after UVB Treatment in Adult Atopic Dermatitis
Dermatology, 1-12 (in press)
DOI 10.1159/000515236, PubMed 33887725

Munthe-Kaas MC, Forthun RB, Brendehaug A, Eek AK, Høysæter T, Osnes LTN, Prescott T, Spetalen S, Hovland R (2021)
Partial Response to Sorafenib in a Child With a Myeloid/Lymphoid Neoplasm, Eosinophilia, and a ZMYM2-FLT3 Fusion
J Pediatr Hematol Oncol, 43 (4), e508-e511
DOI 10.1097/MPH.0000000000001890, PubMed 32852395

Namasivayam V, Silbermann K, Wiese M, Pahnke J, Stefan SM (2021)
C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors
J. Med. Chem., 64 (6), 3350-3366

Nast A, Smith C, Spuls PI, Avila Valle G, Bata-Csörgö Z, Boonen H, De Jong E, Garcia-Doval I, Gisondi P, Kaur-Knudsen D, Mahil S, Mälkönen T, Maul JT, Mburu S, Mrowietz U, Reich K, Remenyik E, Rønholt KM, Sator PG, Schmitt-Egenolf M, Sikora M, Strömer K, Sundnes O, Trigos D, Van Der Kraaij G et al. (2021)
EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris - Part 2: specific clinical and comorbid situations
J Eur Acad Dermatol Venereol, 35 (2), 281-317
DOI 10.1111/jdv.16926, PubMed 33547728

Nobre AR, Risson E, Singh DK, Di Martino JS, Cheung JF, Wang JP, Johnson J, Russnes HG, Bravo-Cordero JJ, Birbrair A, Naume B, Azhar M, Frenette PS, Aguirre-Ghiso JA (2021)
Bone marrow NG2(+)/Nestin(+) mesenchymal stem cells drive DTC dormancy via TGF-beta 2
Nat. Cancer, 2 (3), 327-+

Panagopoulos I, Andersen K, Ramslien LF, Ikonomou IM, Micci F, Heim S (2021)
Therapy-related Myeloid Leukemia With the Translocation t(8;19)(p11;q13) Leading to a KAT6A-LEUTX Fusion Gene
Anticancer Res, 41 (4), 1753-1760
DOI 10.21873/anticanres.14940, PubMed 33813379

Rasmussen LG, Verbeke CS, Sørensen MD, Pfeiffer P, Tan Q, Mortensen MB, Fristrup C, Detlefsen S (2021)
Gene expression profiling of morphologic subtypes of pancreatic ductal adenocarcinoma using surgical and EUS-FNB specimens
Pancreatology, 21 (3), 530-543
DOI 10.1016/j.pan.2021.01.025, PubMed 33637450

Ruiz de Garibay G, García de Jalón E, Stigen E, Lund KB, Popa M, Davidson B, Safont MM, Rygh CB, Espedal H, Barrett TM, Haug BE, McCormack E (2021)
Repurposing 18F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy
Theranostics, 11 (12), 6044-6057
DOI 10.7150/thno.55092, PubMed 33897898

Sántha P, Lenggenhager D, Finstadsveen A, Dorg L, Tøndel K, Amrutkar M, Gladhaug IP, Verbeke C (2021)
Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence
Cancers (Basel), 13 (4)
DOI 10.3390/cancers13040895, PubMed 33672734

Søfteland S, Sebitloane MH, Taylor M, Roald BB, Holmen S, Galappaththi-Arachchige HN, Gundersen SG, Kjetland EF (2021)
A systematic review of handheld tools in lieu of colposcopy for cervical neoplasia and female genital schistosomiasis
Int J Gynaecol Obstet, 153 (2), 190-199
DOI 10.1002/ijgo.13538, PubMed 33316096

Study management group, Kosti A, Rybinski B, Javanmard-Emamghissi H, Laing R, Froghi F, Coe P, Lund J, Moug S, Tierney G, Marriott P, Roberts K, Davidson B, Smith A, Hollyman M (2021)
Protocol letter: multicentre prospective cohort study of the early management of acute pancreatitis in Great Britain and Ireland: PANC Study (Pancreatitis: A National Cohort Study)
Br J Surg (in press)
DOI 10.1093/bjs/znab102, PubMed 33846708

Sundnes O, Ottestad W, Schjalm C, Lundbäck P, la Cour Poulsen L, Mollnes TE, Haraldsen G, Eken T (2021)
Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
Mol Med, 27 (1), 29
DOI 10.1186/s10020-021-00288-1, PubMed 33771098

Vujanić GM, D'Hooghe E, Vokuhl C, Collini P (2021)
Dataset for the reporting of nephrectomy specimens for wilms' tumour treated with preoperative chemotherapy: recommendations from the international society of paediatric oncology renal tumour study group
Histopathology (in press)
DOI 10.1111/his.14394, PubMed 33942359

Zhou W, Xu C, Dong G, Qiao H, Yang J, Liu H, Ding L, Sun K, Zhao W (2021)
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction
Eur J Med Chem, 217, 113326
DOI 10.1016/j.ejmech.2021.113326, PubMed 33756127

 
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