Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Department of Immunology (Div LabMed)

53 publications found

Aaen KH, Anthi AK, Sandlie I, Nilsen J, Mester S, Andersen JT (2021)
The neonatal Fc receptor in mucosal immune regulation
Scand J Immunol, 93 (2), e13017
DOI 10.1111/sji.13017, PubMed 33351196

Aamodt AH, Høgestøl EA, Popperud TH, Holter JC, Dyrhol-Riise AM, Tonby K, Stiksrud B, Quist-Paulsen E, Berge T, Barratt-Due A, Aukrust P, Heggelund L, Blennow K, Zetterberg H, Harbo HF (2021)
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19
J Neurol
DOI 10.1007/s00415-021-10517-6, PubMed 33743046

Akkouh IA, Hughes T, Steen VM, Glover JC, Andreassen OA, Djurovic S, Szabo A (2021)
Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia
Brain Behav Immun, 94, 235-244
DOI 10.1016/j.bbi.2021.01.037, PubMed 33571628

Andersen TK, Grødeland G (2021)
The vaccines can keep up with the SARS-CoV-2 mutations
Tidsskr Nor Laegeforen, 141 (3)
DOI 10.4045/tidsskr.21.0080, PubMed 33624975

Askarian F, Uchiyama S, Masson H, Sørensen HV, Golten O, Bunæs AC, Mekasha S, Røhr ÅK, Kommedal E, Ludviksen JA, Arntzen MØ, Schmidt B, Zurich RH, van Sorge NM, Eijsink VGH, Krengel U, Mollnes TE, Lewis NE, Nizet V, Vaaje-Kolstad G (2021)
The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection
Nat Commun, 12 (1), 1230
DOI 10.1038/s41467-021-21473-0, PubMed 33623002

Azevedo C, Andersen JT, Traverso G, Sarmento B (2021)
The potential of porcine ex vivo platform for intestinal permeability screening of FcRn-targeted drugs
Eur J Pharm Biopharm, 162, 99-104
DOI 10.1016/j.ejpb.2021.03.009, PubMed 33771621

Azevedo C, Pinto S, Benjakul S, Nilsen J, Santos HA, Traverso G, Terje Andersen J, Sarmento B (2021)
Prevention of diabetes-associated fibrosis: Strategies in FcRn-targeted nanosystems for oral drug delivery
Adv Drug Deliv Rev (in press)
DOI 10.1016/j.addr.2021.04.016, PubMed 33887405

Bakker OB, Ramírez-Sánchez AD, Borek ZA, de Klein N, Li Y, Modderman R, Kooy-Winkelaar Y, Johannesen MK, Matarese F, Martens JHA, Kumar V, van Bergen J, Qiao SW, Lundin KEA, Sollid LM, Koning F, Wijmenga C, Withoff S, Jonkers IH (2021)
Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells
Sci Rep, 11 (1), 9252
DOI 10.1038/s41598-021-86612-5, PubMed 33927210

Brennvall HM, Bjune T, Sverdrup O, Raki M, Abedini S (2021)
Glomerulonephritis after contact with horses
Tidsskr. Nor. Laegeforen., 141 (4), 361-363

Brennvall HM, Bjune T, Sverdrup Ø, Ráki M, Abedini S (2021)
Glomerulonephritis after contact with a horse
Tidsskr Nor Laegeforen, 141 (4)
DOI 10.4045/tidsskr.20.0780, PubMed 33685097

Brunet A, Destainville N, Collas P (2021)
Physical constraints in polymer modeling of chromatin associations with the nuclear periphery at kilobase scale
Nucleus, 12 (1), 6-20
DOI 10.1080/19491034.2020.1868105, PubMed 33435761

Christopoulos PF, Gjølberg TT, Krüger S, Haraldsen G, Andersen JT, Sundlisæter E (2021)
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases
Front Immunol, 12, 668207
DOI 10.3389/fimmu.2021.668207, PubMed 33912195

Dahal-Koirala S, Risnes LF, Neumann RS, Christophersen A, Lundin KEA, Sandve GK, Qiao SW, Sollid LM (2021)
Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs
Front Immunol, 12, 639672
DOI 10.3389/fimmu.2021.639672, PubMed 33927715

Debler L, Palmer A, Braumüller S, Klohs B, Mollnes TE, Holzmann K, Huber-Lang M, Halbgebauer R (2021)
Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury
Mediators Inflamm, 2021, 6654318
DOI 10.1155/2021/6654318, PubMed 33574730

Dewan AE, Koentgen F, Johannesen MK, du Pre MF, Sollid LM (2021)
Generation of an HLA-DQ2.5 Knock-In Mouse
Immunohorizons, 5 (1), 25-32
DOI 10.4049/immunohorizons.2000107, PubMed 33461981

Frerker N, Karlsen TA, Lilledahl MB, Brorson SH, Tibballs JE, Brinchmann JE (2021)
Scaffold-Free Engineering of Human Cartilage Implants
Cartilage, 19476035211007923 (in press)
DOI 10.1177/19476035211007923, PubMed 33858229

Garred P, Tenner AJ, Mollnes TE (2021)
Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics
Pharmacol Rev, 73 (2), 792-827
DOI 10.1124/pharmrev.120.000072, PubMed 33687995

Goldman M, Townsend M, Magnussen K, Lozano M, Nissen-Meyer LSH, Lee CK, Leung JN, Takanashi M, McKay J, Kvist M, Robitaille N, Deschênes J, Di Angelantonio E, McMahon A, Roberts D, Maghsudlu M, Castrén J, Tiberghien P, Woimant G, Morel P, Kamel H, Bravo M, Shinar E, Gendelman V, Raz H et al. (2021)
International Forum on Mitigation Strategies to Prevent Faint and Pre-faint Adverse Reactions in Whole Blood Donors: Responses
Vox Sang, 116 (3), e1-e24
DOI 10.1111/vox.13038, PubMed 33754360

Halvorsen EH (2021)
Strange statement about diagnoses
Tidsskr Nor Laegeforen, 141 (3)
DOI 10.4045/tidsskr.21.0081, PubMed 33624973

He L, Valignat MP, Zhang LC, Gelard L, Zhang FH, Le Guen V, Audebert S, Camoin L, Fossum E, Bogen B, Wang H, Henri S, Roncagalli R, Theodoly O, Liang YM, Malissen M, Malissen B (2021)
ARHGAP45 controls naive T- and B- cell entry into lymph nodes and T-cell progenitor thymus seeding
EMBO Rep., 22 (4), e52196

Høydahl LS, Frigstad T, Rasmussen IB, Øynebråten I, Schjetne KW, Andersen JT, Michaelsen TE, Lunde E, Bogen B, Sandlie I (2021)
Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses
Vaccine, 39 (11), 1583-1592
DOI 10.1016/j.vaccine.2021.02.012, PubMed 33612340

Islam R, Islam MM, Nilsson PH, Mohlin C, Hagen KT, Paschalis EI, Woods RL, Bhowmick SC, Dohlman CH, Espevik T, Chodosh J, Gonzalez-Andrades M, Mollnes TE (2021)
Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses
Acta Biomater (in press)
DOI 10.1016/j.actbio.2021.03.047, PubMed 33785451

Lindeman I, Zhou C, Eggesbø LM, Miao Z, Polak J, Lundin KEA, Jahnsen J, Qiao SW, Iversen R, Sollid LM (2021)
Longevity, clonal relationship, and transcriptional program of celiac disease-specific plasma cells
J Exp Med, 218 (2)
DOI 10.1084/jem.20200852, PubMed 33095260

Macpherson A, Laabei M, Ahdash Z, Graewert MA, Birtley JR, Schulze ME, Crennell S, Robinson SA, Holmes B, Oleinikovas V, Nilsson PH, Snowden J, Ellis V, Mollnes TE, Deane CM, Svergun D, Lawson AD, van den Elsen JM (2021)
The allosteric modulation of complement C5 by knob domain peptides
Elife, 10
DOI 10.7554/eLife.63586, PubMed 33570492

Mandrup OA, Ong SC, Lykkemark S, Dinesen A, Rudnik-Jansen I, Dagnæs-Hansen NF, Andersen JT, Alvarez-Vallina L, Howard KA (2021)
Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
Commun Biol, 4 (1), 310
DOI 10.1038/s42003-021-01790-2, PubMed 33686177

Mester S, Evers M, Meyer S, Nilsen J, Greiff V, Sandlie I, Leusen J, Andersen JT (2021)
Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo
mAbs, 13 (1), 1893888

Mirlashari MR, Vetlesen A, Nissen-Meyer LSH, Naper C, Tjønnfjord GE, Njerve IU, Ezligini F, Landmark BF, Meinke S, Sandgren P, Höglund P, Hetland G (2021)
HLA class I depletion by citric acid, and irradiation of apheresis platelets for transfusion of refractory patients
Transfusion, 61 (4), 1222-1234
DOI 10.1111/trf.16282, PubMed 33580979

Narud B, Khezri A, Zeremichael TT, Stenseth EB, Heringstad B, Johannisson A, Morrell JM, Collas P, Myromslien FD, Kommisrud E (2021)
Sperm chromatin integrity and DNA methylation in Norwegian Red bulls of contrasting fertility
Mol Reprod Dev, 88 (3), 187-200
DOI 10.1002/mrd.23461, PubMed 33634579

Nilsson PH, Pettersen K, Oppermann M, Skjeflo EW, Fure H, Christiansen D, Mollnes TE (2021)
Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay
Methods Mol Biol, 2227, 51-59
DOI 10.1007/978-1-0716-1016-9_5, PubMed 33847930

Nissen-Meyer LSH, Brantsæter AB (2021)
The story of an extraordinary year: Challenges and opportunities in responding to Covid-19
Transfus Apher Sci, 60 (2), 103092
DOI 10.1016/j.transci.2021.103092, PubMed 33612447

Panagopoulos I, Andersen K, Eilert-Olsen M, Zeller B, Munthe-Kaas MC, Buechner J, Osnes LTN, Micci F, Heim S (2021)
Therapy-induced Deletion in 11q23 Leading to Fusion of KMT2A With ARHGEF12 and Development of B Lineage Acute Lymphoplastic Leukemia in a Child Treated for Acute Myeloid Leukemia Caused by t(9;11)(p21;q23)/KMT2A-MLLT3
Cancer Genomics Proteomics, 18 (1), 67-81
DOI 10.21873/cgp.20242, PubMed 33419897

Papp G, Szabó K, Jámbor I, Mile M, Berki AR, Arany AC, Makra G, Szodoray P, Csiki Z, Balogh L (2021)
Regular Exercise May Restore Certain Age-Related Alterations of Adaptive Immunity and Rebalance Immune Regulation
Front Immunol, 12, 639308
DOI 10.3389/fimmu.2021.639308, PubMed 33936054

Qiao SW, Dahal-Koirala S, Eggesbø LM, Lundin KEA, Sollid LM (2021)
Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning
Front Immunol, 12, 646163
DOI 10.3389/fimmu.2021.646163, PubMed 33796112

Ramberg H, Richardsen E, de Souza GA, Rakaee M, Stensland ME, Braadland PR, Nygård S, Ögren O, Guldvik IJ, Berge V, Svindland A, Taskén KA, Andersen S (2021)
Proteomic analyses Identify Major Vault Protein as a Prognostic Biomarker for Fatal Prostate Cancer
Carcinogenesis (in press)
DOI 10.1093/carcin/bgab015, PubMed 33609362

Risnes LF, Eggesbø LM, Zühlke S, Dahal-Koirala S, Neumann RS, Lundin KEA, Christophersen A, Sollid LM (2021)
Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease
Mucosal Immunol
DOI 10.1038/s41385-021-00385-8, PubMed 33654213

Rognes IN, Pischke SE, Ottestad W, Røislien J, Berg JP, Johnson C, Eken T, Mollnes TE (2021)
Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study
Mol Med, 27 (1), 35
DOI 10.1186/s10020-021-00286-3, PubMed 33832430

Schultz NH, Sørvoll IH, Michelsen AE, Munthe LA, Lund-Johansen F, Ahlen MT, Wiedmann M, Aamodt AH, Skattør TH, Tjønnfjord GE, Holme PA (2021)
Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination
N Engl J Med
DOI 10.1056/NEJMoa2104882, PubMed 33835768

Sharifi S, Islam MM, Sharifi H, Islam R, Huq TN, Nilsson PH, Mollnes TE, Tran KD, Patzer C, Dohlman CH, Patra HK, Paschalis EI, Gonzalez-Andrades M, Chodosh J (2021)
Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects
Macromol Biosci, 21 (4), e2000379
DOI 10.1002/mabi.202000379, PubMed 33624923

Sharifi S, Islam MM, Sharifi H, Islam R, Koza D, Reyes-Ortega F, Alba-Molina D, Nilsson PH, Dohlman CH, Mollnes TE, Chodosh J, Gonzalez-Andrades M (2021)
Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications
Bioact Mater, 6 (11), 3947-3961
DOI 10.1016/j.bioactmat.2021.03.042, PubMed 33937594

Shemesh O, Polak P, Lundin KEA, Sollid LM, Yaari G (2021)
Machine Learning Analysis of Naïve B-Cell Receptor Repertoires Stratifies Celiac Disease Patients and Controls
Front Immunol, 12, 627813
DOI 10.3389/fimmu.2021.627813, PubMed 33790900

Skottvoll FS, Hansen FA, Harrison S, Boger IS, Mrsa A, Restan MS, Stein M, Lundanes E, Pedersen-Bjergaard S, Aizenshtadt A, Krauss S, Sullivan G, Bogen IL, Wilson SR (2021)
Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies
Anal Chem, 93 (7), 3576-3585
DOI 10.1021/acs.analchem.0c05082, PubMed 33534551

Sollid LM, Lundin KEA, Leivestad T, Spurkland A, Vartdal F (2021)
Erik Thorsby (1938-2021)
Immunogenetics, 73 (3), 203-205
DOI 10.1007/s00251-021-01218-5, PubMed 33956175

Sørensen K, Baevre MS, Tomter G, Llohn AH, Hagen KG, Espinosa A, Jacobsen B, Arsenovic MG, Sørvoll IH, Ulvahaug AN, Sundic T, Akkök ÇA (2021)
The Norwegian experience with nationwide implementation of fetal RHD genotyping and targeted routine antenatal anti-D prophylaxis
Transfus Med
DOI 10.1111/tme.12772, PubMed 33821537

Stamnaes J, Stray D, Stensland M, Sarna VK, Nyman TA, Lundin KEA, Sollid LM (2021)
In Well-Treated Celiac Patients Low-Level Mucosal Inflammation Predicts Response to 14-day Gluten Challenge
Adv Sci (Weinh), 8 (4), 2003526
DOI 10.1002/advs.202003526, PubMed 33643806

Størdal K, Greve-Isdahl M, Surén P (2021)
When the restrictions are worse than the pandemic
Tidsskr Nor Laegeforen, 141 (3)
DOI 10.4045/tidsskr.21.0055, PubMed 33624978

Storm BS, Halvorsen PS, Skulstad H, Dybwik K, Schjalm C, Christiansen D, Wisløff-Aase K, Fosse E, Braaten T, Nielsen EW, Mollnes TE (2021)
Open chest and pericardium facilitate transpulmonary passage of venous air emboli
Acta Anaesthesiol Scand, 65 (5), 648-655
DOI 10.1111/aas.13796, PubMed 33595102

Sundnes O, Ottestad W, Schjalm C, Lundbäck P, la Cour Poulsen L, Mollnes TE, Haraldsen G, Eken T (2021)
Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
Mol Med, 27 (1), 29
DOI 10.1186/s10020-021-00288-1, PubMed 33771098

Szabó K, Jámbor I, Szántó A, Horváth IF, Tarr T, Nakken B, Szodoray P, Papp G (2021)
The Imbalance of Circulating Follicular T Helper Cell Subsets in Primary Sjögren's Syndrome Associates With Serological Alterations and Abnormal B-Cell Distribution
Front Immunol, 12, 639975
DOI 10.3389/fimmu.2021.639975, PubMed 33815392

Thomé CH, Ferreira GA, Pereira-Martins DA, Augusto Dos Santos G, Almeida-Silveira DR, Weinhäuser I, Antônio de Souza G, Houtsma R, Schuringa JJ, Rego EM, Faça VM (2021)
The expression of NTAL and its protein interactors is associated with clinical outcomes in acute myeloid leukemia
Mol Cell Proteomics, 100091 (in press)
DOI 10.1016/j.mcpro.2021.100091, PubMed 33971369

Thorgersen EB, Flatmark K (2021)
ASO Author Reflections: The Peritoneum is an Active Immunological Compartment
Ann Surg Oncol (in press)
DOI 10.1245/s10434-021-10036-8, PubMed 33939046

Udugama M, Hii L, Garvie A, Cervini M, Vinod B, Chan FL, Das PP, Mann JR, Collas P, Voon HPJ, Wong LH (2021)
Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas
Nat Commun, 12 (1), 2584
DOI 10.1038/s41467-021-22543-z, PubMed 33972520

Zhu GH, Azharuddin M, Islam R, Rahmoune H, Deb S, Kanji U, Das J, Osterrieth J, Aulakh P, Ibrahim-Hashi H, Manchanda R, Nilsson PH, Mollnes TE, Bhattacharyya M, Islam MM, Hinkula J, Slater NKH, Patra HK (2021)
Innate Immune Invisible Ultrasmall Gold Nanoparticles-Framework for Synthesis and Evaluation
ACS Appl Mater Interfaces (in press)
DOI 10.1021/acsami.1c02834, PubMed 33978409

Ziouti F, Rummler M, Steyn B, Thiele T, Seliger A, Duda GN, Bogen B, Willie BM, Jundt F (2021)
Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton's Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease
Int J Mol Sci, 22 (8)
DOI 10.3390/ijms22083840, PubMed 33917250

 
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