Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2018 from OUS - Department of Immunology (Div LabMed)
84 publications found
Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd
Sci Rep, 8 (1), 13319
DOI 10.1038/s41598-018-31510-6, PubMed 30190583
Pediatric red cell and platelet transfusions
Transfus Apher Sci, 57 (3), 358-362
DOI 10.1016/j.transci.2018.05.019, PubMed 29804934
Simultaneous Targeting of Multiple Hemagglutinins to APCs for Induction of Broad Immunity against Influenza
J Immunol, 200 (6), 2057-2066
DOI 10.4049/jimmunol.1701088, PubMed 29427414
Staphylococcus aureus Membrane-Derived Vesicles Promote Bacterial Virulence and Confer Protective Immunity in Murine Infection Models
Front Microbiol, 9, 262
DOI 10.3389/fmicb.2018.00262, PubMed 29515544
Integration of multi-omics data and deep phenotyping enables prediction of cytokine responses
Nat Immunol, 19 (7), 776-786
DOI 10.1038/s41590-018-0121-3, PubMed 29784908
A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations
Case Rep Hematol, 2018, 8187659
DOI 10.1155/2018/8187659, PubMed 30510818
Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture
Sci Rep, 8 (1), 10836
DOI 10.1038/s41598-018-28918-5, PubMed 30022069
Inflammation and Mechanical Stress Stimulate Osteogenic Differentiation of Human Aortic Valve Interstitial Cells
Front Physiol, 9, 1635
DOI 10.3389/fphys.2018.01635, PubMed 30524301
TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination
Proc Natl Acad Sci U S A, 115 (41), 10440-10445
DOI 10.1073/pnas.1806314115, PubMed 30209217
The Magnitude and IgG Subclass of Antibodies Elicited by Targeted DNA Vaccines Are Influenced by Specificity for APC Surface Molecules
Immunohorizons, 2 (1), 38-53
DOI 10.4049/immunohorizons.1700038, PubMed 31022690
Lamin A, Chromatin and FPLD2: Not Just a Peripheral Ménage-à-Trois
Front Cell Dev Biol, 6, 73
DOI 10.3389/fcell.2018.00073, PubMed 30057899
Laminopathy-causing lamin A mutations reconfigure lamina-associated domains and local spatial chromatin conformation
Nucleus, 9 (1), 216-226
DOI 10.1080/19491034.2018.1449498, PubMed 29517398
The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks
Hum Mol Genet, 27 (8), 1447-1459
DOI 10.1093/hmg/ddy055, PubMed 29438482
Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s)
Part Fibre Toxicol, 15 (1), 21
DOI 10.1186/s12989-018-0257-1, PubMed 29751765
Cytokine profiles and diagnoses in elderly, hospitalized psychiatric patients
BMC Psychiatry, 18 (1), 315
DOI 10.1186/s12888-018-1900-y, PubMed 30261848
From Inflammasome to Exosome-Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?
Front Immunol, 9, 2188
DOI 10.3389/fimmu.2018.02188, PubMed 30319640
Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes
J Biol Chem, 294 (3), 941-952
DOI 10.1074/jbc.RA118.005736, PubMed 30455354
Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats
J Immunol, 200 (8), 2847-2859
DOI 10.4049/jimmunol.1701464, PubMed 29531166
High-resolution antibody array analysis of proteins from primary human keratinocytes and leukocytes
PLoS One, 13 (12), e0209271
DOI 10.1371/journal.pone.0209271, PubMed 30589857
Microthrombotic renal involvement in an SLE patient with concomitant catastrophic antiphospholipid syndrome: the beneficial effect of rituximab treatment
Lupus, 27 (9), 1552-1558
DOI 10.1177/0961203318768890, PubMed 29635999
Monocytes accumulate in the airways of children with fatal asthma
Clin Exp Allergy, 48 (12), 1631-1639
DOI 10.1111/cea.13265, PubMed 30184280
Tumor Killing by CD4+ T Cells Is Mediated via Induction of Inducible Nitric Oxide Synthase-Dependent Macrophage Cytotoxicity
Front Immunol, 9, 1684
DOI 10.3389/fimmu.2018.01684, PubMed 30083157
Exploration of 27 plasma immune markers: a cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons
BMC Geriatr, 18 (1), 149
DOI 10.1186/s12877-018-0836-x, PubMed 29940870
Normal development of mice lacking PAXX, the paralogue of XRCC4 and XLF
FEBS Open Bio, 8 (3), 426-434
DOI 10.1002/2211-5463.12381, PubMed 29511619
Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population
Front Immunol, 9, 2664
DOI 10.3389/fimmu.2018.02664, PubMed 30515158
Wilhelm His' lasting insights into hindbrain and cranial ganglia development and evolution
Dev Biol, 444 Suppl 1, S14-S24
DOI 10.1016/j.ydbio.2018.02.001, PubMed 29447907
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
Nat Commun, 9 (1), 621
DOI 10.1038/s41467-018-03061-x, PubMed 29434196
Corneal Involvement of Patients with Polymyositis and Dermatomyositis
Ocul Immunol Inflamm, 28 (1), 58-66
DOI 10.1080/09273948.2018.1547407, PubMed 30444429
Lack of Association among Peptidyl Arginine Deiminase Type 4 Autoantibodies, PADI4 Polymorphisms, and Clinical Characteristics in Rheumatoid Arthritis
J Rheumatol, 45 (9), 1211-1219
DOI 10.3899/jrheum.170769, PubMed 29858238
Soluble T-cell receptor design influences functional yield in an E. coli chaperone-assisted expression system
PLoS One, 13 (4), e0195868
DOI 10.1371/journal.pone.0195868, PubMed 29649333
mRNA vaccination with charge-altering releasable transporters elicits human T cell responses and cures established tumors in mice
Proc Natl Acad Sci U S A, 115 (39), E9153-E9161
DOI 10.1073/pnas.1810002115, PubMed 30201728
CD4+ T-cell-Mediated Rejection of MHC Class II-Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs
Cancer Res, 78 (16), 4573-4585
DOI 10.1158/0008-5472.CAN-17-2426, PubMed 29752262
The Palliative Radiotherapy and Inflammation Study (PRAIS) - protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain
BMC Palliat Care, 17 (1), 110
DOI 10.1186/s12904-018-0362-9, PubMed 30266081
Granulocyte and monocyte CD11b expression during plasma separation is dependent on complement factor 5 (C5) - an ex vivo study with blood from a C5-deficient individual
APMIS, 126 (4), 342-352
DOI 10.1111/apm.12821, PubMed 29575196
Cryopreservation of primary B cells minimally influences their signaling responses
Sci Rep, 8 (1), 17651
DOI 10.1038/s41598-018-36121-9, PubMed 30518828
Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism
Thromb Res, 169, 50-56
DOI 10.1016/j.thromres.2018.06.019, PubMed 30015228
Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease
Gastroenterology, 156 (5), 1428-1439.e10
DOI 10.1053/j.gastro.2018.12.013, PubMed 30593798
One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation
J Exp Med, 215 (10), 2686-2695
DOI 10.1084/jem.20172064, PubMed 30181412
Expression of inflammatory cytokines in mesenchymal stromal cells is sensitive to culture conditions and simple cell manipulations
Exp Cell Res, 374 (1), 122-127
DOI 10.1016/j.yexcr.2018.11.014, PubMed 30496759
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a
Nat Commun, 9 (1), 2583
DOI 10.1038/s41467-018-04818-0, PubMed 29968706
Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
Int J Cardiol, 271, 1-7
DOI 10.1016/j.ijcard.2018.04.136, PubMed 29961572
Locomotor central pattern generator excitability states and serotonin sensitivity after spontaneous recovery from a neonatal lumbar spinal cord injury
Brain Res, 1708, 10-19
DOI 10.1016/j.brainres.2018.12.001, PubMed 30521786
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors
Mol Cell Proteomics, 17 (5), 850-870
DOI 10.1074/mcp.RA117.000538, PubMed 29371290
HLA -A, -C, -B, -DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in 4514 healthy Norwegians
Hum Immunol, 79 (7), 527-529
DOI 10.1016/j.humimm.2018.04.012, PubMed 29684411
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4
Clin Exp Immunol, 196 (1), 97-110
DOI 10.1111/cei.13240, PubMed 30444525
Advances in stem cell therapy for amyotrophic lateral sclerosis
Expert Opin Biol Ther, 18 (8), 865-881
DOI 10.1080/14712598.2018.1503248, PubMed 30025485
Minimal residual disease quantification by flow cytometry provides reliable risk stratification in T-cell acute lymphoblastic leukemia
Leukemia, 33 (6), 1324-1336
DOI 10.1038/s41375-018-0307-6, PubMed 30552401
Patterns of Invasive Growth in Malignant Gliomas-The Hippocampus Emerges as an Invasion-Spared Brain Region
Neoplasia, 20 (7), 643-656
DOI 10.1016/j.neo.2018.04.001, PubMed 29793116
Single cell profiling of phospho-protein levels in chronic lymphocytic leukemia
Oncotarget, 9 (10), 9273-9284
DOI 10.18632/oncotarget.23949, PubMed 29507689
Corneal Manifestations of Systemic Sclerosis
Ocul Immunol Inflamm, 27 (6), 968-977
DOI 10.1080/09273948.2018.1489556, PubMed 30015530
Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications
Sci Rep, 8 (1), 498
DOI 10.1038/s41598-017-18985-5, PubMed 29323256
Human and mouse albumin bind their respective neonatal Fc receptors differently
Sci Rep, 8 (1), 14648
DOI 10.1038/s41598-018-32817-0, PubMed 30279529
Animal models for evaluation of albumin-based therapeutics
Curr. Opin. Chem. Eng., 19, 68-76
Donor health assessment - When is blood donation safe?
Transfus Apher Sci, 58 (1), 113-116
DOI 10.1016/j.transci.2018.12.016, PubMed 30630765
The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology
Biol Res, 51 (1), 3
DOI 10.1186/s40659-017-0151-6, PubMed 29316982
Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock
ESC Heart Fail, 5 (3), 292-301
DOI 10.1002/ehf2.12266, PubMed 29424484
IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction
Front Immunol, 9, 2035
DOI 10.3389/fimmu.2018.02035, PubMed 30258440
Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction
Int J Cardiol, 268, 187-192
DOI 10.1016/j.ijcard.2018.05.032, PubMed 29853279
Current use of biosimilar G-CSF for haematopoietic stem cell mobilisation
Bone Marrow Transplant, 54 (6), 858-866
DOI 10.1038/s41409-018-0350-y, PubMed 30283148
Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort study
Brain Behav Immun, 75, 94-100
DOI 10.1016/j.bbi.2018.09.023, PubMed 30261303
Directed reprogramming of comprehensively characterized dental pulp stem cells extracted from natal tooth
Sci Rep, 8 (1), 6168
DOI 10.1038/s41598-018-24421-z, PubMed 29670257
High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections
J Neuroinflammation, 15 (1), 327
DOI 10.1186/s12974-018-1366-3, PubMed 30470234
Recellularization of Decellularized Venous Grafts Using Peripheral Blood: A Critical Evaluation
EBioMedicine, 32, 215-222
DOI 10.1016/j.ebiom.2018.05.012, PubMed 29779699
Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease
J Clin Invest, 128 (6), 2642-2650
DOI 10.1172/JCI98819, PubMed 29757191
The SysteMHC Atlas project
Nucleic Acids Res, 46 (D1), D1237-D1247
DOI 10.1093/nar/gkx664, PubMed 28985418
A high-throughput pipeline for validation of antibodies
Nat Methods, 15 (11), 909-912
DOI 10.1038/s41592-018-0179-8, PubMed 30377371
Low Levels of Immunoglobulins and Mannose-Binding Lectin Are Not Associated With Etiology, Severity, or Outcome in Community-Acquired Pneumonia
Open Forum Infect Dis, 5 (2), ofy002
DOI 10.1093/ofid/ofy002, PubMed 29410975
Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties
Sci Rep, 8 (1), 2101
DOI 10.1038/s41598-018-20525-8, PubMed 29391560
Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation
J Thromb Haemost, 16 (5), 905-918
DOI 10.1111/jth.13979, PubMed 29437288
Dystonia-deafness syndrome caused by ACTB p.Arg183Trp heterozygosity shows striatal dopaminergic dysfunction and response to pallidal stimulation
J Neurodev Disord, 10 (1), 17
DOI 10.1186/s11689-018-9235-z, PubMed 29788902
Ultracentrifugation versus kit exosome isolation: nanoLC-MS and other tools reveal similar performance biomarkers, but also contaminations
Future Sci OA, 5 (1), FSO359
DOI 10.4155/fsoa-2018-0088, PubMed 30652024
C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release
Int J Mol Sci, 19 (10)
DOI 10.3390/ijms19103257, PubMed 30347808
Determination of fetal RHD type in plasma of RhD negative pregnant women
Scand J Clin Lab Invest, 78 (5), 411-416
DOI 10.1080/00365513.2018.1475681, PubMed 29869532
Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport
Mol Immunol, 95, 1-9
DOI 10.1016/j.molimm.2018.01.006, PubMed 29367080
Prenatal iron exposure and childhood type 1 diabetes
Sci Rep, 8 (1), 9067
DOI 10.1038/s41598-018-27391-4, PubMed 29899542
Effect of Genetic and Laboratory Findings on Clinical Course of Antisynthetase Syndrome in a Hungarian Cohort
Biomed Res Int, 2018, 6416378
DOI 10.1155/2018/6416378, PubMed 30498759
Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome
Neonatology, 113 (4), 322-330
DOI 10.1159/000486542, PubMed 29486477
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei in a liver-transplanted patient: a case report
World J Surg Oncol, 16 (1), 180
DOI 10.1186/s12957-018-1482-7, PubMed 30185175
G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis
Ann Clin Transl Neurol, 5 (10), 1303-1309
DOI 10.1002/acn3.642, PubMed 30349866
Characterization of the Small Intestinal Lesion in Celiac Disease by Label-Free Quantitative Mass Spectrometry
Am J Pathol, 188 (7), 1563-1579
DOI 10.1016/j.ajpath.2018.03.017, PubMed 29684362
Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers
Proc Natl Acad Sci U S A, 115 (18), 4737-4742
DOI 10.1073/pnas.1720391115, PubMed 29669917
Addressing Ethical and Procedural Principles for Unrelated Allogeneic Hematopoietic Progenitor Cell Donation in a Changing Medical Environment
Biol Blood Marrow Transplant, 24 (5), 887-894
DOI 10.1016/j.bbmt.2018.01.018, PubMed 29410372
Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases
Vox Sang, 113 (7), 657-668
DOI 10.1111/vox.12703, PubMed 30159896
Iron oxide nanoparticles enhance Toll-like receptor-induced cytokines in a particle size- and actin-dependent manner in human blood
Nanomedicine (Lond), 13 (14), 1773-1785
DOI 10.2217/nnm-2017-0362, PubMed 30084726