Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2017 from OUS - Department of Immunology (Div LabMed)
97 publications found
A DNA Vaccine That Targets Hemagglutinin to Antigen-Presenting Cells Protects Mice against H7 Influenza
J Virol, 91 (23)
DOI 10.1128/JVI.01340-17, PubMed 28931687
Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach
J Med Chem, 60 (24), 10013-10025
DOI 10.1021/acs.jmedchem.7b00883, PubMed 29155568
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
J Immunol, 199 (8), 2910-2920
DOI 10.4049/jimmunol.1700302, PubMed 28855312
Identification and characterization of a new source of adult human neural progenitors
Cell Death Dis, 8 (8), e2991
DOI 10.1038/cddis.2017.368, PubMed 28796246
Rat acute GvHD is Th1 driven and characterized by predominant donor CD4+ T-cell infiltration of skin and gut
Exp Hematol, 50, 33-45.e3
DOI 10.1016/j.exphem.2017.02.002, PubMed 28238806
IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo
Oncoimmunology, 6 (3), e1274478
DOI 10.1080/2162402X.2016.1274478, PubMed 28405496
Corrigendum: Antibody-antigen kinetics constrain intracellular humoral immunity
Sci Rep, 7, 45418
DOI 10.1038/srep45418, PubMed 28382939
Polysaccharides from the South African medicinal plant Artemisia afra: Structure and activity studies
Fitoterapia, 124, 182-187
DOI 10.1016/j.fitote.2017.11.016, PubMed 29155274
Traceability and distribution of Neisseria meningitidis DNA in archived post mortem tissue samples from patients with systemic meningococcal disease
BMC Clin Pathol, 17, 10
DOI 10.1186/s12907-017-0049-9, PubMed 28824331
Transcriptional and functional profiling defines human small intestinal macrophage subsets
J Exp Med, 215 (2), 441-458
DOI 10.1084/jem.20170057, PubMed 29273642
Sensing External and Self-Motion with Hair Cells: A Comparison of the Lateral Line and Vestibular Systems from a Developmental and Evolutionary Perspective
Brain Behav Evol, 90 (2), 98-116
DOI 10.1159/000456646, PubMed 28988233
Cellular reactions and compensatory tissue re-organization during spontaneous recovery after spinal cord injury in neonatal mice
Dev Neurobiol, 77 (8), 928-946
DOI 10.1002/dneu.22479, PubMed 28033684
MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren's syndrome
PLoS One, 12 (3), e0174585
DOI 10.1371/journal.pone.0174585, PubMed 28339495
Unraveling the role of maternal anti-HLA class I antibodies in fetal and neonatal thrombocytopenia-Antibody specificity analysis using epitope data
J Reprod Immunol, 122, 1-9
DOI 10.1016/j.jri.2017.06.003, PubMed 28686909
Association Between Pretransplant Cancer and Survival in Kidney Transplant Recipients
Transplantation, 101 (10), 2599-2605
DOI 10.1097/TP.0000000000001659, PubMed 28207636
The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin
Sci Rep, 7 (1), 7639
DOI 10.1038/s41598-017-07372-9, PubMed 28794452
The Regulatory Role of the Oral Commensal Streptococcus mitis on Human Monocytes
Scand J Immunol, 87 (2), 80-87
DOI 10.1111/sji.12636, PubMed 29194752
Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
Immunity, 46 (6), 1045-1058.e6
DOI 10.1016/j.immuni.2017.06.005, PubMed 28636954
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages
Biochem Biophys Res Commun, 491 (2), 442-448
DOI 10.1016/j.bbrc.2017.07.070, PubMed 28712870
Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement
Scand Cardiovasc J, 52 (1), 43-50
DOI 10.1080/14017431.2017.1416157, PubMed 29233022
Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver
Sci Rep, 7, 37541
DOI 10.1038/srep37541, PubMed 28134251
Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo
Sci Rep, 7 (1), 3852
DOI 10.1038/s41598-017-04121-w, PubMed 28634324
Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies
Lancet Gastroenterol Hepatol, 2 (7), 479-493
DOI 10.1016/S2468-1253(17)30110-3, PubMed 28506538
Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII
Acta Biomater, 58, 158-167
DOI 10.1016/j.actbio.2017.05.052, PubMed 28576714
Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses
J Immunol, 198 (7), 2785-2795
DOI 10.4049/jimmunol.1601881, PubMed 28228559
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.95193, PubMed 28878121
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report
Medicine (Baltimore), 96 (11), e6338
DOI 10.1097/MD.0000000000006338, PubMed 28296762
A Nonadjuvanted IgG2a Monoclonal Antibody against Nucleosomes Elicits Potent T Cell-Dependent, Idiotype-Specific IgG1 Responses and Glomerular IgG1/IgG2a Deposits in Normal Mice
J Immunol, 199 (2), 489-500
DOI 10.4049/jimmunol.1600718, PubMed 28592426
Properdin binding to complement activating surfaces depends on initial C3b deposition
Proc Natl Acad Sci U S A, 114 (4), E534-E539
DOI 10.1073/pnas.1612385114, PubMed 28069958
The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus
J Neurosurg, 129 (3), 829-837
DOI 10.3171/2017.4.JNS17284, PubMed 29053067
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
J Intensive Care, 5, 21
DOI 10.1186/s40560-017-0217-0, PubMed 28261486
Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines - Consequences for defining reference values in healthy humans
Cytokine, 97, 86-95
DOI 10.1016/j.cyto.2017.05.014, PubMed 28595117
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076, PubMed 28695657
Cardiopulmonary Disease Development in Anti-RNA Polymerase III-positive Systemic Sclerosis: Comparative Analyses from an Unselected, Prospective Patient Cohort
J Rheumatol, 44 (4), 459-465
DOI 10.3899/jrheum.160867, PubMed 28089974
In Silico Prediction Analysis of Idiotope-Driven T-B Cell Collaboration in Multiple Sclerosis
Front Immunol, 8, 1255
DOI 10.3389/fimmu.2017.01255, PubMed 29038659
Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins
Cell Rep, 20 (10), 2357-2367
DOI 10.1016/j.celrep.2017.08.036, PubMed 28877470
T Cells in Celiac Disease
J Immunol, 198 (8), 3005-3014
DOI 10.4049/jimmunol.1601693, PubMed 28373482
Do Long-Lived Plasma Cells Maintain a Healthy Microbiota in the Gut?
Trends Immunol, 39 (3), 196-208
DOI 10.1016/j.it.2017.10.006, PubMed 29162322
Programmed cell death as a defence against infection
Nat Rev Immunol, 17 (3), 151-164
DOI 10.1038/nri.2016.147, PubMed 28138137
Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis
Proc Natl Acad Sci U S A, 114 (31), E6390-E6399
DOI 10.1073/pnas.1706818114, PubMed 28720697
Portal vein reconstruction using primary anastomosis or venous interposition allograft in pancreatic surgery
J Vasc Surg Venous Lymphat Disord, 6 (1), 66-74
DOI 10.1016/j.jvsv.2017.09.003, PubMed 29128301
Scandiatransplant acceptable mismatch program (STAMP) a bridge to transplanting highly immunized patients
HLA, 90 (1), 17-24
DOI 10.1111/tan.13046, PubMed 28449350
A tool for integrating genetic and mass spectrometry-based peptide data: Proteogenomics Viewer: PV: A genome browser-like tool, which includes MS data visualization and peptide identification parameters
Bioessays, 39 (7)
DOI 10.1002/bies.201700015, PubMed 28582591
Antibody-secreting plasma cells persist for decades in human intestine
J Exp Med, 214 (2), 309-317
DOI 10.1084/jem.20161590, PubMed 28104812
Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation
Mol Cell Proteomics, 16 (4 suppl 1), S187-S199
DOI 10.1074/mcp.M116.064840, PubMed 28196878
Selective intrathecal enrichment of G1m1-positive B cells in multiple sclerosis
Ann Clin Transl Neurol, 4 (10), 756-761
DOI 10.1002/acn3.451, PubMed 29046884
Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1)
Proteomics, 17 (17-18)
DOI 10.1002/pmic.201600417, PubMed 28755400
5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin
J Exp Clin Cancer Res, 36 (1), 187
DOI 10.1186/s13046-017-0662-6, PubMed 29258566
Immunohistology and remodeling in fatal pediatric and adolescent asthma
Respir Res, 18 (1), 94
DOI 10.1186/s12931-017-0575-0, PubMed 28511697
iNOS- and NOX1-dependent ROS production maintains bacterial homeostasis in the ileum of mice
Mucosal Immunol, 11 (3), 774-784
DOI 10.1038/mi.2017.106, PubMed 29210363
Biomarkers for rheumatoid arthritis: From molecular processes to diagnostic applications-current concepts and future perspectives
Immunol Lett, 189, 13-18
DOI 10.1016/j.imlet.2017.05.010, PubMed 28526580
Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides
J Biol Chem, 292 (22), 9218-9228
DOI 10.1074/jbc.M117.785139, PubMed 28364043
Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses
Mol Immunol, 89, 111-114
DOI 10.1016/j.molimm.2017.05.021, PubMed 28610663
Mass spectrometry-based proteomic exploration of the human immune system: focus on the inflammasome, global protein secretion, and T cells
Expert Rev Proteomics, 14 (5), 395-407
DOI 10.1080/14789450.2017.1319768, PubMed 28406322
Proteomics to study macrophage response to viral infection
J Proteomics, 180, 99-107
DOI 10.1016/j.jprot.2017.06.018, PubMed 28647517
Regulatory immune cells and functions in autoimmunity and transplantation immunology
Autoimmun Rev, 16 (5), 435-444
DOI 10.1016/j.autrev.2017.03.011, PubMed 28286106
Cyclized Oligopeptide Targeting LRP5/6-DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model
Yonsei Med J, 58 (3), 505-513
DOI 10.3349/ymj.2017.58.3.505, PubMed 28332354
Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy
Clin Proteomics, 14, 30
DOI 10.1186/s12014-017-9165-x, PubMed 28814945
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function
Basic Res Cardiol, 112 (3), 20
DOI 10.1007/s00395-017-0610-9, PubMed 28258298
Juvenile myasthenia gravis in Norway: HLA-DRB1*04:04 is positively associated with prepubertal onset
PLoS One, 12 (10), e0186383
DOI 10.1371/journal.pone.0186383, PubMed 29036181
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury
Proc Natl Acad Sci U S A, 114 (14), E2862-E2871
DOI 10.1073/pnas.1618291114, PubMed 28330995
Similar Responses of Intestinal T Cells From Untreated Children and Adults With Celiac Disease to Deamidated Gluten Epitopes
Gastroenterology, 153 (3), 787-798.e4
DOI 10.1053/j.gastro.2017.05.016, PubMed 28535873
Evaluation of commonly used tear sampling methods and their relevance in subsequent biochemical analysis
Ann Clin Biochem, 54 (5), 521-529
DOI 10.1177/0004563217695843, PubMed 28193107
Association between objective signs and subjective symptoms of dry eye disease in patients with systemic sclerosis
Rheumatol Int, 37 (11), 1835-1845
DOI 10.1007/s00296-017-3794-2, PubMed 28884335
Complement in clinical medicine: Clinical trials, case reports and therapy monitoring
Mol Immunol, 89, 10-21
DOI 10.1016/j.molimm.2017.05.013, PubMed 28576323
High-Throughput Single-Cell Analysis of B Cell Receptor Usage among Autoantigen-Specific Plasma Cells in Celiac Disease
J Immunol, 199 (2), 782-791
DOI 10.4049/jimmunol.1700169, PubMed 28600290
Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification
J Am Heart Assoc, 6 (9)
DOI 10.1161/JAHA.117.006339, PubMed 28912209
HLA-DQ-Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption
Gastroenterology, 154 (4), 886-896.e6
DOI 10.1053/j.gastro.2017.11.006, PubMed 29146521
HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge
Gut, 67 (9), 1606-1613
DOI 10.1136/gutjnl-2017-314461, PubMed 28779027
Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies
NPJ Regen Med, 2, 28
DOI 10.1038/s41536-017-0029-9, PubMed 29302362
Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo
Cell Med, 9 (3), 103-116
DOI 10.3727/215517917X693401, PubMed 28713640
The alternative complement pathway is dysregulated in patients with chronic heart failure
Sci Rep, 7, 42532
DOI 10.1038/srep42532, PubMed 28195242
Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases
PLoS One, 12 (3), e0174577
DOI 10.1371/journal.pone.0174577, PubMed 28362874
Development of an inducible platform for intercellular protein delivery
Int J Pharm, 522 (1-2), 1-10
DOI 10.1016/j.ijpharm.2017.02.067, PubMed 28254654
Future Challenges in the Generation of Hepatocyte-Like Cells From Human Pluripotent Stem Cells
Curr. Pathobiol. Rep., 5 (3), 301-314
Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity
Gastroenterology, 154 (3), 529-539.e2
DOI 10.1053/j.gastro.2017.10.040, PubMed 29102613
Stereotyped antibody responses target posttranslationally modified gluten in celiac disease
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.93961, PubMed 28878138
The roles of MHC class II genes and post-translational modification in celiac disease
Immunogenetics, 69 (8-9), 605-616
DOI 10.1007/s00251-017-0985-7, PubMed 28695286
Frontline Science: A hyporesponsive subset of rat NK cells negative for Ly49s3 and NKR-P1B are precursors to the functionally mature NKR-P1B+ subset
J Leukoc Biol, 102 (6), 1289-1298
DOI 10.1189/jlb.1HI0517-177RR, PubMed 28747319
Dyslipidemia in systemic lupus erythematosus
Immunol Res, 65 (2), 543-550
DOI 10.1007/s12026-016-8892-9, PubMed 28168401
The effect of medium composition on deposition of collagen type 1 and expression of osteogenic genes in mesenchymal stem cells derived from human adipose tissue and bone marrow
Process Biochem., 59, 321-328
Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™
Biomed Res Int, 2017, 2059825
DOI 10.1155/2017/2059825, PubMed 29238712
The nuclear receptor ERβ engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading
Genome Biol, 18 (1), 189
DOI 10.1186/s13059-017-1321-0, PubMed 29017520
Interleukin-6 in Allogeneic Stem Cell Transplantation: Its Possible Importance for Immunoregulation and As a Therapeutic Target
Front Immunol, 8, 667
DOI 10.3389/fimmu.2017.00667, PubMed 28642760
Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease
J Nucl Med, 58 (6), 1003-1008
DOI 10.2967/jnumed.116.186007, PubMed 28209904
Combining HIC, SEC, and IEX with Fluorescence Polarization for Drug Target Discovery
LC GC Eur., 30 (5), 232-239
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J Hepatol, 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019, PubMed 28161472
HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease
HLA, 89 (5), 278-284
DOI 10.1111/tan.12986, PubMed 28247576
Plasma immunological markers in pregnancy and cord blood: A possible link between macrophage chemo-attractants and risk of childhood type 1 diabetes
Am J Reprod Immunol, 79 (3)
DOI 10.1111/aji.12802, PubMed 29266506
Modeling and docking of antibody structures with Rosetta
Nat Protoc, 12 (2), 401-416
DOI 10.1038/nprot.2016.180, PubMed 28125104
Neonatal alloimmune thrombocytopaenia associated with maternal HLA antibodies
BMJ Case Rep, 2017
DOI 10.1136/bcr-2016-218269, PubMed 28679510
Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes
Nat Nanotechnol, 12 (6), 589-594
DOI 10.1038/nnano.2017.47, PubMed 28396605
Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model
Int J Nanomedicine, 12, 3927-3940
DOI 10.2147/IJN.S136453, PubMed 28579778
Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial
Eur Heart J, 38 (39), 2936-2943
DOI 10.1093/eurheartj/ehx188, PubMed 28431003
Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome
J Transl Med, 15 (1), 245
DOI 10.1186/s12967-017-1350-1, PubMed 29202780
Hematopoietic stem cell transplantation in autoimmune disorders: From immune-regulatory processes to clinical implications
Autoimmun Rev, 16 (8), 817-825
DOI 10.1016/j.autrev.2017.05.020, PubMed 28572052
Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury
J Physiol, 596 (2), 281-303
DOI 10.1113/JP274484, PubMed 29086918