Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Microbiology

54 publications found

Andersson DI, Balaban NQ, Baquero F, Courvalin P, Glaser P, Gophna U, Kishony R, Molin S, Tønjum T (2020)
Antibiotic resistance: turning evolutionary principles into clinical reality
FEMS Microbiol Rev, 44 (2), 171-188
DOI 10.1093/femsre/fuaa001, PubMed 31981358

Ashuro AA, Lobie TA, Ye DQ, Leng RX, Li BZ, Pan HF, Fan YG (2020)
Review on the Alteration of Gut Microbiota: The Role of HIV Infection and Old Age
AIDS Res Hum Retroviruses, 36 (7), 556-565
DOI 10.1089/AID.2019.0282, PubMed 32323556

Backe PH, Laerdahl JK, Kittelsen LS, Dalhus B, Mørkrid L, Bjørås M (2020)
Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily
Sci Rep, 10 (1), 5656
DOI 10.1038/s41598-020-62548-0, PubMed 32221390

Barlinn R, Trogstad L, Rollag H, Frøen F, Magnus P, Dudman SG (2020)
Parvovirus B19 DNAemia in pregnant women in relation to perinatal death: A nested case-control study within a large population-based pregnancy cohort
Acta Obstet Gynecol Scand, 99 (7), 856-864
DOI 10.1111/aogs.13801, PubMed 31925774

Booth JA, Špírek M, Lobie TA, Skarstad K, Krejci L, Bjørås M (2020)
Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability
Sci Rep, 10 (1), 19422
DOI 10.1038/s41598-020-76426-2, PubMed 33173044

Christensen I, Haug JB, Berild D, Bjørnholt JV, Jelsness-Jørgensen LP (2020)
Hospital physicians' experiences with procalcitonin - implications for antimicrobial stewardship; a qualitative study
BMC Infect Dis, 20 (1), 515
DOI 10.1186/s12879-020-05246-6, PubMed 32677903

Farooq A, Grønmyr S, Ali O, Rognes T, Scheffler K, Bjørås M, Wang J (2020)
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data
Comput Struct Biotechnol J, 18, 2877-2889
DOI 10.1016/j.csbj.2020.09.038, PubMed 33163148

Gilmour BC, Gudmundsrud R, Frank J, Hov A, Lautrup S, Aman Y, Røsjø H, Brenner C, Ziegler M, Tysnes OB, Tzoulis C, Omland T, Søraas A, Holmøy T, Bergersen LH, Storm-Mathisen J, Nilsen H, Fang EF (2020)
Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing
Mech Ageing Dev, 186, 111208
DOI 10.1016/j.mad.2020.111208, PubMed 31953124

Grøsvik K, Tesfahun AN, Muruzábal-Lecumberri I, Haugland GT, Leiros I, Ruoff P, Kvaløy JT, Knævelsrud I, Ånensen H, Alexeeva M, Sato K, Matsuda A, Alseth I, Klungland A, Bjelland S (2020)
The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside
Front Microbiol, 11, 263
DOI 10.3389/fmicb.2020.00263, PubMed 32158436

Hayes A, Nguyen D, Andersson M, Antón A, Bailly JL, Beard S, Benschop KSM, Berginc N, Blomqvist S, Cunningham E, Davis D, Dembinski JL, Diedrich S, Dudman SG, Dyrdak R, Eltringham GJA, Gonzales-Goggia S, Gunson R, Howson-Wells HC, Jääskeläinen AJ, López-Labrador FX, Maier M, Majumdar M, Midgley S, Mirand A et al. (2020)
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
J Med Virol, 92 (8), 1065-1074
DOI 10.1002/jmv.25659, PubMed 31883139

Helset E, Nordøy I, Sporsem H, Bakke VD, Bugge JF, Gammelsrud KW, Zucknick M, von der Lippe E (2020)
Factors increasing the risk of inappropriate vancomycin therapy in ICU patients: A prospective observational study
Acta Anaesthesiol Scand, 64 (9), 1295-1304
DOI 10.1111/aas.13658, PubMed 32578201

Hoel H, Heggelund L, Reikvam DH, Stiksrud B, Ueland T, Michelsen AE, Otterdal K, Muller KE, Lind A, Muller F, Dudman S, Aukrust P, Dyrhol-Riise AM, Holter JC, Trøseid M (2020)
Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement
J Intern Med, 289 (4), 523-531
DOI 10.1111/joim.13178, PubMed 32976665

Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P et al. (2020)
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538

Hua Y, Bai X, Zhang J, Jernberg C, Chromek M, Hansson S, Frykman A, Yang X, Xiong Y, Wan C, Matussek A (2020)
Molecular characteristics of eae-positive clinical Shiga toxin-producing Escherichia coli in Sweden
Emerg Microbes Infect, 9 (1), 2562-2570
DOI 10.1080/22221751.2020.1850182, PubMed 33179570

Jøntvedt Jørgensen M, Holter JC, Christensen EE, Schjalm C, Tonby K, Pischke SE, Jenum S, Skeie LG, Nur S, Lind A, Opsand H, Enersen TB, Grøndahl R, Hermann A, Dudman S, Muller F, Ueland T, Mollnes TE, Aukrust P, Heggelund L, Holten AR, Dyrhol-Riise AM (2020)
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Sci Rep, 10 (1), 21697
DOI 10.1038/s41598-020-78710-7, PubMed 33303843

Khelik K, Sandve GK, Nederbragt AJ, Rognes T (2020)
NucBreak: location of structural errors in a genome assembly by using paired-end Illumina reads
BMC Bioinformatics, 21 (1), 66
DOI 10.1186/s12859-020-3414-0, PubMed 32085722

Kong XY, Vik ES, Nawaz MS, Berges N, Dahl TB, Vågbø C, Suganthan R, Segers F, Holm S, Quiles-Jiménez A, Gregersen I, Fladeby C, Aukrust P, Bjørås M, Klungland A, Halvorsen B, Alseth I (2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res, 48 (8), 4463-4479
DOI 10.1093/nar/gkaa115, PubMed 32083667

Lanternier F, Seidel D, Pagano L, Styczynski J, Mikulska M, Pulcini C, Maertens J, Munoz P, Garcia-Vidal C, Rijnders B, Arendrup MC, Sabino R, Verissimo C, Gaustad P, Klimko N, Arikan-Akdagli S, Arsic V, Barac A, Skiada A, Klingspor L, Herbrecht R, Donnelly P, Cornely OA, Lass-Flörl C, Lortholary O (2020)
Invasive pulmonary aspergillosis treatment duration in haematology patients in Europe: An EFISG, IDWP-EBMT, EORTC-IDG and SEIFEM survey
Mycoses, 63 (5), 420-429
DOI 10.1111/myc.13056, PubMed 32009262

Li M, Klungland A (2020)
Modifications and interactions at the R-loop
DNA Repair (Amst), 96, 102958
DOI 10.1016/j.dnarep.2020.102958, PubMed 32961406

Lobie TA, Woldeamanuel Y, Asrat D, Beyene D, Bjørås M, Aseffa A (2020)
Genetic diversity and drug resistance pattern of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in the Benishangul Gumuz region and its surroundings, Northwest Ethiopia
PLoS One, 15 (4), e0231320
DOI 10.1371/journal.pone.0231320, PubMed 32267877

Lorentzen EM, Henriksen S, Kaur A, Kro GB, Hammarström C, Hirsch HH, Midtvedt K, Rinaldo CH (2020)
Early fulminant BK polyomavirus-associated nephropathy in two kidney transplant patients with low neutralizing antibody titers receiving allografts from the same donor
Virol J, 17 (1), 5
DOI 10.1186/s12985-019-1275-9, PubMed 31924245

Louwe MC, Olsen MB, Kaasbøll OJ, Yang K, Fosshaug LE, Alfsnes K, Øgaard JDS, Rashidi A, Skulberg VM, Yang M, de Miranda Fonseca D, Sharma A, Aronsen JM, Schrumpf E, Ahmed MS, Dahl CP, Nyman TA, Ueland T, Melum E, Halvorsen BE, Bjørås M, Attramadal H, Sjaastad I, Aukrust P, Yndestad A (2020)
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377

Macpherson ME, Hov JR, Ueland T, Dahl TB, Kummen M, Otterdal K, Holm K, Berge RK, Mollnes TE, Trøseid M, Halvorsen B, Aukrust P, Fevang B, Jørgensen SF (2020)
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155

Matsuyama M, Søraas A, Yu S, Kim K, Stavrou EX, Caimi PF, Wald D, deLima M, Dahl JA, Horvath S, Matsuyama S (2020)
Analysis of epigenetic aging in vivo and in vitro: Factors controlling the speed and direction
Exp Biol Med (Maywood), 245 (17), 1543-1551
DOI 10.1177/1535370220947015, PubMed 32762265

Melby KK, Carlsen KL, Håland G, Samdal HH, Carlsen KH (2020)
Helicobacter pylori in early childhood and asthma in adolescence
BMC Res Notes, 13 (1), 79
DOI 10.1186/s13104-020-04941-6, PubMed 32070394

Navarro JF, Croteau DL, Jurek A, Andrusivova Z, Yang B, Wang Y, Ogedegbe B, Riaz T, Støen M, Desler C, Rasmussen LJ, Tønjum T, Galas MC, Lundeberg J, Bohr VA (2020)
Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease
iScience, 23 (10), 101556
DOI 10.1016/j.isci.2020.101556, PubMed 33083725

Nedal A, Ræder SB, Dalhus B, Helgesen E, Forstrøm RJ, Lindland K, Sumabe BK, Martinsen JH, Kragelund BB, Skarstad K, Bjørås M, Otterlei M (2020)
Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis
Nucleic Acids Res, 48 (10), 5540-5554
DOI 10.1093/nar/gkaa278, PubMed 32347931

Nestegard O, Johnsen KM, Sørbye SW, Halvorsen FA, Tønnessen T, Paulssen EJ, Melby KK, Goll R, Florholmen J (2020)
Clinical characterization of Helicobacter pylori infected patients 15 years after unsuccessful eradication
PLoS One, 15 (9), e0238944
DOI 10.1371/journal.pone.0238944, PubMed 32966303

Nilsen J, Trabjerg E, Grevys A, Azevedo C, Brennan SO, Stensland M, Wilson J, Sand KMK, Bern M, Dalhus B, Roopenian DC, Sandlie I, Rand KD, Andersen JT (2020)
An intact C-terminal end of albumin is required for its long half-life in humans
Commun Biol, 3 (1), 181
DOI 10.1038/s42003-020-0903-7, PubMed 32313072

Ögren J, Dienus O, Beser J, Henningsson AJ, Matussek A (2020)
Protozoan infections are under-recognized in Swedish patients with gastrointestinal symptoms
Eur J Clin Microbiol Infect Dis, 39 (11), 2153-2160
DOI 10.1007/s10096-020-03974-w, PubMed 32638222

Orlien SMS, Ahmed TA, Ismael NY, Berhe Belay N, Kran AB, Gundersen SG, Johannessen A (2020)
Field performance of HBsAg rapid diagnostic tests in rural Ethiopia
J Virol Methods, 289, 114061
DOI 10.1016/j.jviromet.2020.114061, PubMed 33388369

Osnes MN, Didelot X, Korne-Elenbaas J, Alfsnes K, Brynildsrud OB, Syversen G, Nilsen ØJ, De Blasio BF, Caugant DA, Eldholm V (2020)
Sudden emergence of a Neisseria gonorrhoeae clade with reduced susceptibility to extended-spectrum cephalosporins, Norway
Microb Genom, 6 (12)
DOI 10.1099/mgen.0.000480, PubMed 33200978

Połeć A, Rowe AD, Blicher P, Suganthan R, Bjørås M, Bøe SO (2020)
PML Regulates the Epidermal Differentiation Complex and Skin Morphogenesis during Mouse Embryogenesis
Genes (Basel), 11 (10)
DOI 10.3390/genes11101130, PubMed 32992884

Quiles-Jiménez A, Gregersen I, Mittelstedt Leal de Sousa M, Abbas A, Kong XY, Alseth I, Holm S, Dahl TB, Skagen K, Skjelland M, Aukrust P, Bjørås M, Halvorsen B (2020)
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
Biochem Biophys Res Commun, 533 (4), 631-637
DOI 10.1016/j.bbrc.2020.09.057, PubMed 33004177

Ramstad SN, Taxt AM, Naseer U, Wasteson Y, Bjørnholt JV, Brandal LT (2020)
Effects of antimicrobials on Shiga toxin production in high-virulent Shiga toxin-producing Escherichia coli
Microb Pathog, 152, 104636
DOI 10.1016/j.micpath.2020.104636, PubMed 33242644

Rodriguez-Vargas JM, Martin-Hernandez K, Wang W, Kunath N, Suganthan R, Amé JC, Oliver FJ, Ye J, Bjørås M, Dantzer F (2020)
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation
Cell Death Dis, 11 (11), 954
DOI 10.1038/s41419-020-03167-5, PubMed 33159039

Sahaf Naeini A, Farooq A, Bjørås M, Wang J (2020)
IGAP-integrative genome analysis pipeline reveals new gene regulatory model associated with nonspecific TF-DNA binding affinity
Comput Struct Biotechnol J, 18, 1270-1286
DOI 10.1016/j.csbj.2020.05.024, PubMed 32612751

Sankar A, Lerdrup M, Manaf A, Johansen JV, Gonzalez JM, Borup R, Blanshard R, Klungland A, Hansen K, Andersen CY, Dahl JA, Helin K, Hoffmann ER (2020)
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes
Nat Cell Biol, 22 (4), 380-388
DOI 10.1038/s41556-020-0494-z, PubMed 32231309

Saue T, Bast R, Gomes ASP, Jensen HJA, Visscher L, Aucar IA, Di Remigio R, Dyall KG, Eliav E, Fasshauer E, Fleig T, Halbert L, Hedegård ED, Helmich-Paris B, Iliaš M, Jacob CR, Knecht S, Laerdahl JK, Vidal ML, Nayak MK, Olejniczak M, Olsen JMH, Pernpointner M, Senjean B, Shee A et al. (2020)
The DIRAC code for relativistic molecular calculations
J Chem Phys, 152 (20), 204104
DOI 10.1063/5.0004844, PubMed 32486677

Scheffler K, Jalland CMO, Benestad SL, Moldal T, Ersdal C, Gunnes G, Suganthan R, Bjørås M, Tranulis MA (2020)
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease
Free Radic Biol Med, 152, 348-354
DOI 10.1016/j.freeradbiomed.2020.03.030, PubMed 32259578

Strand J, Gul KA, Erichsen HC, Lundman E, Berge MC, Trømborg AK, Sørgjerd LK, Ytre-Arne M, Hogner S, Halsne R, Gaup HJ, Osnes LT, Kro GAB, Sorte HS, Mørkrid L, Rowe AD, Tangeraas T, Jørgensen JV, Alme C, Bjørndalen TEH, Rønnestad AE, Lang AM, Rootwelt T, Buechner J, Øverland T et al. (2020)
Second-Tier Next Generation Sequencing Integrated in Nationwide Newborn Screening Provides Rapid Molecular Diagnostics of Severe Combined Immunodeficiency
Front Immunol, 11, 1417
DOI 10.3389/fimmu.2020.01417, PubMed 32754152

Taxt AM, Avershina E, Frye SA, Naseer U, Ahmad R (2020)
Rapid identification of pathogens, antibiotic resistance genes and plasmids in blood cultures by nanopore sequencing
Sci Rep, 10 (1), 7622
DOI 10.1038/s41598-020-64616-x, PubMed 32376847

Taxt AM, Grødeland G, Lind A, Müller F (2020)
Status of COVID-19 vaccine development
Tidsskr Nor Laegeforen, 140 (13)
DOI 10.4045/tidsskr.20.0676, PubMed 32998488

Tollånes MC, Bakken Kran AM, Abildsnes E, Jenum PA, Breivik AC, Sandberg S (2020)
Evaluation of eleven rapid tests for detection of antibodies against SARS-CoV-2
Clin Chem Lab Med, 58 (9), 1595-1600
DOI 10.1515/cclm-2020-0628, PubMed 32598303

Ueland T, Heggelund L, Lind A, Holten AR, Tonby K, Michelsen AE, Jenum S, Jørgensen MJ, Barratt-Due A, Skeie LG, Nordøy I, Aanensen Fraz MS, Quist-Paulsen E E, Pischke SE, Johal SK, Hesstvedt L, Bogen M, Fevang B, Halvorsen B, Müller F, Bekken GK, Mollnes TE, Dudman S, Aukrust P, Dyrhol-Riise AM et al. (2020)
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109

Vander Zanden CM, Czarny RS, Ho EN, Robertson AB, Ho PS (2020)
Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function
Nucleic Acids Res, 48 (7), 3962-3974
DOI 10.1093/nar/gkaa117, PubMed 32095813

Welekidan LN, Skjerve E, Dejene TA, Gebremichael MW, Brynildsrud O, Agdestein A, Tessema GT, Tønjum T, Yimer SA (2020)
Characteristics of pulmonary multidrug-resistant tuberculosis patients in Tigray Region, Ethiopia: A cross-sectional study
PLoS One, 15 (8), e0236362
DOI 10.1371/journal.pone.0236362, PubMed 32797053

Welekidan LN, Skjerve E, Dejene TA, Gebremichael MW, Brynildsrud O, Tønjum T, Yimer SA (2020)
Frequency and patterns of first- and second-line drug resistance-conferring mutations in Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in a cross-sectional study in Tigray Region, Ethiopia
J Glob Antimicrob Resist, 24, 6-13
DOI 10.1016/j.jgar.2020.11.017, PubMed 33279682

Yang M, Lin X, Segers F, Suganthan R, Hildrestrand GA, Rinholm JE, Aas PA, Sousa MML, Holm S, Bolstad N, Warren D, Berge RK, Johansen RF, Yndestad A, Kristiansen E, Klungland A, Luna L, Eide L, Halvorsen B, Aukrust P, Bjørås M (2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476

Yang X, Sun H, Fan R, Fu S, Zhang J, Matussek A, Xiong Y, Bai X (2020)
Genetic diversity of the intimin gene (eae) in non-O157 Shiga toxin-producing Escherichia coli strains in China
Sci Rep, 10 (1), 3275
DOI 10.1038/s41598-020-60225-w, PubMed 32094410

Yang Y, Choppavarapu L, Fang K, Naeini AS, Nosirov B, Li J, Yang K, He Z, Zhou Y, Schiff R, Li R, Hu Y, Wang J, Jin VX (2020)
The 3D genomic landscape of differential response to EGFR/HER2 inhibition in endocrine-resistant breast cancer cells
Biochim Biophys Acta Gene Regul Mech, 1863 (11), 194631
DOI 10.1016/j.bbagrm.2020.194631, PubMed 32956836

Yimer SA, Kalayou S, Homberset H, Birhanu AG, Riaz T, Zegeye ED, Lutter T, Abebe M, Holm-Hansen C, Aseffa A, Tønjum T (2020)
Lineage-Specific Proteomic Signatures in the Mycobacterium tuberculosis Complex Reveal Differential Abundance of Proteins Involved in Virulence, DNA Repair, CRISPR-Cas, Bioenergetics and Lipid Metabolism
Front Microbiol, 11, 550760
DOI 10.3389/fmicb.2020.550760, PubMed 33072011

Ylinen E, Salmenlinna S, Halkilahti J, Jahnukainen T, Korhonen L, Virkkala T, Rimhanen-Finne R, Nuutinen M, Kataja J, Arikoski P, Linkosalo L, Bai X, Matussek A, Jalanko H, Saxén H (2020)
Hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli in children: incidence, risk factors, and clinical outcome
Pediatr Nephrol, 35 (9), 1749-1759
DOI 10.1007/s00467-020-04560-0, PubMed 32323005

Zwiggelaar RT, Lindholm HT, Fosslie M, Terndrup Pedersen M, Ohta Y, Díez-Sánchez A, Martín-Alonso M, Ostrop J, Matano M, Parmar N, Kvaløy E, Spanjers RR, Nazmi K, Rye M, Drabløs F, Arrowsmith C, Arne Dahl J, Jensen KB, Sato T, Oudhoff MJ (2020)
LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium
Sci Adv, 6 (37)
DOI 10.1126/sciadv.abc0367, PubMed 32917713

 
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