The SENSOR study Publications

Publications 2024

  1. Bjerre Trent P, Eriksson AG, Staff AC, Juul-Hansen KE, Burger EA, Wangen KR (2024)
    A cost-effectiveness analysis of sentinel lymph node biopsy compared with lymphadenectomy in intermediate- and high-risk endometrial carcinoma
    Int J Gynecol Cancer (in press)
    DOI 10.1136/ijgc-2024-005906, PubMed 39433423
  2. Bjerre Trent PK, Nordskar NJ, Wangen KR, Engeskaug MI, Opheim MLØ, Aune G, Staff AC, Thorsen L, Falk RS, Eriksson AGZ (2024)
    Corrigendum to "Self-reported lower extremity lymphedema and quality of life after surgical staging of endometrial carcinoma: A population based cross-sectional study" [Gynecologic Oncology 175 (2023) 72-80]
    Gynecol Oncol, 183, 7-8
    DOI 10.1016/j.ygyno.2024.02.026, PubMed 38484693
  3. Cun HT, Bernard L, Lande KT, Lawson BC, Nesbakken AJ, Davidson B, Lindemann K, Fellman B, Sørlie T, Soliman PT, Eriksson AGZ (2024)
    Comprehensive molecular characterization of early stage grade 3 endometrioid endometrial adenocarcinoma
    Gynecol Oncol, 189, 138-145
    DOI 10.1016/j.ygyno.2024.07.677, PubMed 39126895
  4. Dagher C, Bjerre Trent P, Alwaqfi R, Davidson B, Ellenson L, Zhou QC, Iasonos A, Mueller JJ, Alektiar K, Makker V, Kim S, Leitao MM, Abu-Rustum NR, Eriksson AGZ (2024)
    Oncologic outcomes based on lymphovascular space invasion in node-negative FIGO 2009 stage I endometrioid endometrial adenocarcinoma: a multicenter retrospective cohort study
    Int J Gynecol Cancer, 34 (10), 1485-1492
    DOI 10.1136/ijgc-2024-005746, PubMed 39074932
  5. Davidson B, Holth A, Lindemann K, Zahl Eriksson AG, Nilsen TA, Torgunrud A (2024)
    Molecular characteristics of tubo-ovarian carcinosarcoma at different anatomic locations
    Virchows Arch (in press)
    DOI 10.1007/s00428-024-03821-9, PubMed 38733380
  6. Davidson B, Teien Lande K, Nebdal D, Nesbakken AJ, Holth A, Lindemann K, Zahl Eriksson AG, Sørlie T (2024)
    Endometrial carcinomas with ambiguous histology often harbor TP53 mutations
    Virchows Arch (in press)
    DOI 10.1007/s00428-024-03912-7, PubMed 39235515
  7. Fotopoulou C, Eriksson AG, Baiocchi G, Zivanovic O (2024)
    Surgery for gynecological cancers in the era of personalized medicine: a novel paradigm
    Int J Gynecol Cancer, 34 (3), 351
    DOI 10.1136/ijgc-2024-005299, PubMed 38438173
  8. Fotopoulou C, Eriksson AG, Planchamp F, Morice P, Taylor A, Sturdza A, Florin Coza O, Halaska MJ, Martinelli F, Armbrust R, Chargari C (2024)
    European Society of Gynaecological Oncology expanded quality indicators and accreditation for cervical cancer management
    Int J Gynecol Cancer, 34 (4), 480-489
    DOI 10.1136/ijgc-2024-005293, PubMed 38395448
  9. Ledermann JA, Matias-Guiu X, Amant F, Concin N, Davidson B, Fotopoulou C, González-Martin A, Gourley C, Leary A, Lorusso D, Banerjee S, Chiva L, Cibula D, Colombo N, Croce S, Eriksson AG, Falandry C, Fischerova D, Harter P, Joly F, Lazaro C, Lok C, Mahner S, Marmé F, Marth C et al. (2024)
    ESGO-ESMO-ESP consensus conference recommendations on ovarian cancer: pathology and molecular biology and early, advanced and recurrent disease
    Ann Oncol, 35 (3), 248-266
    DOI 10.1016/j.annonc.2023.11.015, PubMed 38307807
  10. Luijten MMW, van Weelden WJ, Lalisang RI, Bulten J, Lindemann K, van Beekhuizen HJ, Trum H, Boll D, Werner HMJ, van Lonkhuijzen LRCW, Yigit R, Krakstad C, Witteveen PO, Galaal K, van Ginkel AA, Bignotti E, Weinberger V, Sweegers S, Eriksson AGZ, Keizer DM, van de Stolpe A, Romano A, Pijnenborg JMA, European Network For Individualized Treatment In Endometrial Cancer (2024)
    Hormone Receptor Expression and Activity for Different Tumour Locations in Patients with Advanced and Recurrent Endometrial Carcinoma
    Cancers (Basel), 16 (11)
    DOI 10.3390/cancers16112084, PubMed 38893205
  11. Morice P, Scambia G, Abu-Rustum NR, Acien M, Arena A, Brucker S, Cheong Y, Collinet P, Fanfani F, Filippi F, Eriksson AGZ, Gouy S, Harter P, Matias-Guiu X, Pados G, Pakiz M, Querleu D, Rodolakis A, Rousset-Jablonski C, Stepanyan A, Testa AC, Macklon KT, Tsolakidis D, De Vos M, Planchamp F et al. (2024)
    Fertility-sparing treatment and follow-up in patients with cervical cancer, ovarian cancer, and borderline ovarian tumours: guidelines from ESGO, ESHRE, and ESGE
    Lancet Oncol, 25 (11), e602-e610
    DOI 10.1016/S1470-2045(24)00262-6, PubMed 39216500
  12. Nikolova T, Bilir E, Bizzarri N, Fotopoulou C, van Gorp T, Kacperczyk-Bartnik J, Razumova Z, Strojna AN, Eriksson AG, Pakiz M, Mirza MR, Fagotti A, Concin N (2024)
    Gender equality, diversity, and inclusion among gynaecologic oncologists: European Network of Young Gynae Oncologists (ENYGO)-European Society of Gynaecological Oncology (ESGO) project
    Int J Gynecol Cancer, 34 (11), 1685-1690
    DOI 10.1136/ijgc-2024-005697, PubMed 39395820
  13. Rios-Doria E, Abu-Rustum NR, Glaser G, McGree M, Eriksson AG, Pham M, Soliman P, Ataseven B, Alektiar K, Zamarin D, Leitao ML, Mueller J (2024)
    2009 International Federation of Gynecology and Obstetrics (FIGO) stage IIIA endometrial cancer: oncologic outcomes based on involvement of adnexa, serosa, or both
    Int J Gynecol Cancer, 34 (10), 1580-1587
    DOI 10.1136/ijgc-2024-005567, PubMed 39074930
  14. Rios-Doria E, Nobre SP, Sassine D, Glaser G, Eriksson AG, Ataseven B, du Bois A, Makker V, Alektiar K, Leitao MM, Abu-Rustum NR, Mueller JJ (2024)
    Impact of adjuvant therapy on oncologic outcomes in uterine-confined clear cell carcinoma of the endometrium
    Gynecol Oncol, 190, 236-242
    DOI 10.1016/j.ygyno.2024.08.019, PubMed 39243699

Publications 2023

  1. Bilir E, Ahmed W, Kacperczyk-Bartnik J, Nasser S, Bjerre Trent P, Boria F, Tsibulak I, Chacon E, Martinelli F, Strojna AN, Morgan G, Bizzarri N, Eriksson AG, Theofanakis C (2023)
    Social media ambassadors and collaboration with OncoAlert: a European Network of Young Gynae Oncologists study of comparative Twitter analysis of #ESGO2021 and #ESGO2022
    Int J Gynecol Cancer, 33 (6), 964-970
    DOI 10.1136/ijgc-2023-004371, PubMed 37130625
  2. Bjerre Trent P, Falk RS, Staff AC, Jorde D, Eriksson AG (2023)
    Translation and cross-cultural adaptation of the Gynecologic Cancer Lymphedema Questionnaire and the Lower Extremity Lymphedema Screening Questionnaire
    Int J Gynecol Cancer, 33 (2), 231-235
    DOI 10.1136/ijgc-2022-003979, PubMed 36600491
  3. Bjerre Trent PK, Nordskar NJ, Wangen KR, Engeskaug MI, Opheim MLØ, Aune G, Staff AC, Thorsen L, Falk RS, Eriksson AGZ (2023)
    Self-reported lower extremity lymphedema and quality of life after surgical staging of endometrial carcinoma: A population based cross-sectional study
    Gynecol Oncol, 175, 72-80
    DOI 10.1016/j.ygyno.2023.05.070, PubMed 37327542
  4. Fotopoulou C, Eriksson AG, Yagel I, Chang SJ, Lim MC (2023)
    Surgery for Recurrent Epithelial Ovarian Cancer
    Curr Oncol Rep, 26 (1), 46-54
    DOI 10.1007/s11912-023-01480-8, PubMed 38091202
  5. Kacperczyk-Bartnik J, Bilir E, Nasser S, Strojna A, Eriksson AGZ (2023)
    Is it possible to block cancer? The example of #VaginalCancer on Instagram
    Int J Gynecol Cancer, 33 (9), 1488-1489
    DOI 10.1136/ijgc-2023-004844, PubMed 37591610
  6. Opheim LØ, Engeskaug I, Bjerre Trent PK, Thorsen L, Staff AC, Nordskar NJ, Utne I, Hagen M, Eriksson AGZ (2023)
    Associations between modifiable lifestyle factors and health-related quality of life among endometrial carcinoma survivors - A cross-sectional study
    Gynecol Oncol, 179, 52-62
    DOI 10.1016/j.ygyno.2023.10.012, PubMed 37924595

Publications 2022

  1. Brunetti M, Panagopoulos I, Vitelli V, Andersen K, Hveem TS, Davidson B, Eriksson AGZ, Trent PKB, Heim S, Micci F (2022)
    Endometrial Carcinoma: Molecular Cytogenetics and Transcriptomic Profile
    Cancers (Basel), 14 (14)
    DOI 10.3390/cancers14143536, PubMed 35884597
  2. Daviu C, Blaakaer J, Eriksson AGZ, Herrstedt J, Vandborg MP, Rasmussen AMO, Fuglsang K (2022)
    Nonepithelial ovarian cancer - the current clinical practice in the Nordic countries. Survey from the surgical subcommittee of the Nordic society of gynecological oncology (NSGO)
    Acta Oncol, 61 (8), 939-945
    DOI 10.1080/0284186X.2022.2088249, PubMed 35762031
  3. Kurnit KC, Nobre SP, Fellman BM, Iglesias DA, Lindemann K, Jhingran A, Eriksson AGZ, Ataseven B, Glaser GE, Mueller JJ, Westin SN, Soliman PT (2022)
    Adjuvant therapy in women with early stage uterine serous carcinoma: A multi-institutional study
    Gynecol Oncol, 167 (3), 452-457
    DOI 10.1016/j.ygyno.2022.09.025, PubMed 36243601

Publications 2021

  1. Bhandoria GP, Nair N, Jones SEF, Eriksson AG, Hsu HC, Noll F, Ahmed W, International Gynecological Cancer Society (2021)
    International Gynaecological Cancer Society (IGCS) 2020 Annual Global Meeting: Twitter activity analysis
    Int J Gynecol Cancer, 31 (11), 1453-1458
    DOI 10.1136/ijgc-2021-002781, PubMed 34489352
  2. Davidson B, Kleinberg L, Børresen IM, Slettevoll F, Fangberget A, Hindosh D, Zahl Eriksson AG, Bjerkehagen B (2021)
    Primary uterine ectomesenchymoma harboring a DICER1 mutation: case report with molecular analysis
    Virchows Arch, 479 (2), 419-424
    DOI 10.1007/s00428-021-03057-x, PubMed 33595736
  3. Eriksson AGZ, Davidson B, Bjerre Trent P, Eyjólfsdóttir B, Dahl GF, Wang Y, Staff AC (2021)
    Update on Sentinel Lymph Node Biopsy in Surgical Staging of Endometrial Carcinoma
    J Clin Med, 10 (14)
    DOI 10.3390/jcm10143094, PubMed 34300260
  4. Eriksson AGZ, Mueller JJ (2021)
    Advances in management of nonendometrioid endometrial carcinoma, with an emphasis on the sentinel lymph node technique
    Curr Opin Oncol, 33 (5), 457-463
    DOI 10.1097/CCO.0000000000000777, PubMed 34264897
  5. van der Hage J, Sandrucci S, Audisio R, Wyld L, Søreide K, ESSO core curriculum contributors, Amaral T, Audisio R, Bahadoer V, Beets G, Benstead K, Berge Nilsen E, Bol K, Brandl A, Braun J, Cufer T, Dopazo C, Edhemovic I, Eriksen JG, Fiore M, van Ginhoven T, Gonzalez-Moreno S, van der Hage J, Hutteman M, Masannat Y et al. (2021)
    The ESSO core curriculum committee update on surgical oncology
    Eur J Surg Oncol, 47 (11), e1-e30
    DOI 10.1016/j.ejso.2021.10.003, PubMed 34657781
  6. van Weelden WJ, Lalisang RI, Bulten J, Lindemann K, van Beekhuizen HJ, Trum H, Boll D, Werner HMJ, van Lonkhuijzen LRCW, Yigit R, Forsse D, Witteveen PO, Galaal K, van Ginkel A, Bignotti E, Weinberger V, Sweegers S, Kroep JR, Cabrera S, Snijders MPLM, Inda MA, Eriksson AGZ, European Network for Individualized Treatment in Endometrial Cancer, Krakstad C, Romano A et al. (2021)
    Impact of hormonal biomarkers on response to hormonal therapy in advanced and recurrent endometrial cancer
    Am J Obstet Gynecol, 225 (4), 407.e1-407.e16
    DOI 10.1016/j.ajog.2021.05.007, PubMed 34019887

Publications 2020

  1. Cibula D, Planchamp F, Fischerova D, Fotopoulou C, Kohler C, Landoni F, Mathevet P, Naik R, Ponce J, Raspagliesi F, Rodolakis A, Tamussino K, Taskiran C, Vergote I, Wimberger P, Zahl Eriksson AG, Querleu D (2020)
    European Society of Gynaecological Oncology quality indicators for surgical treatment of cervical cancer
    Int J Gynecol Cancer, 30 (1), 3-14
    DOI 10.1136/ijgc-2019-000878, PubMed 31900285
  2. Falconer H, Zahl Eriksson AG, Rudnicki M (2020)
    Is robot-assisted laparoscopy safe for surgical treatment of cervical cancer?
    Acta Obstet Gynecol Scand, 99 (1), 5-6
    DOI 10.1111/aogs.13766, PubMed 31879949
  3. Lanner M, Nikolova T, Gutic B, Nikolova N, Pletnev A, Selcuk I, Vlachos DE, Razumova Z, Bizzarri N, Theofanakis C, Lepka P, Kahramanoglu I, Han S, Nasser S, Molnar S, Hudry D, Montero-Macías R, de Lange N, Macuks R, Hasanov MF, Karimbayli R, Gagua I, Andrade C, Pardal C, Dotlic J et al. (2020)
    Subspecialty training in Europe: a report by the European Network of Young Gynaecological Oncologists
    Int J Gynecol Cancer, 31 (4), 575-584
    DOI 10.1136/ijgc-2020-002176, PubMed 33361458
  4. Ramirez PT, Chiva L, Eriksson AGZ, Frumovitz M, Fagotti A, Gonzalez Martin A, Jhingran A, Pareja R (2020)
    COVID-19 Global Pandemic: Options for Management of Gynecologic Cancers
    Int J Gynecol Cancer, 30 (5), 561-563
    DOI 10.1136/ijgc-2020-001419, PubMed 32221023
  5. Ramirez PT, Pareja R, Eriksson AGZ, Frumovitz M (2020)
    International Gynecologic Cancer Society 2019 meeting summary
    Int J Gynecol Cancer, 30 (2), 167-173
    DOI 10.1136/ijgc-2019-001146, PubMed 32029483

Publications 2019

  1. Eriksson AG, Fallaas Dahl G, Nesbakken AJ, Lund KV, Amant F (2019)
    Endometrial cancer during pregnancy: management strategies
    Int J Gynecol Cancer, 29 (7), 1221-1224
    DOI 10.1136/ijgc-2019-000756, PubMed 31434687
  2. Falconer H, Palsdottir K, Stalberg K, Dahm-Kähler P, Ottander U, Lundin ES, Wijk L, Kimmig R, Jensen PT, Zahl Eriksson AG, Mäenpää J, Persson J, Salehi S (2019)
    Robot-assisted approach to cervical cancer (RACC): an international multi-center, open-label randomized controlled trial
    Int J Gynecol Cancer, 29 (6), 1072-1076
    DOI 10.1136/ijgc-2019-000558, PubMed 31203203
  3. Lecuru FR, McCormack M, Hillemanns P, Anota A, Leitao M, Mathevet P, Zweemer R, Fujiwara K, Zanagnolo V, Zahl Eriksson AG, Hudson E, Ferron G, Plante M (2019)
    SENTICOL III: an international validation study of sentinel node biopsy in early cervical cancer. A GINECO, ENGOT, GCIG and multicenter study
    Int J Gynecol Cancer, 29 (4), 829-834
    DOI 10.1136/ijgc-2019-000332, PubMed 30898938
  4. Multinu F, Ducie JA, Eriksson AGZ, Schlappe BA, Cliby WA, Glaser GE, Grassi T, Keeney GL, Weaver AL, Abu-Rustum NR, Leitao MM, Mariani A (2019)
    Role of lymphadenectomy in endometrial cancer with nonbulky lymph node metastasis: Comparison of comprehensive surgical staging and sentinel lymph node algorithm
    Gynecol Oncol, 155 (2), 177-185
    DOI 10.1016/j.ygyno.2019.09.011, PubMed 31604668
  5. Schlappe BA, Weaver AL, McGree ME, Ducie J, Zahl Eriksson AG, Dowdy SC, Cliby WA, Glaser GE, Abu-Rustum NR, Mariani A, Leitao MM (2019)
    Multicenter study comparing oncologic outcomes after lymph node assessment via a sentinel lymph node algorithm versus comprehensive pelvic and paraaortic lymphadenectomy in patients with serous and clear cell endometrial carcinoma
    Gynecol Oncol, 156 (1), 62-69
    DOI 10.1016/j.ygyno.2019.11.002, PubMed 31776037

Publications 2018

  1. Agostini A, Brunetti M, Davidson B, Tropé CG, Eriksson AGZ, Heim S, Panagopoulos I, Micci F (2018)
    The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas
    Sci Rep, 8 (1), 11069
    DOI 10.1038/s41598-018-29332-7, PubMed 30038317
  2. Schlappe BA, Weaver AL, Ducie JA, Eriksson AGZ, Dowdy SC, Cliby WA, Glaser GE, Soslow RA, Alektiar KM, Makker V, Abu-Rustum NR, Mariani A, Leitao MM (2018)
    Multicenter study comparing oncologic outcomes between two nodal assessment methods in patients with deeply invasive endometrioid endometrial carcinoma: A sentinel lymph node algorithm versus a comprehensive pelvic and paraaortic lymphadenectomy
    Gynecol Oncol, 151 (2), 235-242
    DOI 10.1016/j.ygyno.2018.08.022, PubMed 30177461

Publications 2017

  1. Cowan RA, Eriksson AGZ, Jaber SM, Zhou Q, Iasonos A, Zivanovic O, Leitao MM, Abu-Rustum NR, Chi DS, Gardner GJ (2017)
    A comparative analysis of prediction models for complete gross resection in secondary cytoreductive surgery for ovarian cancer
    Gynecol Oncol, 145 (2), 230-235
    DOI 10.1016/j.ygyno.2017.02.010, PubMed 28285846
  2. Ducie JA, Eriksson AGZ, Ali N, McGree ME, Weaver AL, Bogani G, Cliby WA, Dowdy SC, Bakkum-Gamez JN, Soslow RA, Keeney GL, Abu-Rustum NR, Mariani A, Leitao MM (2017)
    Comparison of a sentinel lymph node mapping algorithm and comprehensive lymphadenectomy in the detection of stage IIIC endometrial carcinoma at higher risk for nodal disease
    Gynecol Oncol, 147 (3), 541-548
    DOI 10.1016/j.ygyno.2017.09.030, PubMed 28965698
  3. Eriksson AG, Beavis A, Soslow RA, Zhou Q, Abu-Rustum NR, Gardner GJ, Zivanovic O, Long Roche K, Sonoda Y, Leitao MM, Jewell EL (2017)
    A Comparison of the Detection of Sentinel Lymph Nodes Using Indocyanine Green and Near-Infrared Fluorescence Imaging Versus Blue Dye During Robotic Surgery in Uterine Cancer
    Int J Gynecol Cancer, 27 (4), 743-747
    DOI 10.1097/IGC.0000000000000959, PubMed 28375931
  4. Eriksson AGZ, Graul A, Yu MC, Halko A, Chi DS, Zivanovic O, Gardner GJ, Sonoda Y, Barakat RR, Abu-Rustum NR, Leitao MM (2017)
    Minimal access surgery compared to laparotomy for secondary surgical cytoreduction in patients with recurrent ovarian carcinoma: Perioperative and oncologic outcomes
    Gynecol Oncol, 146 (2), 263-267
    DOI 10.1016/j.ygyno.2017.05.022, PubMed 28527673

Publications 2016

  1. Eriksson AG, Montovano M, Beavis A, Soslow RA, Zhou Q, Abu-Rustum NR, Gardner GJ, Zivanovic O, Barakat RR, Brown CL, Levine DA, Sonoda Y, Leitao MM, Jewell EL (2016)
    Impact of Obesity on Sentinel Lymph Node Mapping in Patients with Newly Diagnosed Uterine Cancer Undergoing Robotic Surgery
    Ann Surg Oncol, 23 (8), 2522-8
    DOI 10.1245/s10434-016-5134-2, PubMed 26905542
  2. Leitao MM, Narain WR, Boccamazzo D, Sioulas V, Cassella D, Ducie JA, Eriksson AG, Sonoda Y, Chi DS, Brown CL, Levine DA, Jewell EL, Zivanovic O, Barakat RR, Abu-Rustum NR, Gardner GJ (2016)
    Impact of Robotic Platforms on Surgical Approach and Costs in the Management of Morbidly Obese Patients with Newly Diagnosed Uterine Cancer
    Ann Surg Oncol, 23 (7), 2192-8
    DOI 10.1245/s10434-015-5062-6, PubMed 26744108
  3. Mueller JJ, Zhou QC, Iasonos A, O'Cearbhaill RE, Alvi FA, El Haraki A, Eriksson AG, Gardner GJ, Sonoda Y, Levine DA, Aghajanian C, Chi DS, Abu-Rustum NR, Zivanovic O (2016)
    Neoadjuvant chemotherapy and primary debulking surgery utilization for advanced-stage ovarian cancer at a comprehensive cancer center
    Gynecol Oncol, 140 (3), 436-42
    DOI 10.1016/j.ygyno.2016.01.008, PubMed 26777991

Publications 2015

  1. St Clair CM, Eriksson AG, Ducie JA, Jewell EL, Alektiar KM, Hensley ML, Soslow RA, Abu-Rustum NR, Leitao MM (2015)
    Low-Volume Lymph Node Metastasis Discovered During Sentinel Lymph Node Mapping for Endometrial Carcinoma
    Ann Surg Oncol, 23 (5), 1653-9
    DOI 10.1245/s10434-015-5040-z, PubMed 26714954
  2. Zahl Eriksson AG, Ducie J, Ali N, McGree ME, Weaver AL, Bogani G, Cliby WA, Dowdy SC, Bakkum-Gamez JN, Abu-Rustum NR, Mariani A, Leitao MM (2015)
    Comparison of a sentinel lymph node and a selective lymphadenectomy algorithm in patients with endometrioid endometrial carcinoma and limited myometrial invasion
    Gynecol Oncol, 140 (3), 394-9
    DOI 10.1016/j.ygyno.2015.12.028, PubMed 26747778

Publications 2011

  1. Staff AC, Trovik J, Eriksson AG, Wik E, Wollert KC, Kempf T, Salvesen HB (2011)
    Elevated plasma growth differentiation factor-15 correlates with lymph node metastases and poor survival in endometrial cancer
    Clin Cancer Res, 17 (14), 4825-33
    DOI 10.1158/1078-0432.CCR-11-0715, PubMed 21616994

Publications 2002

  1. Blaas HG, Eriksson AG, Salvesen KA, Isaksen CV, Christensen B, Møllerløkken G, Eik-Nes SH (2002)
    Brains and faces in holoprosencephaly: pre- and postnatal description of 30 cases
    Ultrasound Obstet Gynecol, 19 (1), 24-38
    DOI 10.1046/j.0960-7692.2001.00154.x, PubMed 11851965