“Centre for Cancer Cell Reprogramming”, affiliated with the Institute of Clinical Medicine at University of Oslo, has been funded by the Research Council of Norway as a new Centre of Excellence.
Jørgen Wesche appointed group leader for the Mesenchymal Cancer Biology Group at the Department of Tumor Biology
Jørgen Wesche earned his PhD in Sjur Olsnes's group in 2001, studying intracellular transport and membrane translocation. During his postdoctoral training, spending some time at Institute Curie in Paris, he has changed his focus towards problems with more translational relevance, specializing in live cell imaging, fibroblast growth factor receptor (FGFR) signaling and importance of FGFR in cell migration/invasion. Aberrations in FGFR signaling are found in several types of sarcoma and that´s the main reason way Jørgen started to get interested in sarcoma biology and treatment. He has several exciting ideas on how to further develop his research into more translational/clinical relevance.
Professor Per Ottar Seglen, formerly head of the Proteomics & Mammalian Cell Biology Section at the Institute for Cancer Research, OUH, currently a guest researcher at NCMM, has been awarded the prestigious King Olav V’s prize for Cancer Research 2017.
The award, formally announced by the Norwegian Cancer Society today, is recognized as one of the Norwegian cancer research community’s most respected prizes. Professor Seglen has been awarded the prize in recognition of his ground-breaking research into autophagic-lysosomal protein degradation and its relationship to cancer.
The prize will be officially presented by King Harald V, on behalf of the Cancer Society, at a special ceremony on 6 June 2017. The prize is NOK 1 million.
Welcome to the next Oslo University Hospital research seminar entitled "Health after transplantation".
Time: Monday, March 6th, 2017, at 14:30 – 16:00.
Place: Red Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.
Like a fingerprint, the connections of the human brain render us distinct from one another. In a study published in the February 20th issue of Nature Neuroscience (journal impact factor 16.7), entitled "Delayed stabilization and individualization in connectome development are related to psychiatric disorders", researchers at NORMENT reveal that such a unique, fingerprint-like pattern evolves during development and is sensitive to mental health. First and last authors are Tobias Kaufmann and Lars T. Westlye (photo).
The study has already gained attention, and the results have been discussed in articles published in Science Daily and Medical News Today.
Professor Arne Klungland, section head at the Department of Microbiology, will hold a lecture on the subject of embryonic development during a breakfast meeting held by the The Norwegian Biotechnology Advisory Board (Bioteknologirådet).
Klungland is the leader of several research projects aiming at understanding the first few days during embryonic development, and gain insight into the early development of various diseases.
Time: March 1st 8.15-9.30 AM (breakfast from 8.15, lecture starts 8.30)
Place: Håndverkeren, Galleriet (1st floor)
This is a unique seminar with the Olav Thon Foundation's International Research Awardees for Mathematics and Natural Science and Medicine 2017.
The first talk will be held by International Research Prize winner Jan Hoeijmakers from Erasmus University Rotterdam, who is one of the most significant scientists in molecular genetics of our time.
Further talks will be held by Research Awardee Mahmood Amiry-Moghaddam on Parkinson's disease, and by Research Awardees Henrik Zetterberg and Nenad Bogdanovic on Alzheimer research.
Time and place: March 2nd, 2017 12:00 PM - 03:00 PM, Runde Auditorium R-105 at Domus Medica, Gaustad
Deadline for registration: February 23rd
Sports play an important role in our society. Four Norwegian researchers, two from OUS, have published an article in EMBO reports where they discuss problems occurring in the testing of athletes for doping.
The authors (E. Boye and T. Skotland from OUS (photo), J. Nissen-Meyer from UiO and B. Østerud, UiTø) describe how the World Antidoping Agency (WADA) pretends never to make mistakes and is resistant to any form of discussion with other scientists. This attitude creates false positives and athletes are being sanctioned while innocent, with dramatic consequences for the individual. It is argued that both the technological, ethical and legal procedures should be revised and an independent body should monitor the function of WADA.
Welcome to the next Oslo University Hospital research seminar entitled "Early phase drug development: From idea to concept".
Time: Monday, February 6th, 2017, at 14:30 – 16:00.
Place: Blue Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.
"Science" article from Johanna Olweus's group highlighted by editorial in New England Journal of Medicine
The article "Targeting of cancer neoantigens with donor-derived T cell receptor repertoires" by Erlend Strønen et al, published in Science in June 2016, is highlighted by an editorial in the "Clinical Implications of Basic Research" section in the Feb 2nd edition of New England Journal of Medicine.
The editorial is entitled "The Antigenicity of the Tumor Cell — Context Matters".
Every year 16.000 Norwegians are stricken with stroke, and more than 60.000 have previously had one or more strokes. It is therefore important that the foremost Norwegian experts in the field gather in order and be updated on what is new within preventive, acute treatment and rehabilitation from stroke.
David Russell from the Department of Neurology at the Division of Surgery and Clinical Neuroscience at Oslo University Hospital welcomes participants to the 6th national conference on stroke - "den 6. Nasjonale konferanse om Hjerneslag".
The South-Eastern Norway Regional Health Authority (Helse Sør-Øst) aims to profile ongoing excellent research in the region by calling special attention to a "Scientist of the Month".
For the month of January 2017, this honour went to Theis Tønnessen, leader of the "Genetics of autoimmunity and cancer" group at the Department of Medical Genetics at the Division of Diagnostics and Intervention, Oslo University Hospital.
Welcome to the next Oslo University Hospital research seminar entitled "Sepsis: New definitions and future research".
Time: Monday, Thursday, January 26th, 2017, at 13:45 – 15:15.
Place: Red Auditorium, Rikshospitalet, Sognsvannsveien 20, Oslo.
Oslo University Hospital hereby announce research awards in the following two catagories for 2017:
- Excellent Researcher Award (one prize, 300.000 NOK)
- Early Career Award (two prizes of 150.000 NOK each)
The candidate must be employed by Oslo University Hospital or University of Oslo, and be a member of a research group at Oslo University Hospital/University of Oslo.
Welcome to the next Oslo University Hospital research seminar entitled "Antimicrobial resistance - how bad is the situation in the world of virus, fungus and mycoplasma?".
Time: Monday, January 16th, 2017, at 14:30 – 16:00.
Place: Blue Auditorium, Rikshospitalet, Sognsvannsveien 20
Findings from Rusten group published in Nature on microenvironmental autophagy draw nationwide attention
Nadja Katheder and collaborators in the lab of Tor Erik Rusten, the Department of Molecular Cell Biology, and CCB has published an article entitled "Microenvironmental autophagy supports tumor growth", in an advanced online publication 11th of January in the journal Nature (journal impact factor 41.46).
The findings have been subject to news coverage by the Norwegian national broadcasting corporation (NRK).
The prestigious journal "Developmental Cell" has recently published an article in their "Previews" section, entitled "Breaking Down Neighbors to Fuel Tumorigenesis". Here, the authors discuss how the work of Katheder and colleagues "opens new avenues for understanding and manipulating cancers through cell-cell communication."
In the Nature Methods (journal impact factor 25.3) January 2017 issue “Epitranscriptome analysis” is presented as the method of the year. In recent years, it has become clear that RNA molecules, including mRNAs, can be dynamically modified. Thus, this allows for a new strategy for gene regulation with vital biological consequences. Epitranscriptome analysis relates to methods that can profile RNA modifications in a sequence specific manner. In a commentary to this discovery, Klungland and co-workers from Department of Microbiology and Department of Gynecology, OUS, discuss the role of such modifications for the maturation of sperm and egg (meiosis) and pluripotent cells.
The board of the South-Eastern Norway Regional Health Authority (Helse Sør-Øst) has distributed financial resources to new research projects for 2017. Of the in total 568 incoming applications 121 new projects were granted support.
A substantial amount of the resources goes to young researchers. Support is given to a number og doctoral and post doctoral stipendiates, as well as to researcher grants and career grants. The latter category is for young outstanding researchers planning to establish an independent research group.
As part of the collaboration between Oslo Cancer Cluster and Ullern high shool, a total of 40 students visited six different laboratories at the Oslo University Hospital and the National Institute for Public Health last week. A journalist from Framtida.no interviewed the six students who visited the Department for Tumor biologi. Researchers Siri Tveito and Karen-Marie Heintz guided them through immunoflourescence, PCR, gel electrophoresis and other techniques in the lab, and the students were eager to learn about the life of a cancer researcher.
First author Kristina Berg Lorvik and senior author Alexandre Corthay
Collaborative efforts by researchers at the Department of Immunology and the Department of Pathology revealed the unexpected potential of tumor-specific Th2 cells for cancer immunotherapy by adoptive cell transfer (ACT) in mice.
The study was published in the December 1st 2016 issue of Cancer Research, the flagship journal of the American Association for Cancer Research. An immunofluorescence microscopy image from the paper was selected to illustrate the journal cover.