Genome Biology Group

Rolf I. Skotheim

The research group aims to improve the diagnosis and management of cancer by utilizing genome technologies. The research projects are primarily focusing on prostate cancer, although the group also performs research on ovarian, testicular, and colorectal cancers. Cancer genomes and transcriptomes are studied by a combination of computational biology and wet-lab based approaches. Mutation analyses in cancer clearly benefit from knowing which genes and variants that are actually expressed. In this line, the group has particularly specialized in RNA-level analyses. To perform meaningful translational and genome-scale cancer research, interdisciplinary work is required. As such, the personnel have their basic education across the disciplines of biology, informatics, and medicine.

The research group includes a project group in Cancer informatics, led by Dr. Bjarne Johannessen.

Diseases
Prostate cancer
Ovarian cancer
Testicular germ cell tumour
Colorectal cancer

Projects
Interfocal heterogeneity of prostate cancer, and implications for precision cancer management
RNA variation caused by aberrant splicing and as a source of cancer biomarkers
Fusion gene identification and characterisation


Contact information:

Department of Molecular Oncology, Institute for Cancer Research
Oslo University Hospital-Radiumhospitalet
P.O.Box 4953 Nydalen, NO-0424 Oslo, Norway
Phone: +47 2278 1727 / +47 2293 4000
E mail: rolf.i.skotheim@rr-research.no