Publications

Publications from OUS - Genome Biology Group (Skotheim)

111 publications found

Publications 2024

1. Skotheim RI, Bogaard M, Carm KT, Axcrona U, Axcrona K (2024)
   Prostate cancer: Molecular aspects, consequences, and opportunities of the multifocal nature
   Biochim Biophys Acta Rev Cancer, 1879 (2), 189080
   DOI 10.1016/j.bbcan.2024.189080, PubMed 38272101
2. Sveen A, Johannessen B, Klokkerud SM, Kraggerud SM, Meza-Zepeda LA, Bjørnslett M, Bischof K, Myklebost O, Taskén K, Skotheim RI, Dørum A, Davidson B, Lothe RA (2024)
   Evolutionary mode and timing of dissemination of high-grade serous carcinomas
   JCI Insight, 9 (3)
   DOI 10.1172/jci.insight.170423, PubMed 38175731

Publications 2023

1. Bogaard M, Skotheim RI, Maltau AV, Kidd SG, Lothe RA, Axcrona K, Axcrona U (2023)
   'High proliferative cribriform prostate cancer' defines a patient subgroup with an inferior prognosis
   Histopathology, 83 (6), 853-869
   DOI 10.1111/his.15012, PubMed 37501635
2. Meier Strømme J, Johannessen B, Skotheim RI (2023)
   Deviating Alternative Splicing as a Molecular Subtype of Microsatellite Stable Colorectal Cancer
   JCO Clin Cancer Inform, 7, e2200159
   DOI 10.1200/CCI.22.00159, PubMed 36821799

Publications 2022

1. Axcrona K, Aas K, Axcrona U, Skotheim RI (2022)
   Re: Spatially Resolved Clonal Copy Number Alterations in Benign and Malignant Tissue
   Eur Urol, 83 (2), 183
   DOI 10.1016/j.eururo.2022.11.013, PubMed 36464529
2. Carm KT, Johannessen B, Bogaard M, Bakken AC, Maltau AV, Hoff AM, Axcrona U, Axcrona K, Lothe RA, Skotheim RI (2022)
   Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer
   Int J Cancer, 152 (5), 945-951
   DOI 10.1002/ijc.34226, PubMed 35880692
3. Fontugne J, Cai PY, Alnajar H, Bhinder B, Park K, Ye H, Beg S, Sailer V, Siddiqui J, Blattner-Johnson M, Croyle JA, Noorzad Z, Calagua C, MacDonald TY, Axcrona U, Bogaard M, Axcrona K, Scherr DS, Sanda MG, Johannessen B, Chinnaiyan AM, Elemento O, Skotheim RI, Rubin MA, Barbieri CE et al. (2022)
   Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci
   JCI Insight, 7 (4)
   DOI 10.1172/jci.insight.155309, PubMed 35050902
4. Grasso C, Popovic M, Isaevska E, Lazzarato F, Fiano V, Zugna D, Pluta J, Weathers B, D'Andrea K, Almstrup K, Anson-Cartwright L, Bishop DT, Chanock SJ, Chen C, Cortessis VK, Dalgaard MD, Daneshmand S, Ferlin A, Foresta C, Frone MN, Gamulin M, Gietema JA, Greene MH, Grotmol T, Hamilton RJ et al. (2022)
   Association Study between Polymorphisms in DNA Methylation-Related Genes and Testicular Germ Cell Tumor Risk
   Cancer Epidemiol Biomarkers Prev, 31 (9), 1769-1779
   DOI 10.1158/1055-9965.EPI-22-0123, PubMed 35700037
5. Hugosson J, Månsson M, Wallström J, Axcrona U, Carlsson SV, Egevad L, Geterud K, Khatami A, Kohestani K, Pihl CG, Socratous A, Stranne J, Godtman RA, Hellström M, GÖTEBORG-2 Trial Investigators (2022)
   Prostate Cancer Screening with PSA and MRI Followed by Targeted Biopsy Only
   N Engl J Med, 387 (23), 2126-2137
   DOI 10.1056/NEJMoa2209454, PubMed 36477032
6. Kidd SG, Bogaard M, Carm KT, Bakken AC, Maltau AMV, Løvf M, Lothe RA, Axcrona K, Axcrona U, Skotheim RI (2022)
   In situ expression of ERG protein in the context of tumor heterogeneity identifies prostate cancer patients with inferior prognosis
   Mol Oncol, 16 (15), 2810-2822
   DOI 10.1002/1878-0261.13225, PubMed 35574900
7. Skotheim RI, Axcrona U, Axcrona K (2022)
   Re: Fibroblast Growth Factor Receptor 1 Drives the Metastatic Progression of Prostate Cancer
   Eur Urol, 81 (4), 431
   DOI 10.1016/j.eururo.2021.12.031, PubMed 35031159
8. Strømme JM, Johannessen B, Kidd SG, Bogaard M, Carm KT, Zhang X, Sveen A, Mathelier A, Lothe RA, Axcrona U, Axcrona K, Skotheim RI (2022)
   Expressed prognostic biomarkers for primary prostate cancer independent of multifocality and transcriptome heterogeneity
   Cancer Gene Ther, 29 (8-9), 1276-1284
   DOI 10.1038/s41417-022-00444-7, PubMed 35194199
9. Wolowczyk C, Neckmann U, Aure MR, Hall M, Johannessen B, Zhao S, Skotheim RI, Andersen SB, Zwiggelaar R, Steigedal TS, Lingjærde OC, Sahlberg KK, Almaas E, Bjørkøy G (2022)
   NRF2 drives an oxidative stress response predictive of breast cancer
   Free Radic Biol Med, 184, 170-184
   DOI 10.1016/j.freeradbiomed.2022.03.029, PubMed 35381325

Publications 2021

1. Kidd SG, Carm KT, Bogaard M, Olsen LG, Bakken AC, Løvf M, Lothe RA, Axcrona K, Axcrona U, Skotheim RI (2021)
   High expression of SCHLAP1 in primary prostate cancer is an independent predictor of biochemical recurrence, despite substantial heterogeneity
   Neoplasia, 23 (6), 634-641
   DOI 10.1016/j.neo.2021.05.012, PubMed 34107378
2. Sveen A, Johannessen B, Eilertsen IA, Røsok BI, Gulla M, Eide PW, Bruun J, Kryeziu K, Meza-Zepeda LA, Myklebost O, Bjørnbeth BA, Skotheim RI, Nesbakken A, Lothe RA (2021)
   The expressed mutational landscape of microsatellite stable colorectal cancers
   Genome Med, 13 (1), 142
   DOI 10.1186/s13073-021-00955-2, PubMed 34470667
3. Tryggestad AMA, Axcrona K, Axcrona U, Bigalke I, Brennhovd B, Inderberg EM, Hønnåshagen TK, Skoge LJ, Solum G, Saebøe-Larssen S, Josefsen D, Olaussen RW, Aamdal S, Skotheim RI, Myklebust TÅ, Schendel DJ, Lilleby W, Dueland S, Kvalheim G (2021)
   Long-term first-in-man Phase I/II study of an adjuvant dendritic cell vaccine in patients with high-risk prostate cancer after radical prostatectomy
   Prostate, 82 (2), 245-253
   DOI 10.1002/pros.24267, PubMed 34762317

Publications 2020

1. Hoff AM, Kraggerud SM, Alagaratnam S, Berg KCG, Johannessen B, Høland M, Nilsen G, Lingjærde OC, Andrews PW, Lothe RA, Skotheim RI (2020)
   Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas
   Endocr Relat Cancer, 27 (9), 457-468
   DOI 10.1530/ERC-20-0064, PubMed 32580154
2. Smeby J, Kryeziu K, Berg KCG, Eilertsen IA, Eide PW, Johannessen B, Guren MG, Nesbakken A, Bruun J, Lothe RA, Sveen A (2020)
   Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity
   EBioMedicine, 59, 102923
   DOI 10.1016/j.ebiom.2020.102923, PubMed 32799124
3. Wise JF, Nakken S, Steen CB, Vodák D, Trøen G, Johannessen B, Lingjærde OC, Hilden V, Blaker YN, Bai B, Aasheim LB, Pasanen A, Lorenz S, Sveen A, Lothe RA, Myklebost O, Leppä S, Meza-Zepeda LA, Beiske K, Lawrence MS, Hovig E, Myklebust JH, Smeland EB, Holte H (2020)
   Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
   Blood Adv, 4 (9), 1859-1866
   DOI 10.1182/bloodadvances.2019001325, PubMed 32374878
4. Zhao S, Hoff AM, Skotheim RI (2020)
   ScaR-a tool for sensitive detection of known fusion transcripts: establishing prevalence of fusions in testicular germ cell tumors
   NAR Genom Bioinform, 2 (1), lqz025
   DOI 10.1093/nargab/lqz025, PubMed 33575572

Publications 2019

1. Brunsell TH, Sveen A, Bjørnbeth BA, Røsok BI, Danielsen SA, Brudvik KW, Berg KCG, Johannessen B, Cengija V, Abildgaard A, Guren MG, Nesbakken A, Lothe RA (2019)
   High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases
   Clin Colorectal Cancer, 19 (1), e26-e47
   DOI 10.1016/j.clcc.2019.09.003, PubMed 31982351
2. Carm KT, Hoff AM, Bakken AC, Axcrona U, Axcrona K, Lothe RA, Skotheim RI, Løvf M (2019)
   Interfocal heterogeneity challenges the clinical usefulness of molecular classification of primary prostate cancer
   Sci Rep, 9 (1), 13579
   DOI 10.1038/s41598-019-49964-7, PubMed 31537872
3. Eilertsen IA, Moosavi SH, Strømme JM, Nesbakken A, Johannessen B, Lothe RA, Sveen A (2019)
   Technical differences between sequencing and microarray platforms impact transcriptomic subtyping of colorectal cancer
   Cancer Lett, 469, 246-255
   DOI 10.1016/j.canlet.2019.10.040, PubMed 31678167
4. Neckmann U, Wolowczyk C, Hall M, Almaas E, Ren J, Zhao S, Johannessen B, Skotheim RI, Bjørkøy G, Ten Dijke P, Holien T (2019)
   GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients
   Cell Commun Signal, 17 (1), 140
   DOI 10.1186/s12964-019-0467-7, PubMed 31694641
5. Smeby J, Sveen A, Eilertsen IA, Danielsen SA, Hoff AM, Eide PW, Johannessen B, Hektoen M, Skotheim RI, Guren MG, Nesbakken A, Lothe RA (2019)
   Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
   Oncogenesis, 8 (6), 35
   DOI 10.1038/s41389-019-0141-3, PubMed 31092812

Publications 2018

1. Celestino R, Nome T, Pestana A, Hoff AM, Gonçalves AP, Pereira L, Cavadas B, Eloy C, Bjøro T, Sobrinho-Simões M, Skotheim RI, Soares P (2018)
   CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension
   BMC Cancer, 18 (1), 68
   DOI 10.1186/s12885-017-3948-3, PubMed 29321030
2. Eilertsen IA, Sveen A, Strømme JM, Skotheim RI, Nesbakken A, Lothe RA (2018)
   Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer
   Int J Cancer, 144 (4), 841-847
   DOI 10.1002/ijc.31809, PubMed 30121958
3. Løvf M, Zhao S, Axcrona U, Johannessen B, Bakken AC, Carm KT, Hoff AM, Myklebost O, Meza-Zepeda LA, Lie AK, Axcrona K, Lothe RA, Skotheim RI (2018)
   Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity
   Eur Urol, 75 (3), 498-505
   DOI 10.1016/j.eururo.2018.08.009, PubMed 30181068
4. Rajpert-De Meyts E, Skotheim RI (2018)
   Complex Polygenic Nature of Testicular Germ Cell Cancer Suggests Multifactorial Aetiology
   Eur Urol, 73 (6), 832-833
   DOI 10.1016/j.eururo.2018.02.023, PubMed 29530636
5. Viswanathan SR, Ha G, Hoff AM, Wala JA, Carrot-Zhang J, Whelan CW, Haradhvala NJ, Freeman SS, Reed SC, Rhoades J, Polak P, Cipicchio M, Wankowicz SA, Wong A, Kamath T, Zhang Z, Gydush GJ, Rotem D, PCF/SU2C International Prostate Cancer Dream Team, Love JC, Getz G, Gabriel S, Zhang CZ, Dehm SM, Nelson PS et al. (2018)
   Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing
   Cell, 174 (2), 433-447.e19
   DOI 10.1016/j.cell.2018.05.036, PubMed 29909985

Publications 2017

1. Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, Myklebost O, Skotheim RI, Sveen A, Lothe RA (2017)
   Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
   Mol Cancer, 16 (1), 116
   DOI 10.1186/s12943-017-0691-y, PubMed 28683746
2. Lågstad S, Zhao S, Hoff AM, Johannessen B, Lingjærde OC, Skotheim RI (2017)
   chimeraviz: a tool for visualizing chimeric RNA
   Bioinformatics, 33 (18), 2954-2956
   DOI 10.1093/bioinformatics/btx329, PubMed 28525538
3. Smebye ML, Agostini A, Johannessen B, Thorsen J, Davidson B, Tropé CG, Heim S, Skotheim RI, Micci F (2017)
   Involvement of DPP9 in gene fusions in serous ovarian carcinoma
   BMC Cancer, 17 (1), 642
   DOI 10.1186/s12885-017-3625-6, PubMed 28893231
4. Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
   Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
   Genome Med, 9 (1), 46
   DOI 10.1186/s13073-017-0434-0, PubMed 28539123
5. Zhao S, Løvf M, Carm KT, Bakken AC, Hoff AM, Skotheim RI (2017)
   Novel transcription-induced fusion RNAs in prostate cancer
   Oncotarget, 8 (30), 49133-49143
   DOI 10.18632/oncotarget.17099, PubMed 28467780

Publications 2016

1. Cekaite L, Eide PW, Lind GE, Skotheim RI, Lothe RA (2016)
   MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer
   Oncotarget, 7 (6), 6476-505
   DOI 10.18632/oncotarget.6390, PubMed 26623728
2. Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne JC, Håkelien AM, Fernandez-Cuesta L, Möhlendick B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GO, Skotheim RI, Lothe RA, Tarpey PS, Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA (2016)
   Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
   Oncotarget, 7 (5), 5273-88
   DOI 10.18632/oncotarget.6567, PubMed 26672768
3. Moen LV, Ramberg H, Zhao S, Grytli HH, Sveen A, Berge V, Skotheim RI, Taskén KA, Skålhegg BS (2016)
   Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness
   Urol Oncol, 35 (3), 111.e1-111.e8
   DOI 10.1016/j.urolonc.2016.10.002, PubMed 27838142
4. Ramberg H, Grytli HH, Nygård S, Wang W, Ögren O, Zhao S, Løvf M, Katz B, Skotheim RI, Bjartell A, Eri LM, Berge V, Svindland A, Taskén KA (2016)
   PBX3 is a putative biomarker of aggressive prostate cancer
   Int J Cancer, 139 (8), 1810-20
   DOI 10.1002/ijc.30220, PubMed 27273830
5. Smebye ML, Haugom L, Davidson B, Trope CG, Heim S, Skotheim RI, Micci F (2016)
   Bilateral ovarian carcinomas differ in the expression of metastasis-related genes
   Oncol Lett, 13 (1), 184-190
   DOI 10.3892/ol.2016.5384, PubMed 28123539

Publications 2015

1. Brabrand S, Johannessen B, Axcrona U, Kraggerud SM, Berg KG, Bakken AC, Bruun J, Fosså SD, Lothe RA, Lehne G, Skotheim RI (2015)
   Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages
   Neoplasia, 17 (2), 167-74
   DOI 10.1016/j.neo.2014.12.005, PubMed 25748235
2. Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
   Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
   Clin Cancer Res, 21 (16), 3759-70
   DOI 10.1158/1078-0432.CCR-14-3294, PubMed 25910952
3. Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA, Skotheim RI (2015)
   Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
   Cancer Res, 76 (1), 108-16
   DOI 10.1158/0008-5472.CAN-15-1790, PubMed 26659575
4. Hoff AM, Johannessen B, Alagaratnam S, Zhao S, Nome T, Løvf M, Bakken AC, Hektoen M, Sveen A, Lothe RA, Skotheim RI (2015)
   Novel RNA variants in colorectal cancers
   Oncotarget, 6 (34), 36587-602
   DOI 10.18632/oncotarget.5500, PubMed 26474385
5. Johannessen B, Sveen A, Skotheim RI (2015)
   TIN: An R Package for Transcriptome Instability Analysis
   Cancer Inform, 14, 109-12
   DOI 10.4137/CIN.S31363, PubMed 26448683
6. Kolberg M, Høland M, Lind GE, Ågesen TH, Skotheim RI, Hall KS, Mandahl N, Smeland S, Mertens F, Davidson B, Lothe RA (2015)
   Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection
   Mol Oncol, 9 (6), 1129-39
   DOI 10.1016/j.molonc.2015.02.005, PubMed 25769404
7. Kumar S, Krabberød AK, Neumann RS, Michalickova K, Zhao S, Zhang X, Shalchian-Tabrizi K (2015)
   BIR Pipeline for Preparation of Phylogenomic Data
   Evol Bioinform Online, 11, 79-83
   DOI 10.4137/EBO.S10189, PubMed 25987827
8. Mesquita D, Barros-Silva JD, Santos J, Skotheim RI, Lothe RA, Paulo P, Teixeira MR (2015)
   Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts
   Oncotarget, 6 (7), 5217-36
   DOI 10.18632/oncotarget.2847, PubMed 25595908
9. Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, McCullagh P, McGrath J, Crundwell M, Skotheim RI, Robson CN, Leung HY, Harries LW, Rajan P, Mills IG, Elliott DJ (2015)
   The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer
   Oncotarget, 6 (33), 34358-74
   DOI 10.18632/oncotarget.6024, PubMed 26452038
10. Rounge TB, Furu K, Skotheim RI, Haugen TB, Grotmol T, Enerly E (2015)
    Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs
    Mol Cancer, 14, 153
    DOI 10.1186/s12943-015-0411-4, PubMed 26265322
11. Sveen A, Kilpinen S, Ruusulehto A, Lothe RA, Skotheim RI (2015)
    Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
    Oncogene, 35 (19), 2413-27
    DOI 10.1038/onc.2015.318, PubMed 26300000

Publications 2014

1. Løvf M, Nome T, Bruun J, Eknaes M, Bakken AC, Mpindi JP, Kilpinen S, Rognum TO, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2014)
   A novel transcript, VNN1-AB, as a biomarker for colorectal cancer
   Int J Cancer, 135 (9), 2077-84
   DOI 10.1002/ijc.28855, PubMed 24687856
2. Nome T, Hoff AM, Bakken AC, Rognum TO, Nesbakken A, Skotheim RI (2014)
   High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants
   PLoS One, 9 (3), e91264
   DOI 10.1371/journal.pone.0091264, PubMed 24608966
3. Oppelt A, Haugsten EM, Zech T, Danielsen HE, Sveen A, Lobert VH, Skotheim RI, Wesche J (2014)
   PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1
   Biochem J, 461 (3), 383-90
   DOI 10.1042/BJ20140132, PubMed 24840251
4. Smebye ML, Sveen A, Haugom L, Davidson B, Tropé CG, Lothe RA, Heim S, Skotheim RI, Micci F (2014)
   Chromosome 19 rearrangements in ovarian carcinomas: zinc finger genes are particularly targeted
   Genes Chromosomes Cancer, 53 (7), 558-67
   DOI 10.1002/gcc.22166, PubMed 24634323
5. Sveen A, Johannessen B, Teixeira MR, Lothe RA, Skotheim RI (2014)
   Transcriptome instability as a molecular pan-cancer characteristic of carcinomas
   BMC Genomics, 15 (1), 672
   DOI 10.1186/1471-2164-15-672, PubMed 25109687
6. Vedeld HM, Skotheim RI, Lothe RA, Lind GE (2014)
   The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer
   Epigenetics, 9 (3), 346-50
   DOI 10.4161/epi.27582, PubMed 24384857

Publications 2013

1. Alagaratnam S, Harrison N, Bakken AC, Hoff AM, Jones M, Sveen A, Moore HD, Andrews PW, Lothe RA, Skotheim RI (2013)
   Transforming pluripotency: an exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells
   Stem Cells Dev, 22 (7), 1136-46
   DOI 10.1089/scd.2012.0369, PubMed 23137282
2. Avery S, Hirst AJ, Baker D, Lim CY, Alagaratnam S, Skotheim RI, Lothe RA, Pera MF, Colman A, Robson P, Andrews PW, Knowles BB (2013)
   BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures
   Stem Cell Reports, 1 (5), 379-86
   DOI 10.1016/j.stemcr.2013.10.005, PubMed 24286026
3. Barros-Silva JD, Paulo P, Bakken AC, Cerveira N, Løvf M, Henrique R, Jerónimo C, Lothe RA, Skotheim RI, Teixeira MR (2013)
   Novel 5' fusion partners of ETV1 and ETV4 in prostate cancer
   Neoplasia, 15 (7), 720-6
   DOI 10.1593/neo.13232, PubMed 23814484
4. Chung CC, Kanetsky PA, Wang Z, Hildebrandt MA, Koster R, Skotheim RI, Kratz CP, Turnbull C, Cortessis VK, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Jacobs KB, Korde LA, Kraggerud SM, Lothe RA, Loud JT, Rahman N, Skinner EC, Thomas DC, Wu X, Yeager M, Schumacher FR et al. (2013)
   Meta-analysis identifies four new loci associated with testicular germ cell tumor
   Nat Genet, 45 (6), 680-5
   DOI 10.1038/ng.2634, PubMed 23666239
5. Kraggerud SM, Hoei-Hansen CE, Alagaratnam S, Skotheim RI, Abeler VM, Rajpert-De Meyts E, Lothe RA (2013)
   Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis
   Endocr Rev, 34 (3), 339-76
   DOI 10.1210/er.2012-1045, PubMed 23575763
6. Løvf M, Thomassen GO, Mertens F, Cerveira N, Teixeira MR, Lothe RA, Skotheim RI (2013)
   Assessment of fusion gene status in sarcomas using a custom made fusion gene microarray
   PLoS One, 8 (8), e70649
   DOI 10.1371/journal.pone.0070649, PubMed 23967081
7. Nome T, Thomassen GO, Bruun J, Ahlquist T, Bakken AC, Hoff AM, Rognum T, Nesbakken A, Lorenz S, Sun J, Barros-Silva JD, Lind GE, Myklebost O, Teixeira MR, Meza-Zepeda LA, Lothe RA, Skotheim RI (2013)
   Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing
   Transl Oncol, 6 (5), 546-53
   DOI 10.1593/tlo.13457, PubMed 24151535
8. Schumacher FR, Wang Z, Skotheim RI, Koster R, Chung CC, Hildebrandt MA, Kratz CP, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Greene MH, Jacobs KB, Kanetsky PA, Kolonel LN, Loud JT, Korde LA, Le Marchand L, Lewinger JP, Lothe RA, Pike MC, Rahman N, Rubertone MV, Schwartz SM et al. (2013)
   Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23
   Hum Mol Genet, 22 (13), 2748-53
   DOI 10.1093/hmg/ddt109, PubMed 23462292

Publications 2012

1. Agesen TH, Sveen A, Merok MA, Lind GE, Nesbakken A, Skotheim RI, Lothe RA (2012)
   ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis
   Gut, 61 (11), 1560-7
   DOI 10.1136/gutjnl-2011-301179, PubMed 22213796
2. Camões MJ, Paulo P, Ribeiro FR, Barros-Silva JD, Almeida M, Costa VL, Cerveira N, Skotheim RI, Lothe RA, Henrique R, Jerónimo C, Teixeira MR (2012)
   Potential downstream target genes of aberrant ETS transcription factors are differentially affected in Ewing's sarcoma and prostate carcinoma
   PLoS One, 7 (11), e49819
   DOI 10.1371/journal.pone.0049819, PubMed 23185447
3. Cekaite L, Rantala JK, Bruun J, Guriby M, Agesen TH, Danielsen SA, Lind GE, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2012)
   MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer
   Neoplasia, 14 (9), 868-79
   DOI 10.1593/neo.121094, PubMed 23019418
4. Celestino R, Sigstad E, Løvf M, Thomassen GO, Grøholt KK, Jørgensen LH, Berner A, Castro P, Lothe RA, Bjøro T, Sobrinho-Simões M, Soares P, Skotheim RI (2012)
   Survey of 548 oncogenic fusion transcripts in thyroid tumors supports the importance of the already established thyroid fusions genes
   Genes Chromosomes Cancer, 51 (12), 1154-64
   DOI 10.1002/gcc.22003, PubMed 22961909
5. Matheu A, Collado M, Wise C, Manterola L, Cekaite L, Tye AJ, Canamero M, Bujanda L, Schedl A, Cheah KS, Skotheim RI, Lothe RA, López de Munain A, Briscoe J, Serrano M, Lovell-Badge R (2012)
   Oncogenicity of the developmental transcription factor Sox9
   Cancer Res, 72 (5), 1301-15
   DOI 10.1158/0008-5472.CAN-11-3660, PubMed 22246670
6. Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012)
   Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma
   PLoS One, 7 (11), e49705
   DOI 10.1371/journal.pone.0049705, PubMed 23185413
7. Paulo P, Ribeiro FR, Santos J, Mesquita D, Almeida M, Barros-Silva JD, Itkonen H, Henrique R, Jerónimo C, Sveen A, Mills IG, Skotheim RI, Lothe RA, Teixeira MR (2012)
   Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements
   Neoplasia, 14 (7), 600-11
   DOI 10.1593/neo.12600, PubMed 22904677
8. Sveen A, Bakken AC, Ågesen TH, Lind GE, Nesbakken A, Nordgård O, Brackmann S, Rognum TO, Lothe RA, Skotheim RI (2012)
   The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer
   Int J Cancer, 131 (6), 1479-85
   DOI 10.1002/ijc.27399, PubMed 22173985
9. Sveen A, Ågesen TH, Nesbakken A, Meling GI, Rognum TO, Liestøl K, Skotheim RI, Lothe RA (2012)
   ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients
   Clin Cancer Res, 18 (21), 6001-10
   DOI 10.1158/1078-0432.CCR-11-3302, PubMed 22991413

Publications 2011

1. Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA, Skotheim RI (2011)
   The testicular germ cell tumour transcriptome
   Int J Androl, 34 (4 Pt 2), e133-50; discussion e150-1
   DOI 10.1111/j.1365-2605.2011.01169.x, PubMed 21651573
2. Danielsen SA, Cekaite L, Ågesen TH, Sveen A, Nesbakken A, Thiis-Evensen E, Skotheim RI, Lind GE, Lothe RA (2011)
   Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome
   PLoS One, 6 (9), e24419
   DOI 10.1371/journal.pone.0024419, PubMed 21909432
3. Lind GE, Danielsen SA, Ahlquist T, Merok MA, Andresen K, Skotheim RI, Hektoen M, Rognum TO, Meling GI, Hoff G, Bretthauer M, Thiis-Evensen E, Nesbakken A, Lothe RA (2011)
   Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
   Mol Cancer, 10, 85
   DOI 10.1186/1476-4598-10-85, PubMed 21777459
4. Løvf M, Thomassen GO, Bakken AC, Celestino R, Fioretos T, Lind GE, Lothe RA, Skotheim RI (2011)
   Fusion gene microarray reveals cancer type-specificity among fusion genes
   Genes Chromosomes Cancer, 50 (5), 348-57
   DOI 10.1002/gcc.20860, PubMed 21305644
5. Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
   FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
   Genes Chromosomes Cancer, 51 (3), 240-9
   DOI 10.1002/gcc.20948, PubMed 22081504
6. Ribeiro FR, Paulo P, Costa VL, Barros-Silva JD, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
   Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene
   PLoS One, 6 (7), e22317
   DOI 10.1371/journal.pone.0022317, PubMed 21814574
7. Sagona AP, Nezis IP, Bache KG, Haglund K, Bakken AC, Skotheim RI, Stenmark H (2011)
   A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis
   PLoS One, 6 (3), e17086
   DOI 10.1371/journal.pone.0017086, PubMed 21455500
8. Sveen A, Agesen TH, Nesbakken A, Rognum TO, Lothe RA, Skotheim RI (2011)
   Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival
   Genome Med, 3 (5), 32
   DOI 10.1186/gm248, PubMed 21619627
9. Ågesen TH, Berg M, Clancy T, Thiis-Evensen E, Cekaite L, Lind GE, Nesland JM, Bakka A, Mala T, Hauss HJ, Fetveit T, Vatn MH, Hovig E, Nesbakken A, Lothe RA, Skotheim RI (2011)
   CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer
   Genes Immun, 12 (8), 653-62
   DOI 10.1038/gene.2011.43, PubMed 21716316

Publications 2010

1. Berg M, Agesen TH, Thiis-Evensen E, INFAC-study group, Merok MA, Teixeira MR, Vatn MH, Nesbakken A, Skotheim RI, Lothe RA (2010)
   Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
   Mol Cancer, 9, 100
   DOI 10.1186/1476-4598-9-100, PubMed 20459617
2. Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA (2010)
   Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
   J Clin Oncol, 28 (9), 1573-82
   DOI 10.1200/JCO.2009.24.8989, PubMed 20159821
3. Burum-Auensen E, Skotheim RI, Schjølberg AR, Røislien J, Lothe RA, Clausen OP (2010)
   Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors
   J Carcinog, 9, 1
   DOI 10.4103/1477-3163.60358, PubMed 20411023
4. Costa VL, Henrique R, Danielsen SA, Duarte-Pereira S, Eknaes M, Skotheim RI, Rodrigues A, Magalhães JS, Oliveira J, Lothe RA, Teixeira MR, Jerónimo C, Lind GE (2010)
   Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples
   Clin Cancer Res, 16 (23), 5842-51
   DOI 10.1158/1078-0432.CCR-10-1312, PubMed 20975101
5. Micci F, Skotheim RI, Haugom L, Weimer J, Eibak AM, Abeler VM, Trope CG, Arnold N, Lothe RA, Heim S (2010)
   Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes
   Genes Chromosomes Cancer, 49 (11), 1046-53
   DOI 10.1002/gcc.20813, PubMed 20725991
6. Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H (2010)
   PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
   Nat Cell Biol, 12 (4), 362-71
   DOI 10.1038/ncb2036, PubMed 20208530

Publications 2009

1. Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA (2009)
   Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
   Neuro Oncol, 11 (5), 514-28
   DOI 10.1215/15228517-2008-127, PubMed 19182148
2. Godmann M, Gashaw I, Eildermann K, Schweyer S, Bergmann M, Skotheim RI, Behr R (2009)
   The pluripotency transcription factor Krüppel-like factor 4 is strongly expressed in intratubular germ cell neoplasia unclassified and seminoma
   Mol Hum Reprod, 15 (8), 479-88
   DOI 10.1093/molehr/gap040, PubMed 19505997
3. Micci F, Weimer J, Haugom L, Skotheim RI, Grunewald R, Abeler VM, Silins I, Lothe RA, Trope CG, Arnold N, Heim S (2009)
   Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
   Genes Chromosomes Cancer, 48 (2), 184-93
   DOI 10.1002/gcc.20628, PubMed 18973136
4. Skotheim RI, Thomassen GO, Eken M, Lind GE, Micci F, Ribeiro FR, Cerveira N, Teixeira MR, Heim S, Rognes T, Lothe RA (2009)
   A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis
   Mol Cancer, 8, 5
   DOI 10.1186/1476-4598-8-5, PubMed 19152679

Publications 2008

1. Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA (2008)
   Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
   Mol Cancer, 7, 94
   DOI 10.1186/1476-4598-7-94, PubMed 19117505
2. Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA (2008)
   TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours
   Mol Cell Endocrinol, 306 (1-2), 75-80
   DOI 10.1016/j.mce.2008.10.043, PubMed 19041365
3. Kilpinen S, Autio R, Ojala K, Iljin K, Bucher E, Sara H, Pisto T, Saarela M, Skotheim RI, Björkman M, Mpindi JP, Haapa-Paananen S, Vainio P, Edgren H, Wolf M, Astola J, Nees M, Hautaniemi S, Kallioniemi O (2008)
   Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues
   Genome Biol, 9 (9), R139
   DOI 10.1186/gb-2008-9-9-r139, PubMed 18803840
4. Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA (2008)
   Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
   J Transl Med, 6, 13
   DOI 10.1186/1479-5876-6-13, PubMed 18346269

Publications 2007

1. Almstrup K, Leffers H, Lothe RA, Skakkebaek NE, Sonne SB, Nielsen JE, Rajpert-De Meyts E, Skotheim RI (2007)
   Improved gene expression signature of testicular carcinoma in situ
   Int J Androl, 30 (4), 292-302; discussion 303
   DOI 10.1111/j.1365-2605.2007.00758.x, PubMed 17488342
2. Kleivi K, Lind GE, Diep CB, Meling GI, Brandal LT, Nesland JM, Myklebost O, Rognum TO, Giercksky KE, Skotheim RI, Lothe RA (2007)
   Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
   Mol Cancer, 6, 2
   DOI 10.1186/1476-4598-6-2, PubMed 17201907
3. Lind GE, Skotheim RI, Lothe RA (2007)
   The epigenome of testicular germ cell tumors
   APMIS, 115 (10), 1147-60
   DOI 10.1111/j.1600-0463.2007.apm_660.xml.x, PubMed 18042148
4. Skotheim RI, Nees M (2007)
   Alternative splicing in cancer: noise, functional, or systematic?
   Int J Biochem Cell Biol, 39 (7-8), 1432-49
   DOI 10.1016/j.biocel.2007.02.016, PubMed 17416541

Publications 2006

1. Iljin K, Wolf M, Edgren H, Gupta S, Kilpinen S, Skotheim RI, Peltola M, Smit F, Verhaegh G, Schalken J, Nees M, Kallioniemi O (2006)
   TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming
   Cancer Res, 66 (21), 10242-6
   DOI 10.1158/0008-5472.CAN-06-1986, PubMed 17079440
2. Lind GE, Skotheim RI, Fraga MF, Abeler VM, Esteller M, Lothe RA (2006)
   Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)
   J Pathol, 210 (4), 441-9
   DOI 10.1002/path.2064, PubMed 17029216
3. Skotheim RI, Autio R, Lind GE, Kraggerud SM, Andrews PW, Monni O, Kallioniemi O, Lothe RA (2006)
   Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes
   Cell Oncol, 28 (5-6), 315-26
   DOI 10.1155/2006/219786, PubMed 17167184
4. von Eyben FE, Jacobsen GK, Skotheim RI, von der Maase H, Rorth M (2006)
   Precursor lesions in testis and dysgenetic gonads
   Hum Pathol, 37 (6), 773; author reply 774
   DOI 10.1016/j.humpath.2006.01.006, PubMed 16733221

Publications 2005

1. Hofer MD, Browne TJ, He L, Skotheim RI, Lothe RA, Rubin MA (2005)
   Identification of two molecular groups of seminomas by using expression and tissue microarrays
   Clin Cancer Res, 11 (16), 5722-9
   DOI 10.1158/1078-0432.CCR-05-0533, PubMed 16115909
2. Lind GE, Skotheim RI, Fraga MF, Abeler VM, Henrique R, Saatcioglu F, Esteller M, Teixeira MR, Lothe RA (2005)
   The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation
   Mol Cancer, 4 (1), 8
   DOI 10.1186/1476-4598-4-8, PubMed 15691383
3. von Eyben FE, Jacobsen GK, Skotheim RI (2005)
   Microinvasive germ cell tumor of the testis
   Virchows Arch, 447 (3), 610-25
   DOI 10.1007/s00428-005-1257-8, PubMed 15968545

Publications 2003

1. Kraggerud SM, Lee MP, Skotheim RI, Stenwig AE, Fosså SD, Feinberg AP, Lothe RA (2003)
   Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors
   Cancer Genet Cytogenet, 147 (1), 1-8
   DOI 10.1016/s0165-4608(03)00160-2, PubMed 14580764

Publications 2002

1. Kraggerud SM, Skotheim RI, Szymanska J, Eknaes M, Fosså SD, Stenwig AE, Peltomäki P, Lothe RA (2002)
   Genome profiles of familial/bilateral and sporadic testicular germ cell tumors
   Genes Chromosomes Cancer, 34 (2), 168-74
   DOI 10.1002/gcc.10058, PubMed 11979550
2. Smith-Sørensen B, Lind GE, Skotheim RI, Fosså SD, Fodstad Ø, Stenwig AE, Jakobsen KS, Lothe RA (2002)
   Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer
   Oncogene, 21 (57), 8878-84
   DOI 10.1038/sj.onc.1205978, PubMed 12483540