”If it were not for the great variability among individuals medicine might as well be science and not an art” Sir William Osler, 1892

The tumor initiation, progression and clinical presentation are directly dependent on its genetic and biochemical environment – the entire body. Our group is working on different projects related to how genetic variation affects occurrence of somatic alterations, gene expression patterns and genome wide copy number alterations in human breast and ovarian tumors. Understanding inherited genetic variability and how it affects crucial biological pathways is likely to lead to new successful prevention and treatment strategies.

The research in the group is focusing on constitutive variation such as single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) in relation to:

• Susceptibility
• Clinical presentation
• Treatment response and adverse side effects of treatment
• Gene regulation and proximal phenotypes (RNA expression and metabolic profiles)

Research project overview

Our EU project RESCUER (RESistance Under Combinatorial Treatment in ER+ and ER- Breast Cancer)

Foto: Bård Gudim AS

• Group pictures
• Group retreats
• Awards

Professor Vessela N. Kristensen, Email: v.n.kristensen@medisin.uio.no
Department of Medical Genetics, Institute of Clinical Medicine,
Oslo University Hospital Ullevål sykehus
Visiting addresse: Kirkeveien 166, Laboratoriebygget,0450 Oslo
Postal address: OUS HF Ullevål sykehus, Postboks 4956 Nydalen, 0424 Oslo
Phone: +47 22 78 13 75, Fax: +47 22 78 13 95, Switchboard: +47 22 93 40 00

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