Publications published since 2005 by Vessela N. Kristensen
317 publications found
Publications 2024
Akman T, Arendt LM, Geisler J, Kristensen VN, Frigessi A, Köhn-Luque A(2024) Modeling of Mouse Experiments Suggests that Optimal Anti-Hormonal Treatment for Breast Cancer is Diet-Dependent Bull Math Biol, 86(4), 42 DOI 10.1007/s11538-023-01253-1, PubMed 38498130
Ankill J, Zhao Z, Tekpli X, Kure EH, Kristensen VN, Mathelier A, Fleischer T(2024) Integrative pan-cancer analysis reveals a common architecture of dysregulated transcriptional networks characterized by loss of enhancer methylation PLoS Comput Biol, 20(11), e1012565 DOI 10.1371/journal.pcbi.1012565, PubMed 39556603
Davidson AL, Michailidou K, Parsons MT, Fortuno C, Bolla MK, Wang Q, Dennis J, Naven M, Abubakar M, Ahearn TU, Alonso MR, Andrulis IL, Antoniou AC, Auvinen P, Behrens S, Bermisheva MA, Bogdanova NV, Bojesen SE, Brüning T, Byers HJ, Camp NJ, Campbell A, Castelao JE, Cessna MH, Chang-Claude Jet al.(2024) Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset Am J Hum Genet, 111(9), 2059-2069 DOI 10.1016/j.ajhg.2024.07.004, PubMed 39096911
Fjermeros K, Ghannoum S, Geisler SB, Bhargava S, Tahiri A, Klajic J, Lüders T, Fongård M, Nawaz MS, Bosnjak-Olsen T, Buvarp UE, Rosenskiold AKJ, Nguyen NT, Sletbak TT, Seyedzadeh M, Selsås K, Porojnicu AC, Skjerven HK, Hovda T, Sahlberg KK, Torland LA, Lyngra M, Hammarström CL, Hönigsperger EB, Noone JCet al.(2024) The NEOLETRIB trial: neoadjuvant treatment with Letrozole and Ribociclib in ER-positive, HER2-negative breast cancer Future Oncol, 20(32), 2457-2466 DOI 10.1080/14796694.2024.2377531, PubMed 39073142
Fleischer T, Haugen MH, Ankill J, Silwal-Pandit L, Børresen-Dale AL, Hedenfalk I, Hatschek T, Tost J, Engebraaten O, Kristensen VN(2024) An integrated omics approach highlights how epigenetic events can explain and predict response to neoadjuvant chemotherapy and bevacizumab in breast cancer Mol Oncol, 18(8), 2042-2059 DOI 10.1002/1878-0261.13656, PubMed 38671580
Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, Mendes de Oliveira E, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santoni F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia RY, Terao C, Riggan MJ, Bolla MK, Yazdanpanah Met al.(2024) Understanding the genetic complexity of puberty timing across the allele frequency spectrum Nat Genet, 56(7), 1397-1411 DOI 10.1038/s41588-024-01798-4, PubMed 38951643
Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, Mendes de Oliveira E, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santoni F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia RY, Terao C, Riggan MJ, Bolla MK, Yazdanpanah Met al.(2024) Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum Nat Genet, 56(8), 1763-1764 DOI 10.1038/s41588-024-01857-w, PubMed 38982295
Liu Y, Peng C, Brorson IS, O'Mahony DG, Kelly RL, Heng YJ, Baker GM, Grenaker Alnæs GI, Bodelon C, Stover DG, Van Allen EM, Eliassen AH, Kristensen VN, Tamimi RM, Kraft P(2024) Germline polygenic risk scores are associated with immune gene expression signature and immune cell infiltration in breast cancer Am J Hum Genet, 111(10), 2150-2163 DOI 10.1016/j.ajhg.2024.08.009, PubMed 39270649
Ohnstad HO, Blix ES, Akslen LA, Gilje B, Raj SX, Skjerven H, Borgen E, Janssen EAM, Mortensen E, Brekke MB, Falk RS, Schlichting E, Boge B, Songe-Møller S, Olsson P, Heie A, Mannsåker B, Vestlid MA, Kursetgjerde T, Gravdehaug B, Suhrke P, Sanchez E, Bublevic J, Røe OD, Geitvik GAet al.(2024) Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer-a prospective national multicentre study (EMIT-1) ESMO Open, 9(6), 103475 DOI 10.1016/j.esmoop.2024.103475, PubMed 38838499
Schmiester L, Brasó-Maristany F, González-Farré B, Pascual T, Gavilá J, Tekpli X, Geisler J, Kristensen VN, Frigessi A, Prat A, Köhn-Luque A(2024) Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition Clin Cancer Res, 30(17), 3779-3787 DOI 10.1158/1078-0432.CCR-24-0244, PubMed 38922642
Shahrouzi P, Azimzade Y, Brankiewicz-Kopcinska W, Bhatia S, Kunke D, Richard D, Tekpli X, Kristensen VN, Duijf PHG(2024) Loss of chromosome cytoband 13q14.2 orchestrates breast cancer pathogenesis and drug response Breast Cancer Res, 26(1), 170 DOI 10.1186/s13058-024-01924-4, PubMed 39605038
Shahrouzi P, Forouz F, Mathelier A, Kristensen VN, Duijf PHG(2024) Copy number alterations: a catastrophic orchestration of the breast cancer genome Trends Mol Med, 30(8), 750-764 DOI 10.1016/j.molmed.2024.04.017, PubMed 38772764
Tinholt M, Tekpli X, Torland LA, Tahiri A, Geisler J, Kristensen V, Sandset PM, Iversen N(2024) The breast cancer coagulome in the tumor microenvironment and its role in prognosis and treatment response to chemotherapy J Thromb Haemost, 22(5), 1319-1335 DOI 10.1016/j.jtha.2024.01.003, PubMed 38237862
Tomasova K, Seborova K, Kroupa M, Horak J, Kavec M, Vodickova L, Rob L, Hruda M, Mrhalova M, Bartakova A, Bouda J, Fleischer T, Kristensen VN, Vodicka P, Vaclavikova R(2024) Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma Heliyon, 10(13), e33525 DOI 10.1016/j.heliyon.2024.e33525, PubMed 39050459
Torland LA, Lai X, Kumar S, Riis MH, Geisler J, Lüders T, Tekpli X, Kristensen V, Sahlberg K, Tahiri A(2024) Benign breast tumors may arise on different immunological backgrounds Mol Oncol, 18(10), 2495-2509 DOI 10.1002/1878-0261.13655, PubMed 38757377
Yiangou K, Mavaddat N, Dennis J, Zanti M, Wang Q, Bolla MK, Abubakar M, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Baten A, Behrens S, Bermisheva M, de Gonzalez AB, Białkowska K, Boddicker N, Bodelon C, Bogdanova NV, Bojesen SE, Brantley KD, Brauch Het al.(2024) Differences in polygenic score distributions in European ancestry populations: implications for breast cancer risk prediction medRxiv DOI 10.1101/2024.02.12.24302043, PubMed 38410445
Zanti M, O'Mahony DG, Parsons MT, Dorling L, Dennis J, Boddicker NJ, Chen W, Hu C, Naven M, Yiangou K, Ahearn TU, Ambrosone CB, Andrulis IL, Antoniou AC, Auer PL, Baynes C, Bodelon C, Bogdanova NV, Bojesen SE, Bolla MK, Brantley KD, Camp NJ, Campbell A, Castelao JE, Cessna MHet al.(2024) Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification medRxiv DOI 10.1101/2024.09.04.24313051, PubMed 39281752
Publications 2023
Chung FF, Maldonado SG, Nemc A, Bouaoun L, Cahais V, Cuenin C, Salle A, Johnson T, Ergüner B, Laplana M, Datlinger P, Jeschke J, Weiderpass E, Kristensen V, Delaloge S, Fuks F, Risch A, Ghantous A, Plass C, Bock C, Kaaks R, Herceg Z(2023) Buffy coat signatures of breast cancer risk in a prospective cohort study Clin Epigenetics, 15(1), 102 DOI 10.1186/s13148-023-01509-6, PubMed 37309009
Daniel P, Balušíková K, Václavíková R, Šeborová K, Ransdorfová Š, Valeriánová M, Wei L, Jelínek M, Tlapáková T, Fleischer T, Kristensen VN, Souček P, Ojima I, Kovář J(2023) ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines Genes (Basel), 14(2) DOI 10.3390/genes14020296, PubMed 36833223
Figlioli G, Billaud A, Ahearn TU, Antonenkova NN, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Blok MJ, Bogdanova NV, Bonanni B, Burwinkel B, Camp NJ, Campbell A, Castelao JE, Cessna MH, Chanock SJ, NBCS Collaborators, Czene K, Devilee P, Dörk T, Engel C, Eriksson M, Fasching PAet al.(2023) FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women Eur J Hum Genet, 31(5), 578-587 DOI 10.1038/s41431-022-01257-w, PubMed 36707629
Figlioli G, Billaud A, Wang Q, Bolla MK, Dennis J, Lush M, Kvist A, Adank MA, Ahearn TU, Antonenkova NN, Auvinen P, Behrens S, Bermisheva M, Bogdanova NV, Bojesen SE, Bonanni B, Brüning T, Camp NJ, Campbell A, Castelao JE, Cessna MH, Nbcs Collaborators, Czene K, Devilee P, Dörk Tet al.(2023) Spectrum and Frequency of Germline FANCM Protein-Truncating Variants in 44,803 European Female Breast Cancer Cases Cancers (Basel), 15(13) DOI 10.3390/cancers15133313, PubMed 37444426
Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, de Oliveira EM, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santon F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia R, Terao C, Riggan M, Bolla MK, Yazdanpanah Met al.(2023) Understanding the genetic complexity of puberty timing across the allele frequency spectrum medRxiv DOI 10.1101/2023.06.14.23291322, PubMed 37503126
Levi H, Carmi S, Rosset S, Yerushalmi R, Zick A, Yablonski-Peretz T, BCAC Consortium, Wang Q, Bolla MK, Dennis J, Michailidou K, Lush M, Ahearn T, Andrulis IL, Anton-Culver H, Antoniou AC, Arndt V, Augustinsson A, Auvinen P, Beane Freeman L, Beckmann M, Behrens S, Bermisheva M, Bodelon C, Bogdanova NVet al.(2023) Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel J Med Genet, 60(12), 1186-1197 DOI 10.1136/jmg-2023-109185, PubMed 37451831
Levy-Jurgenson A, Tekpli X, Kristensen VN, Yakhini Z(2023) Analysis of Spatial Molecular Data Methods Mol Biol, 2614, 349-356 DOI 10.1007/978-1-0716-2914-7_20, PubMed 36587134
Mo T, Brandal SHB, Geier OM, Engebråten O, Nilsen LB, Kristensen VN, Hole KH, Hompland T, Fleischer T, Seierstad T(2023) MRI Assessment of Changes in Tumor Vascularization during Neoadjuvant Anti-Angiogenic Treatment in Locally Advanced Breast Cancer Patients Cancers (Basel), 15(18) DOI 10.3390/cancers15184662, PubMed 37760629
Morra A, Mavaddat N, Muranen TA, Ahearn TU, Allen J, Andrulis IL, Auvinen P, Becher H, Behrens S, Blomqvist C, Bojesen SE, Bolla MK, Brauch H, Camp NJ, Carvalho S, Castelao JE, Cessna MH, Chang-Claude J, Chenevix-Trench G, NBCS Collaborators, Czene K, Decker B, Dennis J, Dörk T, Dorling Let al.(2023) The impact of coding germline variants on contralateral breast cancer risk and survival Am J Hum Genet, 110(3), 475-486 DOI 10.1016/j.ajhg.2023.02.003, PubMed 36827971
Morra A, Schreurs MAC, Andrulis IL, Anton-Culver H, Augustinsson A, Beckmann MW, Behrens S, Bojesen SE, Bolla MK, Brauch H, Broeks A, Buys SS, Camp NJ, Castelao JE, Cessna MH, Chang-Claude J, Chung WK, Collaborators N, Colonna SV, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Dennis Jet al.(2023) Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival Res Sq DOI 10.21203/rs.3.rs-2569372/v1, PubMed 36824750
Morra A, Schreurs MAC, Andrulis IL, Anton-Culver H, Augustinsson A, Beckmann MW, Behrens S, Bojesen SE, Bolla MK, Brauch H, Broeks A, Buys SS, Camp NJ, Castelao JE, Cessna MH, Chang-Claude J, Chung WK, NBCS Collaborators, Colonna SV, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Dennis Jet al.(2023) Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival Cancer Med, 12(15), 16142-16162 DOI 10.1002/cam4.6272, PubMed 37401034
Mueller SH, Lai AG, Valkovskaya M, Michailidou K, Bolla MK, Wang Q, Dennis J, Lush M, Abu-Ful Z, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Baert T, Freeman LEB, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Bogdanova NV, Bojesen SEet al.(2023) Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry Genome Med, 15(1), 7 DOI 10.1186/s13073-022-01152-5, PubMed 36703164
Muranen TA, Morra A, Khan S, Barnes DR, Bolla MK, Dennis J, Keeman R, Leslie G, Parsons MT, Wang Q, Ahearn TU, Aittomäki K, Andrulis IL, Arun BK, Behrens S, Bialkowska K, Bojesen SE, Camp NJ, Chang-Claude J, Czene K, Devilee P, HEBON investigators, Domchek SM, Dunning AM, Engel Cet al.(2023) PREDICT validity for prognosis of breast cancer patients with pathogenic BRCA1/2 variants NPJ Breast Cancer, 9(1), 37 DOI 10.1038/s41523-023-00546-x, PubMed 37173335
Normann LS, Haugen MH, Hongisto V, Aure MR, Leivonen SK, Kristensen VN, Tahiri A, Engebraaten O, Sahlberg KK, Mælandsmo GM(2023) High-throughput screen in vitro identifies dasatinib as a candidate for combinatorial treatment with HER2-targeting drugs in breast cancer PLoS One, 18(1), e0280507 DOI 10.1371/journal.pone.0280507, PubMed 36706086
Vitelli V, Fleischer T, Ankill J, Arjas E, Frigessi A, Kristensen VN, Zucknick M(2023) Transcriptomic pan-cancer analysis using rank-based Bayesian inference Mol Oncol, 17(4), 548-563 DOI 10.1002/1878-0261.13354, PubMed 36562628
Zanti M, O'Mahony DG, Parsons MT, Li H, Dennis J, Aittomäkkiki K, Andrulis IL, Anton-Culver H, Aronson KJ, Augustinsson A, Becher H, Bojesen SE, Bolla MK, Brenner H, Brown MA, Buys SS, Canzian F, Caputo SM, Castelao JE, Chang-Claude J, GC-HBOC study Collaborators, Czene K, Daly MB, De Nicolo A, Devilee Pet al.(2023) A likelihood ratio approach for utilizing case-control data in the clinical classification of rare sequence variants: application to BRCA1 and BRCA2 Hum Mutat, 2023 DOI 10.1155/2023/9961341, PubMed 38725546
Publications 2022
Ahearn TU, Zhang H, Michailidou K, Milne RL, Bolla MK, Dennis J, Dunning AM, Lush M, Wang Q, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Auer PL, Augustinsson A, Baten A, Becher H, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Bojesen SE, Bonanni B, Børresen-Dale AL, Brauch Het al.(2022) Common variants in breast cancer risk loci predispose to distinct tumor subtypes Breast Cancer Res, 24(1), 2 DOI 10.1186/s13058-021-01484-x, PubMed 34983606
Ankill J, Aure MR, Bjørklund S, Langberg S, Oslo Breast Cancer Consortium (OSBREAC) , Kristensen VN, Vitelli V, Tekpli X, Fleischer T(2022) Epigenetic alterations at distal enhancers are linked to proliferation in human breast cancer NAR Cancer, 4(1), zcac008 DOI 10.1093/narcan/zcac008, PubMed 35350772
Bjørklund SS, Aure MR, Häkkinen J, Vallon-Christersson J, Kumar S, Evensen KB, Fleischer T, Tost J, OSBREAC, Sahlberg KK, Mathelier A, Bhanot G, Ganesan S, Tekpli X, Kristensen VN(2022) Subtype and cell type specific expression of lncRNAs provide insight into breast cancer Commun Biol, 5(1), 834 DOI 10.1038/s42003-022-03559-7, PubMed 35982125
Breast Cancer Association Consortium, Mavaddat N, Dorling L, Carvalho S, Allen J, González-Neira A, Keeman R, Bolla MK, Dennis J, Wang Q, Ahearn TU, Andrulis IL, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Bogdanova NV, Bojesen SE, Briceno I, Brüning T, Camp NJ, Campbell A, Castelao JE, Chang-Claude Jet al.(2022) Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes JAMA Oncol, 8(3), e216744 DOI 10.1001/jamaoncol.2021.6744, PubMed 35084436
Castro-Mondragon JA, Aure MR, Lingjærde OC, Langerød A, Martens JWM, Børresen-Dale AL, Kristensen VN, Mathelier A(2022) Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers Nucleic Acids Res, 50(21), 12131-12148 DOI 10.1093/nar/gkac1143, PubMed 36477895
Chen H, Fan S, Stone J, Thompson DJ, Douglas J, Li S, Scott C, Bolla MK, Wang Q, Dennis J, Michailidou K, Li C, Peters U, Hopper JL, Southey MC, Nguyen-Dumont T, Nguyen TL, Fasching PA, Behrens A, Cadby G, Murphy RA, Aronson K, Howell A, Astley S, Couch Fet al.(2022) Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci Breast Cancer Res, 24(1), 27 DOI 10.1186/s13058-022-01524-0, PubMed 35414113
Dennis J, Tyrer JP, Walker LC, Michailidou K, Dorling L, Bolla MK, Wang Q, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Freeman LEB, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bogdanova NV, Bojesen SE, Brenner H, Castelao JE, Chang-Claude J, Chenevix-Trench G, Clarke CLet al.(2022) Rare germline copy number variants (CNVs) and breast cancer risk Commun Biol, 5(1), 65 DOI 10.1038/s42003-021-02990-6, PubMed 35042965
Dixon-Suen SC, Lewis SJ, Martin RM, English DR, Boyle T, Giles GG, Michailidou K, Bolla MK, Wang Q, Dennis J, Lush M, Investigators A, Ahearn TU, Ambrosone CB, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Augustinsson A, Auvinen P, Beane Freeman LE, Becher H, Beckmann MW, Behrens S, Bermisheva Met al.(2022) Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study Br J Sports Med, 56(20), 1157-1170 DOI 10.1136/bjsports-2021-105132, PubMed 36328784
Dorling L, Carvalho S, Allen J, Parsons MT, Fortuno C, González-Neira A, Heijl SM, Adank MA, Ahearn TU, Andrulis IL, Auvinen P, Becher H, Beckmann MW, Behrens S, Bermisheva M, Bogdanova NV, Bojesen SE, Bolla MK, Bremer M, Briceno I, Camp NJ, Campbell A, Castelao JE, Chang-Claude J, Chanock SJet al.(2022) Breast cancer risks associated with missense variants in breast cancer susceptibility genes Genome Med, 14(1), 51 DOI 10.1186/s13073-022-01052-8, PubMed 35585550
Grootes I, Keeman R, Blows FM, Milne RL, Giles GG, Swerdlow AJ, Fasching PA, Abubakar M, Andrulis IL, Anton-Culver H, Beckmann MW, Blomqvist C, Bojesen SE, Bolla MK, Bonanni B, Briceno I, Burwinkel B, Camp NJ, Castelao JE, Choi JY, Clarke CL, Couch FJ, Cox A, Cross SS, Czene Ket al.(2022) Incorporating progesterone receptor expression into the PREDICT breast prognostic model Eur J Cancer, 173, 178-193 DOI 10.1016/j.ejca.2022.06.011, PubMed 35933885
Lemma RB, Fleischer T, Martinsen E, Ledsaak M, Kristensen V, Eskeland R, Gabrielsen OS, Mathelier A(2022) Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers Epigenetics Chromatin, 15(1), 13 DOI 10.1186/s13072-022-00444-9, PubMed 35440061
Lirussi L, Ayyildiz D, Liu Y, Montaldo NP, Carracedo S, Aure MR, Jobert L, Tekpli X, Touma J, Sauer T, Dalla E, Kristensen VN, Geisler J, Piazza S, Tell G, Nilsen H(2022) A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours Nucleic Acids Res, 50(18), 10449-10468 DOI 10.1093/nar/gkac807, PubMed 36156150
Mo T, Brandal SHB, Köhn-Luque A, Engebraaten O, Kristensen VN, Fleischer T, Hompland T, Seierstad T(2022) Quantification of Tumor Hypoxia through Unsupervised Modelling of Consumption and Supply Hypoxia MR Imaging in Breast Cancer Cancers (Basel), 14(5) DOI 10.3390/cancers14051326, PubMed 35267636
Normann LS, Haugen MH, Aure MR, Kristensen VN, Mælandsmo GM, Sahlberg KK(2022) miR-101-5p Acts as a Tumor Suppressor in HER2-Positive Breast Cancer Cells and Improves Targeted Therapy Breast Cancer (Dove Med Press), 14, 25-39 DOI 10.2147/BCTT.S338404, PubMed 35256859
Pedersen CA, Cao MD, Fleischer T, Rye MB, Knappskog S, Eikesdal HP, Lønning PE, Tost J, Kristensen VN, Tessem MB, Giskeødegård GF, Bathen TF(2022) DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival Breast Cancer Res, 24(1), 43 DOI 10.1186/s13058-022-01537-9, PubMed 35751095
Seborova K, Hlavac V, Holy P, Bjørklund SS, Fleischer T, Rob L, Hruda M, Bouda J, Mrhalova M, Allah MMKAO, Vodicka P, Fiala O, Soucek P, Kristensen VN, Vodickova L, Vaclavikova R(2022) Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy Front Oncol, 12, 1016958 DOI 10.3389/fonc.2022.1016958, PubMed 36531044
Tahiri A, Puco K, Naji F, Kristensen VN, Alfsen GC, Farkas L, Nilsen FS, Müller S, Oldenburg J, Geisler J(2022) Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors Oncotarget, 13, 970-981 DOI 10.18632/oncotarget.28257, PubMed 36093296
Publications 2021
Aure MR, Fleischer T, Bjørklund S, Ankill J, Castro-Mondragon JA, OSBREAC, Børresen-Dale AL, Tost J, Sahlberg KK, Mathelier A, Tekpli X, Kristensen VN(2021) Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer Genome Med, 13(1), 72 DOI 10.1186/s13073-021-00880-4, PubMed 33926515
Bahrami N, Jabeen S, Tahiri A, Sauer T, Ødegård HP, Geisler SB, Gravdehaug B, Reitsma LC, Selsås K, Kristensen V, Geisler J(2021) Lack of cross-resistance between non-steroidal and steroidal aromatase inhibitors in breast cancer patients: the potential role of the adipokine leptin Breast Cancer Res Treat, 190(3), 435-449 DOI 10.1007/s10549-021-06399-x, PubMed 34554372
Baxter JS, Johnson N, Tomczyk K, Gillespie A, Maguire S, Brough R, Fachal L, Michailidou K, Bolla MK, Wang Q, Dennis J, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bogdanova NV, Bojesen SEet al.(2021) Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element Am J Hum Genet, 108(7), 1190-1203 DOI 10.1016/j.ajhg.2021.05.013, PubMed 34146516
Ben-Elazar S, Aure MR, Jonsdottir K, Leivonen SK, Kristensen VN, Janssen EAM, Kleivi Sahlberg K, Lingjærde OC, Yakhini Z(2021) miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer PLoS Comput Biol, 17(2), e1008608 DOI 10.1371/journal.pcbi.1008608, PubMed 33566819
Breast Cancer Association Consortium, Dorling L, Carvalho S, Allen J, González-Neira A, Luccarini C, Wahlström C, Pooley KA, Parsons MT, Fortuno C, Wang Q, Bolla MK, Dennis J, Keeman R, Alonso MR, Álvarez N, Herraez B, Fernandez V, Núñez-Torres R, Osorio A, Valcich J, Li M, Törngren T, Harrington PA, Baynes Cet al.(2021) Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women N Engl J Med, 384(5), 428-439 DOI 10.1056/NEJMoa1913948, PubMed 33471991
Escala-Garcia M, Canisius S, Keeman R, Beesley J, Anton-Culver H, Arndt V, Augustinsson A, Becher H, Beckmann MW, Behrens S, Bermisheva M, Bojesen SE, Bolla MK, Brenner H, Canzian F, Castelao JE, Chang-Claude J, Chanock SJ, Couch FJ, Czene K, Daly MB, Dennis J, Devilee P, Dörk T, Dunning AMet al.(2021) Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis Sci Rep, 11(1), 19787 DOI 10.1038/s41598-021-99409-3, PubMed 34611289
Fores-Martos J, Cervera-Vidal R, Sierra-Roca J, Lozano-Asencio C, Fedele V, Cornelissen S, Edvarsen H, Tadeo-Cervera I, Eroles P, Lluch A, Tabares-Seisdedos R, Falcó A, Van't Veer LJ, Schmidt M, Quigley DA, Børresen-Dale AL, Kristensen VN, Balmain A, Climent J(2021) Circadian PERformance in breast cancer: a germline and somatic genetic study of PER3VNTR polymorphisms and gene co-expression NPJ Breast Cancer, 7(1), 118 DOI 10.1038/s41523-021-00329-2, PubMed 34508103
Galili B, Tekpli X, Kristensen VN, Yakhini Z(2021) Efficient gene expression signature for a breast cancer immuno-subtype PLoS One, 16(1), e0245215 DOI 10.1371/journal.pone.0245215, PubMed 33434192
Johnson N, Maguire S, Morra A, Kapoor PM, Tomczyk K, Jones ME, Schoemaker MJ, Gilham C, Bolla MK, Wang Q, Dennis J, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Baynes C, Freeman LEB, Beckmann MW, Benitez J, Bermisheva M, Blomqvist C, Boeckx Bet al.(2021) CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers Br J Cancer, 124(4), 842-854 DOI 10.1038/s41416-020-01185-w, PubMed 33495599
Morra A, Escala-Garcia M, Beesley J, Keeman R, Canisius S, Ahearn TU, Andrulis IL, Anton-Culver H, Arndt V, Auer PL, Augustinsson A, Beane Freeman LE, Becher H, Beckmann MW, Behrens S, Bojesen SE, Bolla MK, Brenner H, Brüning T, Buys SS, Caan B, Campa D, Canzian F, Castelao JE, Chang-Claude Jet al.(2021) Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment Breast Cancer Res, 23(1), 86 DOI 10.1186/s13058-021-01450-7, PubMed 34407845
Morra A, Jung AY, Behrens S, Keeman R, Ahearn TU, Anton-Culver H, Arndt V, Augustinsson A, Auvinen PK, Beane Freeman LE, Becher H, Beckmann MW, Blomqvist C, Bojesen SE, Bolla MK, Brenner H, Briceno I, Brucker SY, Camp NJ, Campa D, Canzian F, Castelao JE, Chanock SJ, Choi JY, Clarke CLet al.(2021) Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium Cancer Epidemiol Biomarkers Prev, 30(4), 623-642 DOI 10.1158/1055-9965.EPI-20-0924, PubMed 33500318
Normann LS, Aure MR, Leivonen SK, Haugen MH, Hongisto V, Kristensen VN, Mælandsmo GM, Sahlberg KK(2021) MicroRNA in combination with HER2-targeting drugs reduces breast cancer cell viability in vitro Sci Rep, 11(1), 10893 DOI 10.1038/s41598-021-90385-2, PubMed 34035375
Park HA, Neumeyer S, Michailidou K, Bolla MK, Wang Q, Dennis J, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Baten A, Beane Freeman LE, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Brucker SYet al.(2021) Mendelian randomisation study of smoking exposure in relation to breast cancer risk Br J Cancer, 125(8), 1135-1145 DOI 10.1038/s41416-021-01432-8, PubMed 34341517
Park J, Choi JY, Choi J, Chung S, Song N, Park SK, Han W, Noh DY, Ahn SH, Lee JW, Kim MK, Jee SH, Wen W, Bolla MK, Wang Q, Dennis J, Michailidou K, Shah M, Conroy DM, Harrington PA, Mayes R, Czene K, Hall P, Teras LR, Patel AVet al.(2021) Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies? Cancers (Basel), 13(10) DOI 10.3390/cancers13102370, PubMed 34069208
Publications 2020
Bergholtz H, Kumar S, Wärnberg F, Lüders T, Kristensen V, Sørlie T(2020) Comparable cancer-relevant mutation profiles in synchronous ductal carcinoma in situ and invasive breast cancer Cancer Rep (Hoboken), 3(3), e1248 DOI 10.1002/cnr2.1248, PubMed 32671987
Egeland NG, Jonsdottir K, Aure MR, Sahlberg K, Kristensen VN, Cronin-Fenton D, Skaland I, Gudlaugsson E, Baak JPA, Janssen EAM(2020) MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers BMC Cancer, 20(1), 377 DOI 10.1186/s12885-020-06857-7, PubMed 32370743
Escala-Garcia M, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Ashworth A, Auer PL, Auvinen P, Beckmann MW, Beesley J, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Blot W, Bogdanova NV, Bojesen SE, Bolla MK, Børresen-Dale AL, Brauch H, Brenner H, Brucker SY, Burwinkel B, Caldas C, Canzian Fet al.(2020) A network analysis to identify mediators of germline-driven differences in breast cancer prognosis Nat Commun, 11(1), 312 DOI 10.1038/s41467-019-14100-6, PubMed 31949161
Fachal L, Aschard H, Beesley J, Barnes DR, Allen J, Kar S, Pooley KA, Dennis J, Michailidou K, Turman C, Soucy P, Lemaçon A, Lush M, Tyrer JP, Ghoussaini M, Moradi Marjaneh M, Jiang X, Agata S, Aittomäki K, Alonso MR, Andrulis IL, Anton-Culver H, Antonenkova NN, Arason A, Arndt Vet al.(2020) Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes Nat Genet, 52(1), 56-73 DOI 10.1038/s41588-019-0537-1, PubMed 31911677
Feng H, Gusev A, Pasaniuc B, Wu L, Long J, Abu-Full Z, Aittomäki K, Andrulis IL, Anton-Culver H, Antoniou AC, Arason A, Arndt V, Aronson KJ, Arun BK, Asseryanis E, Auer PL, Azzollini J, Balmaña J, Barkardottir RB, Barnes DR, Barrowdale D, Beckmann MW, Behrens S, Benitez J, Bermisheva Met al.(2020) Transcriptome-wide association study of breast cancer risk by estrogen-receptor status Genet Epidemiol, 44(5), 442-468 DOI 10.1002/gepi.22288, PubMed 32115800
Graim K, Gorenshteyn D, Robinson DG, Carriero NJ, Cahill JA, Chakrabarti R, Goldschmidt MH, Durham AC, Funk J, Storey JD, Kristensen VN, Theesfeld CL, Sorenmo KU, Troyanskaya OG(2020) Modeling molecular development of breast cancer in canine mammary tumors Genome Res, 31(2), 337-347 DOI 10.1101/gr.256388.119, PubMed 33361113
Kramer I, Hooning MJ, Mavaddat N, Hauptmann M, Keeman R, Steyerberg EW, Giardiello D, Antoniou AC, Pharoah PDP, Canisius S, Abu-Ful Z, Andrulis IL, Anton-Culver H, Aronson KJ, Augustinsson A, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bogdanova NV, Bojesen SE, Bolla MK, Bonanni B, Brauch Het al.(2020) Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk Am J Hum Genet, 107(5), 837-848 DOI 10.1016/j.ajhg.2020.09.001, PubMed 33022221
Levy-Jurgenson A, Tekpli X, Kristensen VN, Yakhini Z(2020) Spatial transcriptomics inferred from pathology whole-slide images links tumor heterogeneity to survival in breast and lung cancer Sci Rep, 10(1), 18802 DOI 10.1038/s41598-020-75708-z, PubMed 33139755
Liu J, Prager-van der Smissen WJC, Collée JM, Bolla MK, Wang Q, Michailidou K, Dennis J, Ahearn TU, Aittomäki K, Ambrosone CB, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Arnold N, Aronson KJ, Augustinsson A, Auvinen P, Becher H, Beckmann MW, Behrens S, Bermisheva M, Bernstein L, Bogdanova NV, Bogdanova-Markov Net al.(2020) Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk Sci Rep, 10(1), 9688 DOI 10.1038/s41598-020-65665-y, PubMed 32546843
Pladsen AV, Nilsen G, Rueda OM, Aure MR, Borgan Ø, Liestøl K, Vitelli V, Frigessi A, Langerød A, Mathelier A, OSBREAC, Engebråten O, Kristensen V, Wedge DC, Van Loo P, Caldas C, Børresen-Dale AL, Russnes HG, Lingjærde OC(2020) DNA copy number motifs are strong and independent predictors of survival in breast cancer Commun Biol, 3(1), 153 DOI 10.1038/s42003-020-0884-6, PubMed 32242091
Ree AH, Nygaard V, Boye K, Heinrich D, Dueland S, Bergheim IR, Johansen C, Beiske K, Negård A, Lund-Iversen M, Nygaard V, Hovig E, Nakken S, Nasser S, Julsrud L, Reisse CH, Ruud EA, Kristensen VN, Flørenes VA, Geitvik GA, Lingjærde OC, Børresen-Dale AL, Russnes HG, Mælandsmo GM, Flatmark K(2020) Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study Acta Oncol, 59(7), 733-740 DOI 10.1080/0284186X.2020.1742377, PubMed 32208873
Tahiri A, Tekpli X, Satheesh SV, DeWijn R, Lüders T, Bukholm IR, Hurtado A, Geisler J, Kristensen VN(2020) Loss of progesterone receptor is associated with distinct tyrosine kinase profiles in breast cancer Breast Cancer Res Treat, 183(3), 585-598 DOI 10.1007/s10549-020-05763-7, PubMed 32710281
Tinholt M, Stavik B, Tekpli X, Garred Ø, Borgen E, Kristensen V, Sahlberg KK, Sandset PM, Iversen N(2020) Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer Oncoimmunology, 9(1), 1824644 DOI 10.1080/2162402X.2020.1824644, PubMed 33457104
von der Lippe Gythfeldt H, Lien T, Tekpli X, Silwal-Pandit L, Borgen E, Garred Ø, Skjerven H, Schlichting E, Lundgren S, Wist E, Naume B, Kristensen V, Børresen-Dale AL, Lingjaerde OC, Engebraaten O(2020) Immune phenotype of tumor microenvironment predicts response to bevacizumab in neoadjuvant treatment of ER-positive breast cancer Int J Cancer, 147(9), 2515-2525 DOI 10.1002/ijc.33108, PubMed 32488909
Zhang H, Ahearn TU, Lecarpentier J, Barnes D, Beesley J, Qi G, Jiang X, O'Mara TA, Zhao N, Bolla MK, Dunning AM, Dennis J, Wang Q, Ful ZA, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Arun BK, Auer PL, Azzollini J, Barrowdale D, Becher H, Beckmann MWet al.(2020) Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses Nat Genet, 52(6), 572-581 DOI 10.1038/s41588-020-0609-2, PubMed 32424353
Zhu Q, Tekpli X, Troyanskaya OG, Kristensen VN(2020) Subtype-specific transcriptional regulators in breast tumors subjected to genetic and epigenetic alterations Bioinformatics, 36(4), 994-999 DOI 10.1093/bioinformatics/btz709, PubMed 31529022
Publications 2019
Bahrami N, Sauer T, Engebretsen S, Aljabri B, Bemanian V, Lindstrøm J, Lüders T, Kristensen V, Lorentzen A, Loeng M, Ødegård HP, Kvaløy JØ, Vestøl IB, Geisler SB, Gravdehaug B, Gundersen JM, Geisler J(2019) The NEOLETEXE trial: a neoadjuvant cross-over study exploring the lack of cross resistance between aromatase inhibitors Future Oncol, 15(32), 3675-3682 DOI 10.2217/fon-2019-0258, PubMed 31513453
Brinkman AB, Nik-Zainal S, Simmer F, Rodríguez-González FG, Smid M, Alexandrov LB, Butler A, Martin S, Davies H, Glodzik D, Zou X, Ramakrishna M, Staaf J, Ringnér M, Sieuwerts A, Ferrari A, Morganella S, Fleischer T, Kristensen V, Gut M, van de Vijver MJ, Børresen-Dale AL, Richardson AL, Thomas G, Gut IGet al.(2019) Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation Nat Commun, 10(1), 1749 DOI 10.1038/s41467-019-09828-0, PubMed 30988298
Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P(2019) Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors Nat Commun, 10(1), 525 DOI 10.1038/s41467-019-08512-7, PubMed 30692535
Dörk T, Peterlongo P, Mannermaa A, Bolla MK, Wang Q, Dennis J, Ahearn T, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Augustinsson A, Freeman LEB, Beckmann MW, Beeghly-Fadiel A, Behrens S, Bermisheva M, Blomqvist C, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Burwinkel B, Canzian F, Chan TLet al.(2019) Two truncating variants in FANCC and breast cancer risk Sci Rep, 9(1), 12524 DOI 10.1038/s41598-019-48804-y, PubMed 31467304
Escala-Garcia M, Guo Q, Dörk T, Canisius S, Keeman R, Dennis J, Beesley J, Lecarpentier J, Bolla MK, Wang Q, Abraham J, Andrulis IL, Anton-Culver H, Arndt V, Auer PL, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bernstein L, Blomqvist C, Boeckx B, Bojesen SE, Bonanni B, Børresen-Dale ALet al.(2019) Genome-wide association study of germline variants and breast cancer-specific mortality Br J Cancer, 120(6), 647-657 DOI 10.1038/s41416-019-0393-x, PubMed 30787463
Ferreira MA, Gamazon ER, Al-Ejeh F, Aittomäki K, Andrulis IL, Anton-Culver H, Arason A, Arndt V, Aronson KJ, Arun BK, Asseryanis E, Azzollini J, Balmaña J, Barnes DR, Barrowdale D, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Białkowska K, Blomqvist C, Bogdanova NV, Bojesen SE, Bolla MK, Borg Aet al.(2019) Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer Nat Commun, 10(1), 1741 DOI 10.1038/s41467-018-08053-5, PubMed 30988301
Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, Michailidou K, Lesseur C, Kuchenbaecker KB, Dennis J, Conti DV, Casey G, Gaudet MM, Huyghe JR, Albanes D, Aldrich MC, Andrew AS, Andrulis IL, Anton-Culver H, Antoniou AC, Antonenkova NN, Arnold SM, Aronson KJ, Arun BK, Bandera EVet al.(2019) Shared heritability and functional enrichment across six solid cancers Nat Commun, 10(1), 431 DOI 10.1038/s41467-018-08054-4, PubMed 30683880
Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, Michailidou K, Lesseur C, Kuchenbaecker KB, Dennis J, Conti DV, Casey G, Gaudet MM, Huyghe JR, Albanes D, Aldrich MC, Andrew AS, Andrulis IL, Anton-Culver H, Antoniou AC, Antonenkova NN, Arnold SM, Aronson KJ, Arun BK, Bandera EVet al.(2019) Publisher Correction: Shared heritability and functional enrichment across six solid cancers Nat Commun, 10(1), 4386 DOI 10.1038/s41467-019-12095-8, PubMed 31548585
Johansson HJ, Socciarelli F, Vacanti NM, Haugen MH, Zhu Y, Siavelis I, Fernandez-Woodbridge A, Aure MR, Sennblad B, Vesterlund M, Branca RM, Orre LM, Huss M, Fredlund E, Beraki E, Garred Ø, Boekel J, Sauer T, Zhao W, Nord S, Höglander EK, Jans DC, Brismar H, Haukaas TH, Bathen TFet al.(2019) Breast cancer quantitative proteome and proteogenomic landscape Nat Commun, 10(1), 1600 DOI 10.1038/s41467-019-09018-y, PubMed 30962452
Lai X, Geier OM, Fleischer T, Garred Ø, Borgen E, Funke SW, Kumar S, Rognes ME, Seierstad T, Børresen-Dale AL, Kristensen VN, Engebraaten O, Köhn-Luque A, Frigessi A(2019) Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data Cancer Res, 79(16), 4293-4304 DOI 10.1158/0008-5472.CAN-18-1804, PubMed 31118201
Lee YS, Krishnan A, Oughtred R, Rust J, Chang CS, Ryu J, Kristensen VN, Dolinski K, Theesfeld CL, Troyanskaya OG(2019) A Computational Framework for Genome-wide Characterization of the Human Disease Landscape Cell Syst, 8(2), 152-162.e6 DOI 10.1016/j.cels.2018.12.010, PubMed 30685436
Lindholm EM, Ragle Aure M, Haugen MH, Kleivi Sahlberg K, Kristensen VN, Nebdal D, Børresen-Dale AL, Lingjaerde OC, Engebraaten O(2019) miRNA expression changes during the course of neoadjuvant bevacizumab and chemotherapy treatment in breast cancer Mol Oncol, 13(10), 2278-2296 DOI 10.1002/1878-0261.12561, PubMed 31402562
Nome ME, Euceda LR, Jabeen S, Debik J, Bathen TF, Giskeødegård GF, Taskén KA, Maelandsmo GM, Halvorsen B, Yndestad A, Borgen E, Garred Ø, Aukrust P, Ueland T, Engebraaten O, Kristensen VN, Tekpli X(2019) Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers Int J Cancer, 146(1), 223-235 DOI 10.1002/ijc.32638, PubMed 31444972
Parashar D, Geethadevi A, Aure MR, Mishra J, George J, Chen C, Mishra MK, Tahiri A, Zhao W, Nair B, Lu Y, Mangala LS, Rodriguez-Aguayo C, Lopez-Berestein G, Camara AKS, Liang M, Rader JS, Ramchandran R, You M, Sood AK, Kristensen VN, Mills GB, Pradeep S, Chaluvally-Raghavan P(2019) miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer Cell Rep, 29(13), 4389-4406.e10 DOI 10.1016/j.celrep.2019.11.085, PubMed 31875548
Tekpli X, Lien T, Røssevold AH, Nebdal D, Borgen E, Ohnstad HO, Kyte JA, Vallon-Christersson J, Fongaard M, Due EU, Svartdal LG, Sveli MAT, Garred Ø, OSBREAC, Frigessi A, Sahlberg KK, Sørlie T, Russnes HG, Naume B, Kristensen VN(2019) An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment Nat Commun, 10(1), 5499 DOI 10.1038/s41467-019-13329-5, PubMed 31796750
Vaclavikova R, Klajic J, Brynychova V, Elsnerova K, Alnaes GIG, Tost J, Kristensen VN, Rob L, Kodet R, Skapa P, Mrhalova M, Soucek P(2019) Development of high‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma Oncol Rep, 42(2), 763-774 DOI 10.3892/or.2019.7186, PubMed 31173253
Publications 2018
Bemanian V, Noone JC, Sauer T, Touma J, Vetvik K, Søderberg-Naucler C, Lindstrøm JC, Bukholm IR, Kristensen VN, Geisler J(2018) Somatic EP300-G211S mutations are associated with overall somatic mutational patterns and breast cancer specific survival in triple-negative breast cancer Breast Cancer Res Treat, 172(2), 339-351 DOI 10.1007/s10549-018-4927-3, PubMed 30132219
Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P(2018) Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors Nat Commun, 9(1), 5397 DOI 10.1038/s41467-018-07842-2, PubMed 30559362
Ghoussaini M, Edwards SL, Michailidou K, Nord S, Cowper-Sal Lari R, Desai K, Kar S, Hillman KM, Kaufmann S, Glubb DM, Beesley J, Dennis J, Bolla MK, Wang Q, Dicks E, Guo Q, Schmidt MK, Shah M, Luben R, Brown J, Czene K, Darabi H, Eriksson M, Klevebring D, Bojesen SEet al.(2018) Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation Nat Commun, 9, 16193 DOI 10.1038/ncomms16193, PubMed 29633761
Höglander EK, Nord S, Wedge DC, Lingjærde OC, Silwal-Pandit L, Gythfeldt HV, Vollan HKM, Fleischer T, Krohn M, Schlitchting E, Borgen E, Garred Ø, Holmen MM, Wist E, Naume B, Van Loo P, Børresen-Dale AL, Engebraaten O, Kristensen V(2018) Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations Genome Med, 10(1), 92 DOI 10.1186/s13073-018-0601-y, PubMed 30497530
Jabeen S, Espinoza JA, Torland LA, Zucknick M, Kumar S, Haakensen VD, Lüders T, Engebraaten O, Børresen-Dale AL, Kyte JA, Gromov P, Naume B, Kristensen V, Gromova I, Tekpli X(2018) Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics Oncoimmunology, 8(2), e1537691 DOI 10.1080/2162402X.2018.1537691, PubMed 30713794
Jabeen S, Zucknick M, Nome M, Dannenfelser R, Fleischer T, Kumar S, Lüders T, von der Lippe Gythfeldt H, Troyanskaya O, Kyte JA, Børresen-Dale AL, Naume B, Tekpli X, Engebraaten O, Kristensen V(2018) Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab Oncoimmunology, 7(11), e1457598 DOI 10.1080/2162402X.2018.1457598, PubMed 30377556
Kaveh F, Baumbusch LO, Nebdal D, Børresen-Dale AL, Lingjærde OC, Edvardsen H, Kristensen VN, Solvang HK(2018) Correction to: A systematic comparison of copy number alterations in four types of female cancer BMC Cancer, 18(1), 80 DOI 10.1186/s12885-017-3766-7, PubMed 29338700
Mauger F, Kernaleguen M, Lallemand C, Kristensen VN, Deleuze JF, Tost J(2018) Enrichment of methylated molecules using enhanced-ice-co-amplification at lower denaturation temperature-PCR (E-ice-COLD-PCR) for the sensitive detection of disease-related hypermethylation Epigenomics, 10(5), 525-537 DOI 10.2217/epi-2017-0166, PubMed 29697281
Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L, Lee A, Tyrer JP, Chen TH, Wang Q, Bolla MK, Yang X, Adank MA, Ahearn T, Aittomäki K, Allen J, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Auer PL, Auvinen P, Barrdahl M, Beane Freeman LE, Beckmann MWet al.(2018) Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes Am J Hum Genet, 104(1), 21-34 DOI 10.1016/j.ajhg.2018.11.002, PubMed 30554720
Nguyen CB, Kumar S, Zucknick M, Kristensen VN, Gjerstad J, Nilsen H, Wyller VB(2018) Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome Brain Behav Immun, 76, 82-96 DOI 10.1016/j.bbi.2018.11.008, PubMed 30419269
O'Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, Black A, Bolla MK, Brauch H, Brenner H, Brinton L, Buchanan DD, Burwinkel B, Chang-Claude J, Chanock SJ, Chen C, Chen MM, Cheng THT, Clarke CL, Clendenning M, Cook LS, Couch FJ, Cox Aet al.(2018) Identification of nine new susceptibility loci for endometrial cancer Nat Commun, 9(1), 3166 DOI 10.1038/s41467-018-05427-7, PubMed 30093612
Painter JN, O'Mara TA, Morris AP, Cheng THT, Gorman M, Martin L, Hodson S, Jones A, Martin NG, Gordon S, Henders AK, Attia J, McEvoy M, Holliday EG, Scott RJ, Webb PM, Fasching PA, Beckmann MW, Ekici AB, Hein A, Rübner M, Hall P, Czene K, Dörk T, Dürst Met al.(2018) Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses Cancer Med, 7(5), 1978-1987 DOI 10.1002/cam4.1445, PubMed 29608257
Prasmickaite L, Tenstad EM, Pettersen S, Jabeen S, Egeland EV, Nord S, Pandya A, Haugen MH, Kristensen VN, Børresen-Dale AL, Oslo Breast Cancer Research Consortium (OSBREAC), Engebråten O, Maelandsmo GM(2018) Basal-like breast cancer engages tumor-supportive macrophages via secreted factors induced by extracellular S100A4 Mol Oncol, 12(9), 1540-1558 DOI 10.1002/1878-0261.12319, PubMed 29741811
Tahiri A, Aure MR, Kristensen VN(2018) MicroRNA Networks in Breast Cancer Cells Methods Mol Biol, 1711, 55-81 DOI 10.1007/978-1-4939-7493-1_4, PubMed 29344885
Tinholt M, Garred Ø, Borgen E, Beraki E, Schlichting E, Kristensen V, Sahlberg KK, Iversen N(2018) Subtype-specific clinical and prognostic relevance of tumor-expressed F5 and regulatory F5 variants in breast cancer: the CoCaV study J Thromb Haemost, 16(7), 1347-1356 DOI 10.1111/jth.14151, PubMed 29766637
Wu L, Shi W, Long J, Guo X, Michailidou K, Beesley J, Bolla MK, Shu XO, Lu Y, Cai Q, Al-Ejeh F, Rozali E, Wang Q, Dennis J, Li B, Zeng C, Feng H, Gusev A, Barfield RT, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Auer PL, Barrdahl Met al.(2018) A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer Nat Genet, 50(7), 968-978 DOI 10.1038/s41588-018-0132-x, PubMed 29915430
Publications 2017
Aure MR, Vitelli V, Jernström S, Kumar S, Krohn M, Due EU, Haukaas TH, Leivonen SK, Vollan HK, Lüders T, Rødland E, Vaske CJ, Zhao W, Møller EK, Nord S, Giskeødegård GF, Bathen TF, Caldas C, Tramm T, Alsner J, Overgaard J, Geisler J, Bukholm IR, Naume B, Schlichting Eet al.(2017) Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome Breast Cancer Res, 19(1), 44 DOI 10.1186/s13058-017-0812-y, PubMed 28356166
Bjørklund SS, Panda A, Kumar S, Seiler M, Robinson D, Gheeya J, Yao M, Alnæs GIG, Toppmeyer D, Riis M, Naume B, Børresen-Dale AL, Kristensen VN, Ganesan S, Bhanot G(2017) Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal Carcinoma Sci Rep, 7(1), 5568 DOI 10.1038/s41598-017-05537-0, PubMed 28717182
Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ, Russnes HG, Pandey BP, Nilsen G, Nord S, Bignell GR, White KP, Børresen-Dale AL, Campbell PJ, Kristensen VN, Stratton MR, Lingjærde OC, Moreau Y, Van Loo P(2017) Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors Nat Commun, 8(1), 1221 DOI 10.1038/s41467-017-01355-0, PubMed 29089486
Clancy T, Dannenfelser R, Troyanskaya O, Malmberg KJ, Hovig E, Kristensen V(2017) Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery Curr Pharm Des, 23(32), 4716-4725 DOI 10.2174/1381612823666170710154936, PubMed 28699527
Dannenfelser R, Nome M, Tahiri A, Ursini-Siegel J, Vollan HKM, Haakensen VD, Helland Å, Naume B, Caldas C, Børresen-Dale AL, Kristensen VN, Troyanskaya OG(2017) Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity Oncotarget, 8(34), 57121-57133 DOI 10.18632/oncotarget.19078, PubMed 28915659
Fleischer T, Klajic J, Aure MR, Louhimo R, Pladsen AV, Ottestad L, Touleimat N, Laakso M, Halvorsen AR, Grenaker Alnæs GI, Riis ML, Helland Å, Hautaniemi S, Lønning PE, Naume B, Børresen-Dale AL, Tost J, Kristensen VN(2017) DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival Oncotarget, 8(1), 1074-1082 DOI 10.18632/oncotarget.13718, PubMed 27911866
Fleischer T, Tekpli X, Mathelier A, Wang S, Nebdal D, Dhakal HP, Sahlberg KK, Schlichting E, Oslo Breast Cancer Research Consortium (OSBREAC), Børresen-Dale AL, Borgen E, Naume B, Eskeland R, Frigessi A, Tost J, Hurtado A, Kristensen VN(2017) DNA methylation at enhancers identifies distinct breast cancer lineages Nat Commun, 8(1), 1379 DOI 10.1038/s41467-017-00510-x, PubMed 29123100
Guo Q, Burgess S, Turman C, Bolla MK, Wang Q, Lush M, Abraham J, Aittomäki K, Andrulis IL, Apicella C, Arndt V, Barrdahl M, Benitez J, Berg CD, Blomqvist C, Bojesen SE, Bonanni B, Brand JS, Brenner H, Broeks A, Burwinkel B, Caldas C, Campa D, Canzian F, Chang-Claude Jet al.(2017) Body mass index and breast cancer survival: a Mendelian randomization analysis Int J Epidemiol, 46(6), 1814-1822 DOI 10.1093/ije/dyx131, PubMed 29232439
Helland T, Henne N, Bifulco E, Naume B, Borgen E, Kristensen VN, Kvaløy JT, Lash TL, Alnæs GIG, van Schaik RH, Janssen EAM, Hustad S, Lien EA, Mellgren G, Søiland H(2017) Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients Breast Cancer Res, 19(1), 125 DOI 10.1186/s13058-017-0916-4, PubMed 29183390
Jiao X, Aravidis C, Marikkannu R, Rantala J, Picelli S, Adamovic T, Liu T, Maguire P, Kremeyer B, Luo L, von Holst S, Kontham V, Thutkawkorapin J, Margolin S, Du Q, Lundin J, Michailidou K, Bolla MK, Wang Q, Dennis J, Lush M, Ambrosone CB, Andrulis IL, Anton-Culver H, Antonenkova NNet al.(2017) PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1 Oncotarget, 8(61), 102769-102782 DOI 10.18632/oncotarget.21800, PubMed 29262523
Kristensen VN(2017) The Antigenicity of the Tumor Cell - Context Matters N Engl J Med, 376(5), 491-493 DOI 10.1056/NEJMcibr1613793, PubMed 28146670
Michailidou K, Lindström S, Dennis J, Beesley J, Hui S, Kar S, Lemaçon A, Soucy P, Glubb D, Rostamianfar A, Bolla MK, Wang Q, Tyrer J, Dicks E, Lee A, Wang Z, Allen J, Keeman R, Eilber U, French JD, Qing Chen X, Fachal L, McCue K, McCart Reed AE, Ghoussaini Met al.(2017) Association analysis identifies 65 new breast cancer risk loci Nature, 551(7678), 92-94 DOI 10.1038/nature24284, PubMed 29059683
Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, Hui S, Lemaçon A, Soucy P, Dennis J, Jiang X, Rostamianfar A, Finucane H, Bolla MK, McGuffog L, Wang Q, Aalfs CM, ABCTB Investigators, Adams M, Adlard J, Agata S, Ahmed S, Ahsan H, Aittomäki K, Al-Ejeh Fet al.(2017) Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer Nat Genet, 49(12), 1767-1778 DOI 10.1038/ng.3785, PubMed 29058716
Ohnstad HO, Borgen E, Falk RS, Lien TG, Aaserud M, Sveli MAT, Kyte JA, Kristensen VN, Geitvik GA, Schlichting E, Wist EA, Sørlie T, Russnes HG, Naume B(2017) Prognostic value of PAM50 and risk of recurrence score in patients with early-stage breast cancer with long-term follow-up Breast Cancer Res, 19(1), 120 DOI 10.1186/s13058-017-0911-9, PubMed 29137653
Quigley DA, Tahiri A, Lüders T, Riis MH, Balmain A, Børresen-Dale AL, Bukholm I, Kristensen V(2017) Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue Oncoimmunology, 6(11), e1356142 DOI 10.1080/2162402X.2017.1356142, PubMed 29147603
Shimelis H, Mesman RLS, Von Nicolai C, Ehlen A, Guidugli L, Martin C, Calléja FMGR, Meeks H, Hallberg E, Hinton J, Lilyquist J, Hu C, Aalfs CM, Aittomäki K, Andrulis I, Anton-Culver H, Arndt V, Beckmann MW, Benitez J, Bogdanova NV, Bojesen SE, Bolla MK, Borresen-Dale AL, Brauch H, Brennan Pet al.(2017) BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer Cancer Res, 77(11), 2789-2799 DOI 10.1158/0008-5472.CAN-16-2568, PubMed 28283652
Silwal-Pandit L, Nord S, von der Lippe Gythfeldt H, Møller EK, Fleischer T, Rødland E, Krohn M, Borgen E, Garred Ø, Olsen T, Vu P, Skjerven H, Fangberget A, Holmen MM, Schlitchting E, Wille E, Nordberg Stokke M, Moen Vollan HK, Kristensen V, Langerød A, Lundgren S, Wist E, Naume B, Lingjærde OC, Børresen-Dale ALet al.(2017) The Longitudinal Transcriptional Response to Neoadjuvant Chemotherapy with and without Bevacizumab in Breast Cancer Clin Cancer Res, 23(16), 4662-4670 DOI 10.1158/1078-0432.CCR-17-0160, PubMed 28487444
Publications 2016
Cheng TH, Thompson DJ, O'Mara TA, Painter JN, Glubb DM, Flach S, Lewis A, French JD, Freeman-Mills L, Church D, Gorman M, Martin L, National Study of Endometrial Cancer Genetics Group (NSECG), Hodgson S, Webb PM, Australian National Endometrial Cancer Study Group (ANECS), Attia J, Holliday EG, McEvoy M, Scott RJ, Henders AK, Martin NG, Montgomery GW, Nyholt DR, Ahmed Set al.(2016) Five endometrial cancer risk loci identified through genome-wide association analysis Nat Genet, 48(6), 667-674 DOI 10.1038/ng.3562, PubMed 27135401
Couch FJ, Kuchenbaecker KB, Michailidou K, Mendoza-Fandino GA, Nord S, Lilyquist J, Olswold C, Hallberg E, Agata S, Ahsan H, Aittomäki K, Ambrosone C, Andrulis IL, Anton-Culver H, Arndt V, Arun BK, Arver B, Barile M, Barkardottir RB, Barrowdale D, Beckmann L, Beckmann MW, Benitez J, Blank SV, Blomqvist Cet al.(2016) Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer Nat Commun, 7, 11375 DOI 10.1038/ncomms11375, PubMed 27117709
Darabi H, Beesley J, Droit A, Kar S, Nord S, Moradi Marjaneh M, Soucy P, Michailidou K, Ghoussaini M, Fues Wahl H, Bolla MK, Wang Q, Dennis J, Alonso MR, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Benitez J, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Broeks A, Brüning Tet al.(2016) Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs) Sci Rep, 6, 32512 DOI 10.1038/srep32512, PubMed 27600471
Demeulemeester J, Kumar P, Møller EK, Nord S, Wedge DC, Peterson A, Mathiesen RR, Fjelldal R, Zamani Esteki M, Theunis K, Fernandez Gallardo E, Grundstad AJ, Borgen E, Baumbusch LO, Børresen-Dale AL, White KP, Kristensen VN, Van Loo P, Voet T, Naume B(2016) Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing Genome Biol, 17(1), 250 DOI 10.1186/s13059-016-1109-7, PubMed 27931250
Dominguez-Valentin M, Gras Navarro A, Rahman AM, Kumar S, Retière C, Ulvestad E, Kristensen V, Lund-Johansen M, Lie BA, Enger PØ, Njølstad G, Kristoffersen E, Lie SA, Chekenya M(2016) Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients Cancer Res, 76(18), 5326-36 DOI 10.1158/0008-5472.CAN-16-1162, PubMed 27406829
Dunning AM, Michailidou K, Kuchenbaecker KB, Thompson D, French JD, Beesley J, Healey CS, Kar S, Pooley KA, Lopez-Knowles E, Dicks E, Barrowdale D, Sinnott-Armstrong NA, Sallari RC, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Hills M, Jarosz M, Drury S, Canisius S, Bolla MK, Dennis Jet al.(2016) Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 Nat Genet, 48(4), 374-86 DOI 10.1038/ng.3521, PubMed 26928228
Easton DF, Lesueur F, Decker B, Michailidou K, Li J, Allen J, Luccarini C, Pooley KA, Shah M, Bolla MK, Wang Q, Dennis J, Ahmad J, Thompson ER, Damiola F, Pertesi M, Voegele C, Mebirouk N, Robinot N, Durand G, Forey N, Luben RN, Ahmed S, Aittomäki K, Anton-Culver Het al.(2016) No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing J Med Genet, 53(5), 298-309 DOI 10.1136/jmedgenet-2015-103529, PubMed 26921362
Eftang LL, Klajic J, Kristensen VN, Tost J, Esbensen QY, Blom GP, Bukholm IR, Bukholm G(2016) GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer BMC Cancer, 16, 225 DOI 10.1186/s12885-016-2247-8, PubMed 26984265
Espinoza JA, Jabeen S, Batra R, Papaleo E, Haakensen V, Timmermans Wielenga V, Møller Talman ML, Brunner N, Børresen-Dale AL, Gromov P, Helland Å, Kristensen VN, Gromova I(2016) Cytokine profiling of tumor interstitial fluid of the breast and its relationship with lymphocyte infiltration and clinicopathological characteristics Oncoimmunology, 5(12), e1248015 DOI 10.1080/2162402X.2016.1248015, PubMed 28123884
Ghoussaini M, French JD, Michailidou K, Nord S, Beesley J, Canisus S, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Dennis J, Bolla MK, Wang Q, Dicks E, Milne RL, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Fletcher Oet al.(2016) Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation Am J Hum Genet, 99(4), 903-911 DOI 10.1016/j.ajhg.2016.07.017, PubMed 27640304
Guo Y, Warren Andersen S, Shu XO, Michailidou K, Bolla MK, Wang Q, Garcia-Closas M, Milne RL, Schmidt MK, Chang-Claude J, Dunning A, Bojesen SE, Ahsan H, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bogdanova NV, Bonanni B, Børresen-Dale AL, Brand J, Brauch Het al.(2016) Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent PLoS Med, 13(8), e1002105 DOI 10.1371/journal.pmed.1002105, PubMed 27551723
Hamdi Y, Soucy P, Adoue V, Michailidou K, Canisius S, Lemaçon A, Droit A, Andrulis IL, Anton-Culver H, Arndt V, Baynes C, Blomqvist C, Bogdanova NV, Bojesen SE, Bolla MK, Bonanni B, Borresen-Dale AL, Brand JS, Brauch H, Brenner H, Broeks A, Burwinkel B, Chang-Claude J, NBCS Collaborators, Couch FJet al.(2016) Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21 Oncotarget, 7(49), 80140-80163 DOI 10.18632/oncotarget.12818, PubMed 27792995
Horne HN, Chung CC, Zhang H, Yu K, Prokunina-Olsson L, Michailidou K, Bolla MK, Wang Q, Dennis J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Fletcher O, Johnson N, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Guénel P, Truong Tet al.(2016) Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus PLoS One, 11(8), e0160316 DOI 10.1371/journal.pone.0160316, PubMed 27556229
Haakensen VD, Nygaard V, Greger L, Aure MR, Fromm B, Bukholm IR, Lüders T, Chin SF, Git A, Caldas C, Kristensen VN, Brazma A, Børresen-Dale AL, Hovig E, Helland Å(2016) Subtype-specific micro-RNA expression signatures in breast cancer progression Int J Cancer, 139(5), 1117-28 DOI 10.1002/ijc.30142, PubMed 27082076
Kar SP, Beesley J, Amin Al Olama A, Michailidou K, Tyrer J, Kote-Jarai Z, Lawrenson K, Lindstrom S, Ramus SJ, Thompson DJ, ABCTB Investigators, Kibel AS, Dansonka-Mieszkowska A, Michael A, Dieffenbach AK, Gentry-Maharaj A, Whittemore AS, Wolk A, Monteiro A, Peixoto A, Kierzek A, Cox A, Rudolph A, Gonzalez-Neira A, Wu AHet al.(2016) Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types Cancer Discov, 6(9), 1052-67 DOI 10.1158/2159-8290.CD-15-1227, PubMed 27432226
Kaveh F, Baumbusch LO, Nebdal D, Børresen-Dale AL, Lingjærde OC, Edvardsen H, Kristensen VN, Solvang HK(2016) A systematic comparison of copy number alterations in four types of female cancer BMC Cancer, 16(1), 913 DOI 10.1186/s12885-016-2899-4, PubMed 27876019
Kleibl Z, Kristensen VN(2016) Women at high risk of breast cancer: Molecular characteristics, clinical presentation and management Breast, 28, 136-44 DOI 10.1016/j.breast.2016.05.006, PubMed 27318168
Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, Tyrer J, Beesley J, Ramus SJ, Li Q, Delgado MK, Lee JM, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Arun BK, Arver B, Bandera EV, Barile M, Barkardottir RB, Barrowdale D, Beckmann MW, Benitez J, Berchuck A, Bisogna Met al.(2016) Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus Nat Commun, 7, 12675 DOI 10.1038/ncomms12675, PubMed 27601076
Lesurf R, Aure MR, Mørk HH, Vitelli V, Oslo Breast Cancer Research Consortium (OSBREAC), Lundgren S, Børresen-Dale AL, Kristensen V, Wärnberg F, Hallett M, Sørlie T(2016) Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer Cell Rep, 16(4), 1166-1179 DOI 10.1016/j.celrep.2016.06.051, PubMed 27396337
Liu J, Lončar I, Collée JM, Bolla MK, Dennis J, Michailidou K, Wang Q, Andrulis IL, Barile M, Beckmann MW, Behrens S, Benitez J, Blomqvist C, Boeckx B, Bogdanova NV, Bojesen SE, Brauch H, Brennan P, Brenner H, Broeks A, Burwinkel B, Chang-Claude J, Chen ST, Chenevix-Trench G, Cheng CYet al.(2016) rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk Sci Rep, 6, 36874 DOI 10.1038/srep36874, PubMed 27845421
Muranen TA, Greco D, Blomqvist C, Aittomäki K, Khan S, Hogervorst F, Verhoef S, Pharoah PDP, Dunning AM, Shah M, Luben R, Bojesen SE, Nordestgaard BG, Schoemaker M, Swerdlow A, García-Closas M, Figueroa J, Dörk T, Bogdanova NV, Hall P, Li J, Khusnutdinova E, Bermisheva M, Kristensen V, Borresen-Dale ALet al.(2016) Genetic modifiers of CHEK2*1100delC-associated breast cancer risk Genet Med, 19(5), 599-603 DOI 10.1038/gim.2016.147, PubMed 27711073
Painter JN, O'Mara TA, Marquart L, Webb PM, Attia J, Medland SE, Cheng T, Dennis J, Holliday EG, McEvoy M, Scott RJ, Ahmed S, Healey CS, Shah M, Gorman M, Martin L, Hodgson SV, Beckmann MW, Ekici AB, Fasching PA, Hein A, Rübner M, Czene K, Darabi H, Hall Pet al.(2016) Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer Cancer Epidemiol Biomarkers Prev, 25(11), 1503-1510 DOI 10.1158/1055-9965.EPI-16-0147, PubMed 27550749
Pelttari LM, Khan S, Vuorela M, Kiiski JI, Vilske S, Nevanlinna V, Ranta S, Schleutker J, Winqvist R, Kallioniemi A, Dörk T, Bogdanova NV, Figueroa J, Pharoah PD, Schmidt MK, Dunning AM, García-Closas M, Bolla MK, Dennis J, Michailidou K, Wang Q, Hopper JL, Southey MC, Rosenberg EH, Fasching PAet al.(2016) RAD51B in Familial Breast Cancer PLoS One, 11(5), e0153788 DOI 10.1371/journal.pone.0153788, PubMed 27149063
Petridis C, Brook MN, Shah V, Kohut K, Gorman P, Caneppele M, Levi D, Papouli E, Orr N, Cox A, Cross SS, Dos-Santos-Silva I, Peto J, Swerdlow A, Schoemaker MJ, Bolla MK, Wang Q, Dennis J, Michailidou K, Benitez J, González-Neira A, Tessier DC, Vincent D, Li J, Figueroa Jet al.(2016) Genetic predisposition to ductal carcinoma in situ of the breast Breast Cancer Res, 18(1), 22 DOI 10.1186/s13058-016-0675-7, PubMed 26884359
Sas-Chen A, Aure MR, Leibovich L, Carvalho S, Enuka Y, Körner C, Polycarpou-Schwarz M, Lavi S, Nevo N, Kuznetsov Y, Yuan J, Azuaje F, Oslo Breast Cancer Research Consortium (OSBREAC)SauerTorillGeislerJürgenHofvindSolveigBathenTone FBorgenElinEngebråtenOlavFodstadØysteinGarredØysteinGeitvikGry AarumKåresenRolfNaumeBjørnMælandsmoGunhild MariRussnesHege GSchlichtingEllenSørlieThereseLingjærdeOle ChristianSahlbergKristine KleiviSkjervenHelle KristineFritzmanBritt, Ulitsky I, Diederichs S, Wiemann S, Yakhini Z, Kristensen VN, Børresen-Dale AL, Yarden Y(2016) LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer EMBO Mol Med, 8(9), 1052-64 DOI 10.15252/emmm.201606198, PubMed 27485121
Schmidt MK, Hogervorst F, van Hien R, Cornelissen S, Broeks A, Adank MA, Meijers H, Waisfisz Q, Hollestelle A, Schutte M, van den Ouweland A, Hooning M, Andrulis IL, Anton-Culver H, Antonenkova NN, Antoniou AC, Arndt V, Bermisheva M, Bogdanova NV, Bolla MK, Brauch H, Brenner H, Brüning T, Burwinkel B, Chang-Claude Jet al.(2016) Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers J Clin Oncol, 34(23), 2750-60 DOI 10.1200/JCO.2016.66.5844, PubMed 27269948
Shi J, Zhang Y, Zheng W, Michailidou K, Ghoussaini M, Bolla MK, Wang Q, Dennis J, Lush M, Milne RL, Shu XO, Beesley J, Kar S, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Zhao Z, Guo X, Benitez J, Beeghly-Fadiel A, Blot W, Bogdanova NV, Bojesen SE, Brauch Het al.(2016) Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer Int J Cancer, 139(6), 1303-1317 DOI 10.1002/ijc.30150, PubMed 27087578
Solvang HK, Frigessi A, Kaveh F, Riis ML, Lüders T, Bukholm IR, Kristensen VN, Andreassen BK(2016) Gene expression analysis supports tumor threshold over 2.0 cm for T-category breast cancer EURASIP J Bioinform Syst Biol, 2016(1), 6 DOI 10.1186/s13637-015-0034-5, PubMed 26900390
Southey MC, Goldgar DE, Winqvist R, Pylkäs K, Couch F, Tischkowitz M, Foulkes WD, Dennis J, Michailidou K, van Rensburg EJ, Heikkinen T, Nevanlinna H, Hopper JL, Dörk T, Claes KB, Reis-Filho J, Teo ZL, Radice P, Catucci I, Peterlongo P, Tsimiklis H, Odefrey FA, Dowty JG, Schmidt MK, Broeks Aet al.(2016) PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS J Med Genet, 53(12), 800-811 DOI 10.1136/jmedgenet-2016-103839, PubMed 27595995
Thienpont B, Steinbacher J, Zhao H, D'Anna F, Kuchnio A, Ploumakis A, Ghesquière B, Van Dyck L, Boeckx B, Schoonjans L, Hermans E, Amant F, Kristensen VN, Peng Koh K, Mazzone M, Coleman M, Carell T, Carmeliet P, Lambrechts D(2016) Tumour hypoxia causes DNA hypermethylation by reducing TET activity Nature, 537(7618), 63-68 DOI 10.1038/nature19081, PubMed 27533040
Tinholt M, Sandset PM, Mowinckel MC, Garred Ø, Sahlberg KK, Kristensen VN, Børresen-Dale AL, Jacobsen AF, Skretting G, Iversen N(2016) Determinants of acquired activated protein C resistance and D-dimer in breast cancer Thromb Res, 145, 78-83 DOI 10.1016/j.thromres.2016.08.003, PubMed 27505249
Wyszynski A, Hong CC, Lam K, Michailidou K, Lytle C, Yao S, Zhang Y, Bolla MK, Wang Q, Dennis J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Peto J, Dos-Santos-Silva I, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Guénel Pet al.(2016) An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression Hum Mol Genet, 25(17), 3863-3876 DOI 10.1093/hmg/ddw223, PubMed 27402876
Zhao Z, Wen W, Michailidou K, Bolla MK, Wang Q, Zhang B, Long J, Shu XO, Schmidt MK, Milne RL, García-Closas M, Chang-Claude J, Lindstrom S, Bojesen SE, Ahsan H, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Beckmann MW, Beeghly-Fadiel A, Benitez J, Blomqvist C, Bogdanova NV, Børresen-Dale ALet al.(2016) Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry Cancer Causes Control, 27(5), 679-93 DOI 10.1007/s10552-016-0741-6, PubMed 27053251
Publications 2015
Alnaes GI, Ronneberg JA, Kristensen VN, Tost J(2015) Heterogeneous DNA Methylation Patterns in the GSTP1 Promoter Lead to Discordant Results between Assay Technologies and Impede Its Implementation as Epigenetic Biomarkers in Breast Cancer Genes (Basel), 6(3), 878-900 DOI 10.3390/genes6030878, PubMed 26393654
Aure MR, Jernström S, Krohn M, Vollan HK, Due EU, Rødland E, Kåresen R, Oslo Breast Cancer Research Consortium (OSBREAC), Ram P, Lu Y, Mills GB, Sahlberg KK, Børresen-Dale AL, Lingjærde OC, Kristensen VN(2015) Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer Genome Med, 7(1), 21 DOI 10.1186/s13073-015-0135-5, PubMed 25873999
Bjørklund SS, Kristensen VN, Seiler M, Kumar S, Alnæs GI, Ming Y, Kerrigan J, Naume B, Sachidanandam R, Bhanot G, Børresen-Dale AL, Ganesan S(2015) Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas BMC Cancer, 15, 524 DOI 10.1186/s12885-015-1510-8, PubMed 26183823
Bjaanæs MM, Fleischer T, Halvorsen AR, Daunay A, Busato F, Solberg S, Jørgensen L, Kure E, Edvardsen H, Børresen-Dale AL, Brustugun OT, Tost J, Kristensen V, Helland Å(2015) Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis Mol Oncol, 10(2), 330-43 DOI 10.1016/j.molonc.2015.10.021, PubMed 26601720
Borge KS, Nord S, Van Loo P, Lingjærde OC, Gunnes G, Alnæs GI, Solvang HK, Lüders T, Kristensen VN, Børresen-Dale AL, Lingaas F(2015) Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN PLoS One, 10(5), e0126371 DOI 10.1371/journal.pone.0126371, PubMed 25955013
Cheng TH, Thompson D, Painter J, O'Mara T, Gorman M, Martin L, Palles C, Jones A, Buchanan DD, Win AK, Hopper J, Jenkins M, Lindor NM, Newcomb PA, Gallinger S, Conti D, Schumacher F, Casey G, Giles GG, Pharoah P, Peto J, Cox A, Swerdlow A, Couch F, Cunningham JMet al.(2015) Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1 Sci Rep, 5, 17369 DOI 10.1038/srep17369, PubMed 26621817
Darabi H, McCue K, Beesley J, Michailidou K, Nord S, Kar S, Humphreys K, Thompson D, Ghoussaini M, Bolla MK, Dennis J, Wang Q, Canisius S, Scott CG, Apicella C, Hopper JL, Southey MC, Stone J, Broeks A, Schmidt MK, Scott RJ, Lophatananon A, Muir K, Beckmann MW, Ekici ABet al.(2015) Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression Am J Hum Genet, 97(1), 22-34 DOI 10.1016/j.ajhg.2015.05.002, PubMed 26073781
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD, Elks CE, Franceschini N, He C, Altmaier E, Brody JA, Franke LL, Huffman JE, Keller MF, McArdle PF, Nutile T, Porcu E, Robino A, Rose LMet al.(2015) Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair Nat Genet, 47(11), 1294-1303 DOI 10.1038/ng.3412, PubMed 26414677
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD, Elks CE, Franceschini N, He C, Altmaier E, Brody JA, Franke LL, Huffman JE, Keller MF, McArdle PF, Nutile T, Porcu E, Robino A, Rose LMet al.(2015) Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair EDITORIAL COMMENT Obstet. Gynecol. Surv., 70(12), 758-762 DOI 10.1097/01.ogx.0000473766.71624.99
Grawenda AM, Møller EK, Lam S, Repapi E, Teunisse AF, Alnæs GI, Børresen-Dale AL, Kristensen VN, Goding CR, Jochemsen AG, Edvardsen H, Bond GL(2015) Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer Cancer Res, 75(4), 698-708 DOI 10.1158/0008-5472.CAN-14-2637, PubMed 25649770
Guo Q, Schmidt MK, Kraft P, Canisius S, Chen C, Khan S, Tyrer J, Bolla MK, Wang Q, Dennis J, Michailidou K, Lush M, Kar S, Beesley J, Dunning AM, Shah M, Czene K, Darabi H, Eriksson M, Lambrechts D, Weltens C, Leunen K, Bojesen SE, Nordestgaard BG, Nielsen SFet al.(2015) Identification of novel genetic markers of breast cancer survival J Natl Cancer Inst, 107(5) DOI 10.1093/jnci/djv081, PubMed 25890600
Győrffy B, Bottai G, Fleischer T, Munkácsy G, Budczies J, Paladini L, Børresen-Dale AL, Kristensen VN, Santarpia L(2015) Aberrant DNA methylation impacts gene expression and prognosis in breast cancer subtypes Int J Cancer, 138(1), 87-97 DOI 10.1002/ijc.29684, PubMed 26174627
Jabeen S, Holmboe L, Alnæs GI, Andersen AM, Hall KS, Kristensen VN(2015) Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate Pharmacogenomics J, 15(5), 385-90 DOI 10.1038/tpj.2015.11, PubMed 25778468
Johnson KC, Koestler DC, Fleischer T, Chen P, Jenson EG, Marotti JD, Onega T, Kristensen VN, Christensen BC(2015) DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer Clin Epigenetics, 7(1), 75 DOI 10.1186/s13148-015-0094-0, PubMed 26213588
Kabisch M, Lorenzo Bermejo J, Dünnebier T, Ying S, Michailidou K, Bolla MK, Wang Q, Dennis J, Shah M, Perkins BJ, Czene K, Darabi H, Eriksson M, Bojesen SE, Nordestgaard BG, Nielsen SF, Flyger H, Lambrechts D, Neven P, Peeters S, Weltens C, Couch FJ, Olson JE, Wang X, Purrington Ket al.(2015) Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer Carcinogenesis, 36(2), 256-71 DOI 10.1093/carcin/bgu326, PubMed 25586992
Lei J, Rudolph A, Moysich KB, Behrens S, Goode EL, Bolla MK, Dennis J, Dunning AM, Easton DF, Wang Q, Benitez J, Hopper JL, Southey MC, Schmidt MK, Broeks A, Fasching PA, Haeberle L, Peto J, Dos-Santos-Silva I, Sawyer EJ, Tomlinson I, Burwinkel B, Marmé F, Guénel P, Truong Tet al.(2015) Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium Hum Genet, 135(1), 137-54 DOI 10.1007/s00439-015-1616-8, PubMed 26621531
Lei J, Rudolph A, Moysich KB, Rafiq S, Behrens S, Goode EL, Pharoah PP, Seibold P, Fasching PA, Andrulis IL, Kristensen VN, Couch FJ, Hamann U, Hooning MJ, Nevanlinna H, Eilber U, Bolla MK, Dennis J, Wang Q, Lindblom A, Mannermaa A, Lambrechts D, García-Closas M, Hall P, Chenevix-Trench Get al.(2015) Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy Breast Cancer Res, 17(1), 18 DOI 10.1186/s13058-015-0522-2, PubMed 25849327
Mavaddat N, Pharoah PD, Michailidou K, Tyrer J, Brook MN, Bolla MK, Wang Q, Dennis J, Dunning AM, Shah M, Luben R, Brown J, Bojesen SE, Nordestgaard BG, Nielsen SF, Flyger H, Czene K, Darabi H, Eriksson M, Peto J, Dos-Santos-Silva I, Dudbridge F, Johnson N, Schmidt MK, Broeks Aet al.(2015) Prediction of breast cancer risk based on profiling with common genetic variants J Natl Cancer Inst, 107(5) DOI 10.1093/jnci/djv036, PubMed 25855707
Meeks HD, Song H, Michailidou K, Bolla MK, Dennis J, Wang Q, Barrowdale D, Frost D, EMBRACE, McGuffog L, Ellis S, Feng B, Buys SS, Hopper JL, Southey MC, Tesoriero A, kConFab Investigators, James PA, Bruinsma F, Campbell IG, Australia Ovarian Cancer Study Group, Broeks A, Schmidt MK, Hogervorst FB, HEBONet al.(2015) BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers J Natl Cancer Inst, 108(2) DOI 10.1093/jnci/djv315, PubMed 26586665
Michailidou K, Beesley J, Lindstrom S, Canisius S, Dennis J, Lush MJ, Maranian MJ, Bolla MK, Wang Q, Shah M, Perkins BJ, Czene K, Eriksson M, Darabi H, Brand JS, Bojesen SE, Nordestgaard BG, Flyger H, Nielsen SF, Rahman N, Turnbull C, BOCS, Fletcher O, Peto J, Gibson Let al.(2015) Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer Nat Genet, 47(4), 373-80 DOI 10.1038/ng.3242, PubMed 25751625
Nielsen HM, How-Kit A, Guerin C, Castinetti F, Vollan HK, De Micco C, Daunay A, Taieb D, Van Loo P, Besse C, Kristensen VN, Hansen LL, Barlier A, Sebag F, Tost J(2015) Copy number variations alter methylation and parallel IGF2 overexpression in adrenal tumors Endocr Relat Cancer, 22(6), 953-67 DOI 10.1530/ERC-15-0086, PubMed 26400872
O'Mara TA, Glubb DM, Painter JN, Cheng T, Dennis J, Australian National Endometrial Cancer Study Group (ANECS), Attia J, Holliday EG, McEvoy M, Scott RJ, Ashton K, Proietto T, Otton G, Shah M, Ahmed S, Healey CS, Gorman M, Martin L, National Study of Endometrial Cancer Genetics Group (NSECG), Hodgson S, Fasching PA, Hein A, Beckmann MW, Ekici AB, Hall Pet al.(2015) Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer Endocr Relat Cancer, 22(5), 851-61 DOI 10.1530/ERC-15-0319, PubMed 26330482
Orr N, Dudbridge F, Dryden N, Maguire S, Novo D, Perrakis E, Johnson N, Ghoussaini M, Hopper JL, Southey MC, Apicella C, Stone J, Schmidt MK, Broeks A, Van't Veer LJ, Hogervorst FB, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Gibson L, Aitken Z, Warren H, Sawyer E, Tomlinson Iet al.(2015) Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 Hum Mol Genet, 24(10), 2966-84 DOI 10.1093/hmg/ddv035, PubMed 25652398
Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2, Hollestelle A, van der Baan FH, Berchuck A, Johnatty SE, Aben KK, Agnarsson BA, Aittomäki K, Alducci E, Andrulis IL, Anton-Culver H, Antonenkova NN, Antoniou AC, Apicella C, Arndt V, Arnold N, Arun BK, Arver B, Ashworth A, Australian Ovarian Cancer Study Group, Baglietto L, Balleine R, Bandera EV, Barrowdale D, Bean YTet al.(2015) No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer Gynecol Oncol, 141(2), 386-401 DOI 10.1016/j.ygyno.2015.04.034, PubMed 25940428
Pirie A, Guo Q, Kraft P, Canisius S, Eccles DM, Rahman N, Nevanlinna H, Chen C, Khan S, Tyrer J, Bolla MK, Wang Q, Dennis J, Michailidou K, Lush M, Dunning AM, Shah M, Czene K, Darabi H, Eriksson M, Lambrechts D, Weltens C, Leunen K, van Ongeval C, Nordestgaard BGet al.(2015) Common germline polymorphisms associated with breast cancer-specific survival Breast Cancer Res, 17(1), 58 DOI 10.1186/s13058-015-0570-7, PubMed 25897948
Potapenko IO, Lüders T, Russnes HG, Helland Å, Sørlie T, Kristensen VN, Nord S, Lingjærde OC, Børresen-Dale AL, Haakensen VD(2015) Glycan-related gene expression signatures in breast cancer subtypes; relation to survival Mol Oncol, 9(4), 861-76 DOI 10.1016/j.molonc.2014.12.013, PubMed 25655580
Quigley DA, Kristensen V(2015) Predicting prognosis and therapeutic response from interactions between lymphocytes and tumor cells Mol Oncol, 9(10), 2054-62 DOI 10.1016/j.molonc.2015.10.003, PubMed 26607741
Seibold P, Schmezer P, Behrens S, Michailidou K, Bolla MK, Wang Q, Flesch-Janys D, Nevanlinna H, Fagerholm R, Aittomäki K, Blomqvist C, Margolin S, Mannermaa A, Kataja V, Kosma VM, Hartikainen JM, Lambrechts D, Wildiers H, Kristensen V, Alnæs GG, Nord S, Borresen-Dale AL, Hooning MJ, Hollestelle A, Jager Aet al.(2015) A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients BMC Cancer, 15, 978 DOI 10.1186/s12885-015-1957-7, PubMed 26674097
Stone J, Thompson DJ, Dos Santos Silva I, Scott C, Tamimi RM, Lindstrom S, Kraft P, Hazra A, Li J, Eriksson L, Czene K, Hall P, Jensen M, Cunningham J, Olson JE, Purrington K, Couch FJ, Brown J, Leyland J, Warren RM, Luben RN, Khaw KT, Smith P, Wareham NJ, Jud SMet al.(2015) Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures Cancer Res, 75(12), 2457-67 DOI 10.1158/0008-5472.CAN-14-2012, PubMed 25862352
Thompson DJ, O'Mara TA, Glubb DM, Painter JN, Cheng T, Folkerd E, Doody D, Dennis J, Webb PM, Australian National Endometrial Cancer Study Group (ANECS), Gorman M, Martin L, Hodgson S, National Study of Endometrial Cancer Genetics Group (NSECG), Michailidou K, Tyrer JP, Maranian MJ, Hall P, Czene K, Darabi H, Li J, Fasching PA, Hein A, Beckmann MW, Ekici ABet al.(2015) CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer Endocr Relat Cancer, 23(2), 77-91 DOI 10.1530/ERC-15-0386, PubMed 26574572
Tinholt M, Vollan HK, Sahlberg KK, Jernström S, Kaveh F, Lingjærde OC, Kåresen R, Sauer T, Kristensen V, Børresen-Dale AL, Sandset PM, Iversen N(2015) Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF Breast Cancer Res, 17(1), 44 DOI 10.1186/s13058-015-0548-5, PubMed 25882602
Zhang B, Shu XO, Delahanty RJ, Zeng C, Michailidou K, Bolla MK, Wang Q, Dennis J, Wen W, Long J, Li C, Dunning AM, Chang-Claude J, Shah M, Perkins BJ, Czene K, Darabi H, Eriksson M, Bojesen SE, Nordestgaard BG, Nielsen SF, Flyger H, Lambrechts D, Neven P, Wildiers Het al.(2015) Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization J Natl Cancer Inst, 107(11) DOI 10.1093/jnci/djv219, PubMed 26296642
Publications 2014
Carvajal-Carmona LG, O'Mara TA, Painter JN, Lose FA, Dennis J, Michailidou K, Tyrer JP, Ahmed S, Ferguson K, Healey CS, Pooley K, Beesley J, Cheng T, Jones A, Howarth K, Martin L, Gorman M, Hodgson S, National Study of Endometrial Cancer Genetics Group (NSECG), Australian National Endometrial Cancer Study Group (ANECS), Wentzensen N, Fasching PA, Hein A, Beckmann MW, Renner SPet al.(2014) Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk Hum Genet, 134(2), 231-45 DOI 10.1007/s00439-014-1515-4, PubMed 25487306
Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin Ket al.(2014) Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers Cancer Cell, 26(6), 863-879 DOI 10.1016/j.ccell.2014.10.010, PubMed 25490449
Fleischer T, Edvardsen H, Solvang HK, Daviaud C, Naume B, Børresen-Dale AL, Kristensen VN, Tost J(2014) Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients Int J Cancer, 134(11), 2615-25 DOI 10.1002/ijc.28606, PubMed 24395279
Fleischer T, Frigessi A, Johnson KC, Edvardsen H, Touleimat N, Klajic J, Riis ML, Haakensen VD, Wärnberg F, Naume B, Helland A, Børresen-Dale AL, Tost J, Christensen BC, Kristensen VN(2014) Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis Genome Biol, 15(8), 435 DOI 10.1186/PREACCEPT-2333349012841587, PubMed 25146004
Ghoussaini M, Edwards SL, Michailidou K, Nord S, Cowper-Sal Lari R, Desai K, Kar S, Hillman KM, Kaufmann S, Glubb DM, Beesley J, Dennis J, Bolla MK, Wang Q, Dicks E, Guo Q, Schmidt MK, Shah M, Luben R, Brown J, Czene K, Darabi H, Eriksson M, Klevebring D, Bojesen SEet al.(2014) Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation Nat Commun, 4, 4999 DOI 10.1038/ncomms5999, PubMed 25248036
Glubb DM, Maranian MJ, Michailidou K, Pooley KA, Meyer KB, Kar S, Carlebur S, O'Reilly M, Betts JA, Hillman KM, Kaufmann S, Beesley J, Canisius S, Hopper JL, Southey MC, Tsimiklis H, Apicella C, Schmidt MK, Broeks A, Hogervorst FB, van der Schoot CE, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan Pet al.(2014) Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1 Am J Hum Genet, 96(1), 5-20 DOI 10.1016/j.ajhg.2014.11.009, PubMed 25529635
Halvorsen AR, Helland A, Fleischer T, Haug KM, Grenaker Alnaes GI, Nebdal D, Syljuåsen RG, Touleimat N, Busato F, Tost J, Saetersdal AB, Børresen-Dale AL, Kristensen V, Edvardsen H(2014) Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy Int J Cancer, 135(9), 2085-95 DOI 10.1002/ijc.28862, PubMed 24658971
Johnson N, Dudbridge F, Orr N, Gibson L, Jones ME, Schoemaker MJ, Folkerd EJ, Haynes BP, Hopper JL, Southey MC, Dite GS, Apicella C, Schmidt MK, Broeks A, Van't Veer LJ, Atsma F, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Ekici AB, Renner SP, Sawyer E, Tomlinson I, Kerin Met al.(2014) Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study Breast Cancer Res, 16(3), R51 DOI 10.1186/bcr3662, PubMed 24887515
Khan S, Greco D, Michailidou K, Milne RL, Muranen TA, Heikkinen T, Aaltonen K, Dennis J, Bolla MK, Liu J, Hall P, Irwanto A, Humphreys K, Li J, Czene K, Chang-Claude J, Hein R, Rudolph A, Seibold P, Flesch-Janys D, Fletcher O, Peto J, dos Santos Silva I, Johnson N, Gibson Let al.(2014) MicroRNA related polymorphisms and breast cancer risk PLoS One, 9(11), e109973 DOI 10.1371/journal.pone.0109973, PubMed 25390939
Klajic J, Busato F, Edvardsen H, Touleimat N, Fleischer T, Bukholm I, Børresen-Dale AL, Lønning PE, Tost J, Kristensen VN(2014) DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors Clin Cancer Res, 20(24), 6357-66 DOI 10.1158/1078-0432.CCR-14-0297, PubMed 25294903
Kristensen VN, Lingjærde OC, Russnes HG, Vollan HK, Frigessi A, Børresen-Dale AL(2014) Principles and methods of integrative genomic analyses in cancer Nat Rev Cancer, 14(5), 299-313 DOI 10.1038/nrc3721, PubMed 24759209
Li J, Lindström LS, Foo JN, Rafiq S, Schmidt MK, Pharoah PD, Michailidou K, Dennis J, Bolla MK, Wang Q, Van 't Veer LJ, Cornelissen S, Rutgers E, Southey MC, Apicella C, Dite GS, Hopper JL, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Blomqvist C, Muranen TA, Aittomäki K, Lindblom Aet al.(2014) 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy Nat Commun, 5, 4051 DOI 10.1038/ncomms5051, PubMed 24937182
Lin WY, Camp NJ, Ghoussaini M, Beesley J, Michailidou K, Hopper JL, Apicella C, Southey MC, Stone J, Schmidt MK, Broeks A, Van't Veer LJ, Th Rutgers EJ, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Fasching PA, Haeberle L, Ekici AB, Beckmann MW, Peto J, Dos-Santos-Silva I, Fletcher O, Johnson Net al.(2014) Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk Hum Mol Genet, 24(1), 285-98 DOI 10.1093/hmg/ddu431, PubMed 25168388
Painter JN, O'Mara TA, Batra J, Cheng T, Lose FA, Dennis J, Michailidou K, Tyrer JP, Ahmed S, Ferguson K, Healey CS, Kaufmann S, Hillman KM, Walpole C, Moya L, Pollock P, Jones A, Howarth K, Martin L, Gorman M, Hodgson S, National Study of Endometrial Cancer Genetics Group (NSECG), CHIBCHA Consortium, De Polanco MM, Sans Met al.(2014) Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk Hum Mol Genet, 24(5), 1478-92 DOI 10.1093/hmg/ddu552, PubMed 25378557
Purrington KS, Slettedahl S, Bolla MK, Michailidou K, Czene K, Nevanlinna H, Bojesen SE, Andrulis IL, Cox A, Hall P, Carpenter J, Yannoukakos D, Haiman CA, Fasching PA, Mannermaa A, Winqvist R, Brenner H, Lindblom A, Chenevix-Trench G, Benitez J, Swerdlow A, Kristensen V, Guénel P, Meindl A, Darabi Het al.(2014) Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade Hum Mol Genet, 23(22), 6034-46 DOI 10.1093/hmg/ddu300, PubMed 24927736
Quigley D, Silwal-Pandit L, Dannenfelser R, Langerød A, Vollan HK, Vaske C, Siegel JU, Troyanskaya O, Chin SF, Caldas C, Balmain A, Børresen-Dale AL, Kristensen V(2014) Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53 Mol Cancer Res, 13(3), 493-501 DOI 10.1158/1541-7786.MCR-14-0387, PubMed 25351767
Reiche K, Kasack K, Schreiber S, Lüders T, Due EU, Naume B, Riis M, Kristensen VN, Horn F, Børresen-Dale AL, Hackermüller J, Baumbusch LO(2014) Long non-coding RNAs differentially expressed between normal versus primary breast tumor tissues disclose converse changes to breast cancer-related protein-coding genes PLoS One, 9(9), e106076 DOI 10.1371/journal.pone.0106076, PubMed 25264628
Sawyer E, Roylance R, Petridis C, Brook MN, Nowinski S, Papouli E, Fletcher O, Pinder S, Hanby A, Kohut K, Gorman P, Caneppele M, Peto J, Dos Santos Silva I, Johnson N, Swann R, Dwek M, Perkins KA, Gillett C, Houlston R, Ross G, De Ieso P, Southey MC, Hopper JL, Provenzano Eet al.(2014) Genetic predisposition to in situ and invasive lobular carcinoma of the breast PLoS Genet, 10(4), e1004285 DOI 10.1371/journal.pgen.1004285, PubMed 24743323
Silwal-Pandit L, Vollan HK, Chin SF, Rueda OM, McKinney S, Osako T, Quigley DA, Kristensen VN, Aparicio S, Børresen-Dale AL, Caldas C, Langerød A(2014) TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance Clin Cancer Res, 20(13), 3569-80 DOI 10.1158/1078-0432.CCR-13-2943, PubMed 24803582
Tinholt M, Viken MK, Dahm AE, Vollan HK, Sahlberg KK, Garred O, Børresen-Dale AL, Jacobsen AF, Kristensen V, Bukholm I, Kåresen R, Schlichting E, Skretting G, Lie BA, Sandset PM, Iversen N(2014) Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study BMC Cancer, 14, 845 DOI 10.1186/1471-2407-14-845, PubMed 25407022
Vollan HK, Rueda OM, Chin SF, Curtis C, Turashvili G, Shah S, Lingjærde OC, Yuan Y, Ng CK, Dunning MJ, Dicks E, Provenzano E, Sammut S, McKinney S, Ellis IO, Pinder S, Purushotham A, Murphy LC, Kristensen VN, METABRIC Group, Brenton JD, Pharoah PD, Børresen-Dale AL, Aparicio S, Caldas C(2014) A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer Mol Oncol, 9(1), 115-27 DOI 10.1016/j.molonc.2014.07.019, PubMed 25169931
Zhao X, Rødland EA, Sørlie T, Vollan HK, Russnes HG, Kristensen VN, Lingjærde OC, Børresen-Dale AL(2014) Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status BMC Cancer, 14, 211 DOI 10.1186/1471-2407-14-211, PubMed 24645668
Publications 2013
Aure MR, Leivonen SK, Fleischer T, Zhu Q, Overgaard J, Alsner J, Tramm T, Louhimo R, Alnæs GI, Perälä M, Busato F, Touleimat N, Tost J, Børresen-Dale AL, Hautaniemi S, Troyanskaya OG, Lingjærde OC, Sahlberg KK, Kristensen VN(2013) Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors Genome Biol, 14(11), R126 DOI 10.1186/gb-2013-14-11-r126, PubMed 24257477
Aure MR, Steinfeld I, Baumbusch LO, Liestøl K, Lipson D, Nyberg S, Naume B, Sahlberg KK, Kristensen VN, Børresen-Dale AL, Lingjærde OC, Yakhini Z(2013) Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data PLoS One, 8(1), e53014 DOI 10.1371/journal.pone.0053014, PubMed 23382830
Bilal E, Dutkowski J, Guinney J, Jang IS, Logsdon BA, Pandey G, Sauerwine BA, Shimoni Y, Moen Vollan HK, Mecham BH, Rueda OM, Tost J, Curtis C, Alvarez MJ, Kristensen VN, Aparicio S, Børresen-Dale AL, Caldas C, Califano A, Friend SH, Ideker T, Schadt EE, Stolovitzky GA, Margolin AA(2013) Improving breast cancer survival analysis through competition-based multidimensional modeling PLoS Comput Biol, 9(5), e1003047 DOI 10.1371/journal.pcbi.1003047, PubMed 23671412
Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, Hillman KM, Mai PL, Lawrenson K, Stutz MD, Lu Y, Karevan R, Woods N, Johnston RL, French JD, Chen X, Weischer M, Nielsen SF, Maranian MJ, Ghoussaini M, Ahmed Set al.(2013) Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer Nat Genet, 45(4), 371-84, 384e1-2 DOI 10.1038/ng.2566, PubMed 23535731
Edvardsen H, Landmark-Høyvik H, Reinertsen KV, Zhao X, Grenaker-Alnæs GI, Nebdal D, Syvänen AC, Rødningen O, Alsner J, Overgaard J, Borresen-Dale AL, Fosså SD, Kristensen VN(2013) SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling Int J Radiat Oncol Biol Phys, 86(4), 791-9 DOI 10.1016/j.ijrobp.2013.02.025, PubMed 23597419
French JD, Ghoussaini M, Edwards SL, Meyer KB, Michailidou K, Ahmed S, Khan S, Maranian MJ, O'Reilly M, Hillman KM, Betts JA, Carroll T, Bailey PJ, Dicks E, Beesley J, Tyrer J, Maia AT, Beck A, Knoblauch NW, Chen C, Kraft P, Barnes D, González-Neira A, Alonso MR, Herrero Det al.(2013) Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers Am J Hum Genet, 92(4), 489-503 DOI 10.1016/j.ajhg.2013.01.002, PubMed 23540573
Garcia-Closas M, Couch FJ, Lindstrom S, Michailidou K, Schmidt MK, Brook MN, Orr N, Rhie SK, Riboli E, Feigelson HS, Le Marchand L, Buring JE, Eccles D, Miron P, Fasching PA, Brauch H, Chang-Claude J, Carpenter J, Godwin AK, Nevanlinna H, Giles GG, Cox A, Hopper JL, Bolla MK, Wang Qet al.(2013) Genome-wide association studies identify four ER negative-specific breast cancer risk loci Nat Genet, 45(4), 392-8, 398e1-2 DOI 10.1038/ng.2561, PubMed 23535733
Klajic J, Fleischer T, Dejeux E, Edvardsen H, Warnberg F, Bukholm I, Lønning PE, Solvang H, Børresen-Dale AL, Tost J, Kristensen VN(2013) Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors BMC Cancer, 13, 456 DOI 10.1186/1471-2407-13-456, PubMed 24093668
Landmark-Høyvik H, Dumeaux V, Nebdal D, Lund E, Tost J, Kamatani Y, Renault V, Børresen-Dale AL, Kristensen V, Edvardsen H(2013) Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II Genomics, 102(4), 278-87 DOI 10.1016/j.ygeno.2013.07.006, PubMed 23880221
Li J, Foo JN, Schoof N, Varghese JS, Fernandez-Navarro P, Gierach GL, Quek ST, Hartman M, Nord S, Kristensen VN, Pollán M, Figueroa JD, Thompson DJ, Li Y, Khor CC, Humphreys K, Liu J, Czene K, Hall P(2013) Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size J Med Genet, 50(10), 666-73 DOI 10.1136/jmedgenet-2013-101708, PubMed 23825393
Margolin AA, Bilal E, Huang E, Norman TC, Ottestad L, Mecham BH, Sauerwine B, Kellen MR, Mangravite LM, Furia MD, Vollan HK, Rueda OM, Guinney J, Deflaux NA, Hoff B, Schildwachter X, Russnes HG, Park D, Vang VO, Pirtle T, Youseff L, Citro C, Curtis C, Kristensen VN, Hellerstein Jet al.(2013) Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer Sci Transl Med, 5(181), 181re1 DOI 10.1126/scitranslmed.3006112, PubMed 23596205
Meyer KB, O'Reilly M, Michailidou K, Carlebur S, Edwards SL, French JD, Prathalingham R, Dennis J, Bolla MK, Wang Q, de Santiago I, Hopper JL, Tsimiklis H, Apicella C, Southey MC, Schmidt MK, Broeks A, Van 't Veer LJ, Hogervorst FB, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Fasching PA, Lux MPet al.(2013) Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1 Am J Hum Genet, 93(6), 1046-60 DOI 10.1016/j.ajhg.2013.10.026, PubMed 24290378
Michailidou K, Hall P, Gonzalez-Neira A, Ghoussaini M, Dennis J, Milne RL, Schmidt MK, Chang-Claude J, Bojesen SE, Bolla MK, Wang Q, Dicks E, Lee A, Turnbull C, Rahman N, Breast and Ovarian Cancer Susceptibility Collaboration, Fletcher O, Peto J, Gibson L, Dos Santos Silva I, Nevanlinna H, Muranen TA, Aittomäki K, Blomqvist C, Czene Ket al.(2013) Large-scale genotyping identifies 41 new loci associated with breast cancer risk Nat Genet, 45(4), 353-61, 361e1-2 DOI 10.1038/ng.2563, PubMed 23535729
Milne RL, Herranz J, Michailidou K, Dennis J, Tyrer JP, Zamora MP, Arias-Perez JI, González-Neira A, Pita G, Alonso MR, Wang Q, Bolla MK, Czene K, Eriksson M, Humphreys K, Darabi H, Li J, Anton-Culver H, Neuhausen SL, Ziogas A, Clarke CA, Hopper JL, Dite GS, Apicella C, Southey MCet al.(2013) A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium Hum Mol Genet, 23(7), 1934-46 DOI 10.1093/hmg/ddt581, PubMed 24242184
Møller EK, Kumar P, Voet T, Peterson A, Van Loo P, Mathiesen RR, Fjelldal R, Grundstad J, Borgen E, Baumbusch LO, Naume B, Børresen-Dale AL, White KP, Nord S, Kristensen VN(2013) Next-generation sequencing of disseminated tumor cells Front Oncol, 3, 320 DOI 10.3389/fonc.2013.00320, PubMed 24427740
Purrington KS, Slager S, Eccles D, Yannoukakos D, Fasching PA, Miron P, Carpenter J, Chang-Claude J, Martin NG, Montgomery GW, Kristensen V, Anton-Culver H, Goodfellow P, Tapper WJ, Rafiq S, Gerty SM, Durcan L, Konstantopoulou I, Fostira F, Vratimos A, Apostolou P, Konstanta I, Kotoula V, Lakis S, Dimopoulos MAet al.(2013) Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer Carcinogenesis, 35(5), 1012-9 DOI 10.1093/carcin/bgt404, PubMed 24325915
Quigley DA, Fiorito E, Nord S, Van Loo P, Alnæs GG, Fleischer T, Tost J, Moen Vollan HK, Tramm T, Overgaard J, Bukholm IR, Hurtado A, Balmain A, Børresen-Dale AL, Kristensen V(2013) The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors Mol Oncol, 8(2), 273-84 DOI 10.1016/j.molonc.2013.11.008, PubMed 24388359
Riis ML, Zhao X, Kaveh F, Vollan HS, Nesbakken AJ, Solvang HK, Lüders T, Bukholm IR, Kristensen VN(2013) Gene expression profile analysis of t1 and t2 breast cancer reveals different activation pathways ISRN Oncol, 2013, 924971 DOI 10.1155/2013/924971, PubMed 23533813
Tahiri A, Leivonen SK, Lüders T, Steinfeld I, Ragle Aure M, Geisler J, Mäkelä R, Nord S, Riis ML, Yakhini Z, Kleivi Sahlberg K, Børresen-Dale AL, Perälä M, Bukholm IR, Kristensen VN(2013) Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors Carcinogenesis, 35(1), 76-85 DOI 10.1093/carcin/bgt333, PubMed 24104550
Tahiri A, Røe K, Ree AH, de Wijn R, Risberg K, Busch C, Lønning PE, Kristensen V, Geisler J(2013) Differential inhibition of ex-vivo tumor kinase activity by vemurafenib in BRAF(V600E) and BRAF wild-type metastatic malignant melanoma PLoS One, 8(8), e72692 DOI 10.1371/journal.pone.0072692, PubMed 24023633
Publications 2012
Engebraaten O, Edvardsen H, Løkkevik E, Naume B, Kristensen V, Ottestad L, Natarajan V(2012) Gefitinib in Combination with Weekly Docetaxel in Patients with Metastatic Breast Cancer Caused Unexpected Toxicity: Results from a Randomized Phase II Clinical Trial ISRN Oncol, 2012, 176789 DOI 10.5402/2012/176789, PubMed 22666610
Ghoussaini M, Fletcher O, Michailidou K, Turnbull C, Schmidt MK, Dicks E, Dennis J, Wang Q, Humphreys MK, Luccarini C, Baynes C, Conroy D, Maranian M, Ahmed S, Driver K, Johnson N, Orr N, dos Santos Silva I, Waisfisz Q, Meijers-Heijboer H, Uitterlinden AG, Rivadeneira F, Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer (HEBON), Hall P, Czene Ket al.(2012) Genome-wide association analysis identifies three new breast cancer susceptibility loci Nat Genet, 44(3), 312-8 DOI 10.1038/ng.1049, PubMed 22267197
Hein R, Maranian M, Hopper JL, Kapuscinski MK, Southey MC, Park DJ, Schmidt MK, Broeks A, Hogervorst FB, Bueno-de-Mesquita HB, Muir KR, Lophatananon A, Rattanamongkongul S, Puttawibul P, Fasching PA, Hein A, Ekici AB, Beckmann MW, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Sawyer E, Tomlinson I, Kerin Met al.(2012) Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC) PLoS One, 7(8), e42380 DOI 10.1371/journal.pone.0042380, PubMed 22879957
Joshi H, Bhanot G, Børresen-Dale AL, Kristensen V(2012) Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway Br J Cancer, 107(10), 1722-8 DOI 10.1038/bjc.2012.461, PubMed 23079576
Joshi H, Nord SH, Frigessi A, Børresen-Dale AL, Kristensen VN(2012) Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes BMC Genomics, 13, 199 DOI 10.1186/1471-2164-13-199, PubMed 22616941
Lambrechts D, Truong T, Justenhoven C, Humphreys MK, Wang J, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Cornelissen S, van Hien R, Sawyer E, Tomlinson I, Kerin M, Miller N, Milne RL, Zamora MP, Pérez JI, Benítez J, Hamann U, Ko YD, Brüning T, GENICA Networket al.(2012) 11q13 is a susceptibility locus for hormone receptor positive breast cancer Hum Mutat, 33(7), 1123-32 DOI 10.1002/humu.22089, PubMed 22461340
Riis ML, Lüders T, Markert EK, Haakensen VD, Nesbakken AJ, Kristensen VN, Bukholm IR(2012) Molecular profiles of pre- and postoperative breast cancer tumours reveal differentially expressed genes ISRN Oncol, 2012, 450267 DOI 10.5402/2012/450267, PubMed 23227362
Stevens KN, Fredericksen Z, Vachon CM, Wang X, Margolin S, Lindblom A, Nevanlinna H, Greco D, Aittomäki K, Blomqvist C, Chang-Claude J, Vrieling A, Flesch-Janys D, Sinn HP, Wang-Gohrke S, Nickels S, Brauch H, GENICA Network, Ko YD, Fischer HP, Schmutzler RK, Meindl A, Bartram CR, Schott S, Engel Cet al.(2012) 19p13.1 is a triple-negative-specific breast cancer susceptibility locus Cancer Res, 72(7), 1795-803 DOI 10.1158/0008-5472.CAN-11-3364, PubMed 22331459
Vachon CM, Scott CG, Fasching PA, Hall P, Tamimi RM, Li J, Stone J, Apicella C, Odefrey F, Gierach GL, Jud SM, Heusinger K, Beckmann MW, Pollan M, Fernández-Navarro P, Gonzalez-Neira A, Benitez J, van Gils CH, Lokate M, Onland-Moret NC, Peeters PH, Brown J, Leyland J, Varghese JS, Easton DFet al.(2012) Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk Cancer Epidemiol Biomarkers Prev, 21(7), 1156-66 DOI 10.1158/1055-9965.EPI-12-0066, PubMed 22454379
Vaclavikova R, Ehrlichova M, Hlavata I, Pecha V, Kozevnikovova R, Trnkova M, Adamek J, Edvardsen H, Kristensen VN, Gut I, Soucek P(2012) Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis Clin Chem Lab Med, 50(11), 1999-2007 DOI 10.1515/cclm-2012-0103, PubMed 23093106
Van Loo P, Nilsen G, Nordgard SH, Vollan HK, Børresen-Dale AL, Kristensen VN, Lingjærde OC(2012) Analyzing cancer samples with SNP arrays Methods Mol Biol, 802, 57-72 DOI 10.1007/978-1-61779-400-1_4, PubMed 22130873
Weischer M, Nordestgaard BG, Pharoah P, Bolla MK, Nevanlinna H, Van't Veer LJ, Garcia-Closas M, Hopper JL, Hall P, Andrulis IL, Devilee P, Fasching PA, Anton-Culver H, Lambrechts D, Hooning M, Cox A, Giles GG, Burwinkel B, Lindblom A, Couch FJ, Mannermaa A, Grenaker Alnæs G, John EM, Dörk T, Flyger Het al.(2012) CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer J Clin Oncol, 30(35), 4308-16 DOI 10.1200/JCO.2012.42.7336, PubMed 23109706
Publications 2011
Broeks A, Schmidt MK, Sherman ME, Couch FJ, Hopper JL, Dite GS, Apicella C, Smith LD, Hammet F, Southey MC, Van 't Veer LJ, de Groot R, Smit VT, Fasching PA, Beckmann MW, Jud S, Ekici AB, Hartmann A, Hein A, Schulz-Wendtland R, Burwinkel B, Marme F, Schneeweiss A, Sinn HP, Sohn Cet al.(2011) Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium Hum Mol Genet, 20(16), 3289-303 DOI 10.1093/hmg/ddr228, PubMed 21596841
Enerly E, Steinfeld I, Kleivi K, Leivonen SK, Aure MR, Russnes HG, Rønneberg JA, Johnsen H, Navon R, Rødland E, Mäkelä R, Naume B, Perälä M, Kallioniemi O, Kristensen VN, Yakhini Z, Børresen-Dale AL(2011) miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors PLoS One, 6(2), e16915 DOI 10.1371/journal.pone.0016915, PubMed 21364938
Haakensen VD, Bjøro T, Lüders T, Riis M, Bukholm IK, Kristensen VN, Troester MA, Homen MM, Ursin G, Børresen-Dale AL, Helland Å(2011) Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas BMC Cancer, 11, 332 DOI 10.1186/1471-2407-11-332, PubMed 21812955
Haakensen VD, Lingjaerde OC, Lüders T, Riis M, Prat A, Troester MA, Holmen MM, Frantzen JO, Romundstad L, Navjord D, Bukholm IK, Johannesen TB, Perou CM, Ursin G, Kristensen VN, Børresen-Dale AL, Helland A(2011) Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features BMC Med Genomics, 4, 77 DOI 10.1186/1755-8794-4-77, PubMed 22044755
Kristensen VN(2011) Divide and conquer: the genetic basis of molecular subclassification of breast cancer EMBO Mol Med, 3(4), 183-5 DOI 10.1002/emmm.201100128, PubMed 21394915
Kristensen VN, Vaske CJ, Ursini-Siegel J, Van Loo P, Nordgard SH, Sachidanandam R, Sørlie T, Wärnberg F, Haakensen VD, Helland Å, Naume B, Perou CM, Haussler D, Troyanskaya OG, Børresen-Dale AL(2011) Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling Proc Natl Acad Sci U S A, 109(8), 2802-7 DOI 10.1073/pnas.1108781108, PubMed 21908711
Milne RL, Goode EL, García-Closas M, Couch FJ, Severi G, Hein R, Fredericksen Z, Malats N, Zamora MP, Arias Pérez JI, Benítez J, Dörk T, Schürmann P, Karstens JH, Hillemanns P, Cox A, Brock IW, Elliot G, Cross SS, Seal S, Turnbull C, Renwick A, Rahman N, Shen CY, Yu JCet al.(2011) Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer Cancer Epidemiol Biomarkers Prev, 20(10), 2222-31 DOI 10.1158/1055-9965.EPI-11-0569, PubMed 21795498
Reinertsen KV, Grenaker Alnæs GI, Landmark-Høyvik H, Loge JH, Wist E, Kristensen VN, Fosså SD, Edvardsen H(2011) Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway Brain Behav Immun, 25(7), 1376-83 DOI 10.1016/j.bbi.2011.04.001, PubMed 21496483
Solvang HK, Lingjærde OC, Frigessi A, Børresen-Dale AL, Kristensen VN(2011) Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer BMC Bioinformatics, 12, 197 DOI 10.1186/1471-2105-12-197, PubMed 21609452
Weigman VJ, Chao HH, Shabalin AA, He X, Parker JS, Nordgard SH, Grushko T, Huo D, Nwachukwu C, Nobel A, Kristensen VN, Børresen-Dale AL, Olopade OI, Perou CM(2011) Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival Breast Cancer Res Treat, 133(3), 865-80 DOI 10.1007/s10549-011-1846-y, PubMed 22048815
Zhao X, Rødland EA, Sørlie T, Naume B, Langerød A, Frigessi A, Kristensen VN, Børresen-Dale AL, Lingjærde OC(2011) Combining gene signatures improves prediction of breast cancer survival PLoS One, 6(3), e17845 DOI 10.1371/journal.pone.0017845, PubMed 21423775
Publications 2010
Biong M, Gram IT, Brill I, Johansen F, Solvang HK, Alnaes GI, Fagerheim T, Bremnes Y, Chanock SJ, Burdett L, Yeager M, Ursin G, Kristensen VN(2010) Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density BMC Med Genomics, 3, 9 DOI 10.1186/1755-8794-3-9, PubMed 20302654
Børresen-Dale AL, Sørlie T, Kristensen VN(2010) On the molecular biology of breast cancer Mol Oncol, 4(3), 171-3 DOI 10.1016/j.molonc.2010.04.007, PubMed 20483673
Dejeux E, Rønneberg JA, Solvang H, Bukholm I, Geisler S, Aas T, Gut IG, Børresen-Dale AL, Lønning PE, Kristensen VN, Tost J(2010) DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response Mol Cancer, 9, 68 DOI 10.1186/1476-4598-9-68, PubMed 20338046
Edvardsen H, Brunsvig PF, Solvang H, Tsalenko A, Andersen A, Syvanen AC, Yakhini Z, Børresen-Dale AL, Olsen H, Aamdal S, Kristensen VN(2010) SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance Pharmacogenomics J, 10(6), 513-23 DOI 10.1038/tpj.2010.6, PubMed 20157331
Fu YP, Edvardsen H, Kaushiva A, Arhancet JP, Howe TM, Kohaar I, Porter-Gill P, Shah A, Landmark-Høyvik H, Fosså SD, Ambs S, Naume B, Børresen-Dale AL, Kristensen VN, Prokunina-Olsson L(2010) NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations Mol Cancer, 9, 113 DOI 10.1186/1476-4598-9-113, PubMed 20482849
Haakensen VD, Biong M, Lingjærde OC, Holmen MM, Frantzen JO, Chen Y, Navjord D, Romundstad L, Lüders T, Bukholm IK, Solvang HK, Kristensen VN, Ursin G, Børresen-Dale AL, Helland A(2010) Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density Breast Cancer Res, 12(4), R65 DOI 10.1186/bcr2632, PubMed 20799965
Jovanovic J, Rønneberg JA, Tost J, Kristensen V(2010) The epigenetics of breast cancer Mol Oncol, 4(3), 242-54 DOI 10.1016/j.molonc.2010.04.002, PubMed 20627830
Kristensen V, Borresen-Dale AL(2010) Mutations for the people EMBO Mol Med, 2(5), 143-5 DOI 10.1002/emmm.201000071, PubMed 20461736
Landmark-Høyvik H, Reinertsen KV, Loge JH, Kristensen VN, Dumeaux V, Fosså SD, Børresen-Dale AL, Edvardsen H(2010) The genetics and epigenetics of fatigue PM R, 2(5), 456-65 DOI 10.1016/j.pmrj.2010.04.003, PubMed 20656628
Muggerud AA, Rønneberg JA, Wärnberg F, Botling J, Busato F, Jovanovic J, Solvang H, Bukholm I, Børresen-Dale AL, Kristensen VN, Sørlie T, Tost J(2010) Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer Breast Cancer Res, 12(1), R3 DOI 10.1186/bcr2466, PubMed 20056007
Pedersen RS, Brasch-Andersen C, Sim SC, Bergmann TK, Halling J, Petersen MS, Weihe P, Edvardsen H, Kristensen VN, Brøsen K, Ingelman-Sundberg M(2010) Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations Eur J Clin Pharmacol, 66(12), 1199-205 DOI 10.1007/s00228-010-0864-8, PubMed 20665013
Riis ML, Lüders T, Nesbakken AJ, Vollan HS, Kristensen V, Bukholm IR(2010) Expression of BMI-1 and Mel-18 in breast tissue--a diagnostic marker in patients with breast cancer BMC Cancer, 10, 686 DOI 10.1186/1471-2407-10-686, PubMed 21162745
Rønneberg JA, Fleischer T, Solvang HK, Nordgard SH, Edvardsen H, Potapenko I, Nebdal D, Daviaud C, Gut I, Bukholm I, Naume B, Børresen-Dale AL, Tost J, Kristensen V(2010) Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer Mol Oncol, 5(1), 61-76 DOI 10.1016/j.molonc.2010.11.004, PubMed 21212030
Van Loo P, Nordgard SH, Lingjærde OC, Russnes HG, Rye IH, Sun W, Weigman VJ, Marynen P, Zetterberg A, Naume B, Perou CM, Børresen-Dale AL, Kristensen VN(2010) Allele-specific copy number analysis of tumors Proc Natl Acad Sci U S A, 107(39), 16910-5 DOI 10.1073/pnas.1009843107, PubMed 20837533
Publications 2009
Dunning AM, Healey CS, Baynes C, Maia AT, Scollen S, Vega A, Rodríguez R, Barbosa-Morais NL, Ponder BA, SEARCH, Low YL, Bingham S, EPIC, Haiman CA, Le Marchand L, MEC, Broeks A, Schmidt MK, ABCS, Hopper J, Southey M, ABCFS, Beckmann MW, Fasching PA, BBCCet al.(2009) Association of ESR1 gene tagging SNPs with breast cancer risk Hum Mol Genet, 18(6), 1131-9 DOI 10.1093/hmg/ddn429, PubMed 19126777
Gaudet MM, Milne RL, Cox A, Camp NJ, Goode EL, Humphreys MK, Dunning AM, Morrison J, Giles GG, Severi G, Baglietto L, English DR, Couch FJ, Olson JE, Wang X, Chang-Claude J, Flesch-Janys D, Abbas S, Salazar R, Mannermaa A, Kataja V, Kosma VM, Lindblom A, Margolin S, Heikkinen Tet al.(2009) Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium Cancer Epidemiol Biomarkers Prev, 18(5), 1610-6 DOI 10.1158/1055-9965.EPI-08-0745, PubMed 19423537
Glynn SA, Boersma BJ, Howe TM, Edvardsen H, Geisler SB, Goodman JE, Ridnour LA, Lønning PE, Børresen-Dale AL, Naume B, Kristensen VN, Chanock SJ, Wink DA, Ambs S(2009) A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide Clin Cancer Res, 15(12), 4165-73 DOI 10.1158/1078-0432.CCR-09-0119, PubMed 19509150
Kraggerud SM, Oldenburg J, Alnaes GI, Berg M, Kristensen VN, Fossa SD, Lothe RA(2009) Functional glutathione S-transferase genotypes among testicular germ cell tumor survivors: associations with primary and post-chemotherapy tumor histology Pharmacogenet Genomics, 19(10), 751-9 DOI 10.1097/FPC.0b013e3283304253, PubMed 19741569
Leivonen SK, Mäkelä R, Ostling P, Kohonen P, Haapa-Paananen S, Kleivi K, Enerly E, Aakula A, Hellström K, Sahlberg N, Kristensen VN, Børresen-Dale AL, Saviranta P, Perälä M, Kallioniemi O(2009) Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines Oncogene, 28(44), 3926-36 DOI 10.1038/onc.2009.241, PubMed 19684618
Potapenko IO, Haakensen VD, Lüders T, Helland A, Bukholm I, Sørlie T, Kristensen VN, Lingjaerde OC, Børresen-Dale AL(2009) Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression Mol Oncol, 4(2), 98-118 DOI 10.1016/j.molonc.2009.12.001, PubMed 20060370
Sun W, Wright FA, Tang Z, Nordgard SH, Van Loo P, Yu T, Kristensen VN, Perou CM(2009) Integrated study of copy number states and genotype calls using high-density SNP arrays Nucleic Acids Res, 37(16), 5365-77 DOI 10.1093/nar/gkp493, PubMed 19581427
Publications 2008
Baumbusch LO, Aarøe J, Johansen FE, Hicks J, Sun H, Bruhn L, Gunderson K, Naume B, Kristensen VN, Liestøl K, Børresen-Dale AL, Lingjaerde OC(2008) Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors BMC Genomics, 9, 379 DOI 10.1186/1471-2164-9-379, PubMed 18691401
Dumeaux V, Børresen-Dale AL, Frantzen JO, Kumle M, Kristensen VN, Lund E(2008) Gene expression analyses in breast cancer epidemiology: the Norwegian Women and Cancer postgenome cohort study Breast Cancer Res, 10(1), R13 DOI 10.1186/bcr1859, PubMed 18271962
Horlings HM, Bergamaschi A, Nordgard SH, Kim YH, Han W, Noh DY, Salari K, Joosse SA, Reyal F, Lingjaerde OC, Kristensen VN, Børresen-Dale AL, Pollack J, van de Vijver MJ(2008) ESR1 gene amplification in breast cancer: a common phenomenon? Nat Genet, 40(7), 807-8; author reply 810-2 DOI 10.1038/ng0708-807, PubMed 18583965
Kristensen VN, Børresen-Dale AL(2008) SNPs associated with molecular subtypes of breast cancer: on the usefulness of stratified Genome-wide Association Studies (GWAS) in the identification of novel susceptibility loci Mol Oncol, 2(1), 12-5 DOI 10.1016/j.molonc.2008.02.003, PubMed 19383324
Kulle B, Frigessi A, Edvardsen H, Kristensen V, Wojnowski L(2008) Accounting for haplotype phase uncertainty in linkage disequilibrium estimation Genet Epidemiol, 32(2), 168-78 DOI 10.1002/gepi.20273, PubMed 17968987
Kulle B, Frigessi A, Edvardsen H, Kristensen V, Wojnowski L(2008) Accounting for haplotype phase uncertainty in linkage disequilibrium estimation (vol 32, pg 168, 2008) Genet. Epidemiol., 32(6), 586-587 DOI 10.1002/gepi.20332
Nordgard SH, Alnaes GI, Hihn B, Lingjaerde OC, Liestøl K, Tsalenko A, Sørlie T, Lønning PE, Børresen-Dale AL, Kristensen VN(2008) Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival Int J Cancer, 123(3), 577-85 DOI 10.1002/ijc.23541, PubMed 18498133
Nordgard SH, Johansen FE, Alnaes GI, Bucher E, Syvänen AC, Naume B, Børresen-Dale AL, Kristensen VN(2008) Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients Genes Chromosomes Cancer, 47(8), 680-96 DOI 10.1002/gcc.20569, PubMed 18398821
Rønneberg JA, Tost J, Solvang HK, Alnaes GI, Johansen FE, Brendeford EM, Yakhini Z, Gut IG, Lønning PE, Børresen-Dale AL, Gabrielsen OS, Kristensen VN(2008) GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas Cancer Res, 68(14), 5562-71 DOI 10.1158/0008-5472.CAN-07-5828, PubMed 18632608
Tongbai R, Idelman G, Nordgard SH, Cui W, Jacobs JL, Haggerty CM, Chanock SJ, Børresen-Dale AL, Livingston G, Shaunessy P, Chiang CH, Kristensen VN, Bilke S, Gardner K(2008) Transcriptional networks inferred from molecular signatures of breast cancer Am J Pathol, 172(2), 495-509 DOI 10.2353/ajpath.2008.061079, PubMed 18187569
Vaclavikova R, Nordgard SH, Alnaes GI, Hubackova M, Kubala E, Kodet R, Mrhalova M, Novotny J, Gut I, Kristensen VN, Soucek P(2008) Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients Pharmacogenet Genomics, 18(3), 263-73 DOI 10.1097/FPC.0b013e3282f60a91, PubMed 18300948
Publications 2007
Brunsvig PF, Andersen A, Aamdal S, Kristensen V, Olsen H(2007) Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy BMC Cancer, 7, 197 DOI 10.1186/1471-2407-7-197, PubMed 17956601
Chanock SJ, Burdett L, Yeager M, Llaca V, Langerød A, Presswalla S, Kaaresen R, Strausberg RL, Gerhard DS, Kristensen V, Perou CM, Børresen-Dale AL(2007) Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas Breast Cancer Res, 9(1), R5 DOI 10.1186/bcr1637, PubMed 17224074
Edvardsen H, Kristensen VN, Grenaker Alnaes GI, Bøhn M, Erikstein B, Helland A, Børresen-Dale AL, Fosså SD(2007) Germline glutathione S-transferase variants in breast cancer: relation to diagnosis and cutaneous long-term adverse effects after two fractionation patterns of radiotherapy Int J Radiat Oncol Biol Phys, 67(4), 1163-71 DOI 10.1016/j.ijrobp.2006.11.009, PubMed 17336217
Edvardsen H, Tefre T, Jansen L, Vu P, Haffty BG, Fosså SD, Kristensen VN, Børresen-Dale AL(2007) Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence Radiat Oncol, 2, 25 DOI 10.1186/1748-717X-2-25, PubMed 17623063
Garcia-Closas M, Kristensen V, Langerød A, Qi Y, Yeager M, Burdett L, Welch R, Lissowska J, Peplonska B, Brinton L, Gerhard DS, Gram IT, Perou CM, Børresen-Dale AL, Chanock S(2007) Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer Int J Cancer, 121(11), 2532-8 DOI 10.1002/ijc.22985, PubMed 17683073
Garcia-Closas M, Troester MA, Qi Y, Langerød A, Yeager M, Lissowska J, Brinton L, Welch R, Peplonska B, Gerhard DS, Gram IT, Kristensen V, Børresen-Dale AL, Chanock S, Perou CM(2007) Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status Cancer Epidemiol Biomarkers Prev, 16(11), 2269-75 DOI 10.1158/1055-9965.EPI-07-0449, PubMed 18006915
Kellen E, Hemelt M, Broberg K, Golka K, Kristensen VN, Hung RJ, Matullo G, Mittal RD, Porru S, Povey A, Schulz WA, Shen J, Buntinx F, Zeegers MP, Taioli E(2007) Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review Am J Epidemiol, 165(11), 1221-30 DOI 10.1093/aje/kwm003, PubMed 17404387
Nordgard SH, Johansen FE, Alnaes GI, Naume B, Børresen-Dale AL, Kristensen VN(2007) Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes Breast Cancer Res, 9(6), 113 DOI 10.1186/bcr1784, PubMed 18036273
Nordgard SH, Ritchie MD, Jensrud SD, Motsinger AA, Alnaes GI, Lemmon G, Berg M, Geisler S, Moore JH, Lønning PE, Børresen-Dale AL, Kristensen VN(2007) ABCB1 and GST polymorphisms associated with TP53 status in breast cancer Pharmacogenet Genomics, 17(2), 127-36 DOI 10.1097/FPC.0b013e328011abaa, PubMed 17301692
Roca X, Olson AJ, Rao AR, Enerly E, Kristensen VN, Børresen-Dale AL, Andresen BS, Krainer AR, Sachidanandam R(2007) Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics Genome Res, 18(1), 77-87 DOI 10.1101/gr.6859308, PubMed 18032726
Yosef N, Yakhini Z, Tsalenko A, Kristensen V, Børresen-Dale AL, Ruppin E, Sharan R(2007) A supervised approach for identifying discriminating genotype patterns and its application to breast cancer data Bioinformatics, 23(2), e91-8 DOI 10.1093/bioinformatics/btl298, PubMed 17237111
Publications 2006
Edvardsen H, Irene Grenaker Alnaes G, Tsalenko A, Mulcahy T, Yuryev A, Lindersson M, Lien S, Omholt S, Syvänen AC, Børresen-Dale AL, Kristensen VN(2006) Experimental validation of data mined single nucleotide polymorphisms from several databases and consecutive dbSNP builds Pharmacogenet Genomics, 16(3), 207-17 DOI 10.1097/01.fpc.0000194422.12770.fb, PubMed 16495780
Kristensen V, Aven T, Ford D(2006) A new perspective on Renn and Klinke's approach to risk evaluation and management Reliab. Eng. Syst. Saf., 91(4), 421-432 DOI 10.1016/j.ress.2005.02.006
Kristensen VN, Edvardsen H, Tsalenko A, Nordgard SH, Sørlie T, Sharan R, Vailaya A, Ben-Dor A, Lønning PE, Lien S, Omholt S, Syvänen AC, Yakhini Z, Børresen-Dale AL(2006) Genetic variation in putative regulatory loci controlling gene expression in breast cancer Proc Natl Acad Sci U S A, 103(20), 7735-40 DOI 10.1073/pnas.0601893103, PubMed 16684880
Kristensen VN, Tsalenko A, Geisler J, Faldaas A, Grenaker GI, Lingjaerde OC, Fjeldstad S, Yakhini Z, Lønning PE, Børresen-Dale AL(2006) Multilocus analysis of SNP and metabolic data within a given pathway BMC Genomics, 7, 5 DOI 10.1186/1471-2164-7-5, PubMed 16412218
Lahermo P, Liljedahl U, Alnaes G, Axelsson T, Brookes AJ, Ellonen P, Groop PH, Halldén C, Holmberg D, Holmberg K, Keinänen M, Kepp K, Kere J, Kiviluoma P, Kristensen V, Lindgren C, Odeberg J, Osterman P, Parkkonen M, Saarela J, Sterner M, Strömqvist L, Talas U, Wessman M, Palotie Aet al.(2006) A quality assessment survey of SNP genotyping laboratories Hum Mutat, 27(7), 711-4 DOI 10.1002/humu.20346, PubMed 16786507
Paracchini V, Raimondi S, Gram IT, Kang D, Kocabas NA, Kristensen VN, Li D, Parl FF, Rylander-Rudqvist T, Soucek P, Zheng W, Wedren S, Taioli E(2006) Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review Am J Epidemiol, 165(2), 115-25 DOI 10.1093/aje/kwj365, PubMed 17053044
Staalesen V, Knappskog S, Chrisanthar R, Nordgard SH, Løkkevik E, Anker G, Ostenstad B, Lundgren S, Risberg T, Mjaaland I, Gram IT, Kristensen VN, Børresen-Dale AL, Lillehaug JR, Lønning PE(2006) The novel p21 polymorphism p21G251A is associated with locally advanced breast cancer Clin Cancer Res, 12(20 Pt 1), 6000-4 DOI 10.1158/1078-0432.CCR-05-2822, PubMed 17062672
Tommiska J, Jansen L, Kilpivaara O, Edvardsen H, Kristensen V, Tamminen A, Aittomäki K, Blomqvist C, Børresen-Dale AL, Nevanlinna H(2006) ATM variants and cancer risk in breast cancer patients from Southern Finland BMC Cancer, 6, 209 DOI 10.1186/1471-2407-6-209, PubMed 16914028
Tsalenko A, Sharan R, Kristensen V, Edvardsen H, Børresen-Dale AL, Ben-Dor A, Yakhini Z(2006) Analysis of SNP-expression association matrices J Bioinform Comput Biol, 4(2), 259-74 DOI 10.1142/s0219720006001953, PubMed 16819783
Vinnem JE, Witso ES, Kristensen V(2006) Use of ALARP evaluations and risk acceptance criteria for risk informed decision-making in the Norwegian offshore petroleum industry PROC MONOGR ENG WATE, 2567-+
Publications 2005
Aven T, Kristensen V(2005) Perspectives on risk: review and discussion of the basis for establishing a unified and holistic approach Reliab. Eng. Syst. Saf., 90(1), 1-14 DOI 10.1016/j.ress.2004.10.008
Come SE, Buzdar AU, Ingle JN, Arteaga CL, Brodie AM, Colditz GA, Johnston SR, Kristensen VN, Lønning PE, McDonnell DP, Osborne CK, Russo J, Santen RJ, Yee D, Hart CS(2005) Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement Clin Cancer Res, 11(2 Pt 2), 861s-4s PubMed 15701878
Kristensen VN, Sørlie T, Geisler J, Langerød A, Yoshimura N, Kåresen R, Harada N, Lønning PE, Børresen-Dale AL(2005) Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications Clin Cancer Res, 11(2 Pt 2), 878s-83s PubMed 15701881
Kristensen VN, Sørlie T, Geisler J, Yoshimura N, Linegjaerde OC, Glad I, Frigessi A, Harada N, Lønning PE, Børresen-Dale AL(2005) Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer J Steroid Biochem Mol Biol, 95(1-5), 105-11 DOI 10.1016/j.jsbmb.2005.04.028, PubMed 16023338
Tsalenko A, Sharan R, Edvardsen H, Kristensen V, Børresen-Dale AL, Ben-Dor A, Yakhini Z(2005) Analysis of SNP-expression association matrices Proc IEEE Comput Syst Bioinform Conf, 135-43 DOI 10.1109/csb.2005.14, PubMed 16447971
Shahrouzi P, Azimzade Y, Brankiewicz-Kopcinska W, Bhatia S, Kunke D, Richard D, Tekpli X, Kristensen VN, Duijf PHG(2024) Loss of chromosome cytoband 13q14.2 orchestrates breast cancer pathogenesis and drug response Breast Cancer Res, 26(1), 170 DOI 10.1186/s13058-024-01924-4, PubMed 39605038
Ankill J, Zhao Z, Tekpli X, Kure EH, Kristensen VN, Mathelier A, Fleischer T(2024) Integrative pan-cancer analysis reveals a common architecture of dysregulated transcriptional networks characterized by loss of enhancer methylation PLoS Comput Biol, 20(11), e1012565 DOI 10.1371/journal.pcbi.1012565, PubMed 39556603
Zanti M, O'Mahony DG, Parsons MT, Dorling L, Dennis J, Boddicker NJ, Chen W, Hu C, Naven M, Yiangou K, Ahearn TU, Ambrosone CB, Andrulis IL, Antoniou AC, Auer PL, Baynes C, Bodelon C, Bogdanova NV, Bojesen SE, Bolla MK, Brantley KD, Camp NJ, Campbell A, Castelao JE, Cessna MHet al.(2024) Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification medRxiv DOI 10.1101/2024.09.04.24313051, PubMed 39281752