Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Dept. of Microbiology, Cellular Responses to DNA Damage (Bjørås)

17 publications found

Ashuro AA, Lobie TA, Ye DQ, Leng RX, Li BZ, Pan HF, Fan YG (2020)
Review on the Alteration of Gut Microbiota: The Role of HIV Infection and Old Age
AIDS Res Hum Retroviruses, 36 (7), 556-565
DOI 10.1089/AID.2019.0282, PubMed 32323556

Backe PH, Laerdahl JK, Kittelsen LS, Dalhus B, Mørkrid L, Bjørås M (2020)
Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily
Sci Rep, 10 (1), 5656
DOI 10.1038/s41598-020-62548-0, PubMed 32221390

Booth JA, Špírek M, Lobie TA, Skarstad K, Krejci L, Bjørås M (2020)
Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability
Sci Rep, 10 (1), 19422
DOI 10.1038/s41598-020-76426-2, PubMed 33173044

Farooq A, Grønmyr S, Ali O, Rognes T, Scheffler K, Bjørås M, Wang J (2020)
HMST-Seq-Analyzer: A new python tool for differential methylation and hydroxymethylation analysis in various DNA methylation sequencing data
Comput Struct Biotechnol J, 18, 2877-2889
DOI 10.1016/j.csbj.2020.09.038, PubMed 33163148

Grøsvik K, Tesfahun AN, Muruzábal-Lecumberri I, Haugland GT, Leiros I, Ruoff P, Kvaløy JT, Knævelsrud I, Ånensen H, Alexeeva M, Sato K, Matsuda A, Alseth I, Klungland A, Bjelland S (2020)
The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside
Front Microbiol, 11, 263
DOI 10.3389/fmicb.2020.00263, PubMed 32158436

Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P et al. (2020)
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538

Kong XY, Vik ES, Nawaz MS, Berges N, Dahl TB, Vågbø C, Suganthan R, Segers F, Holm S, Quiles-Jiménez A, Gregersen I, Fladeby C, Aukrust P, Bjørås M, Klungland A, Halvorsen B, Alseth I (2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res, 48 (8), 4463-4479
DOI 10.1093/nar/gkaa115, PubMed 32083667

Lobie TA, Woldeamanuel Y, Asrat D, Beyene D, Bjørås M, Aseffa A (2020)
Genetic diversity and drug resistance pattern of Mycobacterium tuberculosis strains isolated from pulmonary tuberculosis patients in the Benishangul Gumuz region and its surroundings, Northwest Ethiopia
PLoS One, 15 (4), e0231320
DOI 10.1371/journal.pone.0231320, PubMed 32267877

Louwe MC, Olsen MB, Kaasbøll OJ, Yang K, Fosshaug LE, Alfsnes K, Øgaard JDS, Rashidi A, Skulberg VM, Yang M, de Miranda Fonseca D, Sharma A, Aronsen JM, Schrumpf E, Ahmed MS, Dahl CP, Nyman TA, Ueland T, Melum E, Halvorsen BE, Bjørås M, Attramadal H, Sjaastad I, Aukrust P, Yndestad A (2020)
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377

Nedal A, Ræder SB, Dalhus B, Helgesen E, Forstrøm RJ, Lindland K, Sumabe BK, Martinsen JH, Kragelund BB, Skarstad K, Bjørås M, Otterlei M (2020)
Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis
Nucleic Acids Res, 48 (10), 5540-5554
DOI 10.1093/nar/gkaa278, PubMed 32347931

Nilsen J, Trabjerg E, Grevys A, Azevedo C, Brennan SO, Stensland M, Wilson J, Sand KMK, Bern M, Dalhus B, Roopenian DC, Sandlie I, Rand KD, Andersen JT (2020)
An intact C-terminal end of albumin is required for its long half-life in humans
Commun Biol, 3 (1), 181
DOI 10.1038/s42003-020-0903-7, PubMed 32313072

Połeć A, Rowe AD, Blicher P, Suganthan R, Bjørås M, Bøe SO (2020)
PML Regulates the Epidermal Differentiation Complex and Skin Morphogenesis during Mouse Embryogenesis
Genes (Basel), 11 (10)
DOI 10.3390/genes11101130, PubMed 32992884

Quiles-Jiménez A, Gregersen I, Mittelstedt Leal de Sousa M, Abbas A, Kong XY, Alseth I, Holm S, Dahl TB, Skagen K, Skjelland M, Aukrust P, Bjørås M, Halvorsen B (2020)
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
Biochem Biophys Res Commun, 533 (4), 631-637
DOI 10.1016/j.bbrc.2020.09.057, PubMed 33004177

Rodriguez-Vargas JM, Martin-Hernandez K, Wang W, Kunath N, Suganthan R, Amé JC, Oliver FJ, Ye J, Bjørås M, Dantzer F (2020)
Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation
Cell Death Dis, 11 (11), 954
DOI 10.1038/s41419-020-03167-5, PubMed 33159039

Sahaf Naeini A, Farooq A, Bjørås M, Wang J (2020)
IGAP-integrative genome analysis pipeline reveals new gene regulatory model associated with nonspecific TF-DNA binding affinity
Comput Struct Biotechnol J, 18, 1270-1286
DOI 10.1016/j.csbj.2020.05.024, PubMed 32612751

Scheffler K, Jalland CMO, Benestad SL, Moldal T, Ersdal C, Gunnes G, Suganthan R, Bjørås M, Tranulis MA (2020)
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease
Free Radic Biol Med, 152, 348-354
DOI 10.1016/j.freeradbiomed.2020.03.030, PubMed 32259578

Yang M, Lin X, Segers F, Suganthan R, Hildrestrand GA, Rinholm JE, Aas PA, Sousa MML, Holm S, Bolstad N, Warren D, Berge RK, Johansen RF, Yndestad A, Kristiansen E, Klungland A, Luna L, Eide L, Halvorsen B, Aukrust P, Bjørås M (2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476

 
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