Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2021 from OUS - Division of Cardiovascular and Pulmonary Diseases

158 publications found

Aabel EW, Chivulescu M, Dejgaard LA, Ribe M, Gjertsen E, Hopp E, Hunt TE, Lie ØH, Haugaa KH (2021)
Tricuspid Annulus Disjunction: Novel Findings by Cardiac Magnetic Resonance in Patients With Mitral Annulus Disjunction
JACC Cardiovasc Imaging, 14 (8), 1535-1543
DOI 10.1016/j.jcmg.2021.01.028, PubMed 33744128

Aakre KM, Hellebø Ottesen A, Strand H, Ludvig Faaren A, Alaour B, Torsvik J, Sylte MS, Marber M, Christensen G, Røsjø H, Omland T (2021)
Biological variation of secretoneurin; a novel cardiovascular biomarker implicated in arrhythmogenesis
Clin Biochem (in press)
DOI 10.1016/j.clinbiochem.2021.09.014, PubMed 34624255

Abadpour S, Wang CC, Niemi EM, Scholz H (2021)
Tissue Engineering Strategies for Improving Beta Cell Transplantation Outcome
Curr. Transplant. Rep., 8 (3), 205-219
DOI 10.1007/s40472-021-00333-2

Abraham WT, Lindenfeld J, Ponikowski P, Agostoni P, Butler J, Desai AS, Filippatos G, Gniot J, Fu M, Gullestad L, Howlett JG, Nicholls SJ, Redon J, Schenkenberger I, Silva-Cardoso J, Störk S, Krzysztof Wranicz J, Savarese G, Brueckmann M, Jamal W, Nordaby M, Peil B, Ritter I, Ustyugova A, Zeller C et al. (2021)
Effect of empagliflozin on exercise ability and symptoms in heart failure patients with reduced and preserved ejection fraction, with and without type 2 diabetes
Eur Heart J, 42 (6), 700-710
DOI 10.1093/eurheartj/ehaa943, PubMed 33351892

Agricola E, Ancona F, Brochet E, Donal E, Dweck M, Faletra F, Lancellotti P, Mahmoud-Elsayed H, Marsan NA, Maurovich-Hovart P, Monaghan M, Ribeiro J, Sade LE, Swaans M, Von Bardeleben RS, Wunderlich N, Zamorano JL, Popescu BA, Cosyns B, Edvardsen T, Reviewers: This document was reviewed by members of the 2018-2020 EACVI Scientific Documents Committee (2021)
The structural heart disease interventional imager rationale, skills and training: a position paper of the European Association of Cardiovascular Imaging
Eur Heart J Cardiovasc Imaging, 22 (5), 471-479
DOI 10.1093/ehjci/jeab005, PubMed 33564848

Alm-Kruse K, Sørensen G, Osbakk SA, Sunde K, Bendz B, Andersen GØ, Fiane A, Hagen OA, Kramer-Johansen J (2021)
Outcome in refractory out-of-hospital cardiac arrest before and after implementation of an ECPR protocol
Resuscitation, 162, 35-42
DOI 10.1016/j.resuscitation.2021.01.038, PubMed 33581226

Aune SK, Byrkjeland R, Solheim S, Arnesen H, Trøseid M, Awoyemi A, Seljeflot I, Helseth R (2021)
Gut related inflammation and cardiorespiratory fitness in patients with CAD and type 2 diabetes: a sub-study of a randomized controlled trial on exercise training
Diabetol Metab Syndr, 13 (1), 36
DOI 10.1186/s13098-021-00655-2, PubMed 33794977

Awoyemi A, Mayerhofer C, Felix AS, Hov JR, Moscavitch SD, Lappegård KT, Hovland A, Halvorsen S, Halvorsen B, Gregersen I, Svardal A, Berge RK, Hansen SH, Götz A, Holm K, Aukrust P, Åkra S, Seljeflot I, Solheim S, Lorenzo A, Gullestad L, Trøseid M, Broch K (2021)
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial
EBioMedicine, 70, 103511
DOI 10.1016/j.ebiom.2021.103511, PubMed 34329947

Azevedo ACA, Barros MVL, Klaboe LG, Edvardsen T, Costa HS, Paixao GMM, Junior ORS, Nunes MCP, Rocha MOC (2021)
Association between myocardial mechanical dispersion and ventricular arrhythmogenicity in chagas cardiomyopathy
Int J Cardiovasc Imaging, 37 (9), 2727-2734
DOI 10.1007/s10554-021-02246-8, PubMed 33881664

Bendiksen BA, McGinley G, Sjaastad I, Zhang L, Espe EKS (2021)
A 4D continuous representation of myocardial velocity fields from tissue phase mapping magnetic resonance imaging
PLoS One, 16 (3), e0247826
DOI 10.1371/journal.pone.0247826, PubMed 33647070

Berger SG, Sjaastad I, Stokke MK (2021)
Right ventricular involvement in hypertrophic cardiomyopathy: evidence and implications from current literature
Scand Cardiovasc J, 55 (4), 195-204
DOI 10.1080/14017431.2021.1901979, PubMed 33759664

Berishvili E, Casiraghi F, Amarelli C, Scholz H, Piemonti L, Berney T, Montserrat N (2021)
Mini-organs forum: how to advance organoid technology to organ transplant community
Transpl Int, 34 (9), 1588-1593
DOI 10.1111/tri.13988, PubMed 34448263

Bjaanæs MM, Nilsen G, Halvorsen AR, Russnes HG, Solberg S, Jørgensen L, Brustugun OT, Lingjærde OC, Helland Å (2021)
Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors
BMC Cancer, 21 (1), 1089
DOI 10.1186/s12885-021-08811-7, PubMed 34625038

Bjerring AW, Edvardsen T, Sarvari SI, Solberg EE (2021)
A. Bjerring og medarbeiderne svarer
Tidsskr Nor Laegeforen, 141
DOI 10.4045/tidsskr.21.0583, PubMed 34505484

Bjerring AW, Fosså SD, Haugnes HS, Nome R, Stokke TM, Haugaa KH, Kiserud CE, Edvardsen T, Sarvari SI (2021)
The cardiac impact of cisplatin-based chemotherapy in survivors of testicular cancer: a 30-year follow-up
Eur Heart J Cardiovasc Imaging, 22 (4), 443-450
DOI 10.1093/ehjci/jeaa289, PubMed 33152065

Bjørkavoll-Bergseth M, Erevik CB, Kleiven Ø, Eijsvogels TMH, Skadberg Ø, Frøysa V, Wiktorski T, Auestad B, Edvardsen T, Moberg Aakre K, Ørn S (2021)
Determinants of Interindividual Variation in Exercise-Induced Cardiac Troponin I Levels
J Am Heart Assoc, 10 (17), e021710
DOI 10.1161/JAHA.121.021710, PubMed 34459237

Blöndal M, Ainla T, Eha J, Lõiveke P, Marandi T, Saar A, Veldre G, Edfors R, Lewinter C, Jernberg T, Jortveit J, Halvorsen S, Becker D, Csanádi Z, Ferenci T, Andréka P, Jánosi A (2021)
Comparison of management and outcomes of ST-segment elevation myocardial infarction patients in Estonia, Hungary, Norway and Sweden according to national ongoing registries
Eur Heart J Qual Care Clin Outcomes (in press)
DOI 10.1093/ehjqcco/qcaa098, PubMed 33710273

Brautaset Englund KV, Østby CM, Rolid K, Gude E, Andreassen AK, Gullestad L, Broch K (2021)
Intravenous iron supplement for iron deficiency in cardiac transplant recipients (IronIC): A randomized clinical trial
J Heart Lung Transplant, 40 (5), 359-367
DOI 10.1016/j.healun.2021.01.1390, PubMed 33612360

Brautaset Englund KV, Østby CM, Tjønnås G, Gude E, Andreassen AK, Gullestad L, Broch K (2021)
Prevalence of iron deficiency in heart transplant recipients
Clin Transplant, 35 (8), e14346
DOI 10.1111/ctr.14346, PubMed 33969559

Brekke PH, Rama T, Pilán I, Nytrø Ø, Øvrelid L (2021)
Synthetic data for annotation and extraction of family history information from clinical text
J Biomed Semantics, 12 (1), 11
DOI 10.1186/s13326-021-00244-2, PubMed 34261535

Broch K, Anstensrud AK, Woxholt S, Sharma K, Tøllefsen IM, Bendz B, Aakhus S, Ueland T, Amundsen BH, Damås JK, Berg ES, Bjørkelund E, Bendz C, Hopp E, Kleveland O, Stensæth KH, Opdahl A, Kløw NE, Seljeflot I, Andersen GØ, Wiseth R, Aukrust P, Gullestad L (2021)
Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction
J Am Coll Cardiol, 77 (15), 1845-1855
DOI 10.1016/j.jacc.2021.02.049, PubMed 33858620

Budts W, Miller O, Babu-Narayan SV, Li W, Valsangiacomo Buechel E, Frigiola A, van den Bosch A, Bonello B, Mertens L, Hussain T, Parish V, Habib G, Edvardsen T, Geva T, Roos-Hesselink JW, Hanseus K, Dos Subira L, Baumgartner H, Gatzoulis M, Di Salvo G (2021)
Imaging the adult with simple shunt lesions: position paper from the EACVI and the ESC WG on ACHD. Endorsed by AEPC (Association for European Paediatric and Congenital Cardiology)
Eur Heart J Cardiovasc Imaging, 22 (6), e58-e70
DOI 10.1093/ehjci/jeaa314, PubMed 33338215

Bugge AS, Kvitting JE, Sundset A, Birkeland S (2021)
Lung autotransplantation and extra-anatomic bypass to treat an aortobronchial fistula after previous surgery for aortic coarctation
J Card Surg, 36 (8), 2924-2927
DOI 10.1111/jocs.15660, PubMed 34018253

Bularga A, Saraste A, Fontes-Carvalho R, Holte E, Cameli M, Michalski B, Williams MC, Podlesnikar T, D'Andrea A, Stankovic I, Mills NL, Manka R, Newby DE, Schultz-Menger J, Haugaa KH, Dweck MR (2021)
EACVI survey on investigations and imaging modalities in chronic coronary syndromes
Eur Heart J Cardiovasc Imaging, 22 (1), 1-7
DOI 10.1093/ehjci/jeaa300, PubMed 33165600

Bürker BS, Malt UF, Gude E, Grov I, Relbo Authen A, Dew MA, Gullestad L (2021)
Symptoms of anxiety after heart transplantation and their association with mortality: A secondary analysis
Clin Transplant, 35 (7), e14323
DOI 10.1111/ctr.14323, PubMed 33882158

Chivulescu M, Krohg-Sørensen K, Scheirlynck E, Lindberg BR, Dejgaard LA, Lie ØH, Helle-Valle T, Skjølsvik ET, Estensen ME, Edvardsen T, Lingaas PS, Haugaa KH (2021)
Mitral annulus disjunction is associated with adverse outcome in Marfan and Loeys-Dietz syndromes
Eur Heart J Cardiovasc Imaging, 22 (9), 1035-1044
DOI 10.1093/ehjci/jeaa324, PubMed 33280029

Christensen AH, Nygaard S, Rolid K, Nytrøen K, Gullestad L, Fiane A, Thaulow E, Døhlen G, Saul JP, Wyller VBB (2021)
Early Signs of Sinoatrial Reinnervation in the Transplanted Heart
Transplantation, 105 (9), 2086-2096
DOI 10.1097/TP.0000000000003580, PubMed 33323767

Christensen AH, Platonov PG, Jensen HK, Chivulescu M, Svensson A, Dahlberg P, Madsen T, Frederiksen TC, Heliö T, Lie ØH, Haugaa KH, Hastrup Svendsen J, Bundgaard H (2021)
Genotype-phenotype correlation in arrhythmogenic right ventricular cardiomyopathy-risk of arrhythmias and heart failure
J Med Genet (in press)
DOI 10.1136/jmedgenet-2021-107911, PubMed 34400560

Christensen AH, Platonov PG, Svensson A, Jensen HK, Rootwelt-Norberg C, Dahlberg P, Madsen T, Frederiksen TC, Heliö T, Haugaa KH, Bundgaard H, Svendsen JH (2021)
Complications of implantable cardioverter-defibrillator treatment in arrhythmogenic right ventricular cardiomyopathy
Europace (in press)
DOI 10.1093/europace/euab112, PubMed 34279601

Coats AJS, Anker SD, Baumbach A, Alfieri O, von Bardeleben RS, Bauersachs J, Bax JJ, Boveda S, Čelutkienė J, Cleland JG, Dagres N, Deneke T, Farmakis D, Filippatos G, Hausleiter J, Hindricks G, Jankowska EA, Lainscak M, Leclercq C, Lund LH, McDonagh T, Mehra MR, Metra M, Mewton N, Mueller C et al. (2021)
The management of secondary mitral regurgitation in patients with heart failure: a joint position statement from the Heart Failure Association (HFA), European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA), and European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC
Eur Heart J, 42 (13), 1254-1269
DOI 10.1093/eurheartj/ehab086, PubMed 33734354

Cohen A, Donal E, Delgado V, Pepi M, Tsang T, Gerber B, Soulat-Dufour L, Habib G, Lancellotti P, Evangelista A, Cujec B, Fine N, Andrade MJ, Sprynger M, Dweck M, Edvardsen T, Popescu BA, Reviewers: This document was reviewed by members of the 2018–2020 EACVI Scientific Documents Committee, chair of the 2018–2020 EACVI Scientific Documents Committee (2021)
EACVI recommendations on cardiovascular imaging for the detection of embolic sources: endorsed by the Canadian Society of Echocardiography
Eur Heart J Cardiovasc Imaging, 22 (6), e24-e57
DOI 10.1093/ehjci/jeab008, PubMed 33709114

Collet JP, Thiele H, Barbato E, Barthélémy O, Bauersachs J, Bhatt DL, Dendale P, Dorobantu M, Edvardsen T, Folliguet T, Gale CP, Gilard M, Jobs A, Jüni P, Lambrinou E, Lewis BS, Mehilli J, Meliga E, Merkely B, Mueller C, Roffi M, Rutten FH, Sibbing D, Siontis GCM, ESC Scientific Document Group (2021)
2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
Eur Heart J, 42 (14), 1289-1367
DOI 10.1093/eurheartj/ehaa575, PubMed 32860058

D'Andrea A, Dweck MR, Holte E, Fontes-Carvalho R, Cameli M, Aboumarie HS, Diener HC, Haugaa KH (2021)
EACVI survey on the management of patients with patent foramen ovale and cryptogenic stroke
Eur Heart J Cardiovasc Imaging, 22 (2), 135-141
DOI 10.1093/ehjci/jeaa318, PubMed 33346351

da Silva GJJ, Altara R, Booz GW, Cataliotti A (2021)
Atrial Natriuretic Peptide31-67: A Novel Therapeutic Factor for Cardiovascular Diseases
Front Physiol, 12, 691407
DOI 10.3389/fphys.2021.691407, PubMed 34305645

Dahl FA, Rama T, Hurlen P, Brekke PH, Husby H, Gundersen T, Nytrø Ø, Øvrelid L (2021)
Neural classification of Norwegian radiology reports: using NLP to detect findings in CT-scans of children
BMC Med Inform Decis Mak, 21 (1), 84
DOI 10.1186/s12911-021-01451-8, PubMed 33663479

Danielsen TK, Sadredini M, Manotheepan R, Aronsen JM, Frisk M, Hansen MH, Andressen KW, Hougen K, Levy FO, Louch WE, Sejersted OM, Sjaastad I, Stokke MK (2021)
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front Cardiovasc Med, 7, 623922
DOI 10.3389/fcvm.2020.623922, PubMed 33569394

Das J, Idh N, Sikkeland LIB, Paues J, Lerm M (2021)
DNA methylome-based validation of induced sputum as an effective protocol to study lung immunity: construction of a classifier of pulmonary cell types
Epigenetics
DOI 10.1080/15592294.2021.1969499, PubMed 34482796

de Lange C, Quattrone A, Try K, Bakke AH, Borger Kvaslerud A, Haugaa K, Estensen ME (2021)
Is experienced pregnancy in women with repaired tetralogy of Fallot related to diffuse myocardial fibrosis?
Int J Cardiol (in press)
DOI 10.1016/j.ijcard.2021.09.033, PubMed 34555445

Degtiarova G, Claus P, Duchenne J, Bogaert J, Nuyts J, Vöros G, Willems R, Larsen CK, Aalen JM, Fjeld JG, Stokke C, Hopp E, Smiseth OA, Voigt JU, Gheysens O (2021)
Left ventricular regional glucose metabolism in combination with septal scar extent identifies CRT responders
Eur J Nucl Med Mol Imaging, 48 (8), 2437-2446
DOI 10.1007/s00259-020-05161-7, PubMed 33416956

Didriksen H, Molberg Ø, Fretheim H, Gude E, Jordan S, Brunborg C, Palchevskiy V, Garen T, Midtvedt Ø, Andreassen AK, Distler O, Belperio J, Hoffmann-Vold AM (2021)
Association of Lymphangiogenic Factors With Pulmonary Arterial Hypertension in Systemic Sclerosis
Arthritis Rheumatol, 73 (7), 1277-1287
DOI 10.1002/art.41665, PubMed 33497027

Due-Tønnessen N, Egeland CH, Meyerdierks OJ, Opdahl A (2021)
Is radial artery occlusion and local vascular complications following transradial coronary procedures affected by the type of haemostasis device used? A non-inferiority Randomized Controlled Trial (RadCom trial)
Eur J Cardiovasc Nurs, 20 (6), 580-587
DOI 10.1093/eurjcn/zvab004, PubMed 33615328

Durheim MT, Bendstrup E, Carlson L, Sutinen EM, Hyldgaard C, Kalafatis D, Myllärniemi M, Sköld CM, Sjåheim T (2021)
Outcomes of patients with advanced idiopathic pulmonary fibrosis treated with nintedanib or pirfenidone in a real-world multicentre cohort
Respirology, 26 (10), 982-988
DOI 10.1111/resp.14116, PubMed 34291523

Durko AP, Pibarot P, Atluri P, Bapat V, Cameron DE, Casselman FPA, Chen EP, Dahle G, Elefteriades JA, Lancellotti P, Prager RL, Rosenhek R, Speir A, Stijnen M, Tasca G, Yoganathan A, Walther T, De Paulis R, (Task Force Chairman); EACTS–STS–AATS Valve Labelling Task Force (2021)
Essential information on surgical heart valve characteristics for optimal valve prosthesis selection: expert consensus document from the European Association for Cardio-Thoracic Surgery (EACTS)-The Society of Thoracic Surgeons (STS)-American Association for Thoracic Surgery (AATS) Valve Labelling Task Force
Eur J Cardiothorac Surg, 59 (1), 54-64
DOI 10.1093/ejcts/ezaa263, PubMed 33021620

Edvardsen T, Donal E, Marsan NA, Maurovich-Horvat P, Dweck MR, Maurer G, Petersen SE, Cosyns B (2021)
The year 2020 in the European Heart Journal - Cardiovascular Imaging: part I
Eur Heart J Cardiovasc Imaging (in press)
DOI 10.1093/ehjci/jeab148, PubMed 34463734

Ezeofor V', Bray N, Bryning L, Hashmi F, Hoel H, Parker D, Edwards RT (2021)
Economic model to examine the cost-effectiveness of FlowOx home therapy compared to standard care in patients with peripheral artery disease
PLoS One, 16 (1), e0244851
DOI 10.1371/journal.pone.0244851, PubMed 33444396

Falk RS, Mariampillai JE, Prestgaard EE, Heir T, Bodegård J, Robsahm TE, Grundvold I, Skretteberg PT, Engeseth K, Bjornholt JV, Stavem K, Liestøl K, Sandvik L, Thaulow E, Erikssen G, Kjeldsen SE, Gjesdal K, Erikssen JE (2021)
The Oslo Ischaemia Study: cohort profile
BMJ Open, 11 (10), e049111
DOI 10.1136/bmjopen-2021-049111, PubMed 34645662

Föhse FK, Rollefstad S, Ikdahl E, Wibetoe G, Sexton J, Hisdal J, Semb AG (2021)
Degree of arterial stiffness is comparable across inflammatory joint disease entities
Scand J Rheumatol
DOI 10.1080/03009742.2021.1920169, PubMed 34132621

Fraz MSA, Moe N, Revheim ME, Stavrinou ML, Durheim MT, Nordøy I, Macpherson ME, Aukrust P, Jørgensen SF, Aaløkken TM, Fevang B (2021)
Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency-Features of CT and 18F-FDG Positron Emission Tomography/CT in Clinically Progressive Disease
Front Immunol, 11, 617985
DOI 10.3389/fimmu.2020.617985, PubMed 33584710

Frisk M, Le C, Shen X, Røe ÅT, Hou Y, Manfra O, Silva GJJ, van Hout I, Norden ES, Aronsen JM, Laasmaa M, Espe EKS, Zouein FA, Lambert RR, Dahl CP, Sjaastad I, Lunde IG, Coffey S, Cataliotti A, Gullestad L, Tønnessen T, Jones PP, Altara R, Louch WE (2021)
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J Am Coll Cardiol, 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044, PubMed 33509397

Gallard A, Galli E, Hubert A, Bidaut A, Le Rolle V, Smiseth O, Voigt JU, Donal E, Hernández AI (2021)
Echocardiographic view and feature selection for the estimation of the response to CRT
PLoS One, 16 (6), e0252857
DOI 10.1371/journal.pone.0252857, PubMed 34111154

Galli E, Le Rolle V, Smiseth OA, Duchenne J, Aalen JM, Larsen CK, Sade EA, Hubert A, Anilkumar S, Penicka M, Linde C, Leclercq C, Hernandez A, Voigt JU, Donal E (2021)
Importance of Systematic Right Ventricular Assessment in Cardiac Resynchronization Therapy Candidates: A Machine Learning Approach
J Am Soc Echocardiogr, 34 (5), 494-502
DOI 10.1016/j.echo.2020.12.025, PubMed 33422667

Galli E, Oger E, Aalen JM, Duchenne J, Larsen CK, Sade E, Hubert A, Gallard A, Penicka M, Linde C, Le Rolle V, Hernandez A, Leclercq C, Voigt JU, Smiseth OA, Donal E (2021)
Left atrial strain is a predictor of left ventricular systolic and diastolic reverse remodelling in CRT candidates
Eur Heart J Cardiovasc Imaging (in press)
DOI 10.1093/ehjci/jeab163, PubMed 34432006

Galli E, Smiseth OA, Aalen JM, Larsen CK, Sade E, Hubert A, Anilkumar S, Penicka M, Linde C, Le Rolle V, Hernandez A, Leclercq C, Duchenne J, Voigt JU, Donal E (2021)
Prognostic utility of the assessment of diastolic function in patients undergoing cardiac resynchronization therapy
Int J Cardiol, 331, 144-151
DOI 10.1016/j.ijcard.2021.01.046, PubMed 33535079

Ghila L, Legøy TA, Mathisen AF, Abadpour S, Paulo JA, Scholz H, Ræder H, Chera S (2021)
Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors
Int J Mol Sci, 22 (7)
DOI 10.3390/ijms22073698, PubMed 33918250

Grosch IB, Andresen B, Diep LM, Diseth TH, Möller T (2021)
Quality of life and emotional vulnerability in a national cohort of adolescents living with Fontan circulation
Cardiol Young, 1-9 (in press)
DOI 10.1017/S1047951121003188, PubMed 34387177

Grote Beverborg N, Später D, Knöll R, Hidalgo A, Yeh ST, Elbeck Z, Silljé HHW, Eijgenraam TR, Siga H, Zurek M, Palmér M, Pehrsson S, Albery T, Bomer N, Hoes MF, Boogerd CJ, Frisk M, van Rooij E, Damle S, Louch WE, Wang QD, Fritsche-Danielson R, Chien KR, Hansson KM, Mullick AE et al. (2021)
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
Nat Commun, 12 (1), 5180
DOI 10.1038/s41467-021-25439-0, PubMed 34462437

Gude E, Fiane AE (2021)
Can mechanical circulatory support be an effective treatment for HFpEF patients?
Heart Fail Rev
DOI 10.1007/s10741-021-10154-1, PubMed 34370150

Habeichi NJ, Tannous C, Yabluchanskiy A, Altara R, Mericskay M, Booz GW, Zouein FA (2021)
Insights into the modulation of the interferon response and NAD+ in the context of COVID-19
Int Rev Immunol
DOI 10.1080/08830185.2021.1961768, PubMed 34378474

Hasselberg NE, Kagiyama N, Soyama Y, Sugahara M, Goda A, Ryo-Koriyama K, Batel O, Chakinala M, Simon MA, Gorcsan J (2021)
The Prognostic Value of Right Atrial Strain Imaging in Patients with Precapillary Pulmonary Hypertension
J Am Soc Echocardiogr, 34 (8), 851-861.e1
DOI 10.1016/j.echo.2021.03.007, PubMed 33774108

Hauge SW, Dalen H, Estensen ME, Persson RM, Abebe S, Mekonnen D, Nega B, Solholm A, Farstad M, Bogale N, Graven T, Nielssen NE, Brekke HK, Vikenes K, Haaverstad R (2021)
Short-term outcome after open-heart surgery for severe chronic rheumatic heart disease in a low-income country, with comparison with an historical control group: an observational study
Open Heart, 8 (2)
DOI 10.1136/openhrt-2021-001706, PubMed 34376574

Heck SL, Mecinaj A, Ree AH, Hoffmann P, Schulz-Menger J, Fagerland MW, Gravdehaug B, Røsjø H, Steine K, Geisler J, Gulati G, Omland T (2021)
Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy (PRADA): Extended Follow-Up of a 2×2 Factorial, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Candesartan and Metoprolol
Circulation, 143 (25), 2431-2440
DOI 10.1161/CIRCULATIONAHA.121.054698, PubMed 33993702

Helseth R, Kleveland O, Ueland T, Wiseth R, Damas JK, Broch K, Michelsen A, Bendz B, Gullestad L, Aukrust P, Seljeflot I (2021)
Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction
Open Heart, 8 (1)
DOI 10.1136/openhrt-2020-001492, PubMed 33972404

Hoel H, Pettersen EM, Høiseth LØ, Mathiesen I, Seternes A, Hisdal J (2021)
Lower Extremity Intermittent Negative Pressure for Intermittent Claudication. Follow-Up after 24 Weeks of Treatment
Ann Vasc Surg, 75, 253-258
DOI 10.1016/j.avsg.2021.03.016, PubMed 33823265

Hoel H, Pettersen EM, Høiseth LØ, Mathiesen I, Seternes A, Seljeflot I, Hisdal J (2021)
Effects of intermittent negative pressure treatment on circulating vascular biomarkers in patients with intermittent claudication
Vasc Med, 26 (5), 489-496
DOI 10.1177/1358863X211007933, PubMed 33985385

Høiseth LØ, Melau J, Bonnevie-Svendsen M, Nyborg C, Eijsvogels TMH, Hisdal J (2021)
Core Temperature during Cold-Water Triathlon Swimming
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Stroke, STROKEAHA120033016 (in press)
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Does Cold-Water Endurance Swimming Affect Pulmonary Function in Healthy Adults?
Sports (Basel), 9 (1)
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Inoue K, Khan FH, Remme EW, Ohte N, García-Izquierdo E, Chetrit M, Moñivas-Palomero V, Mingo-Santos S, Andersen ØS, Gude E, Andreassen AK, Wang TKM, Kikuchi S, Stugaard M, Ha JW, Klein AL, Nagueh SF, Smiseth OA (2021)
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Johnsen GM, Fjeldstad HES, Drabbels JJM, Haasnoot GW, Eikmans M, Størvold GL, Alnaes-Katjavivi P, Jacobsen DP, Scherjon SA, Redman CWG, Claas FHJ, Staff AC (2021)
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Jørgensen JJ, Monrad-Hansen PW, Gaarder C, Næss PA (2021)
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Kaplan A, Altara R, Manca M, Gunes HM, Cataliotti A, Booz GW, Zouein FA (2021)
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Karvelsson ST, Sigurdsson A, Seip K, Grinde MT, Wang Q, Johannsson F, Mælandsmo GM, Moestue SA, Rolfsson O, Halldorsson S (2021)
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Mol Cancer Res, 19 (9), 1546-1558
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Karvelsson ST, Wang Q, Hilmarsdottir B, Sigurdsson A, Moestue SA, Mælandsmo GM, Halldorsson S, Gudmundsson S, Rolfsson O (2021)
Argininosuccinate lyase is a metabolic vulnerability in breast development and cancer
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Kasiakogias A, Rosei EA, Camafort M, Ehret G, Faconti L, Ferreira JP, Brguljan J, Januszewicz A, Kahan T, Manolis A, Tsioufis K, Weber T, von Lueder TG, Smiseth OA, Wachtell K, Kjeldsen SE, Zannad F, Mancia G, Kreutz R (2021)
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Kirkels FP, Lie ØH, Cramer MJ, Chivulescu M, Rootwelt-Norberg C, Asselbergs FW, Teske AJ, Haugaa KH (2021)
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JACC Cardiovasc Imaging, 14 (5), 900-910
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Kjønås D, Dahle G, Schirmer H, Malm S, Eidet J, Aaberge L, Steigen T, Aakhus S, Busund R, Rösner A (2021)
Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway
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Klepaker G, Henneberger PK, Hertel JK, Holla ØL, Kongerud J, Fell AKM (2021)
Influence of asthma and obesity on respiratory symptoms, work ability and lung function: findings from a cross-sectional Norwegian population study
BMJ Open Respir Res, 8 (1)
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Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart
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Kotchetkov R, Susman D, Bhutani D, Broch K, Dispenzieri A, Buadi FK (2021)
Chemotherapy-based approach is the preferred treatment for sporadic late-onset nemaline myopathy with a monoclonal protein
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Kristiansen O, Sverre E, Peersen K, Fagerland MW, Gjertsen E, Gullestad L, Perk J, Dammen T, Husebye E, Vethe NT, Munkhaugen J (2021)
The relationship between directly measured statin adherence, self-reported adherence measures and cholesterol levels in patients with coronary heart disease
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Krogh MR, Halvorsen PS, Grymyr OHN, Bergsland J, Elle OJ, Fosse E, Remme EW (2021)
Continuous Estimation of Acute Changes in Preload Using Epicardially Attached Accelerometers
IEEE Trans Biomed Eng, 68 (7), 2067-2075
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Kvaslerud AB, Santic K, Hussain AI, Auensen A, Fiane A, Skulstad H, Aaberge L, Gullestad L, Broch K (2021)
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PLoS One, 16 (4), e0249610
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Kvitting JE, Beitnes JO, Lundblad R (2021)
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Gen Thorac Cardiovasc Surg
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Lanari J, Hagness M, Sartori A, Rosso E, Gringeri E, Dueland S, Cillo U, Line PD (2021)
Liver transplantation versus liver resection for colorectal liver metastasis: a survival benefit analysis in patients stratified according to tumor burden score
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Langlo KAR, Silva GJJ, Overrein TS, Adams V, Wisløff U, Dalen H, Rolim N, Hallan SI (2021)
Circulating microRNAs May Serve as Biomarkers for Hypertensive Emergency End-Organ Injuries and Address Underlying Pathways in an Animal Model
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Lauppe RE, Liseth Hansen J, Gerdesköld C, Rozenbaum MH, Strand AM, Vakevainen M, Kuusisto J, Gude E, Gustafsson F, Smith JG (2021)
Nationwide prevalence and characteristics of transthyretin amyloid cardiomyopathy in Sweden
Open Heart, 8 (2)
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Lauritzen KH, Olsen MB, Ahmed MS, Yang K, Rinholm JE, Bergersen LH, Esbensen QY, Sverkeli LJ, Ziegler M, Attramadal H, Halvorsen B, Aukrust P, Yndestad A (2021)
Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication
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Lekva T, Roland MCP, Estensen ME, Norwitz ER, Tilburgs T, Henriksen T, Bollerslev J, Normann KR, Magnus P, Olstad OK, Aukrust P, Ueland T (2021)
Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence
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Lerum TV, Aaløkken TM, Brønstad E, Aarli B, Ikdahl E, Lund KMA, Durheim MT, Rodriguez JR, Meltzer C, Tonby K, Stavem K, Skjønsberg OH, Ashraf H, Einvik G (2021)
Dyspnoea, lung function and CT findings 3 months after hospital admission for COVID-19
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Healthcare professionals in COVID-19-intensive care units in Norway: preparedness and working conditions: a cohort study
BMJ Open, 11 (10), e049135
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Lie ØH, Chivulescu M, Rootwelt-Norberg C, Ribe M, Bogsrud MP, Lyseggen E, Beitnes JO, Almaas V, Haugaa KH (2021)
Left Ventricular Dysfunction in Arrhythmogenic Cardiomyopathy: Association With Exercise Exposure, Genetic Basis, and Prognosis
J Am Heart Assoc, 10 (8), e018680
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Lie SL, Hisdal J, Høiseth LØ (2021)
Cerebral blood flow velocity during simultaneous changes in mean arterial pressure and cardiac output in healthy volunteers
Eur J Appl Physiol, 121 (8), 2207-2217
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Marstein HS, Godang K, Flatø B, Sjaastad I, Bollerslev J, Sanner H (2021)
Bone mineral density and explanatory factors in children and adults with juvenile dermatomyositis at long term follow-up; a cross sectional study
Pediatr Rheumatol Online J, 19 (1), 56
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Martinez FJ, Yow E, Flaherty KR, Snyder LD, Durheim MT, Wisniewski SR, Sciurba FC, Raghu G, Brooks MM, Kim DY, Dilling DF, Criner GJ, Kim H, Belloli EA, Nambiar AM, Scholand MB, Anstrom KJ, Noth I, CleanUP-IPF Investigators of the Pulmonary Trials Cooperative (2021)
Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial
JAMA, 325 (18), 1841-1851
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Melau J, Hisdal J, Solberg PA (2021)
Impact of a 10,000-m Cold-Water Swim on Norwegian Naval Special Forces Recruits
J Spec Oper Med, 21 (3), 55-59
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Melichova D, Nguyen TM, Salte IM, Klaeboe LG, Sjøli B, Karlsen S, Dahlslett T, Leren IS, Edvardsen T, Brunvand H, Haugaa KH (2021)
Strain echocardiography improves prediction of arrhythmic events in ischemic and non-ischemic dilated cardiomyopathy
Int J Cardiol, 342, 56-62
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Møller J, Altraja A, Sjåheim T, Rasmussen F, Madsen LB, Bendstrup E (2021)
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Mullens W, Auricchio A, Martens P, Witte K, Cowie MR, Delgado V, Dickstein K, Linde C, Vernooy K, Leyva F, Bauersachs J, Israel CW, Lund L, Donal E, Boriani G, Jaarsma T, Berruezo A, Traykov V, Yousef Z, Kalarus Z, Cosedis Nielsen J, Steffel J, Vardas P, Coats A, Seferovic P et al. (2021)
Optimized Implementation of cardiac resynchronization therapy - a call for action for referral and optimization of care
Europace (in press)
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Mullens W, Auricchio A, Martens P, Witte K, Cowie MR, Delgado V, Dickstein K, Linde C, Vernooy K, Leyva F, Bauersachs J, Israel CW, Lund LH, Donal E, Boriani G, Jaarsma T, Berruezo A, Traykov V, Yousef Z, Kalarus Z, Nielsen JC, Steffel J, Vardas P, Coats A, Seferovic P et al. (2021)
Optimized implementation of cardiac resynchronization therapy: a call for action for referral and optimization of care
Europace, 23 (8), 1324-1342
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Myhre PL, Ottesen AH, Faaren AL, Tveit SH, Springett J, Pyylampi J, Stridsberg M, Christensen G, Høiseth AD, Omland T, Røsjø H (2021)
Performance of a Novel Research-Use-Only Secretoneurin ELISA in Patients with Suspected Acute Coronary Syndrome: Comparison with an Established Secretoneurin Radioimmunoassay
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Nguyen TT, Espinoza AW, Hyler S, Remme EW, D'hooge J, Hoff L (2021)
Myocardial Strain Measured by Epicardial Transducers-Comparison Between Velocity Estimators
Ultrasound Med Biol, 47 (5), 1377-1396
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Nordén ES, Bendiksen BA, Andresen H, Bergo KK, Espe EK, Hasic A, Hauge-Iversen IM, Veras I, Hussain RI, Sjaastad I, Christensen G, Cataliotti A (2021)
Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload
ESC Heart Fail, 8 (2), 918-927
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Nordeng J, Schandiz H, Solheim S, Åkra S, Hoffman P, Roald B, Bendz B, Arnesen H, Helseth R, Seljeflot I (2021)
The Inflammasome Signaling Pathway Is Actively Regulated and Related to Myocardial Damage in Coronary Thrombi from Patients with STEMI
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Nyborg C, Bonnevie-Svendsen M, Melsom HS, Melau J, Seljeflot I, Hisdal J (2021)
Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon
Sports (Basel), 9 (9)
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Nyborg C, Melsom HS, Bonnevie-Svendsen M, Melau J, Seljeflot I, Hisdal J (2021)
Transient Reduction of FMD-Response and L-Arginine Accompanied by Increased Levels of E-Selectin, VCAM, and ICAM after Prolonged Strenuous Exercise
Sports (Basel), 9 (6)
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Odland HH, Holm T, Gammelsrud LO, Cornelussen R, Kongsgaard E (2021)
Determinants of LV dP/dtmax and QRS duration with different fusion strategies in cardiac resynchronisation therapy
Open Heart, 8 (1)
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Odland HH, Villegas-Martinez M, Ross S, Holm T, Cornelussen R, Remme EW, Kongsgard E (2021)
Shortening of time-to-peak left ventricular pressure rise (Td) in cardiac resynchronization therapy
ESC Heart Fail
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Ooms JF, Wang DD, Rajani R, Redwood S, Little SH, Chuang ML, Popma JJ, Dahle G, Pfeiffer M, Kanda B, Minet M, Hirsch A, Budde RP, De Jaegere PP, Prendergast B, O'Neill W, Van Mieghem NM (2021)
Computed Tomography-Derived 3D Modeling to Guide Sizing and Planning of Transcatheter Mitral Valve Interventions
JACC Cardiovasc Imaging, 14 (8), 1644-1658
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Ostvik A, Salte IM, Smistad E, Nguyen TM, Melichova D, Brunvand H, Haugaa K, Edvardsen T, Grenne B, Lovstakken L (2021)
Myocardial Function Imaging in Echocardiography Using Deep Learning
IEEE Trans Med Imaging, 40 (5), 1340-1351
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Otterstad JE, Norum IB, Ruddox V, Le ACM, Bendz B, Munkhaugen J, Klungsøyr O, Edvardsen T (2021)
Prognostic impact of non-improvement of global longitudinal strain in patients with revascularized acute myocardial infarction
Int J Cardiovasc Imaging
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Quattrone A, Lie OH, Nestaas E, de Lange C, Try K, Lindberg HL, Skulstad H, Erikssen G, Edvardsen T, Haugaa K, Estensen ME (2021)
Impact of pregnancy and risk factors for ventricular arrhythmias in women with tetralogy of Fallot
Open Heart, 8 (1)
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Rabben T, Mansoor SM, Bay D, Sundhagen JO, Guevara C, Jorgensen JJ (2021)
Screening for Abdominal Aortic Aneurysms and Risk Factors in 65-Year-Old Men in Oslo, Norway
Vasc Health Risk Manag, 17, 561-570
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Riemer TG, Villagomez Fuentes LE, Algharably EAE, Schäfer MS, Mangelsen E, Fürtig MA, Bittner N, Bär A, Zaidi Touis L, Wachtell K, Majic T, Dinges MJ, Kreutz R (2021)
Do β-Blockers Cause Depression?: Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy
Hypertension, 77 (5), 1539-1548
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Riveland E, Larsen TH, Edvardsen T, Saeed S (2021)
Metastatic tumor of the interventricular septum mimicking myocardial calcification: The role of multimodality imaging
Echocardiography, 38 (5), 774-776
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Rohner E, Witman N, Sohlmer J, De Genst E, Louch WE, Sahara M, Chien KR (2021)
An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation
Mol Med, 27 (1), 102
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Rootwelt-Norberg C, Lie ØH, Chivulescu M, Castrini AI, Sarvari SI, Lyseggen E, Almaas VM, Bogsrud MP, Edvardsen T, Haugaa KH (2021)
Sex differences in disease progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy
Europace, 23 (7), 1084-1091
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Rutkovskiy A, Lyngbakken MN, Dahl MB, Bye A, Pedersen MH, Wisløff U, Christensen G, Høiseth AD, Omland T, Røsjø H (2021)
Circulating MicroRNA-210 Concentrations in Patients with Acute Heart Failure: Data from the Akershus Cardiac Examination 2 Study
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Rypdal KB, Erusappan PM, Melleby AO, Seifert DE, Palmero S, Strand ME, Tønnessen T, Dahl CP, Almaas V, Hubmacher D, Apte SS, Christensen G, Lunde IG (2021)
The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts
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Sadredini M, Haugsten Hansen M, Frisk M, Louch WE, Lehnart SE, Sjaastad I, Stokke MK (2021)
CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
Am J Physiol Heart Circ Physiol, 321 (2), H446-H460
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Sadredini M, Manotheepan R, Lehnart SE, Anderson ME, Sjaastad I, Stokke MK (2021)
The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1
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Salte IM, Østvik A, Smistad E, Melichova D, Nguyen TM, Karlsen S, Brunvand H, Haugaa KH, Edvardsen T, Lovstakken L, Grenne B (2021)
Artificial Intelligence for Automatic Measurement of Left Ventricular Strain in Echocardiography
JACC Cardiovasc Imaging, 14 (10), 1918-1928
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Samuelsen PJ, Eggen AE, Steigen T, Wilsgaard T, Kristensen A, Skogsholm A, Holme E, van den Heuvel C, Nordrehaug JE, Bendz B, Nilsen DWT, Bønaa KH (2021)
Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT)
PLoS One, 16 (3), e0247358
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Schwartz PJ, Moreno C, Kotta MC, Pedrazzini M, Crotti L, Dagradi F, Castelletti S, Haugaa KH, Denjoy I, Shkolnikova MA, Brink PA, Heradien MJ, Seyen SRM, Spätjens RLHMG, Spazzolini C, Volders PGA (2021)
Mutation location and IKs regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region
Eur Heart J (in press)
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Senior R, Lindner JR, Edvardsen T, Cosyns B (2021)
Ultrasound contrast agent hypersensitivity in patients allergic to polyethylene glycol: position statement by the European Association of Cardiovascular Imaging
Eur Heart J Cardiovasc Imaging, 22 (9), 959-960
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Setterberg IE, Le C, Frisk M, Li J, Louch WE (2021)
The Physiology and Pathophysiology of T-Tubules in the Heart
Front Physiol, 12, 718404
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Shi LB, Wang YC, Chu SY, De Bortoli A, Schuster P, Solheim E, Chen J (2021)
The impacts of contact force, power and application time on ablation effect indicated by serial measurements of impedance drop in both conventional and high-power short-duration ablation settings of atrial fibrillation
J Interv Card Electrophysiol
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Sigurdardottir S, Bjerkely B, Jenssen TG, Mathisen P, von der Lippe C, Ørstavik K, Heimdal K, Dahle DO, Weedon-Fekjær MS, Solberg O, Pihlstrøm HK (2021)
The impact of demographic and clinical characteristics on the trajectories of health-related quality of life among patients with Fabry disease
Orphanet J Rare Dis, 16 (1), 427
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Sikkeland LIB, Durheim MT, Riste TB, Kongerud J, Alexis NE, Holm AM (2021)
Relation of sputum neutrophilia to the development of chronic lung allograft dysfunction after lung transplantation
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Sitges M, Ajmone Marsan N, Cameli M, D'Andrea A, Carvalho RF, Holte E, Michalski B, Podlesnikar T, Popescu BA, Schulz-Menger J, Stankovic I, Haugaa KH, Dweck MR (2021)
EACVI survey on the evaluation of left ventricular diastolic function
Eur Heart J Cardiovasc Imaging, 22 (10), 1098-1105
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Skaga E, Skretteberg MA, Johannesen TB, Brandal P, Vik-Mo EO, Helseth E, Langmoen IA (2021)
Real-world validity of randomized controlled phase III trials in newly diagnosed glioblastoma: to whom do the results of the trials apply?
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Skåre C, Karlsen H, Strand-Amundsen RJ, Eriksen M, Skulberg VM, Sunde K, Tønnessen TI, Olasveengen TM (2021)
Cerebral perfusion and metabolism with mean arterial pressure 90 vs. 60 mmHg in a porcine post cardiac arrest model with and without targeted temperature management
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Skjølsvik ET, Haugen Lie Ø, Chivulescu M, Ribe M, Castrini AI, Broch K, Pripp AH, Edvardsen T, Haugaa KH (2021)
Progression of cardiac disease in patients with lamin A/C mutations
Eur Heart J Cardiovasc Imaging (in press)
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Sletten OJ, Aalen JM, Izci H, Duchenne J, Remme EW, Larsen CK, Hopp E, Galli E, Sirnes PA, Kongsgard E, Donal E, Voigt JU, Smiseth OA, Skulstad H (2021)
Lateral Wall Dysfunction Signals Onset of Progressive Heart Failure in Left Bundle Branch Block
JACC Cardiovasc Imaging (in press)
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Smiseth OA, Baron T, Marino PN, Marwick TH, Flachskampf FA (2021)
Imaging of the left atrium: pathophysiology insights and clinical utility
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Smiseth OA, Donal E, Penicka M, Sletten OJ (2021)
How to measure left ventricular myocardial work by pressure-strain loops
Eur Heart J Cardiovasc Imaging, 22 (3), 259-261
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Soknes MD, Lingaas PS, Lundblad R, Kvitting JE (2021)
Total aortic arch replacement using the thoraflex hybrid prosthesis: early- and medium-term results from a Scandinavian center
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