
Arnoldo Frigessi
- Director of OCBE (Statistician), Professor
- +47 22 85 10 04 / 957 35 574
Arnoldo Frigessi is department head at the Oslo University Hospital and professor of statistics at the University of Oslo. He is director of the Oslo Center for Biostatistics and Epidemiology. He leads the centre for research based innovation BigInsight (https://www.biginsight.no/), a consortium of partners from academia and the public and private sectors. From 2023, he will be the director of the centre of excellence Integreat- The Norwegian centre for knowledge-driven machine learning, funded by the Research Council of Norway.
Frigessi develops new methods in statistics, machine learning and stochastic models to study principles, dynamics and patterns of complex dependence. Currently, he has research collaborations in genomics, personalised medicine, infectious disease modeling including Covid-19, digital twins and preference learning. Frigessi is elected member of the Norwegian Academy of Sciences and Letters and knighted Cavaliere Ordine al Merito della Repubblica Italiana.
Publications 2023
A multicenter randomized trial for quality of life evaluation by non-invasive intelligent tools during post-curative treatment follow-up for head and neck cancer: Clinical study protocol
Front Oncol, 13, 1048593
DOI 10.3389/fonc.2023.1048593, PubMed 36798825
A real-time regional model for COVID-19: Probabilistic situational awareness and forecasting
PLoS Comput Biol, 19 (1), e1010860
DOI 10.1371/journal.pcbi.1010860, PubMed 36689468
Effects of non-compulsory and mandatory COVID-19 interventions on travel distance and time away from home, Norway, 2021
Euro Surveill, 28 (17)
DOI 10.2807/1560-7917.ES.2023.28.17.2200382, PubMed 37103789
Phenotypic deconvolution in heterogeneous cancer cell populations using drug-screening data
Cell Rep Methods, 3 (3), 100417
DOI 10.1016/j.crmeth.2023.100417, PubMed 37056380
Transcriptomic pan-cancer analysis using rank-based Bayesian inference
Mol Oncol, 17 (4), 548-563
DOI 10.1002/1878-0261.13354, PubMed 36562628
Publications 2022
Reduced heart rate variability is related to the number of metabolic syndrome components and manifest diabetes in the sixth Tromsø study 2007-2008
Sci Rep, 12 (1), 11998
DOI 10.1038/s41598-022-15824-0, PubMed 35835836
Increased household transmission and immune escape of the SARS-CoV-2 Omicron compared to Delta variants
Nat Commun, 13 (1), 5706
DOI 10.1038/s41467-022-33233-9, PubMed 36175424
Pre-diagnostic DNA methylation in blood leucocytes in cutaneous melanoma; a nested case-control study within the Norwegian Women and Cancer cohort
Sci Rep, 12 (1), 14200
DOI 10.1038/s41598-022-18585-y, PubMed 35987900
Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2-host protein-protein interaction network
Brief Bioinform, 23 (6)
DOI 10.1093/bib/bbac456, PubMed 36305426
Publications 2021
Spatial modelling of Lexis mortality data
Spat. Stat., 44, 100532
DOI 10.1016/j.spasta.2021.100532
A scalable solver for a stochastic, hybrid cellular automaton model of personalized breast cancer therapy
Int J Numer Method Biomed Eng, 38 (1), e3542
DOI 10.1002/cnm.3542, PubMed 34716985
Increased transmissibility of the alpha SARS-CoV-2 variant: evidence from contact tracing data in Oslo, January to February 2021
Infect Dis (Lond), 54 (1), 72-77
DOI 10.1080/23744235.2021.1977382, PubMed 34618665
Publications 2020
Contrasting DCIS and invasive breast cancer by subtype suggests basal-like DCIS as distinct lesions
NPJ Breast Cancer, 6, 26
DOI 10.1038/s41523-020-0167-x, PubMed 32577501
Time-aggregated mobile phone mobility data are sufficient for modelling influenza spread: the case of Bangladesh
J R Soc Interface, 17 (167), 20190809
DOI 10.1098/rsif.2019.0809, PubMed 32546112
Lifetime Ultraviolet Radiation Exposure and DNA Methylation in Blood Leukocytes: The Norwegian Women and Cancer Study
Sci Rep, 10 (1), 4521
DOI 10.1038/s41598-020-61430-3, PubMed 32161338
DNA copy number motifs are strong and independent predictors of survival in breast cancer
Commun Biol, 3 (1), 153
DOI 10.1038/s42003-020-0884-6, PubMed 32242091
Publications 2019
A BAYESIAN MALLOWS APPROACH TO NONTRANSITIVE PAIR COMPARISON DATA: HOW HUMAN ARE SOUNDS?
Ann. Appl. Stat., 13 (1), 492-519
DOI 10.1214/18-AOAS1203
A theoretical single-parameter model for urbanisation to study infectious disease spread and interventions
PLoS Comput Biol, 15 (3), e1006879
DOI 10.1371/journal.pcbi.1006879, PubMed 30845153
Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data
Cancer Res, 79 (16), 4293-4304
DOI 10.1158/0008-5472.CAN-18-1804, PubMed 31118201
Model-Based Learning from Preference Data
ANNU REV STAT APPL, 6, 329-354
DOI 10.1146/annurev-statistics-031017-100213
Diverse personalized recommendations with uncertainty from implicit preference data with the Bayesian Mallows model
Knowledge-Based Syst., 186, 104960
DOI 10.1016/j.knosys.2019.104960
A Bayesian two-way latent structure model for genomic data integration reveals few pan-genomic cluster subtypes in a breast cancer cohort
Bioinformatics, 35 (23), 4886-4897
DOI 10.1093/bioinformatics/btz381, PubMed 31077301
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
Nat Commun, 10 (1), 5499
DOI 10.1038/s41467-019-13329-5, PubMed 31796750
Publications 2018
The peer effect on pain tolerance
Scand J Pain, 18 (3), 467-477
DOI 10.1515/sjpain-2018-0060, PubMed 29794275
A three minutes supine position test reveals higher risk of spinal anesthesia induced hypotension during cesarean delivery. An observational study
F1000Res, 7, 1028
DOI 10.12688/f1000research.15142.1, PubMed 30135733
A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework
BMC Genomics, 19 (1), 494
DOI 10.1186/s12864-018-4859-7, PubMed 29940862
Bayesian spatial monotonic multiple regression
Biometrika, 105 (3), 691-707
DOI 10.1093/biomet/asy019
EXTREME VALUE MODELLING OF WATER-RELATED INSURANCE CLAIMS
Ann. Appl. Stat., 12 (1), 246-282
DOI 10.1214/17-AOAS1081
Covariate Selection in High-Dimensional Generalized Linear Models With Measurement Error
J. Comput. Graph. Stat., 27 (4), 739-749
DOI 10.1080/10618600.2018.1425626
Probabilistic preference learning with the Mallows rank model
J. Mach. Learn. Res., 18, 1-49
Publications 2017
Time-varying rankings with the Bayesian Mallows model
Stat, 6 (1), 14-30
DOI 10.1002/sta4.132
Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome
Breast Cancer Res, 19 (1), 44
DOI 10.1186/s13058-017-0812-y, PubMed 28356166
Joint Bayesian modeling of time to malaria and mosquito abundance in Ethiopia
BMC Infect Dis, 17 (1), 415
DOI 10.1186/s12879-017-2496-4, PubMed 28606100
DNA methylation at enhancers identifies distinct breast cancer lineages
Nat Commun, 8 (1), 1379
DOI 10.1038/s41467-017-00510-x, PubMed 29123100
Simulating the life course of psoriasis patients: the interplay between therapy intervention and marital status
J Eur Acad Dermatol Venereol, 32 (1), 62-67
DOI 10.1111/jdv.14567, PubMed 28850745
Publications 2016
Structure learning in Bayesian Networks using regular vines
Comput. Stat. Data Anal., 101, 186-208
DOI 10.1016/j.csda.2016.03.003
Gene expression analysis supports tumor threshold over 2.0 cm for T-category breast cancer
EURASIP J Bioinform Syst Biol, 2016 (1), 6
DOI 10.1186/s13637-015-0034-5, PubMed 26900390
Tilting the lasso by knowledge-based post-processing
BMC Bioinformatics, 17 (1), 344
DOI 10.1186/s12859-016-1210-7, PubMed 27590269
Publications 2015
(sfi)(2) Statistics for Innovation - The experience of the Oslo centre in industrial statistics
Appl. Stoch. Models. Bus. Ind., 31 (1), 82-93
DOI 10.1002/asmb.2113
Rejoinder to '(sfi)(2) Statistics for Innovation The experience of the Oslo centre in industrial statistics'
Appl. Stoch. Models. Bus. Ind., 31 (1), 96
DOI 10.1002/asmb.2114
How well do regional climate models simulate the spatial dependence of precipitation? An application of pair-copula constructions
J. Geophys. Res.-Atmos., 120 (7), 2624-2646
DOI 10.1002/2014JD022748
Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors
Circ Res, 118 (1), 83-94
DOI 10.1161/CIRCRESAHA.115.306629, PubMed 26487741
MEASUREMENT ERROR IN LASSO: IMPACT AND LIKELIHOOD BIAS CORRECTION
Stat. Sin., 25 (2), 809-829
DOI 10.5705/ss.2013.180
Publications 2014
Alcohol and Emotional Contagion: An Examination of the Spreading of Smiles in Male and Female Drinking Groups
Clin Psychol Sci, 3 (5), 686-701
DOI 10.1177/2167702614548892, PubMed 26504673
Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis
Genome Biol, 15 (8), 435
DOI 10.1186/PREACCEPT-2333349012841587, PubMed 25146004
Principles and methods of integrative genomic analyses in cancer
Nat Rev Cancer, 14 (5), 299-313
DOI 10.1038/nrc3721, PubMed 24759209
Development and validation of a gene profile predicting benefit of postmastectomy radiotherapy in patients with high-risk breast cancer: a study of gene expression in the DBCG82bc cohort
Clin Cancer Res, 20 (20), 5272-80
DOI 10.1158/1078-0432.CCR-14-0458, PubMed 25149560
Publications 2013
Statistical Corrections of Invalid Correlation Matrices
Scand. J. Stat., 40 (4), 807-824
DOI 10.1111/sjos.12035
The Genomic HyperBrowser: an analysis web server for genome-scale data
Nucleic Acids Res, 41 (Web Server issue), W133-41
DOI 10.1093/nar/gkt342, PubMed 23632163
A Bayesian hierarchical model with spatial variable selection: the effect of weather on insurance claims
J R Stat Soc Ser C Appl Stat, 62 (1), 85-100
DOI 10.1111/j.1467-9876.2012.01039.x, PubMed 23396890
Publications 2012
Antibiotic resistance in hospitals: a ward-specific random effect model in a low antibiotic consumption environment
Stat Med, 32 (8), 1407-18
DOI 10.1002/sim.5636, PubMed 23027651
Genetic variants affecting the neural processing of human facial expressions: evidence using a genome-wide functional imaging approach
Transl Psychiatry, 2 (7), e143
DOI 10.1038/tp.2012.67, PubMed 22828495
Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes
BMC Genomics, 13, 199
DOI 10.1186/1471-2164-13-199, PubMed 22616941
A characterization of internet dating network structures among nordic men who have sex with men
PLoS One, 7 (7), e39717
DOI 10.1371/journal.pone.0039717, PubMed 22808052
Publications 2011
Estimated comparative integration hotspots identify different behaviors of retroviral gene transfer vectors
PLoS Comput Biol, 7 (12), e1002292
DOI 10.1371/journal.pcbi.1002292, PubMed 22144885
Statistical rehabilitation of improper correlation matrices
Quant. Financ., 11 (7), 1081-1090
DOI 10.1080/14697680903390118
Identifying elemental genomic track types and representing them uniformly
BMC Bioinformatics, 12, 494
DOI 10.1186/1471-2105-12-494, PubMed 22208806
Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype
J Bone Miner Res, 26 (8), 1793-801
DOI 10.1002/jbmr.396, PubMed 21452281
Genome-wide study identifies PTPRO and WDR72 and FOXQ1-SUMO1P1 interaction associated with neurocognitive function
J Psychiatr Res, 46 (2), 271-8
DOI 10.1016/j.jpsychires.2011.11.001, PubMed 22126837
Evaluation of a dynamic downscaling of precipitation over the Norwegian mainland
Tellus Ser. A-Dyn. Meteorol. Oceanol., 63 (4), 746-756
DOI 10.1111/j.1600-0870.2011.00525.x
The differential disease regulome
BMC Genomics, 12, 353
DOI 10.1186/1471-2164-12-353, PubMed 21736759
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer
BMC Bioinformatics, 12, 197
DOI 10.1186/1471-2105-12-197, PubMed 21609452
Combining gene signatures improves prediction of breast cancer survival
PLoS One, 6 (3), e17845
DOI 10.1371/journal.pone.0017845, PubMed 21423775
Publications 2010
On the simplified pair-copula construction - Simply useful or too simplistic?
J. Multivar. Anal., 101 (5), 1296-1310
DOI 10.1016/j.jmva.2009.12.001
In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome
PLoS One, 5 (11), e14002
DOI 10.1371/journal.pone.0014002, PubMed 21124964
The Genomic HyperBrowser: inferential genomics at the sequence level
Genome Biol, 11 (12), R121
DOI 10.1186/gb-2010-11-12-r121, PubMed 21182759
Publications 2009
A stochastic model for the assessment of the transmission pathways of heart and skeleton muscle inflammation, pancreas disease and infectious salmon anaemia in marine fish farms in Norway
Prev Vet Med, 93 (1), 51-61
DOI 10.1016/j.prevetmed.2009.09.010, PubMed 19811843
Investigating possible subtypes of schizophrenia patients and controls based on brain cortical thickness (vol 164, pg 254, 2008)
Psychiatry Res. Neuroimaging, 171 (3), 258
DOI 10.1016/j.pscychresns.2008.12.001
Eight genes are highly associated with BMD variation in postmenopausal Caucasian women
Bone, 46 (3), 604-12
DOI 10.1016/j.bone.2009.11.007, PubMed 19922823
Pair-copula constructions of multiple dependence
Insur. Math. Econ., 44 (2), 182-198
DOI 10.1016/j.insmatheco.2007.02.001
Publications 2008
Indirect genomic effects on survival from gene expression data
Genome Biol, 9 (3), R58
DOI 10.1186/gb-2008-9-3-r58, PubMed 18358079
UNSUPERVISED EMPIRICAL BAYESIAN MULTIPLE TESTING WITH EXTERNAL COVARIATES
Ann. Appl. Stat., 2 (2), 714-735
DOI 10.1214/08-AOAS158
Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure
J Mol Cell Cardiol, 45 (2), 261-9
DOI 10.1016/j.yjmcc.2008.05.009, PubMed 18585734
Accounting for haplotype phase uncertainty in linkage disequilibrium estimation
Genet Epidemiol, 32 (2), 168-78
DOI 10.1002/gepi.20273, PubMed 17968987
Accounting for haplotype phase uncertainty in linkage disequilibrium estimation (vol 32, pg 168, 2008)
Genet. Epidemiol., 32 (6), 586-587
DOI 10.1002/gepi.20332
Investigating possible subtypes of schizophrenia patients and controls based on brain cortical thickness
Psychiatry Res, 164 (3), 254-64
DOI 10.1016/j.pscychresns.2007.12.017, PubMed 19022629
Validation of oligoarrays for quantitative exploration of the transcriptome
BMC Genomics, 9, 258
DOI 10.1186/1471-2164-9-258, PubMed 18513391
Publications 2007
Predicting survival from microarray data--a comparative study
Bioinformatics, 23 (16), 2080-7
DOI 10.1093/bioinformatics/btm305, PubMed 17553857
Climatically driven synchrony of gerbil populations allows large-scale plague outbreaks
Proc Biol Sci, 274 (1621), 1963-9
DOI 10.1098/rspb.2007.0568, PubMed 17550884
Effects of alcohol consumption and antipsychotic medication on brain morphology in schizophrenia
Schizophr Res, 90 (1-3), 52-61
DOI 10.1016/j.schres.2006.11.008, PubMed 17218084
Regional thinning of the cerebral cortex in schizophrenia: effects of diagnosis, age and antipsychotic medication
Schizophr Res, 98 (1-3), 16-28
DOI 10.1016/j.schres.2007.09.015, PubMed 17933495
A stochastic model for infectious salmon anemia (ISA) in Atlantic salmon farming
J R Soc Interface, 4 (15), 699-706
DOI 10.1098/rsif.2007.0217, PubMed 17301014
What can statistics contribute to a causal understanding?
Scand. J. Stat., 34 (1), 155-168
DOI 10.1111/j.1467-9469.2006.00549.x
Publications 2006
BDNF gene variants and brain morphology in schizophrenia
Am J Med Genet B Neuropsychiatr Genet, 141B (5), 513-23
DOI 10.1002/ajmg.b.30338, PubMed 16741916
Brain-derived neurotrophic factor gene (BDNF) variants and schizophrenia: an association study
Prog Neuropsychopharmacol Biol Psychiatry, 30 (5), 924-33
DOI 10.1016/j.pnpbp.2006.02.008, PubMed 16581172
Incidence and clinical presentation of IBD in children: comparison between prospective and retrospective data in a selected Norwegian population
Scand J Gastroenterol, 41 (12), 1433-9
DOI 10.1080/00365520600789891, PubMed 17101574
Publications 2005
Bayesian population dynamics of interacting species: great gerbils and fleas in Kazakhstan
Biometrics, 61 (1), 230-8
DOI 10.1111/j.0006-341X.2005.030536.x, PubMed 15737098
Genome-wide estimation of transcript concentrations from spotted cDNA microarray data
Nucleic Acids Res, 33 (17), e143
DOI 10.1093/nar/gni141, PubMed 16204447
Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer
J Steroid Biochem Mol Biol, 95 (1-5), 105-11
DOI 10.1016/j.jsbmb.2005.04.028, PubMed 16023338
The influence of missing value imputation on detection of differentially expressed genes from microarray data
Bioinformatics, 21 (23), 4272-9
DOI 10.1093/bioinformatics/bti708, PubMed 16216830
Publications 2004
Analysis of the humoral immune response to immunoselected phage-displayed peptides by a microarray-based method
Proteomics, 4 (9), 2572-82
DOI 10.1002/pmic.200300768, PubMed 15352232
Editorial: a special ENBIS issue of SMIJ
Stat. Model., 4 (4), 245-247
DOI 10.1191/1471082X04st077ed
Estimating functions in indirect inference
J. R. Stat. Soc. Ser. B-Stat. Methodol., 66, 447-462
DOI 10.1111/j.1369-7412.2003.05341.x
A genetic and spatial Bayesian analysis of mastitis resistance
Genet Sel Evol, 36 (5), 527-42
DOI 10.1186/1297-9686-36-5-527, PubMed 15339631
Publications 2002
Statistical models and methods for discontinuous phenomena
J. Nonparametr. Stat., 14 (1-2), 1-5
DOI 10.1080/10485250211393
Handling non-extreme events in extreme value modelling of streamflow droughts
IAHS-AISH P (274), 281-288
Stationary space-time Gaussian fields and their time autoregressive representation
Stat. Model., 2 (2), 139-161
DOI 10.1191/1471082x02st029oa
Publications 2000
Penalized pseudolikelihood inference in spatial interaction models with covariates
Scand. J. Stat., 27 (3), 445-458
Antithetic coupling of two Gibbs sampler chains
Ann. Stat., 28 (4), 1128-1149
[Gastrointestinal endoscopy in children]
Tidsskr Nor Laegeforen, 120 (29), 3503-6
PubMed 11188374
Smoothed Langevin proposals in Metropolis-Hastings algorithms
Stat. Probab. Lett., 49 (4), 345-354
DOI 10.1016/S0167-7152(00)00067-5
Publications 1997
Bayesian image classification with Baddeley's delta loss
J. Comput. Graph. Stat., 6 (1), 55-73
DOI 10.2307/1390724
Publications 1994
A stochastic model for neuronal bursting
Biosystems, 33 (1), 1-16
DOI 10.1016/0303-2647(94)90056-6, PubMed 7803696
Publications 1989
A stochastic model for the membrane potential of a stimulated neuron
J Math Biol, 27 (6), 681-92
DOI 10.1007/BF00276950, PubMed 2607222