Ove Øyås

  • Researcher; PhD

I am a computational systems biologist at the Oslo Centre for Biostatistics and Epidemiology (OCBE) who integrates data with mathematical models to understand biology.

Ongoing projects focus on identifying biomarkers in omics data from inflammatory bowel disease patients and connecting treatment to health outcomes in people with gender incongruence or dysphoria.

My previous research focused on multi-omics data analysis and metabolic modeling of humans, other animals, and host-associated microbes such as pathogens or gut microbiomes.

Most of my research involves development of scalable computational methods that make it possible to answer new biological questions, often with a focus on genome-scale metabolism.

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Publications 2024

Kobel CM, Merkesvik J, Burgos IMT, Lai W, Øyås O, Pope PB, Hvidsten TR, Aho VTE (2024)
Integrating host and microbiome biology using holo-omics
Mol Omics, 20 (7), 438-452
DOI 10.1039/d4mo00017j, PubMed 38963125

Vacchini A, Chancellor A, Yang Q, Colombo R, Spagnuolo J, Berloffa G, Joss D, Øyås O, Lecchi C, De Simone G, Beshirova A, Nosi V, Loureiro JP, Morabito A, De Gregorio C, Pfeffer M, Schaefer V, Prota G, Zippelius A, Stelling J, Häussinger D, Brunelli L, Villalta P, Lepore M, Davoli E et al. (2024)
Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells
Sci Immunol, 9 (95), eadn0126
DOI 10.1126/sciimmunol.adn0126, PubMed 38728413

Wedmark YK, Vik JO, Øyås O (2024)
A hierarchy of metabolite exchanges in metabolic models of microbial species and communities
PLoS Comput Biol, 20 (9), e1012472
DOI 10.1371/journal.pcbi.1012472, PubMed 39325831

Publications 2023

Agboola JO, Rocha SDC, Mensah DD, Hansen JØ, Øyås O, Lapeña D, Mydland LT, Arntzen MØ, Horn SJ, Øverland M (2023)
Effect of yeast species and processing on intestinal microbiota of Atlantic salmon (Salmo salar) fed soybean meal-based diets in seawater
Anim Microbiome, 5 (1), 21
DOI 10.1186/s42523-023-00242-y, PubMed 37016467

Molversmyr H, Øyås O, Rotnes F, Vik JO (2023)
Extracting functionally accurate context-specific models of Atlantic salmon metabolism
NPJ Syst Biol Appl, 9 (1), 19
DOI 10.1038/s41540-023-00280-x, PubMed 37244928

Publications 2022

Agboola JO, Mensah DD, Hansen JØ, Lapeña D, Mydland LT, Arntzen MØ, Horn SJ, Øyås O, Press CM, Øverland M (2022)
Effects of Yeast Species and Processing on Intestinal Health and Transcriptomic Profiles of Atlantic Salmon (Salmo salar) Fed Soybean Meal-Based Diets in Seawater
Int J Mol Sci, 23 (3)
DOI 10.3390/ijms23031675, PubMed 35163597

Weththasinghe P, Rocha SDC, Øyås O, Lagos L, Hansen JØ, Mydland LT, Øverland M (2022)
Modulation of Atlantic salmon (Salmo salar) gut microbiota composition and predicted metabolic capacity by feeding diets with processed black soldier fly (Hermetia illucens) larvae meals and fractions
Anim Microbiome, 4 (1), 9
DOI 10.1186/s42523-021-00161-w, PubMed 35033208

Zakhartsev M, Rotnes F, Gulla M, Øyås O, van Dam JCJ, Suarez-Diez M, Grammes F, Hafþórsson RA, van Helvoirt W, Koehorst JJ, Schaap PJ, Jin Y, Mydland LT, Gjuvsland AB, Sandve SR, Martins Dos Santos VAP, Vik JO (2022)
SALARECON connects the Atlantic salmon genome to growth and feed efficiency
PLoS Comput Biol, 18 (6), e1010194
DOI 10.1371/journal.pcbi.1010194, PubMed 35687595

Publications 2021

Morales-Lange B, Agboola JO, Hansen JØ, Lagos L, Øyås O, Mercado L, Mydland LT, Øverland M (2021)
The Spleen as a Target to Characterize Immunomodulatory Effects of Down-Stream Processed Cyberlindnera jadinii Yeasts in Atlantic Salmon Exposed to a Dietary Soybean Meal Challenge
Front Immunol, 12, 708747
DOI 10.3389/fimmu.2021.708747, PubMed 34489959

Publications 2020

Øyås O, Borrell S, Trauner A, Zimmermann M, Feldmann J, Liphardt T, Gagneux S, Stelling J, Sauer U, Zampieri M (2020)
Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis
Proc Natl Acad Sci U S A, 117 (15), 8494-8502
DOI 10.1073/pnas.1915551117, PubMed 32229570

Publications 2019

Yilmaz B, Juillerat P, Øyås O, Ramon C, Bravo FD, Franc Y, Fournier N, Michetti P, Mueller C, Geuking M, Pittet VEH, Maillard MH, Rogler G, Swiss IBD Cohort Investigators, Wiest R, Stelling J, Macpherson AJ (2019)
Microbial network disturbances in relapsing refractory Crohn's disease
Nat Med, 25 (2), 323-336
DOI 10.1038/s41591-018-0308-z, PubMed 30664783

Yilmaz B, Juillerat P, Øyås O, Ramon C, Bravo FD, Franc Y, Fournier N, Michetti P, Mueller C, Geuking M, Pittet VEH, Maillard MH, Rogler G, Swiss IBD Cohort Investigators, Wiest R, Stelling J, Macpherson AJ (2019)
Publisher Correction: Microbial network disturbances in relapsing refractory Crohn's disease
Nat Med, 25 (4), 701
DOI 10.1038/s41591-019-0411-9, PubMed 30846883

Publications 2014

Røkke G, Korvald E, Pahr J, Oyås O, Lale R (2014)
BioBrick assembly standards and techniques and associated software tools
Methods Mol Biol, 1116, 1-24
DOI 10.1007/978-1-62703-764-8_1, PubMed 24395353

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