Manuela Zucknick

  • Director of OCBE (Statistician); Professor
  • +47 908 12 078

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Publications 2023

Alavi DT, Henriksen HB, Lauritzen PM, Zucknick M, Bøhn SK, Henriksen C, Paur I, Smeland S, Blomhoff R (2023)
Effect of a one-year personalized intensive dietary intervention on body composition in colorectal cancer patients: Results from a randomized controlled trial
Clin Nutr ESPEN, 57, 414-422
DOI 10.1016/j.clnesp.2023.06.037, PubMed 37739688

Brynjulvsen M, Solli E, Walewska M, Zucknick M, Djirackor L, Langmoen IA, Mughal AA, Skaga E, Vik-Mo EO, Sandberg CJ (2023)
Functional and Molecular Heterogeneity in Glioma Stem Cells Derived from Multiregional Sampling
Cancers (Basel), 15 (24)
DOI 10.3390/cancers15245826, PubMed 38136371

Hanes R, Ayuda-Durán P, Rønneberg L, Nakken S, Hovig E, Zucknick M, Enserink JM (2023)
screenwerk: a modular tool for the design and analysis of drug combination screens
Bioinformatics, 39 (1)
DOI 10.1093/bioinformatics/btac840, PubMed 36573326

Hsieh PH, Lopes-Ramos CM, Zucknick M, Sandve GK, Glass K, Kuijjer ML (2023)
Adjustment of spurious correlations in co-expression measurements from RNA-Sequencing data
Bioinformatics, 39 (10)
DOI 10.1093/bioinformatics/btad610, PubMed 37802917

Klevberg GL, Zucknick M, Jahnsen R, Eliasson AC (2023)
Development of Hand Use with and Without Intensive Training Among Children with Unilateral Cerebral Palsy in Scandinavia
Dev Neurorehabil, 26 (3), 163-171
DOI 10.1080/17518423.2023.2193256, PubMed 36945898

Rønneberg L, Kirk PDW, Zucknick M (2023)
Dose-response prediction for in-vitro drug combination datasets: a probabilistic approach
BMC Bioinformatics, 24 (1), 161
DOI 10.1186/s12859-023-05256-6, PubMed 37085771

Sailer U, Zucknick M, Laeng B (2023)
Caressed by music: Related preferences for velocity of touch and tempo of music?
Front Psychol, 14, 1135988
DOI 10.3389/fpsyg.2023.1135988, PubMed 36935986

Schmutz M, Zucknick M, Schlenk RF, Mertens D, Benner A, Weichenhan D, Mücke O, Döhner K, Plass C, Bullinger L, Claus R (2023)
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
Clin Epigenetics, 15 (1), 171
DOI 10.1186/s13148-023-01580-z, PubMed 37885041

Vigeland MD, Flåm ST, Vigeland MD, Espeland A, Zucknick M, Wigemyr M, Bråten LCH, Gjefsen E, Zwart JA, Storheim K, Pedersen LM, Selmer K, Lie BA, Gervin K, The Aim Study Group (2023)
Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes
Antibiotics (Basel), 12 (7)
DOI 10.3390/antibiotics12071217, PubMed 37508313

Vilming B, Fallås Dahl J, Bentzen AG, Ingebrigtsen VA, Berge Nilsen E, Vistad I, Dørum A, Solheim O, Bjørge L, Zucknick M, Aune G, Lindemann K (2023)
Real-world data on niraparib maintenance treatment in patients with non-gBRCA mutated platinum-sensitive recurrent ovarian cancer
Int J Gynecol Cancer, 33 (12), 1898-1905
DOI 10.1136/ijgc-2023-004484, PubMed 38000795

Vitelli V, Fleischer T, Ankill J, Arjas E, Frigessi A, Kristensen VN, Zucknick M (2023)
Transcriptomic pan-cancer analysis using rank-based Bayesian inference
Mol Oncol, 17 (4), 548-563
DOI 10.1002/1878-0261.13354, PubMed 36562628

Publications 2022

Degnes ML, Westerberg AC, Zucknick M, Powell TL, Jansson T, Henriksen T, Roland MCP, Michelsen TM (2022)
Placenta-derived proteins across gestation in healthy pregnancies-a novel approach to assess placental function?
BMC Med, 20 (1), 227
DOI 10.1186/s12916-022-02415-z, PubMed 35773701

Kolan SS, Li G, Grimolizzi F, Sexton J, Goll G, Kvien TK, Sundlisæter NP, Zucknick M, Lillegraven S, Haavardsholm EA, Skålhegg BS (2022)
Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis
Front Pharmacol, 13, 1075603
DOI 10.3389/fphar.2022.1075603, PubMed 36467057

LeBlanc M, Rueegg CS, Bekiroğlu N, Esterhuizen TM, Fagerland MW, Falk RS, Frøslie KF, Graf E, Heinze G, Held U, Holst R, Lange T, Mazumdar M, Myrberg IH, Posch M, Sergeant JC, Vach W, Vance EA, Weedon-Fekjaer H, Zucknick M (2022)
Statistical advising: Professional development opportunities for the biostatistician
Stat Med, 41 (5), 847-859
DOI 10.1002/sim.9290, PubMed 35194815

Madjar K, Zucknick M, Ickstadt K, Rahnenführer J (2022)
Correction to: Combining heterogeneous subgroups with graph-structured variable selection priors for Cox regression
BMC Bioinformatics, 23 (1), 32
DOI 10.1186/s12859-021-04552-3, PubMed 35016608

Mørk M, Hoksrud AF, Soberg HL, Zucknick M, Heide M, Groven KS, Røe C (2022)
"Psychometric properties of the Norwegian foot function index revised short form"
BMC Musculoskelet Disord, 23 (1), 416
DOI 10.1186/s12891-022-05374-x, PubMed 35505330

Zhao Z, Wang S, Zucknick M, Aittokallio T (2022)
Tissue-specific identification of multi-omics features for pan-cancer drug response prediction
iScience, 25 (8), 104767
DOI 10.1016/j.isci.2022.104767, PubMed 35992090

Zhao Z, Zucknick M, Aittokallio T (2022)
EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets
Bioinform Adv, 2 (1), vbac073
DOI 10.1093/bioadv/vbac073, PubMed 36699400

Publications 2021

Heinicke F, Zhong X, Flåm ST, Breidenbach J, Leithaug M, Mæhlen MT, Lillegraven S, Aga AB, Norli ES, Mjaavatten MD, Haavardsholm EA, Zucknick M, Rayner S, Lie BA (2021)
MicroRNA Expression Differences in Blood-Derived CD19+ B Cells of Methotrexate Treated Rheumatoid Arthritis Patients
Front Immunol, 12, 663736
DOI 10.3389/fimmu.2021.663736, PubMed 33897713

Klevberg GL, Jahnsen R, Elkjaer S, Zucknick M (2021)
Hand use development in children with unilateral cerebral palsy
Dev Med Child Neurol, 63 (12), 1462-1468
DOI 10.1111/dmcn.14957, PubMed 34152004

Kristiansen O, Zucknick M, Reine TM, Kolset SO, Jansson T, Powell TL, Haugen G, Henriksen T, Michelsen TM (2021)
Mediators Linking Maternal Weight to Birthweight and Neonatal Fat Mass in Healthy Pregnancies
J Clin Endocrinol Metab, 106 (7), 1977-1993
DOI 10.1210/clinem/dgab166, PubMed 33713406

Madjar K, Zucknick M, Ickstadt K, Rahnenführer J (2021)
Combining heterogeneous subgroups with graph-structured variable selection priors for Cox regression
BMC Bioinformatics, 22 (1), 586
DOI 10.1186/s12859-021-04483-z, PubMed 34895139

Rønneberg L, Cremaschi A, Hanes R, Enserink JM, Zucknick M (2021)
bayesynergy: flexible Bayesian modelling of synergistic interaction effects in in vitro drug combination experiments
Brief Bioinform, 22 (6)
DOI 10.1093/bib/bbab251, PubMed 34308471

Schellhorn T, Zucknick M, Askim T, Munthe-Kaas R, Ihle-Hansen H, Seljeseth YM, Knapskog AB, Næss H, Ellekjær H, Thingstad P, Wyller TB, Saltvedt I, Beyer MK (2021)
Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study
BMC Geriatr, 21 (1), 362
DOI 10.1186/s12877-021-02327-2, PubMed 34126944

Zhao Z, Banterle M, Bottolo L, Richardson S, Lewin A, Zucknick M (2021)
BayesSUR: An R Package for High-Dimensional Multivariate Bayesian Variable and Covariance Selection in Linear Regression
J. Stat. Softw., 100 (11), 1-32
DOI 10.18637/jss.v100.i11

Publications 2020

Bragstad LK, Hjelle EG, Zucknick M, Sveen U, Thommessen B, Bronken BA, Martinsen R, Kitzmüller G, Mangset M, Kvigne KJ, Hilari K, Lightbody CE, Kirkevold M (2020)
The effects of a dialogue-based intervention to promote psychosocial well-being after stroke: a randomized controlled trial
Clin Rehabil, 34 (8), 1056-1071
DOI 10.1177/0269215520929737, PubMed 32517513

Epting D, Senaratne LDS, Ott E, Holmgren A, Sumathipala D, Larsen SM, Wallmeier J, Bracht D, Frikstad KM, Crowley S, Sikiric A, Barøy T, Käsmann-Kellner B, Decker E, Decker C, Bachmann N, Patzke S, Phelps IG, Katsanis N, Giles R, Schmidts M, Zucknick M, Lienkamp SS, Omran H, Davis EE et al. (2020)
Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome
Hum Mutat, 41 (12), 2179-2194
DOI 10.1002/humu.24127, PubMed 33131181

Guldvik IJ, Zuber V, Braadland PR, Grytli HH, Ramberg H, Lilleby W, Thiede B, Zucknick M, Saatcioglu F, Gislefoss R, Kvåle R, George A, Grönberg H, Wiklund F, Neal DE, Gnanapragasam VJ, Taskén KA, Mills IG (2020)
Identification and Validation of Leucine-rich α-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification
Eur Urol Open Sci, 21, 51-60
DOI 10.1016/j.euros.2020.08.007, PubMed 34337468

Heinicke F, Zhong X, Zucknick M, Breidenbach J, Sundaram AYM, T Flåm S, Leithaug M, Dalland M, Rayner S, Lie BA, Gilfillan GD (2020)
An extension to: Systematic assessment of commercially available low-input miRNA library preparation kits
RNA Biol, 17 (9), 1284-1292
DOI 10.1080/15476286.2020.1761081, PubMed 32436772

Helset E, Nordøy I, Sporsem H, Bakke VD, Bugge JF, Gammelsrud KW, Zucknick M, von der Lippe E (2020)
Factors increasing the risk of inappropriate vancomycin therapy in ICU patients: A prospective observational study
Acta Anaesthesiol Scand, 64 (9), 1295-1304
DOI 10.1111/aas.13658, PubMed 32578201

Langseth MS, Andersen GØ, Husebye T, Arnesen H, Zucknick M, Solheim S, Eritsland J, Seljeflot I, Opstad TB, Helseth R (2020)
Neutrophil extracellular trap components and myocardial recovery in post-ischemic acute heart failure
PLoS One, 15 (10), e0241333
DOI 10.1371/journal.pone.0241333, PubMed 33119664

Maros ME, Capper D, Jones DTW, Hovestadt V, von Deimling A, Pfister SM, Benner A, Zucknick M, Sill M (2020)
Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data
Nat Protoc, 15 (2), 479-512
DOI 10.1038/s41596-019-0251-6, PubMed 31932775

Pietka W, Sundnes O, Hammarström C, Zucknick M, Khnykin D, Haraldsen G (2020)
Lack of interleukin-33 and its receptor does not prevent calcipotriol-induced atopic dermatitis-like inflammation in mice
Sci Rep, 10 (1), 6451
DOI 10.1038/s41598-020-63410-z, PubMed 32296080

Zhao Z, Zucknick M (2020)
Structured penalized regression for drug sensitivity prediction
J. R. Stat. Soc. Ser. C-Appl. Stat., 69 (3), 525-545
DOI 10.1111/rssc.12400

Publications 2019

Heinicke F, Zhong X, Zucknick M, Breidenbach J, Sundaram AYM, T Flåm S, Leithaug M, Dalland M, Farmer A, Henderson JM, Hussong MA, Moll P, Nguyen L, McNulty A, Shaffer JM, Shore S, Yip HK, Vitkovska J, Rayner S, Lie BA, Gilfillan GD (2019)
Systematic assessment of commercially available low-input miRNA library preparation kits
RNA Biol, 17 (1), 75-86
DOI 10.1080/15476286.2019.1667741, PubMed 31559901

Hjelle EG, Bragstad LK, Kirkevold M, Zucknick M, Bronken BA, Martinsen R, Kvigne KJ, Kitzmüller G, Mangset M, Thommessen B, Sveen U (2019)
Effect of a dialogue-based intervention on psychosocial well-being 6 months after stroke in Norway: A randomized controlled trial
J Rehabil Med, 51 (8), 557-565
DOI 10.2340/16501977-2585, PubMed 31411337

Hjelle EG, Bragstad LK, Zucknick M, Kirkevold M, Thommessen B, Sveen U (2019)
The General Health Questionnaire-28 (GHQ-28) as an outcome measurement in a randomized controlled trial in a Norwegian stroke population
BMC Psychol, 7 (1), 18
DOI 10.1186/s40359-019-0293-0, PubMed 30902115

Hjelle EG, Bragstad LK, Zucknick M, Kirkevold M, Thommessen B, Sveen U (2019)
The General Health Questionnaire-28 (GHQ-28) as an outcome measurement in a randomized controlled trial in a Norwegian stroke population
BMC Psychol., 7 (1), 18
DOI 10.1186/s40359-019-0293-0

Joshi S, De Angelis PM, Zucknick M, Schjølberg AR, Andersen SN, Clausen OPF (2019)
Role of the Wnt signaling pathway in keratoacanthoma
Cancer Rep (Hoboken), 3 (2), e1219
DOI 10.1002/cnr2.1219, PubMed 32672002

Schulze-Edinghausen L, Dürr C, Öztürk S, Zucknick M, Benner A, Kalter V, Ohl S, Close V, Wuchter P, Stilgenbauer S, Lichter P, Seiffert M (2019)
Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia
Cancers (Basel), 11 (6)
DOI 10.3390/cancers11060822, PubMed 31200555

Volchenkov R, Matthews J, Zucknick M, Skålhegg BS (2019)
Shared epitope is associated with the reactivity of Th17 cells to cigarette smoke extract regardless of smoking history
Cell Mol Immunol, 16 (7), 674-675
DOI 10.1038/s41423-019-0230-4, PubMed 31076726

Publications 2018

Dürr C, Hanna BS, Schulz A, Lucas F, Zucknick M, Benner A, Clear A, Ohl S, Öztürk S, Zenz T, Stilgenbauer S, Li-Weber M, Krammer PH, Gribben JG, Lichter P, Seiffert M (2018)
Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin
Haematologica, 103 (4), 688-697
DOI 10.3324/haematol.2017.177808, PubMed 29326123

Henriksen HB, Berntsen S, Paur I, Zucknick M, Skjetne AJ, Bøhn SK, Henriksen C, Smeland S, Carlsen MH, Blomhoff R (2018)
Validation of two short questionnaires assessing physical activity in colorectal cancer patients
BMC Sports Sci Med Rehabil, 10, 8
DOI 10.1186/s13102-018-0096-2, PubMed 29854408

Ickstadt K, Schafer M, Zucknick M (2018)
Toward Integrative Bayesian Analysis in Molecular Biology
ANNU REV STAT APPL, 5, 141-167
DOI 10.1146/annurev-statistics-031017-100438

Jabeen S, Espinoza JA, Torland LA, Zucknick M, Kumar S, Haakensen VD, Lüders T, Engebraaten O, Børresen-Dale AL, Kyte JA, Gromov P, Naume B, Kristensen V, Gromova I, Tekpli X (2018)
Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics
Oncoimmunology, 8 (2), e1537691
DOI 10.1080/2162402X.2018.1537691, PubMed 30713794

Jabeen S, Zucknick M, Nome M, Dannenfelser R, Fleischer T, Kumar S, Lüders T, von der Lippe Gythfeldt H, Troyanskaya O, Kyte JA, Børresen-Dale AL, Naume B, Tekpli X, Engebraaten O, Kristensen V (2018)
Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab
Oncoimmunology, 7 (11), e1457598
DOI 10.1080/2162402X.2018.1457598, PubMed 30377556

Klevberg GL, Elvrum AG, Zucknick M, Elkjaer S, Østensjø S, Krumlinde-Sundholm L, Kjeken I, Jahnsen R (2018)
Development of bimanual performance in young children with cerebral palsy
Dev Med Child Neurol, 60 (5), 490-497
DOI 10.1111/dmcn.13680, PubMed 29392717

LeBlanc M, Nustad HE, Zucknick M, Page CM (2018)
Quality control for Illumina 450K methylation data in the absence of iDat files using correlation structure in pedigrees and repeated measures
BMC Genet, 19 (Suppl 1), 66
DOI 10.1186/s12863-018-0636-5, PubMed 30255766

Nguyen CB, Kumar S, Zucknick M, Kristensen VN, Gjerstad J, Nilsen H, Wyller VB (2018)
Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome
Brain Behav Immun, 76, 82-96
DOI 10.1016/j.bbi.2018.11.008, PubMed 30419269

Nustad HE, Page CM, Reiner AH, Zucknick M, LeBlanc M (2018)
A Bayesian mixed modeling approach for estimating heritability
BMC Proc, 12 (Suppl 9), 31
DOI 10.1186/s12919-018-0131-z, PubMed 30275883

Opheim GL, Zucknick M, Henriksen T, Haugen G (2018)
A maternal meal affects clinical Doppler parameters in the fetal middle cerebral artery
PLoS One, 13 (12), e0209990
DOI 10.1371/journal.pone.0209990, PubMed 30596747

Tanbo TG, Zucknick M, Eskild A (2018)
Maternal concentrations of human chorionic gonadotrophin in very early IVF pregnancies and duration of pregnancy: a follow-up study
Reprod Biomed Online, 37 (2), 208-215
DOI 10.1016/j.rbmo.2018.04.048, PubMed 29773310

Zimmo K, Laine K, Fosse E, Zimmo M, Ali-Masri H, Zucknick M, Vikanes Å, Hassan S (2018)
Episiotomy practice in six Palestinian hospitals: a population-based cohort study among singleton vaginal births
BMJ Open, 8 (7), e021629
DOI 10.1136/bmjopen-2018-021629, PubMed 30012790

Zimmo KM, Laine K, Fosse E, Zimmo M, Ali-Masri H, Böttcher B, Zucknick M, Vikanes Å, Hassan S (2018)
Impact of animated instruction on tablets and hands-on training in applying bimanual perineal support on episiotomy rates: an intervention study
Int Urogynecol J, 30 (8), 1343-1350
DOI 10.1007/s00192-018-3711-6, PubMed 30008080

Øystese KAB, Berg JP, Normann KR, Zucknick M, Casar-Borota O, Bollerslev J (2018)
The role of E and N-cadherin in the postoperative course of gonadotroph pituitary tumours
Endocrine, 62 (2), 351-360
DOI 10.1007/s12020-018-1679-0, PubMed 30051197

Øystese KAB, Hisanawi S, Zucknick M, Bollerslev J, Ringstad G (2018)
Are volume measurements of non-functioning pituitary adenomas reliable?
Endocrine, 63 (1), 171-176
DOI 10.1007/s12020-018-1752-8, PubMed 30259294

Publications 2017

Goeppert B, Roessler S, Becker N, Zucknick M, Vogel MN, Warth A, Pathil-Warth A, Mehrabi A, Schirmacher P, Mollenhauer J, Renner M (2017)
DMBT1 expression in biliary carcinogenesis with correlation of clinicopathological data
Histopathology, 70 (7), 1064-1071
DOI 10.1111/his.13175, PubMed 28130841

Henriksen HB, Ræder H, Bøhn SK, Paur I, Kværner AS, Billington SÅ, Eriksen MT, Wiedsvang G, Erlund I, Færden A, Veierød MB, Zucknick M, Smeland S, Blomhoff R (2017)
The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: a food-based multicentre randomized controlled trial
BMC Cancer, 17 (1), 83
DOI 10.1186/s12885-017-3072-4, PubMed 28137255

Holm MB, Bastani NE, Holme AM, Zucknick M, Jansson T, Refsum H, Mørkrid L, Blomhoff R, Henriksen T, Michelsen TM (2017)
Uptake and release of amino acids in the fetal-placental unit in human pregnancies
PLoS One, 12 (10), e0185760
DOI 10.1371/journal.pone.0185760, PubMed 28982184

Majak GB, Reisæter AV, Zucknick M, Lorentzen B, Vangen S, Henriksen T, Michelsen TM (2017)
Preeclampsia in kidney transplanted women; Outcomes and a simple prognostic risk score system
PLoS One, 12 (3), e0173420
DOI 10.1371/journal.pone.0173420, PubMed 28319175

Treppmann T, Ickstadt K, Zucknick M (2017)
Integration of Multiple Genomic Data Sources in a Bayesian Cox Model for Variable Selection and Prediction
Comput Math Methods Med, 2017, 7340565
DOI 10.1155/2017/7340565, PubMed 28828032

Wolf C, Garding A, Filarsky K, Bahlo J, Robrecht S, Becker N, Zucknick M, Rouhi A, Weigel A, Claus R, Weichenhan D, Eichhorst B, Fischer K, Hallek M, Kuchenbauer F, Plass C, Döhner H, Stilgenbauer S, Lichter P, Mertens D (2017)
NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib
Int J Cancer, 142 (2), 322-333
DOI 10.1002/ijc.31057, PubMed 28921505

Øystese KA, Casar-Borota O, Normann KR, Zucknick M, Berg JP, Bollerslev J (2017)
Estrogen Receptor α, a Sex-Dependent Predictor of Aggressiveness in Nonfunctioning Pituitary Adenomas: SSTR and Sex Hormone Receptor Distribution in NFPA
J Clin Endocrinol Metab, 102 (9), 3581-3590
DOI 10.1210/jc.2017-00792, PubMed 28911153

Øystese KA, Zucknick M, Casar-Borota O, Ringstad G, Bollerslev J (2017)
Early postoperative growth in non-functioning pituitary adenomas; A tool to tailor safe follow-up
Endocrine, 57 (1), 35-45
DOI 10.1007/s12020-017-1314-5, PubMed 28516382

Publications 2016

Filarsky K, Garding A, Becker N, Wolf C, Zucknick M, Claus R, Weichenhan D, Plass C, Döhner H, Stilgenbauer S, Lichter P, Mertens D (2016)
Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling
Haematologica, 101 (6), e249-53
DOI 10.3324/haematol.2015.138172, PubMed 27081174

Joshi S, Schjølberg AR, Ekstrøm PO, De Angelis PM, Zucknick M, Andersen SN, Clausen OP (2016)
Tp53/p53 status in keratoacanthomas
J Cutan Pathol, 43 (7), 571-8
DOI 10.1111/cup.12713, PubMed 27020606

Kap EJ, Seibold P, Scherer D, Habermann N, Balavarca Y, Jansen L, Zucknick M, Becker N, Hoffmeister M, Ulrich A, Benner A, Ulrich CM, Burwinkel B, Brenner H, Chang-Claude J (2016)
SNPs in transporter and metabolizing genes as predictive markers for oxaliplatin treatment in colorectal cancer patients
Int J Cancer, 138 (12), 2993-3001
DOI 10.1002/ijc.30026, PubMed 26835885

Kostareli E, Hielscher T, Zucknick M, Baboci L, Wichmann G, Holzinger D, Mücke O, Pawlita M, Del Mistro A, Boscolo-Rizzo P, Da Mosto MC, Tirelli G, Plinkert P, Dietz A, Plass C, Weichenhan D, Hess J (2016)
Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients
Epigenetics, 11 (1), 61-73
DOI 10.1080/15592294.2015.1137414, PubMed 26786582

Madhavan D, Peng C, Wallwiener M, Zucknick M, Nees J, Schott S, Rudolph A, Riethdorf S, Trumpp A, Pantel K, Sohn C, Chang-Claude J, Schneeweiss A, Burwinkel B (2016)
Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis
Carcinogenesis, 37 (5), 461-70
DOI 10.1093/carcin/bgw008, PubMed 26785733

Mock A, Geisenberger C, Orlik C, Warta R, Schwager C, Jungk C, Dutruel C, Geiselhart L, Weichenhan D, Zucknick M, Nied AK, Friauf S, Exner J, Capper D, Hartmann C, Lahrmann B, Grabe N, Debus J, von Deimling A, Popanda O, Plass C, Unterberg A, Abdollahi A, Schmezer P, Herold-Mende C (2016)
LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients
Int J Cancer, 139 (2), 424-32
DOI 10.1002/ijc.30069, PubMed 26934681

Publications 2015

Chen H, Zucknick M, Werner S, Knebel P, Brenner H (2015)
Head-to-Head Comparison and Evaluation of 92 Plasma Protein Biomarkers for Early Detection of Colorectal Cancer in a True Screening Setting
Clin Cancer Res, 21 (14), 3318-26
DOI 10.1158/1078-0432.CCR-14-3051, PubMed 26015516

Goeppert B, Frauenschuh L, Zucknick M, Roessler S, Mehrabi A, Hafezi M, Stenzinger A, Warth A, Pathil A, Renner M, Schirmacher P, Weichert W (2015)
Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract cancer
Br J Cancer, 113 (9), 1343-9
DOI 10.1038/bjc.2015.337, PubMed 26461054

Zucknick M, Saadati M, Benner A (2015)
Nonidentical twins: Comparison of frequentist and Bayesian lasso for Cox models
Biom J, 57 (6), 959-81
DOI 10.1002/bimj.201400160, PubMed 26417963

Publications 2014

Brocks D, Assenov Y, Minner S, Bogatyrova O, Simon R, Koop C, Oakes C, Zucknick M, Lipka DB, Weischenfeldt J, Feuerbach L, Cowper-Sal Lari R, Lupien M, Brors B, Korbel J, Schlomm T, Tanay A, Sauter G, Gerhäuser C, Plass C, ICGC Early Onset Prostate Cancer Project (2014)
Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer
Cell Rep, 8 (3), 798-806
DOI 10.1016/j.celrep.2014.06.053, PubMed 25066126

Claus R, Lucas DM, Ruppert AS, Williams KE, Weng D, Patterson K, Zucknick M, Oakes CC, Rassenti LZ, Greaves AW, Geyer S, Wierda WG, Brown JR, Gribben JG, Barrientos JC, Rai KR, Kay NE, Kipps TJ, Shields P, Zhao W, Grever MR, Plass C, Byrd JC (2014)
Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia
Blood, 124 (1), 42-8
DOI 10.1182/blood-2014-02-555722, PubMed 24868078

Madhavan D, Wallwiener M, Bents K, Zucknick M, Nees J, Schott S, Cuk K, Riethdorf S, Trumpp A, Pantel K, Sohn C, Schneeweiss A, Surowy H, Burwinkel B (2014)
Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis
Breast Cancer Res Treat, 146 (1), 163-74
DOI 10.1007/s10549-014-2946-2, PubMed 24838941

Poetsch AR, Lipka DB, Witte T, Claus R, Nöllke P, Zucknick M, Olk-Batz C, Fluhr S, Dworzak M, De Moerloose B, Starý J, Zecca M, Hasle H, Schmugge M, van den Heuvel-Eibrink MM, Locatelli F, Niemeyer CM, Flotho C, Plass C (2014)
RASA4 undergoes DNA hypermethylation in resistant juvenile myelomonocytic leukemia
Epigenetics, 9 (9), 1252-60
DOI 10.4161/epi.29941, PubMed 25147919

Sonnet M, Claus R, Becker N, Zucknick M, Petersen J, Lipka DB, Oakes CC, Andrulis M, Lier A, Milsom MD, Witte T, Gu L, Kim-Wanner SZ, Schirmacher P, Wulfert M, Gattermann N, Lübbert M, Rosenbauer F, Rehli M, Bullinger L, Weichenhan D, Plass C (2014)
Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia
Genome Med, 6 (4), 34
DOI 10.1186/gm551, PubMed 24944583

Yang R, Pfütze K, Zucknick M, Sutter C, Wappenschmidt B, Marme F, Qu B, Cuk K, Engel C, Schott S, Schneeweiss A, Brenner H, Claus R, Plass C, Bugert P, Hoth M, Sohn C, Schmutzler R, Bartram CR, Burwinkel B (2014)
DNA methylation array analyses identified breast cancer-associated HYAL2 methylation in peripheral blood
Int J Cancer, 136 (8), 1845-55
DOI 10.1002/ijc.29205, PubMed 25213452

Publications 2013

Cuk K, Zucknick M, Madhavan D, Schott S, Golatta M, Heil J, Marmé F, Turchinovich A, Sinn P, Sohn C, Junkermann H, Schneeweiss A, Burwinkel B (2013)
Plasma microRNA panel for minimally invasive detection of breast cancer
PLoS One, 8 (10), e76729
DOI 10.1371/journal.pone.0076729, PubMed 24194846

Garding A, Bhattacharya N, Claus R, Ruppel M, Tschuch C, Filarsky K, Idler I, Zucknick M, Caudron-Herger M, Oakes C, Fleig V, Keklikoglou I, Allegra D, Serra L, Thakurela S, Tiwari V, Weichenhan D, Benner A, Radlwimmer B, Zentgraf H, Wiemann S, Rippe K, Plass C, Döhner H, Lichter P et al. (2013)
Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB
PLoS Genet, 9 (4), e1003373
DOI 10.1371/journal.pgen.1003373, PubMed 23593011

Goeppert B, Konermann C, Schmidt CR, Bogatyrova O, Geiselhart L, Ernst C, Gu L, Becker N, Zucknick M, Mehrabi A, Hafezi M, Klauschen F, Stenzinger A, Warth A, Breuhahn K, Renner M, Weichert W, Schirmacher P, Plass C, Weichenhan D (2013)
Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway
Hepatology, 59 (2), 544-54
DOI 10.1002/hep.26721, PubMed 24002901

Lambert SR, Witt H, Hovestadt V, Zucknick M, Kool M, Pearson DM, Korshunov A, Ryzhova M, Ichimura K, Jabado N, Fontebasso AM, Lichter P, Pfister SM, Collins VP, Jones DT (2013)
Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma
Acta Neuropathol, 126 (2), 291-301
DOI 10.1007/s00401-013-1124-7, PubMed 23660940

Oakes CC, Claus R, Gu L, Assenov Y, Hüllein J, Zucknick M, Bieg M, Brocks D, Bogatyrova O, Schmidt CR, Rassenti L, Kipps TJ, Mertens D, Lichter P, Döhner H, Stilgenbauer S, Byrd JC, Zenz T, Plass C (2013)
Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia
Cancer Discov, 4 (3), 348-61
DOI 10.1158/2159-8290.CD-13-0349, PubMed 24356097

Publications 2012

Baer C, Claus R, Frenzel LP, Zucknick M, Park YJ, Gu L, Weichenhan D, Fischer M, Pallasch CP, Herpel E, Rehli M, Byrd JC, Wendtner CM, Plass C (2012)
Extensive promoter DNA hypermethylation and hypomethylation is associated with aberrant microRNA expression in chronic lymphocytic leukemia
Cancer Res, 72 (15), 3775-85
DOI 10.1158/0008-5472.CAN-12-0803, PubMed 22710432

Claus R, Lucas DM, Stilgenbauer S, Ruppert AS, Yu L, Zucknick M, Mertens D, Bühler A, Oakes CC, Larson RA, Kay NE, Jelinek DF, Kipps TJ, Rassenti LZ, Gribben JG, Döhner H, Heerema NA, Marcucci G, Plass C, Byrd JC (2012)
Quantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia
J Clin Oncol, 30 (20), 2483-91
DOI 10.1200/JCO.2011.39.3090, PubMed 22564988

Claus R, Pfeifer D, Almstedt M, Zucknick M, Hackanson B, Plass C, Lübbert M (2012)
Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
Leuk Res, 37 (2), 190-6
DOI 10.1016/j.leukres.2012.10.015, PubMed 23158571

Cuk K, Zucknick M, Heil J, Madhavan D, Schott S, Turchinovich A, Arlt D, Rath M, Sohn C, Benner A, Junkermann H, Schneeweiss A, Burwinkel B (2012)
Circulating microRNAs in plasma as early detection markers for breast cancer
Int J Cancer, 132 (7), 1602-12
DOI 10.1002/ijc.27799, PubMed 22927033

Madhavan D, Zucknick M, Wallwiener M, Cuk K, Modugno C, Scharpff M, Schott S, Heil J, Turchinovich A, Yang R, Benner A, Riethdorf S, Trumpp A, Sohn C, Pantel K, Schneeweiss A, Burwinkel B (2012)
Circulating miRNAs as surrogate markers for circulating tumor cells and prognostic markers in metastatic breast cancer
Clin Cancer Res, 18 (21), 5972-82
DOI 10.1158/1078-0432.CCR-12-1407, PubMed 22952344

Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, Pfaff E, Tönjes M, Sill M, Bender S, Kool M, Zapatka M, Becker N, Zucknick M, Hielscher T, Liu XY, Fontebasso AM, Ryzhova M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald MC et al. (2012)
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
Cancer Cell, 22 (4), 425-37
DOI 10.1016/j.ccr.2012.08.024, PubMed 23079654

Publications 2011

Claus R, Hackanson B, Poetsch AR, Zucknick M, Sonnet M, Blagitko-Dorfs N, Hiller J, Wilop S, Brümmendorf TH, Galm O, Platzbecker U, Byrd JC, Döhner K, Döhner H, Lübbert M, Plass C (2011)
Quantitative analyses of DAPK1 methylation in AML and MDS
Int J Cancer, 131 (2), E138-42
DOI 10.1002/ijc.26429, PubMed 21918973

Heckmann D, Laufs S, Maier P, Zucknick M, Giordano FA, Veldwijk MR, Eckstein V, Wenz F, Zeller WJ, Fruehauf S, Allgayer H (2011)
A Lentiviral CXCR4 overexpression and knockdown model in colorectal cancer cell lines reveals plerixafor-dependent suppression of SDF-1α-induced migration and invasion
Onkologie, 34 (10), 502-8
DOI 10.1159/000332390, PubMed 21985848

Kayser S, Zucknick M, Döhner K, Krauter J, Köhne CH, Horst HA, Held G, von Lilienfeld-Toal M, Wilhelm S, Rummel M, Germing U, Götze K, Nachbaur D, Schlegelberger B, Göhring G, Späth D, Morlok C, Teleanu V, Ganser A, Döhner H, Schlenk RF, German-Austrian AML Study Group (2011)
Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies
Blood, 119 (2), 551-8
DOI 10.1182/blood-2011-07-367508, PubMed 22096250

Olk-Batz C, Poetsch AR, Nöllke P, Claus R, Zucknick M, Sandrock I, Witte T, Strahm B, Hasle H, Zecca M, Stary J, Bergstraesser E, De Moerloose B, Trebo M, van den Heuvel-Eibrink MM, Wojcik D, Locatelli F, Plass C, Niemeyer CM, Flotho C, European Working Group of Myelodysplastic Syndromes in Childhood (EWOG-MDS) (2011)
Aberrant DNA methylation characterizes juvenile myelomonocytic leukemia with poor outcome
Blood, 117 (18), 4871-80
DOI 10.1182/blood-2010-08-298968, PubMed 21406719

Publications 2010

Benner A, Zucknick M, Hielscher T, Ittrich C, Mansmann U (2010)
High-dimensional Cox models: the choice of penalty as part of the model building process
Biom J, 52 (1), 50-69
DOI 10.1002/bimj.200900064, PubMed 20166132

Kayser S, Döhner K, Krauter J, Köhne CH, Horst HA, Held G, von Lilienfeld-Toal M, Wilhelm S, Kündgen A, Götze K, Rummel M, Nachbaur D, Schlegelberger B, Göhring G, Späth D, Morlok C, Zucknick M, Ganser A, Döhner H, Schlenk RF, German-Austrian AMLSG (2010)
The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML
Blood, 117 (7), 2137-45
DOI 10.1182/blood-2010-08-301713, PubMed 21127174

Paige AJ, Zucknick M, Janczar S, Paul J, Mein CA, Taylor KJ, Stewart M, Gourley C, Richardson S, Perren T, Ganesan TS, Smyth JF, Brown R, Gabra H (2010)
WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis
Eur J Cancer, 46 (4), 818-25
DOI 10.1016/j.ejca.2009.12.021, PubMed 20074932

Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Krönke J, Bullinger L, Späth D, Kayser S, Zucknick M, Götze K, Horst HA, Germing U, Döhner H, Döhner K (2010)
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
J Clin Oncol, 28 (22), 3636-43
DOI 10.1200/JCO.2010.28.3762, PubMed 20567020

Schröder C, Jacob A, Tonack S, Radon TP, Sill M, Zucknick M, Rüffer S, Costello E, Neoptolemos JP, Crnogorac-Jurcevic T, Bauer A, Fellenberg K, Hoheisel JD (2010)
Dual-color proteomic profiling of complex samples with a microarray of 810 cancer-related antibodies
Mol Cell Proteomics, 9 (6), 1271-80
DOI 10.1074/mcp.M900419-MCP200, PubMed 20164060

Sill M, Schröder C, Hoheisel JD, Benner A, Zucknick M (2010)
Assessment and optimisation of normalisation methods for dual-colour antibody microarrays
BMC Bioinformatics, 11, 556
DOI 10.1186/1471-2105-11-556, PubMed 21073702

Wagner K, Damm F, Göhring G, Görlich K, Heuser M, Schäfer I, Ottmann O, Lübbert M, Heit W, Kanz L, Schlimok G, Raghavachar AA, Fiedler W, Kirchner HH, Brugger W, Zucknick M, Schlegelberger B, Heil G, Ganser A, Krauter J (2010)
Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor
J Clin Oncol, 28 (14), 2356-64
DOI 10.1200/JCO.2009.27.6899, PubMed 20368538

Winkler D, Schneider C, Zucknick M, Bögelein D, Schulze K, Zenz T, Mohr J, Philippen A, Huber H, Bühler A, Habermann A, Benner A, Döhner H, Stilgenbauer S, Mertens D (2010)
Protein expression analysis of chronic lymphocytic leukemia defines the effect of genetic aberrations and uncovers a correlation of CDK4, P27 and P53 with hierarchical risk
Haematologica, 95 (11), 1880-8
DOI 10.3324/haematol.2010.025734, PubMed 20713460

Publications 2009

Giordano FA, Appelt JU, Zucknick M, Abba M, Zeller WJ, Fruehauf S, Allgayer H, Laufs S (2009)
Cold spots in hot spots: transcription start sites of active genes are spared from HIV vector integration
AIDS, 23 (18), 2535-7
DOI 10.1097/QAD.0b013e3283336432, PubMed 19841571

Publications 2008

Sharma R, Hoskins JM, Rivory LP, Zucknick M, London R, Liddle C, Clarke SJ (2008)
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients
Clin Cancer Res, 14 (3), 817-25
DOI 10.1158/1078-0432.CCR-07-0425, PubMed 18245544

Sharma R, Zucknick M, London R, Kacevska M, Liddle C, Clarke SJ (2008)
Systemic inflammatory response predicts prognosis in patients with advanced-stage colorectal cancer
Clin Colorectal Cancer, 7 (5), 331-7
DOI 10.3816/CCC.2008.n.044, PubMed 18794066

Zucknick M, Richardson S, Stronach EA (2008)
Comparing the characteristics of gene expression profiles derived by univariate and multivariate classification methods
Stat Appl Genet Mol Biol, 7 (1), Article7
DOI 10.2202/1544-6115.1307, PubMed 18312212

Publications 2004

Schwender H, Zucknick M, Ickstadt K, Bolt HM, GENICA network (2004)
A pilot study on the application of statistical classification procedures to molecular epidemiological data
Toxicol Lett, 151 (1), 291-9
DOI 10.1016/j.toxlet.2004.02.021, PubMed 15177665

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