Altered metabolism of the gut microbiome is associated with PSC

We have previously shown that patients with PSC have alterations to the composition of their gut bacteria (microbiome) but how these changes affect liver disease is still unknown.

To address this question, we studied the genetics of the gut microbiome and found that bacteria in PSC patients have signifcantly lower numbers of genes relating to vitamin B6 and branched-chain amino acid synthesis.

Vitamin B6 and branched-chain amino acids are essential nutrients and our findings suggest that changes of the gut microbiome in PSC may influence the levels of important circulating metabolites that impact disease.

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