New books on drug target discovery and validation edited by Mouldy Sioud
Mouldy Sioud
Target Discovery and Validation Reviews and Protocols" Volumes 1 and 2 - edited by Mouldy Sioud from the Department of Immunology at the Norwegian Radium Hospital- are recently published by Humana Press - a leading publisher of medical and scientific books.
The books review the most progressive and current methods for drug target discovery and validation. Also, they explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders.
From major journals, first or last author from the Institute for Cancer Research
Unal B, Saatcioglu F(2025) Targeting the unfolded protein response for cancer therapy: mitigating tumor adaptation and immune suppression Biomark Res, 13(1), 156 DOI 10.1186/s40364-025-00813-y, PubMed 41372991
Pinto R, Sjurgard IV, Pharo H, Mala T, Vedeld HM, Lind GE(2025) Molecular stratification of esophageal adenocarcinoma: implications for prognosis and treatment strategy Oncogene(in press) DOI 10.1038/s41388-025-03650-3, PubMed 41361079
Lapão A, Johnson LS, Trachsel-Moncho L, Rodgers SJ, Singh S, Ng MYW, Nakken S, Eskelinen EL, Simonsen A(2025) The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism Elife, 14 DOI 10.7554/eLife.105541, PubMed 41294009
Rey-Iborra E, Emaldi M, Madariaga M, Pulido R, Nunes-Xavier CE(2026) 3D Spheroids to Study the Impact of Immune Checkpoint Proteins in Solid Tumors Methods Mol Biol, 2959, 141-156 DOI 10.1007/978-1-0716-4734-9_10, PubMed 41028264
Emaldi M, Rey-Iborra E, Alamillo-Maeso P, Pulido R, Nunes-Xavier CE(2026) Analysis of the Functional Impact of Glycosylation on Immune Checkpoint Proteins Methods Mol Biol, 2959, 55-72 DOI 10.1007/978-1-0716-4734-9_4, PubMed 41028258
Pharo H, Brandt-Winge S, Thorkildsen EM, Vedeld HM, Lind GE(2026) DNA Methylation Analyses of Tissue Samples and Cell-Free DNA by Droplet Digital PCR Methods Mol Biol, 2969, 179-193 DOI 10.1007/978-1-0716-4767-7_12, PubMed 41073866